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1NOF
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1nof
THE FIRST CRYSTALLOGRAPHIC STRUCTURE OF A XYLANASE FROM GLYCOSYL HYDROLASE FAMILY 5: IMPLICATIONS FOR CATALYSIS
Descriptor:xylanase
Authors:Larson, S.B., Day, J., McPherson, A., Barba De La Rosa, A.P., Keen, N.T.
Deposit date:2003-01-16
Release date:2003-09-16
Modification date:2012-02-08
Method:X-RAY DIFFRACTION (1.42 Å)
Cite:First crystallographic structure of a xylanase from glycoside hydrolase family 5: implications for catalysis.
Biochemistry, 42, 2003
1OGS
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1ogs
HUMAN ACID-BETA-GLUCOSIDASE
Descriptor:GLUCOSYLCERAMIDASE (E.C.3.2.1.45)
Authors:Dvir, H., Harel, M., Mccarthy, A.A., Toker, L., Silman, I., Futerman, A.H., Sussman, J.L.
Deposit date:2003-05-13
Release date:2003-07-03
Modification date:2012-01-25
Method:X-RAY DIFFRACTION (2 Å)
Cite:X-Ray Structure of Human Acid-Beta-Glucosidase, the Defective Enzyme in Gaucher Disease
Embo Rep., 4, 2003
1Y7V
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1y7v
X-RAY STRUCTURE OF HUMAN ACID-BETA-GLUCOSIDASE COVALENTLY BOUND TO CONDURITOL B EPOXIDE
Descriptor:Glucosylceramidase (E.C.3.2.1.45)
Authors:Premkumar, L., Sawkar, A.R., Boldin-Adamsky, S., Toker, L., Silman, I., Kelly, J.W., Futerman, A.H., Sussman, J.L., Israel Structural Proteomics Center (ISPC)
Deposit date:2004-12-10
Release date:2005-04-12
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:X-ray structure of human acid-beta-glucosidase covalently bound to conduritol-B-epoxide. Implications for Gaucher disease.
J.Biol.Chem., 280, 2005
2F61
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2f61
CRYSTAL STRUCTURE OF PARTIALLY DEGLYCOSYLATED ACID BETA-GLUCOSIDASE
Descriptor:Acid beta-glucosidase (E.C.3.2.1.45)
Authors:Hegde, R.S., Grabowski, G.
Deposit date:2005-11-28
Release date:2005-12-27
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Analyses of Variant Acid beta-Glucosidases: EFFECTS OF GAUCHER DISEASE MUTATIONS.
J.Biol.Chem., 281, 2006
2J25
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2j25
PARTIALLY DEGLYCOSYLATED GLUCOCERAMIDASE
Descriptor:GLUCOSYLCERAMIDASE (E.C.3.2.1.45)
Authors:Brumshtein, B., Wormald, M.R., Silman, I., Futerman, A.H., Sussman, J.L.
Deposit date:2006-08-16
Release date:2006-12-06
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural Comparison of Differently Glycosylated Forms of Acid-Beta-Glucosidase, the Defective Enzyme in Gaucher Disease
Acta Crystallogr.,Sect.D, 62, 2006
2NSX
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2nsx
STRUCTURE OF ACID-BETA-GLUCOSIDASE WITH PHARMACOLOGICAL CHAPERONE PROVIDES INSIGHT INTO GAUCHER DISEASE
Descriptor:Glucosylceramidase (E.C.3.2.1.45)
Authors:Lieberman, R.L., Petsko, G.A., Ringe, D.
Deposit date:2006-11-06
Release date:2006-12-26
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.11 Å)
Cite:Structure of acid beta-glucosidase with pharmacological chaperone provides insight into Gaucher disease.
Nat.Chem.Biol., 3, 2007
2NT0
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2nt0
ACID-BETA-GLUCOSIDASE LOW PH, GLYCEROL BOUND
Descriptor:Glucosylceramidase (E.C.3.2.1.45)
Authors:Lieberman, R.L., Petsko, G.A., Ringe, D.
Deposit date:2006-11-06
Release date:2006-12-26
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:Structure of acid beta-glucosidase with pharmacological chaperone provides insight into Gaucher disease.
Nat.Chem.Biol., 3, 2007
2NT1
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2nt1
STRUCTURE OF ACID-BETA-GLUCOSIDASE AT NEUTRAL PH
Descriptor:Glucosylceramidase (E.C.3.2.1.45)
Authors:Lieberman, R.L., Petsko, G.A., Ringe, D.
Deposit date:2006-11-06
Release date:2006-12-26
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure of acid beta-glucosidase with pharmacological chaperone provides insight into Gaucher disease.
Nat.Chem.Biol., 3, 2007
2V3D
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2v3d
ACID-BETA-GLUCOSIDASE WITH N-BUTYL-DEOXYNOJIRIMYCIN
Descriptor:GLUCOSYLCERAMIDASE (E.C.3.2.1.45)
Authors:Brumshtein, B., Greenblatt, H.M., Butters, T.D., Shaaltiel, Y., Aviezer, D., Silman, I., Futerman, A.H., Sussman, J.L.
Deposit date:2007-06-17
Release date:2007-08-14
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:Crystal Structures of Complexes of N-Butyl- and N-Nonyl-Deoxynojirimycin Bound to Acid Beta-Glucosidase: Insights Into the Mechanism of Chemical Chaperone Action in Gaucher Disease.
J.Biol.Chem., 282, 2007
2V3E
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2v3e
ACID-BETA-GLUCOSIDASE WITH N-NONYL-DEOXYNOJIRIMYCIN
Descriptor:GLUCOSYLCERAMIDASE (E.C.3.2.1.45)
Authors:Brumshtein, B., Greenblatt, H.M., Butters, T.D., Shaaltiel, Y., Aviezer, D., Silman, I., Futerman, A.H., Sussman, J.L.
Deposit date:2007-06-17
Release date:2007-08-21
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal Structures of Complexes of N-Butyl- and N-Nonyl-Deoxynojirimycin Bound to Acid Beta-Glucosidase: Insights Into the Mechanism of Chemical Chaperone Action in Gaucher Disease.
J.Biol.Chem., 282, 2007
2V3F
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2v3f
ACID-BETA-GLUCOSIDASE PRODUCED IN CARROT
Descriptor:GLUCOSYLCERAMIDASE (E.C.3.2.1.45)
Authors:Shaaltiel, Y., Bartfeld, D., Hashmueli, S., Baum, G., Brill-Almon, E., Galili, G., Dym, O., Boldin-Adamsky, S.A., Silman, I., Sussman, J.L., Futerman, A.H., Aviezer, D., Center(Ispc), Israel Structural Proteomics
Deposit date:2007-06-17
Release date:2008-04-08
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Production of Glucocerebrosidase with Terminal Mannose Glycans for Enzyme Replacement Therapy of Gaucher'S Disease Using a Plant Cell System.
Plant Biotechnol.J., 5, 2007
2VT0
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2vt0
X-RAY STRUCTURE OF A CONJUGATE WITH CONDURITOL-BETA-EPOXIDE OF ACID-BETA-GLUCOSIDASE OVEREXPRESSED IN CULTURED PLANT CELLS
Descriptor:GLUCOSYLCERAMIDASE (E.C.3.2.1.45)
Authors:Brumshtein, B., Greenblatt, H.M., Shaaltiel, Y., Aviezer, D., Silman, I., Futerman, A.H., Sussman, J.L.
Deposit date:2008-05-03
Release date:2008-09-23
Modification date:2012-10-10
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Acid Beta-Glucosidase: Insights from Structural Analysis and Relevance to Gaucher Disease Therapy.
Biol.Chem., 389, 2008
2WCG
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2wcg
X-RAY STRUCTURE OF ACID-BETA-GLUCOSIDASE WITH N-OCTYL(CYCLIC GUANIDINE)-NOJIRIMYCIN IN THE ACTIVE SITE
Descriptor:GLUCOSYLCERAMIDASE (E.C.3.2.1.45)
Authors:Brumshtein, B., Aguilar, M., Garcia-Moreno, M.I., Mellet, C.O., Garcia-Fernandez, J.M., Silman, I., Shaaltiel, Y., Aviezer, D., Sussman, J.L., Futerman, A.H.
Deposit date:2009-03-12
Release date:2009-11-24
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:6-Amino-6-Deoxy-5,6-Di-N-(N'-Octyliminomethylidene)Nojirimycin: Synthesis, Biological Evaluation, and Crystal Structure in Complex with Acid Beta-Glucosidase.
Chembiochem, 10, 2009
2WKL
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2wkl
VELAGLUCERASE ALFA
Descriptor:GLUCOSYLCERAMIDASE (E.C.3.2.1.45)
Authors:Brumshtein, B., Salinas, P., Peterson, B., Chan, V., Silman, I., Sussman, J.L., Savickas, P.J., Robinson, G.S., Futerman, A.H.
Deposit date:2009-06-15
Release date:2009-09-22
Modification date:2009-12-08
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Characterization of Gene-Activated Human Acid-Beta-Glucosidase: Crystal Structure, Glycan Composition and Internalization Into Macrophages.
Glycobiology, 20, 2010
2WNW
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2wnw
THE CRYSTAL STRUCTURE OF SRFJ FROM SALMONELLA TYPHIMURIUM
Descriptor:ACTIVATED BY TRANSCRIPTION FACTOR SSRB
Authors:Kim, Y.-G., Kim, J.-H., Kim, K.-J.
Deposit date:2009-07-20
Release date:2010-03-02
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal Structure of the Salmonella Enterica Serovar Typhimurium Virulence Factor Srfj, a Glycoside Hydrolase Family Enzyme.
J.Bacteriol., 191, 2009
2XWD
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2xwd
X-RAY STRUCTURE OF ACID-BETA-GLUCOSIDASE WITH 5N,6O-(N'-(N-OCTYL)IMINO)NOJIRIMYCIN IN THE ACTIVE SITE
Descriptor:GLUCOSYLCERAMIDASE (E.C.3.2.1.45)
Authors:Brumshtein, B., Aguilar-Moncayo, M., Benito, J.M., Ortiz Mellet, C., Garcia Fernandez, J.M., Silman, I., Shaaltiel, Y., Sussman, J.L., Futerman, A.H.
Deposit date:2010-11-01
Release date:2011-09-14
Method:X-RAY DIFFRACTION (2.66 Å)
Cite:Cyclodextrin-Mediated Crystallization of Acid Beta-Glucosidase in Complex with Amphiphilic Bicyclic Nojirimycin Analogues.
Org.Biomol.Chem., 9, 2011
2XWE
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2xwe
X-RAY STRUCTURE OF ACID-BETA-GLUCOSIDASE WITH 5N,6S-(N'-(N-OCTYL)IMINO)-6-THIONOJIRIMYCIN IN THE ACTIVE SITE
Descriptor:GLUCOSYLCERAMIDASE (E.C.3.2.1.45)
Authors:Brumshtein, B., Aguilar-Moncayo, M., Benito, J.M., Ortiz Mellet, C., Garcia Fernandez, J.M., Silman, I., Shaaltiel, Y., Sussman, J.L., Futerman, A.H.
Deposit date:2010-11-02
Release date:2011-09-14
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:Cyclodextrin-Mediated Crystallization of Acid Beta-Glucosidase in Complex with Amphiphilic Bicyclic Nojirimycin Analogues.
Org.Biomol.Chem., 9, 2011
2Y24
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2y24
STRUCTURAL BASIS FOR SUBSTRATE RECOGNITION BY ERWINIA CHRYSANTHEMI GH5 GLUCURONOXYLANASE
Descriptor:XYLANASE (E.C.3.2.1.8, 3.2.1.136)
Authors:Urbanikova, L., Vrsanska, M., Krogh, K.B., Hoff, T., Biely, P.
Deposit date:2010-12-13
Release date:2011-06-01
Modification date:2011-12-21
Method:X-RAY DIFFRACTION (1.39 Å)
Cite:Structural Basis for Substrate Recognition by Erwinia Chrysanthemi Gh30 Glucuronoxylanase.
FEBS J., 278, 2011
3GTN
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3gtn
CRYSTAL STRUCTURE OF XYNC FROM BACILLUS SUBTILIS 168
Descriptor:Glucuronoxylanase xynC (E.C.3.2.1.136)
Authors:St John, F.J., Hurlbert, J.C., Pozharski, E.
Deposit date:2009-03-27
Release date:2009-04-28
Modification date:2010-06-09
Method:X-RAY DIFFRACTION (2.68 Å)
Cite:Crystallization and crystallographic analysis of Bacillus subtilis xylanase C.
Acta Crystallogr.,Sect.F, 65, 2009
3GXD
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3gxd
CRYSTAL STRUCTURE OF APO ACID-BETA-GLUCOSIDASE PH 4.5
Descriptor:Glucosylceramidase (E.C.3.2.1.45)
Authors:Lieberman, R.L.
Deposit date:2009-04-02
Release date:2009-05-05
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Effects of pH and iminosugar pharmacological chaperones on lysosomal glycosidase structure and stability.
Biochemistry, 48, 2009
3GXF
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3gxf
CRYSTAL STRUCTURE OF ACID-BETA-GLUCOSIDASE WITH ISOFAGOMINE AT NEUTRAL PH
Descriptor:Glucosylceramidase (E.C.3.2.1.45)
Authors:Lieberman, R.L.
Deposit date:2009-04-02
Release date:2009-05-05
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Effects of pH and iminosugar pharmacological chaperones on lysosomal glycosidase structure and stability.
Biochemistry, 48, 2009
3GXI
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3gxi
CRYSTAL STRUCTURE OF ACID-BETA-GLUCOSIDASE AT PH 5.5
Descriptor:Glucosylceramidase (E.C.3.2.1.45)
Authors:Lieberman, R.L.
Deposit date:2009-04-02
Release date:2009-05-05
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (1.84 Å)
Cite:Effects of pH and iminosugar pharmacological chaperones on lysosomal glycosidase structure and stability.
Biochemistry, 48, 2009
3GXM
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3gxm
CRYSTAL STRUCTURE OF ACID-BETA-GLUCOSIDASE AT PH 4.5, PHOSPHATE CRYSTALLIZATION CONDITION
Descriptor:Glucosylceramidase (E.C.3.2.1.45)
Authors:Lieberman, R.L.
Deposit date:2009-04-02
Release date:2009-05-05
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Effects of pH and iminosugar pharmacological chaperones on lysosomal glycosidase structure and stability.
Biochemistry, 48, 2009
3KE0
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3ke0
CRYSTAL STRUCTURE OF N370S GLUCOCEREBROSIDASE AT ACIDIC PH.
Descriptor:Glucosylceramidase (E.C.3.2.1.45)
Authors:Wei, R.R., Boucher, S., Pan, C.Q., Edmunds, T.
Deposit date:2009-10-23
Release date:2010-10-27
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal Structure of Glucocerebrosidase Containing the N370S Mutation, Implications for Chaperon Therapy
To be Published
3KEH
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3keh
CRYSTAL STRUCTURE OF N370S GLUCOCEREBROSIDASE MUTANT AT PH 7.4
Descriptor:Glucocerebrosidase (E.C.3.2.1.45)
Authors:Wei, R.R., Boucher, S., Pan, C.Q., Edmunds, T.
Deposit date:2009-10-26
Release date:2010-10-27
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal Structure of Glucocerebrosidase Containing the N370S mutation: Implication on Chaperon Therapy
To be Published
<12>
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