6XM7
| Crystal structure of DCA-S bound to Co-LSD4 from Sphingobium sp. strain SYK-6 | Descriptor: | (2E)-3-{4-hydroxy-3-[(E)-2-(4-hydroxy-3-methoxyphenyl)ethenyl]-5-methoxyphenyl}prop-2-enoic acid, COBALT (II) ION, DIMETHYL SULFOXIDE, ... | Authors: | Kuatsjah, E, Chan, A.C, Katahira, R, Beckham, G.T, Murphy, M.E, Eltis, L.D. | Deposit date: | 2020-06-29 | Release date: | 2021-05-12 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | Structural and functional analysis of lignostilbene dioxygenases from Sphingobium sp. SYK-6. J.Biol.Chem., 296, 2021
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6XM6
| Crystal structure of cobalt-bound LSD4 from Sphingobium sp. strain SYK-6 | Descriptor: | COBALT (II) ION, Dioxygenase | Authors: | Kuatsjah, E, Chan, A.C, Katahira, R, Beckham, G.T, Murphy, M.E, Eltis, L.D. | Deposit date: | 2020-06-29 | Release date: | 2021-05-12 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | Structural and functional analysis of lignostilbene dioxygenases from Sphingobium sp. SYK-6. J.Biol.Chem., 296, 2021
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6XMA
| Crystal structure of iron-bound LSD4 from Sphingobium sp. strain SYK-6 | Descriptor: | Dioxygenase, FE (III) ION, SULFATE ION | Authors: | Kuatsjah, E, Chan, A.C, Katahira, R, Beckham, G.T, Murphy, M.E, Eltis, L.D. | Deposit date: | 2020-06-29 | Release date: | 2021-05-12 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | Structural and functional analysis of lignostilbene dioxygenases from Sphingobium sp. SYK-6. J.Biol.Chem., 296, 2021
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5J53
| The Structure and Mechanism of NOV1, a Resveratrol-Cleaving Dioxygenase | Descriptor: | Carotenoid oxygenase, FE (III) ION, OXYGEN MOLECULE, ... | Authors: | McAndrew, R.P, Pereira, J.H, Sathitsuksanoh, N, Sale, K.L, Simmons, B.A, Adams, P.D. | Deposit date: | 2016-04-01 | Release date: | 2016-11-30 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.61 Å) | Cite: | Structure and mechanism of NOV1, a resveratrol-cleaving dioxygenase. Proc. Natl. Acad. Sci. U.S.A., 113, 2016
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6XM9
| Crystal structure of vanillin bound to Co-LSD4 from Sphingobium sp. strain SYK-6 | Descriptor: | 4-hydroxy-3-methoxybenzaldehyde, ACETATE ION, COBALT (II) ION, ... | Authors: | Kuatsjah, E, Chan, A.C, Katahira, R, Beckham, G.T, Murphy, M.E, Eltis, L.D. | Deposit date: | 2020-06-29 | Release date: | 2021-05-12 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.651 Å) | Cite: | Structural and functional analysis of lignostilbene dioxygenases from Sphingobium sp. SYK-6. J.Biol.Chem., 296, 2021
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5J55
| The Structure and Mechanism of NOV1, a Resveratrol-Cleaving Dioxygenase | Descriptor: | 4-hydroxy-3-methoxybenzaldehyde, Carotenoid oxygenase, FE (III) ION, ... | Authors: | McAndrew, R.P, Pereira, J.H, Sathitsuksanoh, N, Sale, K.L, Simmons, B.A, Adams, P.D. | Deposit date: | 2016-04-01 | Release date: | 2016-11-30 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Structure and mechanism of NOV1, a resveratrol-cleaving dioxygenase. Proc. Natl. Acad. Sci. U.S.A., 113, 2016
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7WH0
| structure of C elegans BCMO-1 | Descriptor: | Beta-Carotene 15,15'-MonoOxygenase, FE (III) ION, GLYCEROL, ... | Authors: | Pan, W, Liu, L. | Deposit date: | 2021-12-29 | Release date: | 2022-02-02 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structural and Functional Analysis of Nonheme Iron Enzymes BCMO-1 and BCMO-2 from Caenorhabditis elegans . Front Mol Biosci, 9, 2022
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4RSC
| Crystal structure of RPE65 in complex with emixustat and palmitate | Descriptor: | (1R)-3-amino-1-[3-(cyclohexylmethoxy)phenyl]propan-1-ol, FE (II) ION, PALMITIC ACID, ... | Authors: | Kiser, P.D, Shi, W, Palczewski, K. | Deposit date: | 2014-11-07 | Release date: | 2015-04-15 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Catalytic mechanism of a retinoid isomerase essential for vertebrate vision. Nat.Chem.Biol., 11, 2015
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6XM8
| Crystal structure of lignostilbene bound to Co-LSD4 from Sphingobium sp. strain SYK-6 | Descriptor: | COBALT (II) ION, DIMETHYL SULFOXIDE, Dioxygenase, ... | Authors: | Kuatsjah, E, Chan, A.C, Katahira, R, Beckham, G.T, Murphy, M.E, Eltis, L.D. | Deposit date: | 2020-06-29 | Release date: | 2021-05-12 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Structural and functional analysis of lignostilbene dioxygenases from Sphingobium sp. SYK-6. J.Biol.Chem., 296, 2021
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5U97
| Crystal structure of Co-CAO1 in complex with piceatannol | Descriptor: | BENZOIC ACID, COBALT (II) ION, Carotenoid oxygenase 1, ... | Authors: | Sui, X, Palczewski, K, Banerjee, S, Kiser, P.D. | Deposit date: | 2016-12-15 | Release date: | 2017-05-31 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Structure and Spectroscopy of Alkene-Cleaving Dioxygenases Containing an Atypically Coordinated Non-Heme Iron Center. Biochemistry, 56, 2017
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5J54
| The Structure and Mechanism of NOV1, a Resveratrol-Cleaving Dioxygenase | Descriptor: | Carotenoid oxygenase, FE (III) ION, OXYGEN MOLECULE, ... | Authors: | McAndrew, R.P, Pereira, J.H, Sathitsuksanoh, N, Sale, K.L, Simmons, B.A, Adams, P.D. | Deposit date: | 2016-04-01 | Release date: | 2016-11-30 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.89 Å) | Cite: | Structure and mechanism of NOV1, a resveratrol-cleaving dioxygenase. Proc. Natl. Acad. Sci. U.S.A., 113, 2016
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7WH1
| structure of C elegans BCMO-2 | Descriptor: | Beta-Carotene 15,15'-MonoOxygenase, FE (III) ION, GLYCEROL, ... | Authors: | Pan, W, Liu, L. | Deposit date: | 2021-12-29 | Release date: | 2022-02-02 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural and Functional Analysis of Nonheme Iron Enzymes BCMO-1 and BCMO-2 from Caenorhabditis elegans . Front Mol Biosci, 9, 2022
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7T8P
| CRYSTAL STRUCTURE OF T151V CAO1 | Descriptor: | CHLORIDE ION, Carotenoid oxygenase 1, FE (II) ION | Authors: | Daruwalla, A, Kiser, P.D. | Deposit date: | 2021-12-16 | Release date: | 2023-07-05 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | CRYSTAL STRUCTURE OF T151V CAO1 To Be Published
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5U8Z
| Structure of Fe-CAO1 in complex with beta-fluororesveratrol | Descriptor: | 5-[(Z)-2-fluoro-2-(4-hydroxyphenyl)ethenyl]benzene-1,3-diol, CHLORIDE ION, Carotenoid oxygenase 1, ... | Authors: | Sui, X, Palczewski, K, Kiser, P.D. | Deposit date: | 2016-12-15 | Release date: | 2017-05-31 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structure and Spectroscopy of Alkene-Cleaving Dioxygenases Containing an Atypically Coordinated Non-Heme Iron Center. Biochemistry, 56, 2017
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5U90
| Crystal structure of Co-CAO1 in complex with resveratrol | Descriptor: | COBALT (II) ION, Carotenoid oxygenase 1, DIMETHYL SULFOXIDE, ... | Authors: | Sui, X, Palczewski, k, Banerjee, S, Kiser, P.D. | Deposit date: | 2016-12-15 | Release date: | 2017-05-31 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structure and Spectroscopy of Alkene-Cleaving Dioxygenases Containing an Atypically Coordinated Non-Heme Iron Center. Biochemistry, 56, 2017
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5V2D
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7L0E
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3KVC
| Crystal structure of bovine RPE65 at 1.9 angstrom resolution | Descriptor: | FE (II) ION, Retinoid isomerohydrolase | Authors: | Kiser, P.D, Lodowski, D.T, Golczak, M, Palczewski, K. | Deposit date: | 2009-11-29 | Release date: | 2010-02-02 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Importance of membrane structural integrity for RPE65 retinoid isomerization activity. J.Biol.Chem., 285, 2010
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8FTY
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7K8G
| Crystal structure of bovine RPE65 in complex with 4-fluoro-MB-004 and palmitate | Descriptor: | (1R)-3-amino-1-{4-fluoro-3-[(2-propylpentyl)oxy]phenyl}propan-1-ol, FE (II) ION, PALMITIC ACID, ... | Authors: | Kiser, P.D. | Deposit date: | 2020-09-27 | Release date: | 2021-06-02 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Rational Alteration of Pharmacokinetics of Chiral Fluorinated and Deuterated Derivatives of Emixustat for Retinal Therapy. J.Med.Chem., 64, 2021
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6N20
| Structure of L509V CAO1 - growth condition 2 | Descriptor: | CHLORIDE ION, Carotenoid oxygenase, FE (II) ION | Authors: | Khadka, N, Shi, W, Kiser, P.D. | Deposit date: | 2018-11-12 | Release date: | 2019-06-05 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Evidence for distinct rate-limiting steps in the cleavage of alkenes by carotenoid cleavage dioxygenases. J.Biol.Chem., 294, 2019
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4RYX
| Crystal structure of RPE65 in complex with emixustat and palmitate, P6522 crystal form | Descriptor: | (1R)-3-amino-1-[3-(cyclohexylmethoxy)phenyl]propan-1-ol, (4S)-2-METHYL-2,4-PENTANEDIOL, FE (II) ION, ... | Authors: | Kiser, P.D, Palczewski, K. | Deposit date: | 2014-12-17 | Release date: | 2015-05-27 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Molecular pharmacodynamics of emixustat in protection against retinal degeneration. J.Clin.Invest., 125, 2015
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4OU9
| Crystal structure of apocarotenoid oxygenase in the presence of Triton X-100 | Descriptor: | Apocarotenoid-15,15'-oxygenase, CHLORIDE ION, FE (II) ION | Authors: | Sui, X, Palczewski, K, Kiser, P.D. | Deposit date: | 2014-02-15 | Release date: | 2014-03-19 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Analysis of Carotenoid Isomerase Activity in a Prototypical Carotenoid Cleavage Enzyme, Apocarotenoid Oxygenase (ACO). J.Biol.Chem., 289, 2014
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6N21
| Structure of wild-type CAO1 | Descriptor: | CHLORIDE ION, Carotenoid oxygenase, FE (II) ION | Authors: | Khadka, N, Kiser, P.D. | Deposit date: | 2018-11-12 | Release date: | 2019-06-05 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.04 Å) | Cite: | Evidence for distinct rate-limiting steps in the cleavage of alkenes by carotenoid cleavage dioxygenases. J.Biol.Chem., 294, 2019
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4ZHK
| Crystal structure of RPE65 in complex with MB-002 | Descriptor: | (1R)-1-[3-(cyclohexylmethoxy)phenyl]propane-1,3-diol, (1S)-1-[3-(cyclohexylmethoxy)phenyl]propane-1,3-diol, FE (II) ION, ... | Authors: | Kiser, P.D, Palczewski, K. | Deposit date: | 2015-04-25 | Release date: | 2015-05-27 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.09 Å) | Cite: | Molecular pharmacodynamics of emixustat in protection against retinal degeneration. J.Clin.Invest., 125, 2015
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