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1A9X
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BU of 1a9x by Molmil
CARBAMOYL PHOSPHATE SYNTHETASE: CAUGHT IN THE ACT OF GLUTAMINE HYDROLYSIS
Descriptor: ADENOSINE-5'-DIPHOSPHATE, CARBAMOYL PHOSPHATE SYNTHETASE (LARGE CHAIN), CARBAMOYL PHOSPHATE SYNTHETASE (SMALL CHAIN), ...
Authors:Thoden, J, Holden, H.
Deposit date:1998-04-14
Release date:1998-10-21
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Carbamoyl phosphate synthetase: caught in the act of glutamine hydrolysis.
Biochemistry, 37, 1998
1BXR
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BU of 1bxr by Molmil
STRUCTURE OF CARBAMOYL PHOSPHATE SYNTHETASE COMPLEXED WITH THE ATP ANALOG AMPPNP
Descriptor: CARBAMOYL-PHOSPHATE SYNTHASE, CHLORIDE ION, L-ornithine, ...
Authors:Thoden, J.B, Wesenberg, G, Raushel, F.M, Holden, H.M.
Deposit date:1998-10-08
Release date:1999-04-20
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Carbamoyl phosphate synthetase: closure of the B-domain as a result of nucleotide binding.
Biochemistry, 38, 1999
1C30
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CRYSTAL STRUCTURE OF CARBAMOYL PHOSPHATE SYNTHETASE: SMALL SUBUNIT MUTATION C269S
Descriptor: ADENOSINE-5'-DIPHOSPHATE, CARBAMOYL PHOSPHATE SYNTHETASE: LARGE SUBUNIT, CARBAMOYL PHOSPHATE SYNTHETASE: SMALL SUBUNIT, ...
Authors:Thoden, J.B, Huang, X, Raushel, F.M, Holden, H.M.
Deposit date:1999-07-24
Release date:1999-12-10
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2 Å)
Cite:The small subunit of carbamoyl phosphate synthetase: snapshots along the reaction pathway.
Biochemistry, 38, 1999
1C3O
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CRYSTAL STRUCTURE OF THE CARBAMOYL PHOSPHATE SYNTHETASE: SMALL SUBUNIT MUTANT C269S WITH BOUND GLUTAMINE
Descriptor: ADENOSINE-5'-DIPHOSPHATE, CARBAMOYL PHOSPHATE SYNTHETASE: LARGE SUBUNIT, CARBAMOYL PHOSPHATE SYNTHETASE: SMALL SUBUNIT, ...
Authors:Thoden, J.B, Huang, X, Raushel, F.M, Holden, H.M.
Deposit date:1999-07-28
Release date:1999-12-10
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The small subunit of carbamoyl phosphate synthetase: snapshots along the reaction pathway.
Biochemistry, 38, 1999
1CE8
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CARBAMOYL PHOSPHATE SYNTHETASE FROM ESCHERICHIS COLI WITH COMPLEXED WITH THE ALLOSTERIC LIGAND IMP
Descriptor: ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, INOSINIC ACID, ...
Authors:Thoden, J.B, Raushel, F.M, Holden, H.M.
Deposit date:1999-03-18
Release date:1999-07-26
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The binding of inosine monophosphate to Escherichia coli carbamoyl phosphate synthetase.
J.Biol.Chem., 274, 1999
1CS0
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BU of 1cs0 by Molmil
Crystal structure of carbamoyl phosphate synthetase complexed at CYS269 in the small subunit with the tetrahedral mimic l-glutamate gamma-semialdehyde
Descriptor: ADENOSINE-5'-DIPHOSPHATE, CARBAMOYL PHOSPHATE SYNTHETASE: LARGE SUBUNIT, CARBAMOYL PHOSPHATE SYNTHETASE: SMALL SUBUNIT, ...
Authors:Thoden, J.B, Huang, X, Raushel, F.M, Holden, H.M.
Deposit date:1999-08-16
Release date:1999-12-10
Last modified:2019-11-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:The small subunit of carbamoyl phosphate synthetase: snapshots along the reaction pathway.
Biochemistry, 38, 1999
1JDB
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BU of 1jdb by Molmil
CARBAMOYL PHOSPHATE SYNTHETASE FROM ESCHERICHIA COLI
Descriptor: ADENOSINE-5'-DIPHOSPHATE, CARBAMOYL PHOSPHATE SYNTHETASE, CHLORIDE ION, ...
Authors:Thoden, J.B, Holden, H.M, Wesenberg, G, Raushel, F.M, Rayment, I.
Deposit date:1997-03-25
Release date:1998-06-17
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The structure of carbamoyl phosphate synthetase determined to 2.1 A resolution.
Acta Crystallogr.,Sect.D, 55, 1999
1KEE
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BU of 1kee by Molmil
Inactivation of the Amidotransferase Activity of Carbamoyl Phosphate Synthetase by the Antibiotic Acivicin
Descriptor: ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, Carbamoyl-phosphate synthetase large chain, ...
Authors:Miles, B.W, Thoden, J.B, Holden, H.M, Raushel, F.M.
Deposit date:2001-11-15
Release date:2001-12-21
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Inactivation of the amidotransferase activity of carbamoyl phosphate synthetase by the antibiotic acivicin.
J.Biol.Chem., 277, 2002
1M6V
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BU of 1m6v by Molmil
Crystal Structure of the G359F (small subunit) Point Mutant of Carbamoyl Phosphate Synthetase
Descriptor: ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, L-ornithine, ...
Authors:Thoden, J.B, Huang, X, Raushel, F.M, Holden, H.M.
Deposit date:2002-07-17
Release date:2002-07-31
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Carbamoyl-phosphate synthetase. Creation of an escape route for ammonia
J.Biol.Chem., 277, 2002
1T36
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BU of 1t36 by Molmil
Crystal structure of E. coli carbamoyl phosphate synthetase small subunit mutant C248D complexed with uridine 5'-monophosphate
Descriptor: ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, Carbamoyl-phosphate synthase large chain, ...
Authors:Thoden, J.B, Huang, X, Raushel, F.M, Holden, H.M.
Deposit date:2004-04-24
Release date:2004-09-21
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Long-range allosteric transitions in carbamoyl phosphate synthetase.
Protein Sci., 13, 2004
5DOT
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BU of 5dot by Molmil
Crystal Structure of Human Carbamoyl phosphate synthetase I (CPS1), apo form
Descriptor: 1,2-ETHANEDIOL, Carbamoyl-phosphate synthase [ammonia], mitochondrial, ...
Authors:Polo, L.M, de Cima, S, Fita, I, Rubio, V.
Deposit date:2015-09-11
Release date:2015-12-09
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure of human carbamoyl phosphate synthetase: deciphering the on/off switch of human ureagenesis.
Sci Rep, 5, 2015
5DOU
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BU of 5dou by Molmil
Crystal Structure of Human Carbamoyl phosphate synthetase I (CPS1), ligand-bound form
Descriptor: 1,2-ETHANEDIOL, ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, ...
Authors:de Cima, S, Polo, L.M, Fita, I, Rubio, V.
Deposit date:2015-09-11
Release date:2015-12-09
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure of human carbamoyl phosphate synthetase: deciphering the on/off switch of human ureagenesis.
Sci Rep, 5, 2015
6UEL
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BU of 6uel by Molmil
CPS1 bound to allosteric inhibitor H3B-193
Descriptor: Carbamoyl-phosphate synthase [ammonia], mitochondrial, N~1~-[(4-fluorophenyl)methyl]-N~1~-methyl-N~4~-(4-methyl-1,3-thiazol-2-yl)piperidine-1,4-dicarboxamide, ...
Authors:Larsen, N.A, Nguyen, T.V.
Deposit date:2019-09-21
Release date:2020-03-18
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Small Molecule Inhibition of CPS1 Activity through an Allosteric Pocket.
Cell Chem Biol, 27, 2020
6W2J
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BU of 6w2j by Molmil
CPS1 bound to allosteric inhibitor H3B-374
Descriptor: (2-fluoranyl-4-methoxy-phenyl)-[(3~{R},5~{R})-4-(2-fluoranyl-4-methoxy-phenyl)carbonyl-3,5-dimethyl-piperazin-1-yl]methanone, 1,2-ETHANEDIOL, Carbamoyl-phosphate synthase [ammonia], ...
Authors:Larsen, N.A, Nguyen, T.V.
Deposit date:2020-03-05
Release date:2021-01-13
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.62 Å)
Cite:Discovery of 2,6-Dimethylpiperazines as Allosteric Inhibitors of CPS1.
Acs Med.Chem.Lett., 11, 2020

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