Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

6ALE
DownloadVisualize
BU of 6ale by Molmil
A V-to-F substitution in SK2 channels causes Ca2+ hypersensitivity and improves locomotion in a C. elegans ALS model
Descriptor: (3E)-6,7-dichloro-3-(hydroxyimino)-1,3-dihydro-2H-indol-2-one, CALCIUM ION, Calmodulin-2, ...
Authors:Nam, Y.W, Zhang, M.
Deposit date:2017-08-07
Release date:2018-08-08
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:A V-to-F substitution in SK2 channels causes Ca2+hypersensitivity and improves locomotion in a C. elegans ALS model.
Sci Rep, 8, 2018
6CZQ
DownloadVisualize
BU of 6czq by Molmil
A V-to-F substitution in SK2 channels causes Ca2+ hypersensitivity and improves locomotion in a C. elegans ALS model
Descriptor: CALCIUM ION, Calmodulin-1, SULFATE ION, ...
Authors:Nam, Y.W, Zhang, M.
Deposit date:2018-04-09
Release date:2018-08-01
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:A V-to-F substitution in SK2 channels causes Ca2+hypersensitivity and improves locomotion in a C. elegans ALS model.
Sci Rep, 8, 2018
6CNN
DownloadVisualize
BU of 6cnn by Molmil
Cryo-EM structure of the human SK4/calmodulin channel complex in the Ca2+ bound state I
Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, CALCIUM ION, Calmodulin-1, ...
Authors:Lee, C.H, MacKinnon, R.
Deposit date:2018-03-08
Release date:2018-05-02
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Activation mechanism of a human SK-calmodulin channel complex elucidated by cryo-EM structures.
Science, 360, 2018
6CNO
DownloadVisualize
BU of 6cno by Molmil
Cryo-EM structure of the human SK4/calmodulin channel complex in the Ca2+ bound state II
Descriptor: CALCIUM ION, Calmodulin-1, Intermediate conductance calcium-activated potassium channel protein 4
Authors:Lee, C.H, MacKinnon, R.
Deposit date:2018-03-08
Release date:2018-05-02
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (4.7 Å)
Cite:Activation mechanism of a human SK-calmodulin channel complex elucidated by cryo-EM structures.
Science, 360, 2018
6CNM
DownloadVisualize
BU of 6cnm by Molmil
Cryo-EM structure of the human SK4/calmodulin channel complex
Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, Calmodulin-1, DODECYL-BETA-D-MALTOSIDE, ...
Authors:Lee, C.H, MacKinnon, R.
Deposit date:2018-03-08
Release date:2018-05-02
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Activation mechanism of a human SK-calmodulin channel complex elucidated by cryo-EM structures.
Science, 360, 2018
5V03
DownloadVisualize
BU of 5v03 by Molmil
A positive allosteric modulator binding pocket in SK2 ion channels is shared by Riluzole and CyPPA
Descriptor: CALCIUM ION, Calmodulin, N-(4-chlorophenyl)-2-(3,5-dimethyl-1H-pyrazol-1-yl)pyrimidin-4-amine, ...
Authors:Liu, S.
Deposit date:2017-02-28
Release date:2018-03-07
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.58 Å)
Cite:An Intracellular Allosteric Modulator Binding Pocket in SK2 Ion Channels Is Shared by Multiple Chemotypes.
Structure, 26, 2018
5V02
DownloadVisualize
BU of 5v02 by Molmil
A positive allosteric modulator binding pocket in SK2 ion channels is shared by Riluzole and CyPPA
Descriptor: 6-(trifluoromethoxy)-1,3-benzothiazol-2-amine, CALCIUM ION, Calmodulin-1, ...
Authors:Liu, S.
Deposit date:2017-02-28
Release date:2018-03-07
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:An Intracellular Allosteric Modulator Binding Pocket in SK2 Ion Channels Is Shared by Multiple Chemotypes.
Structure, 26, 2018
5WBX
DownloadVisualize
BU of 5wbx by Molmil
Structural insights into the potency of SK/IK channel positive modulators
Descriptor: (3Z)-6-bromo-3-(hydroxyimino)-5-methyl-1,3-dihydro-2H-indol-2-one, CALCIUM ION, Calmodulin-1, ...
Authors:Nam, Y.W, Zhang, M.
Deposit date:2017-06-29
Release date:2017-12-20
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural insights into the potency of SK channel positive modulators.
Sci Rep, 7, 2017
5WC5
DownloadVisualize
BU of 5wc5 by Molmil
Structural insights into the potency of SK/IK channel positive modulators
Descriptor: 7-fluoro-3-(hydroxyamino)-2H-indol-2-one, CALCIUM ION, Calmodulin-1, ...
Authors:Nam, Y.W, Zhang, M.
Deposit date:2017-06-29
Release date:2017-12-20
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural insights into the potency of SK channel positive modulators.
Sci Rep, 7, 2017
4QNH
DownloadVisualize
BU of 4qnh by Molmil
Calcium-calmodulin (T79D) complexed with the calmodulin binding domain from a small conductance potassium channel SK2-a
Descriptor: CALCIUM ION, Calmodulin, SULFATE ION, ...
Authors:Zhang, M, Pascal, J.M, Logothetis, D.E, Zhang, J.F.
Deposit date:2014-06-17
Release date:2014-08-06
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:Selective phosphorylation modulates the PIP2 sensitivity of the CaM-SK channel complex.
Nat.Chem.Biol., 10, 2014
4J9Z
DownloadVisualize
BU of 4j9z by Molmil
Calcium-calmodulin complexed with the calmodulin binding domain from a small conductance potassium channel splice variant and NS309
Descriptor: (3E)-6,7-dichloro-3-(hydroxyimino)-1,3-dihydro-2H-indol-2-one, CALCIUM ION, Calmodulin, ...
Authors:Zhang, M, Pascal, J.M, Zhang, J.-F.
Deposit date:2013-02-17
Release date:2013-03-27
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.66 Å)
Cite:Unstructured to structured transition of an intrinsically disordered protein peptide in coupling Ca2+-sensing and SK channel activation.
Proc.Natl.Acad.Sci.USA, 110, 2013
4J9Y
DownloadVisualize
BU of 4j9y by Molmil
Calcium-calmodulin complexed with the calmodulin binding domain from a small conductance potassium channel splice variant
Descriptor: CALCIUM ION, Calmodulin, GLYCEROL, ...
Authors:Zhang, M, Pascal, J.M, Zhang, J.-F.
Deposit date:2013-02-17
Release date:2013-03-27
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.51 Å)
Cite:Unstructured to structured transition of an intrinsically disordered protein peptide in coupling Ca2+-sensing and SK channel activation.
Proc.Natl.Acad.Sci.USA, 110, 2013
4G28
DownloadVisualize
BU of 4g28 by Molmil
Calcium-calmodulin complexed with the calmodulin binding domain from a small conductance potassium channel splice variant and EBIO-1
Descriptor: 1-ethyl-1,3-dihydro-2H-benzimidazol-2-one, CALCIUM ION, Calmodulin, ...
Authors:Zhang, M, Pascal, J.M, Zhang, J.-F.
Deposit date:2012-07-11
Release date:2012-09-12
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.63 Å)
Cite:Identification of the functional binding pocket for compounds targeting small-conductance Ca(2+)-activated potassium channels.
Nat Commun, 3, 2012
4G27
DownloadVisualize
BU of 4g27 by Molmil
Calcium-calmodulin complexed with the calmodulin binding domain from a small conductance potassium channel splice variant and phenylurea
Descriptor: 1-phenylurea, CALCIUM ION, Calmodulin, ...
Authors:Zhang, M, Pascal, J.M, Zhang, J.-F.
Deposit date:2012-07-11
Release date:2012-09-12
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Identification of the functional binding pocket for compounds targeting small-conductance Ca(2+)-activated potassium channels.
Nat Commun, 3, 2012
3SJQ
DownloadVisualize
BU of 3sjq by Molmil
Crystal structure of a small conductance potassium channel splice variant complexed with calcium-calmodulin
Descriptor: 1-phenylurea, CALCIUM ION, Calmodulin, ...
Authors:Zhang, M, Pascal, J.M, Zhang, J.-F.
Deposit date:2011-06-21
Release date:2012-05-30
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural basis for calmodulin as a dynamic calcium sensor.
Structure, 20, 2012
1QX7
DownloadVisualize
BU of 1qx7 by Molmil
Crystal structure of apoCaM bound to the gating domain of small conductance Ca2+-activated potassium channel
Descriptor: Calmodulin, Small conductance calcium-activated potassium channel protein 2
Authors:Schumacher, M.A, Crum, M, Miller, M.C.
Deposit date:2003-09-04
Release date:2004-08-31
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (3.09 Å)
Cite:Crystal structures of apocalmodulin and an apocalmodulin/SK potassium channel gating domain complex.
STRUCTURE, 12, 2004
1KKD
DownloadVisualize
BU of 1kkd by Molmil
Solution structure of the calmodulin binding domain (CaMBD) of small conductance Ca2+-activated potassium channels (SK2)
Descriptor: Small conductance calcium-activated potassium channel protein 2
Authors:Wissmann, R, Bildl, W, Neumann, H, Rivard, A.F, Kloecker, N, Weitz, D, Schulte, U, Adelman, J.P, Bentrop, D, Fakler, B.
Deposit date:2001-12-07
Release date:2001-12-14
Last modified:2022-02-23
Method:SOLUTION NMR
Cite:A helical region in the C terminus of small-conductance Ca2+-activated K+ channels controls assembly with apo-calmodulin.
J.Biol.Chem., 277, 2002
1G4Y
DownloadVisualize
BU of 1g4y by Molmil
1.60 A CRYSTAL STRUCTURE OF THE GATING DOMAIN FROM SMALL CONDUCTANCE POTASSIUM CHANNEL COMPLEXED WITH CALCIUM-CALMODULIN
Descriptor: CALCIUM ION, CALCIUM-ACTIVATED POTASSIUM CHANNEL RSK2, CALMODULIN, ...
Authors:Schumacher, M.A, Rivard, A, Bachinger, H.P, Adelman, J.P.
Deposit date:2001-01-07
Release date:2001-05-09
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structure of the gating domain of a Ca2+-activated K+ channel complexed with Ca2+/calmodulin.
Nature, 410, 2001

217705

PDB entries from 2024-03-27

PDB statisticsPDBj update infoContact PDBjnumon