1AJ6
  • Download 1aj6
  • View 1aj6
Molmil generated image of 1aj6
NOVOBIOCIN-RESISTANT MUTANT (R136H) OF THE N-TERMINAL 24 KDA FRAGMENT OF DNA GYRASE B COMPLEXED WITH NOVOBIOCIN AT 2.3 ANGSTROMS RESOLUTION
Descriptor:GYRASE, NOVOBIOCIN
Authors:Weston, S.A., Tunnicliffe, A., Pauptit, R.A.
Deposit date:1997-05-15
Release date:1998-05-20
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The entropic penalty of ordered water accounts for weaker binding of the antibiotic novobiocin to a resistant mutant of DNA gyrase: a thermodynamic and crystallographic study.
Biochemistry, 36, 1997
1ID0
  • Download 1id0
  • View 1id0
Molmil generated image of 1id0
CRYSTAL STRUCTURE OF THE NUCLEOTIDE BOND CONFORMATION OF PHOQ KINASE DOMAIN
Descriptor:PHOQ HISTIDINE KINASE (E.C.2.7.1.37 )
Authors:Marina, A., Mott, C., Auyzenberg, A, Waldburger, C.D., Hendrickson, W.A.
Deposit date:2001-04-02
Release date:2001-10-17
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural and mutational analysis of the PhoQ histidine kinase catalytic domain. Insight into the reaction mechanism.
J.Biol.Chem., 276, 2001
1KZN
  • Download 1kzn
  • View 1kzn
Molmil generated image of 1kzn
CRYSTAL STRUCTURE OF E. COLI 24KDA DOMAIN IN COMPLEX WITH CLOROBIOCIN
Descriptor:DNA GYRASE SUBUNIT B (E.C.5.99.1.3)
Authors:Lafitte, D., Lamour, V., Tsvetkov, P.O., Makarov, A.A., Klich, M., Deprez, P., Moras, D., Briand, C., Gilli, R.
Deposit date:2002-02-07
Release date:2002-06-19
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:DNA gyrase interaction with coumarin-based inhibitors: the role of the hydroxybenzoate isopentenyl moiety and the 5'-methyl group of the noviose.
Biochemistry, 41, 2002
1S14
  • Download 1s14
  • View 1s14
Molmil generated image of 1s14
CRYSTAL STRUCTURE OF ESCHERICHIA COLI TOPOISOMERASE IV PARE 24KDA SUBUNIT
Descriptor:Topoisomerase IV subunit B (E.C.5.99.1.-)
Authors:Wei, Y., Gross, C.H.
Deposit date:2004-01-05
Release date:2004-05-04
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structures of Escherichia coli topoisomerase IV ParE subunit (24 and 43 kilodaltons): a single residue dictates differences in novobiocin potency against topoisomerase IV and DNA gyrase.
Antimicrob.Agents Chemother., 48, 2004
1YS3
  • Download 1ys3
  • View 1ys3
Molmil generated image of 1ys3
CRYSTAL STRUCTURE OF THE ATP BINDING DOMAIN OF PRRB FROM MYCOBACTERIUM TUBERCULOSIS
Descriptor:Sensor-type histidine kinase prrB (E.C.2.7.3.-)
Authors:Nowak, E., Panjikar, S., Tucker, P., Mycobacterium Tuberculosis Structural Proteomics Project (XMTB)
Deposit date:2005-02-07
Release date:2005-07-12
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of ATP binding domain of Hidtidine Kinase from MTB
To be Published
1YSR
  • Download 1ysr
  • View 1ysr
Molmil generated image of 1ysr
CRYSTAL STRUCTURE OF ATP BINDING DOMAIN OF PRRB FROM MYCOBACTERIUM TUBERCULOSIS
Descriptor:Sensor-type histidine kinase prrB (E.C.2.7.3.-)
Authors:Nowak, E., Panjikar, S., Tucker, P., Mycobacterium Tuberculosis Structural Proteomics Project (XMTB)
Deposit date:2005-02-09
Release date:2005-07-12
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Crystal Structure of ATP binding domain of PrrB from Mycobacterium Tuberculosis
To be published
3A0T
  • Download 3a0t
  • View 3a0t
Molmil generated image of 3a0t
CATALYTIC DOMAIN OF HISTIDINE KINASE THKA (TM1359) IN COMPLEX WITH ADP AND MG ION (TRIGONAL)
Descriptor:Sensor protein (E.C.2.7.13.3)
Authors:Yamada, S., Sugimoto, H., Kobayashi, M., Ohno, A., Nakamura, H., Shiro, Y.
Deposit date:2009-03-24
Release date:2009-10-20
Modification date:2013-07-10
Method:X-RAY DIFFRACTION (1.91 Å)
Cite:Structure of PAS-linked histidine kinase and the response regulator complex
Structure, 17, 2009
3A0W
  • Download 3a0w
  • View 3a0w
Molmil generated image of 3a0w
CATALYTIC DOMAIN OF HISTIDINE KINASE THKA (TM1359) FOR MAD PHASING (NUCLEOTIDE FREE FORM 2, ORTHOROMBIC)
Descriptor:Sensor protein (E.C.2.7.13.3)
Authors:Yamada, S., Sugimoto, H., Kobayashi, M., Ohno, A., Nakamura, H., Shiro, Y.
Deposit date:2009-03-24
Release date:2009-10-20
Modification date:2009-11-17
Method:X-RAY DIFFRACTION (1.69 Å)
Cite:Structure of PAS-linked histidine kinase and the response regulator complex
Structure, 17, 2009
3A0X
  • Download 3a0x
  • View 3a0x
Molmil generated image of 3a0x
CATALYTIC DOMAIN OF HISTIDINE KINASE THKA (TM1359) (NUCLEOTIDE FREE FORM 1: AMMOMIUM PHOSPHATE, MONOCLINIC)
Descriptor:Sensor protein (E.C.2.7.13.3)
Authors:Yamada, S., Sugimoto, H., Kobayashi, M., Ohno, A., Nakamura, H., Shiro, Y.
Deposit date:2009-03-25
Release date:2009-10-20
Modification date:2009-11-17
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Structure of PAS-linked histidine kinase and the response regulator complex
Structure, 17, 2009
3A0Y
  • Download 3a0y
  • View 3a0y
Molmil generated image of 3a0y
CATALYTIC DOMAIN OF HISTIDINE KINASE THKA (TM1359) (NUCLEOTIDE FREE FORM 3: 1,2-PROPANEDIOL, ORTHOROMBIC)
Descriptor:Sensor protein (E.C.2.7.13.3)
Authors:Yamada, S., Sugimoto, H., Kobayashi, M., Ohno, A., Nakamura, H., Shiro, Y.
Deposit date:2009-03-25
Release date:2009-10-20
Modification date:2009-11-17
Method:X-RAY DIFFRACTION (1.57 Å)
Cite:Structure of PAS-linked histidine kinase and the response regulator complex
Structure, 17, 2009
3A0Z
  • Download 3a0z
  • View 3a0z
Molmil generated image of 3a0z
CATALYTIC DOMAIN OF HISTIDINE KINASE THKA (TM1359) (NUCLEOTIDE FREE FORM 4: ISOPROPANOL, ORTHOROMBIC)
Descriptor:Sensor protein (E.C.2.7.13.3)
Authors:Yamada, S., Sugimoto, H., Kobayashi, M., Ohno, A., Nakamura, H., Shiro, Y.
Deposit date:2009-03-25
Release date:2009-10-20
Modification date:2009-11-17
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structure of PAS-linked histidine kinase and the response regulator complex
Structure, 17, 2009
3CGY
  • Download 3cgy
  • View 3cgy
Molmil generated image of 3cgy
CRYSTAL STRUCTURE OF SALMONELLA SENSOR KINASE PHOQ CATALYTIC DOMAIN IN COMPLEX WITH RADICICOL
Descriptor:Virulence sensor histidine kinase phoQ (E.C.2.7.13.3)
Authors:Guarnieri, M.T., Zhang, L., Shen, J., Zhao, R.
Deposit date:2008-03-06
Release date:2008-05-13
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:The Hsp90 inhibitor radicicol interacts with the ATP-binding pocket of bacterial sensor kinase PhoQ.
J.Mol.Biol., 379, 2008
3CGZ
  • Download 3cgz
  • View 3cgz
Molmil generated image of 3cgz
CRYSTAL STRUCTURE OF SALMONELLA SENSOR KINASE PHOQ CATALYTIC DOMAIN
Descriptor:Virulence sensor histidine kinase phoQ (E.C.2.7.13.3)
Authors:Guarnieri, M.T., Zhang, L., Shen, J., Zhao, R.
Deposit date:2008-03-06
Release date:2008-05-13
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The Hsp90 inhibitor radicicol interacts with the ATP-binding pocket of bacterial sensor kinase PhoQ.
J.Mol.Biol., 379, 2008
3FV5
  • Download 3fv5
  • View 3fv5
Molmil generated image of 3fv5
CRYSTAL STRUCTURE OF E. COLI TOPOISOMERASE IV CO-COMPLEXED WITH INHIBITOR
Descriptor:DNA topoisomerase 4 subunit B (E.C.5.99.1.-)
Authors:Wei, Y., Charifson, P., LeTiran, A.
Deposit date:2009-01-15
Release date:2010-01-26
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Design and syntheses of novel C7-derived-aminobenzimidazole ureas: bacterial gyrase/topoisomerase IV inhibitors with potent Gram-positve antibacterial activity
To be Published
3SL2
  • Download 3sl2
  • View 3sl2
Molmil generated image of 3sl2
ATP FORMS A STABLE COMPLEX WITH THE ESSENTIAL HISTIDINE KINASE WALK (YYCG) DOMAIN
Descriptor:Sensor histidine kinase yycG (E.C.2.7.13.3)
Authors:Celikel, R., Veldore, V.H., Mathews, I., Devine, K., Varughese, K.I.
Deposit date:2011-06-23
Release date:2012-06-27
Modification date:2013-01-23
Method:X-RAY DIFFRACTION (1.61 Å)
Cite:ATP forms a stable complex with the essential histidine kinase WalK (YycG) domain.
Acta Crystallogr.,Sect.D, 68, 2012
3ZXO
  • Download 3zxo
  • View 3zxo
Molmil generated image of 3zxo
CRYSTAL STRUCTURE OF THE MUTANT ATP-BINDING DOMAIN OF MYCOBACTERIUM TUBERCULOSIS DOSS
Descriptor:REDOX SENSOR HISTIDINE KINASE RESPONSE REGULATOR DEVS (E.C.2.7.3.-, 2.7.13.3)
Authors:Cho, H.Y., Cho, H.J., Kang, B.S.
Deposit date:2011-08-13
Release date:2011-08-24
Modification date:2013-05-22
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Activation of ATP Binding for the Autophosphorylation of Doss, a Mycobacterium Tuberculosis Histidine Kinase Lacking an ATP-Lid Motif.
J.Biol.Chem., 288, 2013
3ZXQ
  • Download 3zxq
  • View 3zxq
Molmil generated image of 3zxq
CRYSTAL STRUCTURE OF THE ATP-BINDING DOMAIN OF MYCOBACTERIUM TUBERCULOSIS DOST
Descriptor:HYPOXIA SENSOR HISTIDINE KINASE RESPONSE REGULATOR DOST
Authors:Cho, H.Y., Cho, H.J., Kang, B.S.
Deposit date:2011-08-15
Release date:2011-08-24
Modification date:2013-05-22
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Activation of ATP Binding for the Autophosphorylation of Doss, a Mycobacterium Tuberculosis Histidine Kinase Lacking an ATP-Lid Motif.
J.Biol.Chem., 288, 2013
4DUH
  • Download 4duh
  • View 4duh
Molmil generated image of 4duh
CRYSTAL STRUCTURE OF 24 KDA DOMAIN OF E. COLI DNA GYRASE B IN COMPLEX WITH SMALL MOLECULE INHIBITOR
Descriptor:DNA gyrase subunit B (E.C.5.99.1.3)
Authors:Brvar, M., Renko, M., Perdih, A., Solmajer, T., Turk, D.
Deposit date:2012-02-22
Release date:2012-08-01
Modification date:2012-08-08
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structure-based discovery of substituted 4,5'-bithiazoles as novel DNA gyrase inhibitors.
J.Med.Chem., 55, 2012
4GEE
  • Download 4gee
  • View 4gee
Molmil generated image of 4gee
PYRROLOPYRIMIDINE INHIBITORS OF DNA GYRASE B AND TOPOISOMERASE IV, PART I: STRUCTURE GUIDED DISCOVERY AND OPTIMIZATION OF DUAL TARGETING AGENTS WITH POTENT, BROAD-SPECTRUM ENZYMATIC ACTIVITY.
Descriptor:DNA gyrase subunit B (E.C.5.99.1.3)
Authors:Bensen, D.C., Chen, Z., Tari, L.W.
Deposit date:2012-08-01
Release date:2013-02-13
Modification date:2013-02-27
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Pyrrolopyrimidine inhibitors of DNA gyrase B (GyrB) and topoisomerase IV (ParE). Part I: Structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity.
Bioorg.Med.Chem.Lett., 23, 2013
4GFN
  • Download 4gfn
  • View 4gfn
Molmil generated image of 4gfn
PYRROLOPYRIMIDINE INHIBITORS OF DNA GYRASE B AND TOPOISOMERASE IV, PART I: STRUCTURE GUIDED DISCOVERY AND OPTIMIZATION OF DUAL TARGETING AGENTS WITH POTENT, BROAD-SPECTRUM ENZYMATIC
Descriptor:DNA gyrase subunit B (E.C.5.99.1.3)
Authors:Bensen, D.C., Trzoss, M., Tari, L.W.
Deposit date:2012-08-03
Release date:2013-02-13
Modification date:2013-02-27
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Pyrrolopyrimidine inhibitors of DNA gyrase B (GyrB) and topoisomerase IV (ParE). Part I: Structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity.
Bioorg.Med.Chem.Lett., 23, 2013
4GGL
  • Download 4ggl
  • View 4ggl
Molmil generated image of 4ggl
PYRROLOPYRIMIDINE INHIBITORS OF DNA GYRASE B AND TOPOISOMERASE IV, PART I: STRUCTURE GUIDED DISCOVERY AND OPTIMIZATION OF DUAL TARGETING AGENTS WITH POTENT, BROAD-SPECTRUM ENZYMATIC ACTIVITY
Descriptor:DNA gyrase subunit B (E.C.5.99.1.3)
Authors:Bensen, D.C., Creighton, C.J., Tari, L.W.
Deposit date:2012-08-06
Release date:2013-02-13
Modification date:2013-02-27
Method:X-RAY DIFFRACTION (1.69 Å)
Cite:Pyrrolopyrimidine inhibitors of DNA gyrase B (GyrB) and topoisomerase IV (ParE). Part I: Structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity.
Bioorg.Med.Chem.Lett., 23, 2013
4HXW
  • Download 4hxw
  • View 4hxw
Molmil generated image of 4hxw
PYRROLOPYRIMIDINE INHIBITORS OF DNA GYRASE B AND TOPOISOMERASE IV, PART I: STRUCTURE GUIDED DISCOVERY AND OPTIMIZATION OF DUAL TARGETING AGENTS WITH POTENT, BROAD-SPECTRUM ENZYMATIC ACTIVITY.
Descriptor:DNA gyrase subunit B (E.C.5.99.1.3)
Authors:Bensen, D.C., Trzoss, M., Tari, L.W.
Deposit date:2012-11-12
Release date:2013-02-13
Modification date:2013-02-27
Method:X-RAY DIFFRACTION (1.69 Å)
Cite:Pyrrolopyrimidine inhibitors of DNA gyrase B (GyrB) and topoisomerase IV (ParE). Part I: Structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity.
Bioorg.Med.Chem.Lett., 23, 2013
4HYP
  • Download 4hyp
  • View 4hyp
Molmil generated image of 4hyp
PYRROLOPYRIMIDINE INHIBITORS OF DNA GYRASE B AND TOPOISOMERASE IV, PART I: STRUCTURE GUIDED DISCOVERY AND OPTIMIZATION OF DUAL TARGETING AGENTS WITH POTENT, BROAD-SPECTRUM ENZYMATIC ACTIVITY.
Descriptor:DNA gyrase subunit B (E.C.5.99.1.3)
Authors:Bensen, D.C., Creighton, C.J., Tari, L.W.
Deposit date:2012-11-13
Release date:2013-02-13
Modification date:2013-02-27
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Pyrrolopyrimidine inhibitors of DNA gyrase B (GyrB) and topoisomerase IV (ParE). Part I: Structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity.
Bioorg.Med.Chem.Lett., 23, 2013
4HZ0
  • Download 4hz0
  • View 4hz0
Molmil generated image of 4hz0
PYRROLOPYRIMIDINE INHIBITORS OF DNA GYRASE B AND TOPOISOMERASE IV, PART I: STRUCTURE GUIDED DISCOVERY AND OPTIMIZATION OF DUAL TARGETING AGENTS WITH POTENT, BROAD-SPECTRUM ENZYMATIC ACTIVITY.
Descriptor:DNA topoisomerase 4 subunit B (E.C.5.99.1.-)
Authors:Bensen, D.C., Trzoss, M, Tari, L.W.
Deposit date:2012-11-14
Release date:2013-02-13
Modification date:2013-02-27
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Pyrrolopyrimidine inhibitors of DNA gyrase B (GyrB) and topoisomerase IV (ParE). Part I: Structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity.
Bioorg.Med.Chem.Lett., 23, 2013
4HZ5
  • Download 4hz5
  • View 4hz5
Molmil generated image of 4hz5
PYRROLOPYRIMIDINE INHIBITORS OF DNA GYRASE B AND TOPOISOMERASE IV, PART I: STRUCTURE GUIDED DISCOVERY AND OPTIMIZATION OF DUAL TARGETING AGENTS WITH POTENT, BROAD-SPECTRUM ENZYMATIC ACTIVITY
Descriptor:DNA topoisomerase IV, B subunit
Authors:Bensen, D.C., Creighton, C.J., Tari, L.W.
Deposit date:2012-11-14
Release date:2013-02-13
Modification date:2013-02-27
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Pyrrolopyrimidine inhibitors of DNA gyrase B (GyrB) and topoisomerase IV (ParE). Part I: Structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity.
Bioorg.Med.Chem.Lett., 23, 2013
Copyright © 2013-2016 Protein Data Bank Japan
This is the static version of the PDBj web interface with limited functionality. Try the full version instead.