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1B3U
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CRYSTAL STRUCTURE OF CONSTANT REGULATORY DOMAIN OF HUMAN PP2A, PR65ALPHA
Descriptor: PROTEIN (PROTEIN PHOSPHATASE PP2A)
Authors:Groves, M.R, Hanlon, N, Turowski, P, Hemmings, B, Barford, D.
Deposit date:1998-12-14
Release date:1999-04-12
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The structure of the protein phosphatase 2A PR65/A subunit reveals the conformation of its 15 tandemly repeated HEAT motifs.
Cell(Cambridge,Mass.), 96, 1999
1QBK
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BU of 1qbk by Molmil
STRUCTURE OF THE KARYOPHERIN BETA2-RAN GPPNHP NUCLEAR TRANSPORT COMPLEX
Descriptor: KARYOPHERIN BETA2, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ...
Authors:Chook, Y.M, Blobel, G.
Deposit date:1999-04-23
Release date:1999-06-01
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structure of the nuclear transport complex karyopherin-beta2-Ran x GppNHp.
Nature, 399, 1999
2BKU
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BU of 2bku by Molmil
Kap95p:RanGTP complex
Descriptor: GTP-BINDING NUCLEAR PROTEIN RAN, GUANOSINE-5'-TRIPHOSPHATE, IMPORTIN BETA-1 SUBUNIT, ...
Authors:Lee, S.J, Matsuura, Y, Liu, S.M, Stewart, M.
Deposit date:2005-02-21
Release date:2005-05-04
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural Basis for Nuclear Import Complex Dissociation by Rangtp
Nature, 435, 2005
2DB0
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Crystal structure of PH0542
Descriptor: 253aa long hypothetical protein
Authors:Nishino, A, Handa, N, Kishishita, S, Murayama, K, Shirouzu, M, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2005-12-14
Release date:2006-06-14
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of PH0542
To be Published
2H4M
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Karyopherin Beta2/Transportin-M9NLS
Descriptor: Heterogeneous nuclear ribonucleoprotein A1, Transportin-1
Authors:Chook, Y.M, Cansizoglu, A.E.
Deposit date:2006-05-24
Release date:2006-10-24
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (3.05 Å)
Cite:Rules for nuclear localization sequence recognition by karyopherin beta 2.
Cell(Cambridge,Mass.), 126, 2006
2IE3
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Structure of the Protein Phosphatase 2A Core Enzyme Bound to Tumor-inducing Toxins
Descriptor: MANGANESE (II) ION, Protein Phosphatase 2, regulatory subunit A (PR 65), ...
Authors:Xing, Y, Xu, Y, Chen, Y, Jeffrey, P.D, Chao, Y, Shi, Y.
Deposit date:2006-09-17
Release date:2006-11-07
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure of Protein Phosphatase 2A Core Enzyme Bound to Tumor-Inducing Toxins
Cell(Cambridge,Mass.), 127, 2006
2IE4
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Structure of the Protein Phosphatase 2A Core Enzyme Bound to okadaic acid
Descriptor: MANGANESE (II) ION, OKADAIC ACID, Protein Phosphatase 2, ...
Authors:Xing, Y, Xu, Y, Chen, Y, Jeffrey, P.D, Chao, Y, Shi, Y.
Deposit date:2006-09-17
Release date:2006-11-07
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure of Protein Phosphatase 2A Core Enzyme Bound to Tumor-Inducing Toxins
Cell(Cambridge,Mass.), 127, 2006
2NPP
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Structure of the Protein Phosphatase 2A Holoenzyme
Descriptor: MANGANESE (II) ION, Protein Phosphatase 2, regulatory subunit A (PR 65), ...
Authors:Xu, Y, Chen, Y, Xing, Y, Chao, Y, Shi, Y.
Deposit date:2006-10-28
Release date:2006-12-12
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Structure of the protein phosphatase 2A holoenzyme
Cell(Cambridge,Mass.), 127, 2006
2NYL
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Crystal structure of Protein Phosphatase 2A (PP2A) holoenzyme with the catalytic subunit carboxyl terminus truncated
Descriptor: MANGANESE (II) ION, Protein phosphatase 2, regulatory subunit A (PR 65), ...
Authors:Xing, Y, Xu, Y, Chen, Y, Chao, Y, Lin, Z, Shi, Y.
Deposit date:2006-11-20
Release date:2006-12-12
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (3.8 Å)
Cite:Structure of the Protein Phosphatase 2A Holoenzyme.
Cell(Cambridge,Mass.), 127, 2006
2NYM
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Crystal Structure of Protein Phosphatase 2A (PP2A) with C-terminus truncated catalytic subunit
Descriptor: MANGANESE (II) ION, Protein phosphatase 2, Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform, ...
Authors:Chen, Y, Xing, Y, Xu, Y, Chao, Y, Lin, Z, Jeffrey, P.D, Shi, Y.
Deposit date:2006-11-21
Release date:2006-12-12
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:Structure of the Protein Phosphatase 2A Holoenzyme.
Cell(Cambridge,Mass.), 127, 2006
2IAE
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BU of 2iae by Molmil
Crystal structure of a protein phosphatase 2A (PP2A) holoenzyme.
Descriptor: MANGANESE (II) ION, Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform, Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform, ...
Authors:Cho, U.S, Xu, W.
Deposit date:2006-09-07
Release date:2006-12-26
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Crystal structure of a protein phosphatase 2A heterotrimeric holoenzyme.
Nature, 445, 2007
2OT8
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BU of 2ot8 by Molmil
Karyopherin Beta2/Transportin-hnRNPM NLS Complex
Descriptor: Heterogeneous nuclear ribonucleoprotein M, Transportin-1
Authors:Cansizoglu, A.E, Chook, Y.M.
Deposit date:2007-02-07
Release date:2007-04-10
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structure-based design of a pathway-specific nuclear import inhibitor.
Nat.Struct.Mol.Biol., 14, 2007
2PKG
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BU of 2pkg by Molmil
Structure of a complex between the A subunit of protein phosphatase 2A and the small t antigen of SV40
Descriptor: Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform, Small T antigen, ZINC ION
Authors:Jeffrey, P.D, Shi, Y.
Deposit date:2007-04-17
Release date:2007-05-15
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Structural and biochemical insights into the regulation of protein phosphatase 2A by small t antigen of SV40.
Nat.Struct.Mol.Biol., 14, 2007
2PF4
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BU of 2pf4 by Molmil
Crystal structure of the full-length simian virus 40 small t antigen complexed with the protein phosphatase 2A Aalpha subunit
Descriptor: Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform, Small T antigen, ZINC ION
Authors:Cho, U, Morrone, S, Xu, W.
Deposit date:2007-04-03
Release date:2007-08-07
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structural basis of PP2A inhibition by small t antigen.
Plos Biol., 5, 2007
2Z5N
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BU of 2z5n by Molmil
Complex of Transportin 1 with hnRNP D NLS
Descriptor: Heterogeneous nuclear ribonucleoprotein D0, Transportin-1
Authors:Imasaki, T, Shimizu, T, Hashimoto, H, Hidaka, Y, Kose, S, Imamoto, N, Yamada, M, Sato, M.
Deposit date:2007-07-14
Release date:2007-10-23
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structural basis for substrate recognition and dissociation by human transportin 1
Mol.Cell, 28, 2007
2Z5J
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BU of 2z5j by Molmil
Free Transportin 1
Descriptor: Transportin-1
Authors:Imasaki, T, Shimizu, T, Hashimoto, H, Hidaka, Y, Yamada, M, Sato, M.
Deposit date:2007-07-13
Release date:2007-10-23
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Structural basis for substrate recognition and dissociation by human transportin 1
Mol.Cell, 28, 2007
2Z5O
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BU of 2z5o by Molmil
Complex of Transportin 1 with JKTBP NLS
Descriptor: Heterogeneous nuclear ribonucleoprotein D-like, Transportin-1
Authors:Imasaki, T, Shimizu, T, Hashimoto, H, Hidaka, Y, Kose, S, Imamoto, N, Yamada, M, Sato, M.
Deposit date:2007-07-14
Release date:2007-10-23
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structural basis for substrate recognition and dissociation by human transportin 1
Mol.Cell, 28, 2007
2Z5K
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BU of 2z5k by Molmil
Complex of Transportin 1 with TAP NLS
Descriptor: Nuclear RNA export factor 1, PHOSPHATE ION, Transportin-1
Authors:Imasaki, T, Shimizu, T, Hashimoto, H, Hidaka, Y, Yamada, M, Kose, S, Imamoto, N, Sato, M.
Deposit date:2007-07-14
Release date:2007-10-23
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural basis for substrate recognition and dissociation by human transportin 1
Mol.Cell, 28, 2007
2Z5M
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BU of 2z5m by Molmil
Complex of Transportin 1 with TAP NLS, crystal form 2
Descriptor: Nuclear RNA export factor 1, Transportin-1
Authors:Imasaki, T, Shimizu, T, Hashimoto, H, Hidaka, Y, Kose, S, Imamoto, N, Yamada, M, Sato, M.
Deposit date:2007-07-14
Release date:2007-10-23
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural basis for substrate recognition and dissociation by human transportin 1
Mol.Cell, 28, 2007
2QMR
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BU of 2qmr by Molmil
Karyopherin beta2/transportin
Descriptor: Transportin-1
Authors:Cansizoglu, A.E, Chook, Y.M.
Deposit date:2007-07-16
Release date:2007-10-30
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (3 Å)
Cite:Conformational heterogeneity of karyopherin beta2 is segmental
Structure, 15, 2007
3C5W
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BU of 3c5w by Molmil
Complex between PP2A-specific methylesterase PME-1 and PP2A core enzyme
Descriptor: PP2A A subunit, PP2A C subunit, PP2A-specific methylesterase PME-1
Authors:Xing, Y, Li, Z, Chen, Y, Stock, J, Jeffrey, P.D, Shi, Y.
Deposit date:2008-02-01
Release date:2008-04-15
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural mechanism of demethylation and inactivation of protein phosphatase 2A.
Cell(Cambridge,Mass.), 133, 2008
3DW8
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BU of 3dw8 by Molmil
Structure of a Protein Phosphatase 2A Holoenzyme with B55 subunit
Descriptor: MANGANESE (II) ION, Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform, Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform, ...
Authors:Xu, Y, Chen, Y, Zhang, P, Jeffrey, P.D, Shi, Y.
Deposit date:2008-07-21
Release date:2008-10-07
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Structure of a protein phosphatase 2A holoenzyme: insights into B55-mediated Tau dephosphorylation.
Mol.Cell, 31, 2008
3EA5
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BU of 3ea5 by Molmil
Kap95p Binding Induces the Switch Loops of RanGDP to adopt the GTP-bound Conformation: Implications for Nuclear Import Complex Assembly Dynamics
Descriptor: GTP-binding nuclear protein Ran, GUANOSINE-5'-DIPHOSPHATE, Importin subunit beta-1, ...
Authors:Forwood, J.K, Lonhienne, J.K, Guncar, G, Stewart, M, Marfori, M, Kobe, B.
Deposit date:2008-08-24
Release date:2008-10-21
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Kap95p binding induces the switch loops of RanGDP to adopt the GTP-bound conformation: implications for nuclear import complex assembly dynamics.
J.Mol.Biol., 383, 2008
3FGA
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BU of 3fga by Molmil
Structural Basis of PP2A and Sgo interaction
Descriptor: MANGANESE (II) ION, MICROCYSTIN-LR, Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform, ...
Authors:Xu, Z, Xu, W.
Deposit date:2008-12-05
Release date:2009-09-22
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structure and function of the PP2A-shugoshin interaction
Mol.Cell, 35, 2009
3K7W
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Protein phosphatase 2A core complex bound to dinophysistoxin-2
Descriptor: (2R)-2-hydroxy-3-[(2S,5R,6R,8S)-5-hydroxy-8-{(1R,2E)-3-[(2R,4a'R,5R,6'S,8'R,8a'S)-8'-hydroxy-6'-{(1S,3S)-1-hydroxy-3-[( 2S,6R,11S)-11-methyl-1,7-dioxaspiro[5.5]undec-2-yl]butyl}-7'-methylideneoctahydro-3H,3'H-spiro[furan-2,2'-pyrano[3,2-b]p yran]-5-yl]-1-methylprop-2-en-1-yl}-10-methyl-1,7-dioxaspiro[5.5]undec-10-en-2-yl]-2-methylpropanoic acid, MANGANESE (II) ION, SULFATE ION, ...
Authors:Jeffrey, P.D, Huhn, J, Shi, Y.
Deposit date:2009-10-13
Release date:2009-11-03
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.96 Å)
Cite:A structural basis for the reduced toxicity of dinophysistoxin-2.
Chem.Res.Toxicol., 22, 2009

 

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