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1RV1
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1rv1
CRYSTAL STRUCTURE OF HUMAN MDM2 WITH AN IMIDAZOLINE INHIBITOR
Descriptor:Ubiquitin-protein ligase E3 Mdm2 (E.C.6.3.2.-)
Authors:Lukacs, C., Kammlott, U., Graves, B.
Deposit date:2003-12-12
Release date:2004-01-20
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:In vivo activation of the p53 pathway by small-molecule antagonists of MDM2.
Science, 303, 2004
1T4E
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1t4e
STRUCTURE OF HUMAN MDM2 IN COMPLEX WITH A BENZODIAZEPINE INHIBITOR
Descriptor:Ubiquitin-protein ligase E3 Mdm2 (E.C.6.3.2.-)
Authors:Grasberger, B.L., Schubert, C., Koblish, H.K., Carver, T.E., Franks, C.F., Zhao, S.Y., Lu, T., LaFrance, L.V., Parks, D.J.
Deposit date:2004-04-29
Release date:2005-02-08
Modification date:2011-11-16
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Discovery and cocrystal structure of benzodiazepinedione HDM2 antagonists that activate p53 in cells
J.Med.Chem., 48, 2005
1T4F
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1t4f
STRUCTURE OF HUMAN MDM2 IN COMPLEX WITH AN OPTIMIZED P53 PEPTIDE
Descriptor:Ubiquitin-protein ligase E3 Mdm2 (E.C.6.3.2.-), optimized p53 peptide
Authors:Grasberger, B.L., Schubert, C., Koblish, H.K., Carver, T.E., Franks, C.F., Zhao, S.Y., Lu, T., LaFrance, L.V., Parks, D.J.
Deposit date:2004-04-29
Release date:2005-02-08
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Discovery and cocrystal structure of benzodiazepinedione HDM2 antagonists that activate p53 in cells
J.Med.Chem., 48, 2005
1TTV
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1ttv
NMR STRUCTURE OF A COMPLEX BETWEEN MDM2 AND A SMALL MOLECULE INHIBITOR
Descriptor:Ubiquitin-protein ligase E3 Mdm2 (E.C.6.3.2.-)
Authors:Fry, D.C., Emerson, S.D., Palme, S., Vu, B.T., Liu, C.M., Podlaski, F.
Deposit date:2004-06-23
Release date:2005-01-04
Modification date:2009-02-24
Method:SOLUTION NMR
Cite:NMR structure of a complex between MDM2 and a small molecule inhibitor.
J.Biomol.Nmr, 30, 2004
1UHR
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1uhr
SOLUTION STRUCTURE OF THE SWIB DOMAIN OF MOUSE BRG1-ASSOCIATED FACTOR 60A
Descriptor:SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily D member 1
Authors:Yamada, K., Saito, K., Nameki, N., Inoue, M., Koshiba, S., Shirouzu, M., Terada, T., Yabuki, T., Aoki, M., Matsuda, T., Seki, E., Hirota, H., Yoshida, M., Tanaka, A., Osanai, T., Arakawa, T., Carninci, P., Kawai, J., Hayashizaki, Y., Kigawa, T., Yokoyama, S., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2003-07-09
Release date:2004-08-24
Modification date:2009-02-24
Method:SOLUTION NMR
Cite:Solution structure of the SWIB domain of mouse BRG1-associated factor 60a
To be Published
1V31
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1v31
SOLUTION STRUCTURE OF THE SWIB/MDM2 DOMAIN OF THE HYPOTHETICAL PROTEIN AT5G14170 FROM ARABIDOPSIS THALIANA
Descriptor:hypothetical protein RAFL11-05-P19
Authors:Yoneyama, M., Tochio, N., Koshiba, S., Inoue, M., Kigawa, T., Yokoyama, S., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2003-10-21
Release date:2004-04-21
Modification date:2009-02-24
Method:SOLUTION NMR
Cite:Solution structure of the SWIB/MDM2 domain of the hypothetical protein At5g14170 from Arabidopsis thaliana
To be Published
1V32
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1v32
SOLUTION STRUCTURE OF THE SWIB/MDM2 DOMAIN OF THE HYPOTHETICAL PROTEIN AT5G08430 FROM ARABIDOPSIS THALIANA
Descriptor:hypothetical protein RAFL09-47-K03
Authors:Yoneyama, M., Tochio, N., Koshiba, S., Inoue, M., Kigawa, T., Yokoyama, S., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2003-10-24
Release date:2004-04-24
Modification date:2009-02-24
Method:SOLUTION NMR
Cite:Solution structure of the SWIB/MDM2 domain of the hypothetical protein At5g08430 from Arabidopsis thaliana
To be Published
1Z1M
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1z1m
NMR STRUCTURE OF UNLIGANDED MDM2
Descriptor:Ubiquitin-protein ligase E3 Mdm2 (E.C.6.3.2.-)
Authors:Uhrinova, S., Uhrin, D., Powers, H., Watt, K., Zheleva, D., Fischer, P., McInnes, C., Barlow, P.N.
Deposit date:2005-03-04
Release date:2005-06-28
Modification date:2009-02-24
Method:SOLUTION NMR
Cite:Structure of Free MDM2 N-terminal Domain Reveals Conformational Adjustments that Accompany p53-binding
J.Mol.Biol., 350, 2005
2AXI
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2axi
HDM2 IN COMPLEX WITH A BETA-HAIRPIN
Descriptor:Ubiquitin-protein ligase E3 Mdm2 (E.C.6.3.2.-), cyclic 8-mer peptide
Authors:Mittl, P.R.E., Fasan, R., Robinson, J., Gruetter, M.G.
Deposit date:2005-09-05
Release date:2006-03-21
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Structure-Activity Studies in a Family of beta-Hairpin Protein Epitope Mimetic Inhibitors of the p53-HDM2 Protein-Protein Interaction.
Chembiochem, 7, 2006
2GV2
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2gv2
MDM2 IN COMPLEX WITH AN 8-MER P53 PEPTIDE ANALOGUE
Descriptor:Ubiquitin-protein ligase E3 Mdm2 (E.C.6.3.2.-)
Authors:Schubert, C., Sakurai, K.
Deposit date:2006-05-02
Release date:2006-09-05
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystallographic Analysis of an 8-mer p53 Peptide Analogue Complexed with MDM2.
J.Am.Chem.Soc., 128, 2006
2LZG
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2lzg
NMR STRUCTURE OF MDM2 (6-125) WITH PIP-1
Descriptor:E3 ubiquitin-protein ligase Mdm2
Authors:Michelsen, K.B., Jordan, J.B., Lewis, J., Long, A.M., Yang, E., Rew, Y., Zhou, J., Yakowec, P., Schnier, P.D., Huang, X., Poppe, L.
Deposit date:2012-10-02
Release date:2012-11-07
Method:SOLUTION NMR
Cite:Ordering of the N-Terminus of Human MDM2 by Small Molecule Inhibitors.
J.Am.Chem.Soc., 134, 2012
3EQS
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3eqs
CRYSTAL STRUCTURE OF HUMAN MDM2 IN COMPLEX WITH A 12-MER PEPTIDE INHIBITOR
Descriptor:E3 ubiquitin-protein ligase Mdm2 (E.C.6.3.2.-)
Authors:Pazgier, M., Lu, W.
Deposit date:2008-10-01
Release date:2009-03-17
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structural basis for high-affinity peptide inhibition of p53 interactions with MDM2 and MDMX.
Proc.Natl.Acad.Sci.USA, 106, 2009
3EQY
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3eqy
CRYSTAL STRUCTURE OF HUMAN MDMX IN COMPLEX WITH A 12-MER PEPTIDE INHIBITOR
Descriptor:Mdm4 protein
Authors:Pazgier, M., Lu, W.
Deposit date:2008-10-01
Release date:2009-03-17
Modification date:2014-04-02
Method:X-RAY DIFFRACTION (1.63 Å)
Cite:Structural basis for high-affinity peptide inhibition of p53 interactions with MDM2 and MDMX.
Proc.Natl.Acad.Sci.USA, 106, 2009
3FDO
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3fdo
STRUCTURE OF HUMAN MDMX IN COMPLEX WITH HIGH AFFINITY PEPTIDE
Descriptor:Protein Mdm4, Synthetic high affinity peptide
Authors:Czarna, A.L., Popowicz, G.M., Holak, T.A.
Deposit date:2008-11-26
Release date:2008-12-16
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:High affinity interaction of the p53 peptide-analogue with human Mdm2 and Mdmx
Cell Cycle, 8, 2009
3FE7
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3fe7
CRYSTAL STRUCTURE OF HDMX BOUND TO THE P53-PEPTIDOMIMETIC AC-PHE-MET-AIB-PMP-TRP-GLU-AC3C-LEU-NH2 AT 1.35A
Descriptor:Mdm4 protein, p53-peptidomimetic Ac-Phe-Met-Aib-Pmp-Trp-Glu-Ac3c-Leu-NH2
Authors:Kallen, J.
Deposit date:2008-11-28
Release date:2009-01-27
Modification date:2009-04-07
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Crystal Structures of Human MdmX (HdmX) in Complex with p53 Peptide Analogues Reveal Surprising Conformational Changes
J.Biol.Chem., 284, 2009
3FEA
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3fea
CRYSTAL STRUCTURE OF HDMX BOUND TO THE P53-PEPTIDOMIMETIC AC-PHE-MET-AIB-PMP-6-CL-TRP-GLU-AC3C-LEU-NH2 AT 1.33A
Descriptor:Mdm4 protein, p53-peptidomimetic Ac-Phe-Met-Aib-Pmp-6-Cl-Trp-Glu-Ac3c-Leu-NH2
Authors:Kallen, J.
Deposit date:2008-11-28
Release date:2009-01-27
Modification date:2009-04-07
Method:X-RAY DIFFRACTION (1.33 Å)
Cite:Crystal Structures of Human MdmX (HdmX) in Complex with p53 Peptide Analogues Reveal Surprising Conformational Changes
J.Biol.Chem., 284, 2009
3G03
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3g03
STRUCTURE OF HUMAN MDM2 IN COMPLEX WITH HIGH AFFINITY PEPTIDE
Descriptor:E3 ubiquitin-protein ligase Mdm2, High affinity synthetic peptide
Authors:Czarna, A.L., Popowicz, G.M., Holak, T.A.
Deposit date:2009-01-27
Release date:2009-04-14
Modification date:2009-04-28
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:High affinity interaction of the p53 peptide-analogue with human Mdm2 and Mdmx
Cell Cycle, 8, 2009
3IUX
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3iux
CRYSTAL STRUCTURE OF HUMAN MDM2 IN COMPLEX WITH A POTENT MINIATURE PROTEIN INHIBITOR (18-RESIDUES)
Descriptor:E3 ubiquitin-protein ligase Mdm2 (E.C.6.3.2.-), p53 binding domain
Authors:Pazgier, M., Lu, W.
Deposit date:2009-08-31
Release date:2009-10-27
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Apamin as a template for structure-based rational design of potent peptide activators of p53.
Angew.Chem.Int.Ed.Engl., 48, 2009
3IWY
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3iwy
CRYSTAL STRUCTURE OF HUMAN MDM2 COMPLEXED WITH D-PEPTIDE (12 RESIDUES)
Descriptor:D-peptide inhibitor, E3 ubiquitin-protein ligase Mdm2 (E.C.6.3.2.-)
Authors:Pazgier, M., Lu, W.
Deposit date:2009-09-03
Release date:2010-04-21
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:D-peptide inhibitors of the p53-MDM2 interaction for targeted molecular therapy of malignant neoplasms.
Proc.Natl.Acad.Sci.USA, 398, 2010
3JZK
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3jzk
CRYSTAL STRUCTURE OF MDM2 WITH CHROMENOTRIAZOLOPYRIMIDINE 1
Descriptor:E3 ubiquitin-protein ligase Mdm2 (E.C.6.3.2.-)
Authors:Huang, X.
Deposit date:2009-09-23
Release date:2009-11-17
Modification date:2010-04-28
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Discovery and optimization of chromenotriazolopyrimidines as potent inhibitors of the mouse double minute 2-tumor protein 53 protein-protein interaction.
J.Med.Chem., 52, 2009
3JZO
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3jzo
HUMAN MDMX LIGANDED WITH A 12MER PEPTIDE (PDI)
Descriptor:Protein Mdm4, pDI peptide (12mer)
Authors:Schonbrunn, E., Phan, J.
Deposit date:2009-09-23
Release date:2009-11-10
Modification date:2010-01-26
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure-based design of high affinity peptides inhibiting the interaction of p53 with MDM2 and MDMX.
J.Biol.Chem., 285, 2010
3JZP
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3jzp
HUMAN MDMX LIGANDED WITH A 12MER PEPTIDE INHIBITOR (PDI6W)
Descriptor:Protein Mdm4, pDI6W peptide (12mer)
Authors:Schonbrunn, E., Phan, J.
Deposit date:2009-09-24
Release date:2009-11-10
Modification date:2010-01-26
Method:X-RAY DIFFRACTION (1.74 Å)
Cite:Structure-based design of high affinity peptides inhibiting the interaction of p53 with MDM2 and MDMX.
J.Biol.Chem., 285, 2010
3JZQ
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3jzq
HUMAN MDMX LIGANDED WITH A 12MER PEPTIDE INHIBITOR (PDIQ)
Descriptor:Protein Mdm4, pDIQ peptide (12mer)
Authors:Schonbrunn, E., Phan, J.
Deposit date:2009-09-24
Release date:2009-11-10
Modification date:2010-01-26
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure-based design of high affinity peptides inhibiting the interaction of p53 with MDM2 and MDMX.
J.Biol.Chem., 285, 2010
3JZR
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3jzr
HUMAN MDM2 LIGANDED WITH A 12MER PEPTIDE INHIBITOR (PDI6W)
Descriptor:E3 ubiquitin-protein ligase Mdm2 (E.C.6.3.2.-), pDI6W peptide (12mer)
Authors:Schonbrunn, E., Phan, J.
Deposit date:2009-09-24
Release date:2009-11-10
Modification date:2010-01-26
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure-based design of high affinity peptides inhibiting the interaction of p53 with MDM2 and MDMX.
J.Biol.Chem., 285, 2010
3JZS
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3jzs
HUMAN MDM2 LIGANDED WITH A 12MER PEPTIDE INHIBITOR (PDIQ)
Descriptor:E3 ubiquitin-protein ligase Mdm2 (E.C.6.3.2.-), pDIQ peptide (12mer)
Authors:Schonbrunn, E., Phan, J.
Deposit date:2009-09-24
Release date:2009-11-10
Modification date:2010-01-26
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Structure-based design of high affinity peptides inhibiting the interaction of p53 with MDM2 and MDMX.
J.Biol.Chem., 285, 2010
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entries available on 2014-10-22
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