5CZK
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STRUCTURE OF E. COLI BETA-GLUCURONIDASE BOUND WITH A NOVEL, POTENT INHIBITOR 1-((6,8-DIMETHYL-2-OXO-1,2-DIHYDROQUINOLIN-3-YL)METHYL)-1-(2-HYDROXYETHYL)-3-(4-HYDROXYPHENYL)THIOUREA
Descriptor:Beta-glucuronidase (E.C.3.2.1.31)
Authors:Roberts, A.R., Wallace, B.R., Redinbo, M.R.
Deposit date:2015-07-31
Release date:2015-10-14
Method:X-RAY DIFFRACTION (2.39 Å)
Cite:Structure and Inhibition of Microbiome beta-Glucuronidases Essential to the Alleviation of Cancer Drug Toxicity.
Chem.Biol., 22, 2015
5A1A
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2.2 A RESOLUTION CRYO-EM STRUCTURE OF BETA-GALACTOSIDASE IN COMPLEX WITH A CELL-PERMEANT INHIBITOR
Descriptor:BETA-GALACTOSIDASE (E.C.3.2.1.23)
Authors:Bartesaghi, A., Merk, A., Banerjee, S., Matthies, D., Wu, X., Milne, J., Subramaniam, S.
Deposit date:2015-04-29
Release date:2015-05-06
Modification date:2015-06-24
Method:ELECTRON MICROSCOPY (2.2 Å)
Cite:2.2 A Resolution Cryo-Em Structure of Beta-Galactosidase in Complex with a Cell-Permeant Inhibitor
Science, 348, 2015
4V45
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E. COLI (LACZ) BETA-GALACTOSIDASE-TRAPPED 2-F-GALACTOSYL-ENZYME INTERMEDIATE
Descriptor:Beta-Galactosidase (E.C.3.2.1.23)
Authors:Juers, D.H., McCarter, J.D., Withers, S.G., Matthews, B.W.
Deposit date:2001-09-13
Release date:2014-07-09
Modification date:2014-12-10
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:A Structural View of the Action of Escherichia Coli (Lacz) Beta-Galactosidase
Biochemistry, 40, 2001
4V44
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E. COLI (LACZ) BETA-GALACTOSIDASE IN COMPLEX WITH 2-F-LACTOSE
Descriptor:Beta-Galactosidase (E.C.3.2.1.23)
Authors:Juers, D.H., McCarter, J.D., Withers, S.G., Matthews, B.W.
Deposit date:2001-09-13
Release date:2014-07-09
Modification date:2014-12-10
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:A Structural View of the Action of Escherichia Coli (Lacz) Beta-Galactosidase
Biochemistry, 40, 2001
4V41
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E. COLI (LAC Z) BETA-GALACTOSIDASE (NCS CONSTRAINED MONOMER-MONOCLINIC)
Descriptor:BETA-GALACTOSIDASE (E.C.3.2.1.23)
Authors:Juers, D.H., Jacobson, R.H., Wigley, D., Zhang, X.J., Huber, R.E., Tronrud, D.E., Matthews, B.W.
Deposit date:2000-06-07
Release date:2014-07-09
Modification date:2014-12-10
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:High resolution refinement of beta-galactosidase in a new crystal form reveals multiple metal-binding sites and provides a structural basis for alpha-complementation.
Protein Sci., 9, 2000
4V40
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BETA-GALACTOSIDASE
Descriptor:BETA-GALACTOSIDASE
Authors:Jacobson, R.H., Zhang, X., Dubose, R.F., Matthews, B.W.
Deposit date:1994-07-18
Release date:2014-07-09
Modification date:2014-12-10
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Three-dimensional structure of beta-galactosidase from E. coli.
Nature, 369, 1994
4JKM
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CRYSTAL STRUCTURE OF CLOSTRIDIUM PERFRINGENS BETA-GLUCURONIDASE
Descriptor:Beta-glucuronidase (E.C.3.2.1.31), Maltose-binding periplasmic protein
Authors:Wallace, B.D., Redinbo, M.R.
Deposit date:2013-03-09
Release date:2014-09-17
Modification date:2015-10-21
Method:X-RAY DIFFRACTION (2.263 Å)
Cite:Structure and Inhibition of Microbiome beta-Glucuronidases Essential to the Alleviation of Cancer Drug Toxicity.
Chem.Biol., 22, 2015
4JKL
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CRYSTAL STRUCTURE OF STREPTOCOCCUS AGALACTIAE BETA-GLUCURONIDASE IN SPACE GROUP P21212
Descriptor:Beta-glucuronidase (E.C.3.2.1.31)
Authors:Wallace, B.D., Redinbo, M.R.
Deposit date:2013-03-09
Release date:2014-09-17
Modification date:2015-10-21
Method:X-RAY DIFFRACTION (2.288 Å)
Cite:Structure and Inhibition of Microbiome beta-Glucuronidases Essential to the Alleviation of Cancer Drug Toxicity.
Chem.Biol., 22, 2015
4JKK
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CRYSTAL STRUCTURE OF STREPTOCOCCUS AGALACTIAE BETA-GLUCURONIDASE IN SPACE GROUP I222
Descriptor:Beta-glucuronidase (E.C.3.2.1.31)
Authors:Wallace, B.D., Redinbo, M.R.
Deposit date:2013-03-09
Release date:2014-09-17
Modification date:2015-10-21
Method:X-RAY DIFFRACTION (2.59 Å)
Cite:Structure and Inhibition of Microbiome beta-Glucuronidases Essential to the Alleviation of Cancer Drug Toxicity.
Chem.Biol., 22, 2015
4JHZ
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STRUCTURE OF E. COLI BETA-GLUCURONIDASE BOUND WITH A NOVEL, POTENT INHIBITOR 2-[4-(1,3-BENZODIOXOL-5-YLMETHYL)PIPERAZIN-1-YL]-N-[(1S,2S,5S)-2,5-DIMETHOXYCYCLOHEXYL]ACETAMIDE
Descriptor:Beta-glucuronidase (E.C.3.2.1.31)
Authors:Roberts, A.B., Wallace, B.D., Redinbo, M.R.
Deposit date:2013-03-05
Release date:2013-08-28
Method:X-RAY DIFFRACTION (2.831 Å)
Cite:Molecular Insights into Microbial beta-Glucuronidase Inhibition to Abrogate CPT-11 Toxicity.
Mol.Pharmacol., 84, 2013
4DUX
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E. COLI (LACZ) BETA-GALACTOSIDASE (N460S) IN COMPLEX WITH L-RIBOSE
Descriptor:Beta-galactosidase (E.C.3.2.1.23)
Authors:Wheatley, R.W., Lo, S., Janzcewicz, L.J., Dugdale, M.L., Huber, R.E.
Deposit date:2012-02-22
Release date:2013-03-20
Modification date:2013-09-04
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural explanation for allolactose (lac operon inducer) synthesis by lacZ beta-galactosidase and the evolutionary relationship between allolactose synthesis and the lac repressor.
J.Biol.Chem., 288, 2013
4DUW
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E. COLI (LACZ) BETA-GALACTOSIDASE (G974A) IN COMPLEX WITH ALLOLACTOSE
Descriptor:Beta-galactosidase (E.C.3.2.1.23)
Authors:Wheatley, R.W., Lo, S., Janzcewicz, L.J., Dugdale, M.L., Huber, R.E.
Deposit date:2012-02-22
Release date:2013-03-20
Modification date:2013-07-10
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural Explanation for Allolactose (lac operon inducer) Synthesis by lacZ beta-Galactosidase and the Evolutionary Relationship between Allolactose synthesis and the lac Repressor
J.Biol.Chem., 288, 2013
4DUV
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E. COLI (LACZ) BETA-GALACTOSIDASE (G974A) 2-DEOXY-GALACTOSYL-ENZYME AND BIS-TRIS COMPLEX
Descriptor:Beta-galactosidase (E.C.3.2.1.23)
Authors:Wheatley, R.W., Lo, S., Janzcewicz, L.J., Dugdale, M.L., Huber, R.E.
Deposit date:2012-02-22
Release date:2013-04-03
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The Glucose Acceptor site of lacZ beta-galactosidase for the synthesis of allolactose - the natural inducer of the lac operon
To be Published
4CKD
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MODEL OF COMPLEX BETWEEN THE E.COLI ENZYME BETA-GALACTOSIDASE AND FOUR SINGLE CHAIN FV ANTIBODY DOMAINS SCFV13R4.
Descriptor:BETA-GALACTOSIDASE (E.C.3.2.1.23), SCFV13R4 ANTIBODY FV HEAVY CHAIN, SCFV13R4 ANTIBODY FV LIGHT CHAIN
Authors:Vinothkumar, K.R., McMullan, G., Henderson, R.
Deposit date:2014-01-03
Release date:2014-01-15
Modification date:2014-04-23
Method:ELECTRON MICROSCOPY (13 Å)
Cite:Molecular Mechanism of Antibody-Mediated Activation of Beta-Galactosidase.
Structure, 22, 2014
3VDC
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E. COLI (LACZ) BETA-GALACTOSIDASE (N460T) IN COMPLEX WITH IPTG
Descriptor:Beta-galactosidase (E.C.3.2.1.23)
Authors:Wheatley, R.W., Kappelhoff, J.C., Hahn, J.N., Dugdale, M.L., Dutkoski, M.J., Tamman, S.D., Fraser, M.E., Huber, R.E.
Deposit date:2012-01-04
Release date:2012-04-11
Modification date:2013-06-19
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Substitution for Asn460 cripples {beta}-galactosidase (Escherichia coli) by increasing substrate affinity and decreasing transition state stability.
Arch.Biochem.Biophys., 521, 2012
3VDB
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E. COLI (LACZ) BETA-GALACTOSIDASE (N460T) IN COMPLEX WITH GALACTONOLACTONE
Descriptor:Beta-galactosidase (E.C.3.2.1.23)
Authors:Wheatley, R.W., Kappelhoff, J.C., Hahn, J.N., Dugdale, M.L., Dutkoski, M.J., Tamman, S.D., Fraser, M.E., Huber, R.E.
Deposit date:2012-01-04
Release date:2012-04-11
Modification date:2013-06-19
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Substitution for Asn460 cripples {beta}-galactosidase (Escherichia coli) by increasing substrate affinity and decreasing transition state stability.
Arch.Biochem.Biophys., 521, 2012
3VDA
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E. COLI (LACZ) BETA-GALACTOSIDASE (N460T)
Descriptor:Beta-galactosidase (E.C.3.2.1.23)
Authors:Wheatley, R.W., Kappelhoff, J.C., Hahn, J.N., Dugdale, M.L., Dutkoski, M.J., Tamman, S.D., Fraser, M.E., Huber, R.E.
Deposit date:2012-01-04
Release date:2012-04-11
Modification date:2013-06-19
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Substitution for Asn460 cripples {beta}-galactosidase (Escherichia coli) by increasing substrate affinity and decreasing transition state stability.
Arch.Biochem.Biophys., 521, 2012
3VD9
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E. COLI (LACZ) BETA-GALACTOSIDASE (N460S) IN COMPLEX WITH IPTG
Descriptor:Beta-galactosidase (E.C.3.2.1.23)
Authors:Wheatley, R.W., Kappelhoff, J.C., Hahn, J.N., Dugdale, M.L., Dutkoski, M.J., Tamman, S.D., Fraser, M.E., Huber, R.E.
Deposit date:2012-01-04
Release date:2012-04-11
Modification date:2013-06-19
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Substitution for Asn460 cripples {beta}-galactosidase (Escherichia coli) by increasing substrate affinity and decreasing transition state stability.
Arch.Biochem.Biophys., 521, 2012
3VD7
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E. COLI (LACZ) BETA-GALACTOSIDASE (N460S) IN COMPLEX WITH GALACTOTETRAZOLE
Descriptor:Beta-galactosidase (E.C.3.2.1.23)
Authors:Wheatley, R.W., Kappelhoff, J.C., Hahn, J.N., Dugdale, M.L., Dutkoski, M.J., Tamman, S.D., Fraser, M.E., Huber, R.E.
Deposit date:2012-01-04
Release date:2012-04-11
Modification date:2013-06-19
Method:X-RAY DIFFRACTION (2.87 Å)
Cite:Substitution for Asn460 cripples {beta}-galactosidase (Escherichia coli) by increasing substrate affinity and decreasing transition state stability.
Arch.Biochem.Biophys., 521, 2012
3VD5
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E. COLI (LACZ) BETA-GALACTOSIDASE (N460S)
Descriptor:Beta-galactosidase (E.C.3.2.1.23)
Authors:Wheatley, R.W., Kappelhoff, J.C., Hahn, J.N., Dugdale, M.L., Dutkoski, M.J., Tamman, S.D., Fraser, M.E., Huber, R.E.
Deposit date:2012-01-04
Release date:2012-04-11
Modification date:2013-06-19
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Substitution for Asn460 cripples {beta}-galactosidase (Escherichia coli) by increasing substrate affinity and decreasing transition state stability.
Arch.Biochem.Biophys., 521, 2012
3VD4
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E. COLI (LACZ) BETA-GALACTOSIDASE (N460D) IN COMPLEX WITH IPTG
Descriptor:Beta-galactosidase (E.C.3.2.1.23)
Authors:Wheatley, R.W., Kappelhoff, J.C., Hahn, J.N., Dugdale, M.L., Dutkoski, M.J., Tamman, S.D., Fraser, M.E., Huber, R.E.
Deposit date:2012-01-04
Release date:2012-04-11
Modification date:2013-06-19
Method:X-RAY DIFFRACTION (2 Å)
Cite:Substitution for Asn460 cripples {beta}-galactosidase (Escherichia coli) by increasing substrate affinity and decreasing transition state stability.
Arch.Biochem.Biophys., 521, 2012
3VD3
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E. COLI (LACZ) BETA-GALACTOSIDASE (N460D)
Descriptor:Beta-galactosidase (E.C.3.2.1.23)
Authors:Wheatley, R.W., Kappelhoff, J.C., Hahn, J.N., Dugdale, M.L., Dutkoski, M.J., Tamman, S.D., Fraser, M.E., Huber, R.E.
Deposit date:2012-01-04
Release date:2012-04-11
Modification date:2013-06-19
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Substitution for Asn460 cripples {beta}-galactosidase (Escherichia coli) by increasing substrate affinity and decreasing transition state stability.
Arch.Biochem.Biophys., 521, 2012
3T2Q
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E. COLI (LACZ) BETA-GALACTOSIDASE (S796D) IN COMPLEX WITH GALACTONOLACTONE
Descriptor:Beta-galactosidase (E.C.3.2.1.23)
Authors:Jancewicz, L.J., Wheatley, R.W., Sutendra, G., Lee, M., Fraser, M., Huber, R.E.
Deposit date:2011-07-22
Release date:2012-01-18
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Ser-796 of Beta-Galactosidase (E. coli) Plays a Key Role in Maintaining an Optimum Balance between the Opened and Closed Conformations of the Catalytically Important Active Site Loop
Arch.Biochem.Biophys., 517, 2012
3T2P
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E. COLI (LACZ) BETA-GALACTOSIDASE (S796D) IN COMPLEX WITH IPTG
Descriptor:Beta-galactosidase (E.C.3.2.1.23)
Authors:Jancewicz, L.J., Wheatley, R.W., Sutendra, G., Lee, M., Fraser, M., Huber, R.E.
Deposit date:2011-07-22
Release date:2012-01-18
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Ser-796 of Beta-Galactosidase (E. coli) Plays a Key Role in Maintaining an Optimum Balance between the Opened and Closed Conformations of the Catalytically Important Active Site Loop
Arch.Biochem.Biophys., 517, 2012
3T2O
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E. COLI (LACZ) BETA-GALACTOSIDASE (S796D)
Descriptor:Beta-galactosidase (E.C.3.2.1.23)
Authors:Jancewicz, L.J., Wheatley, R.W., Sutendra, G., Lee, M., Fraser, M., Huber, R.E.
Deposit date:2011-07-22
Release date:2012-01-18
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Ser-796 of Beta-Galactosidase (E. coli) Plays a Key Role in Maintaining an Optimum Balance between the Opened and Closed Conformations of the Catalytically Important Active Site Loop
Arch.Biochem.Biophys., 517, 2012
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