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8P5N
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BU of 8p5n by Molmil
Arsenate reductase (ArsC2) from Deinococcus indicus, co-crystallized with arsenate
Descriptor: ARSENATE, GLYCEROL, Low molecular weight phosphatase family protein
Authors:Gouveia, A.G, Matias, P.M, Romao, C.V.
Deposit date:2023-05-24
Release date:2023-08-30
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Unraveling the multifaceted resilience of arsenic resistant bacterium Deinococcus indicus .
Front Microbiol, 14, 2023
8P6M
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BU of 8p6m by Molmil
Arsenate reductase (ArsC2) from Deinococcus indicus
Descriptor: Low molecular weight phosphatase family protein
Authors:Gouveia, A.G, Matias, P.M, Romao, C.V.
Deposit date:2023-05-26
Release date:2023-08-30
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Unraveling the multifaceted resilience of arsenic resistant bacterium Deinococcus indicus .
Front Microbiol, 14, 2023
7UW6
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BU of 7uw6 by Molmil
The co-crystal structure of low molecular weight protein tyrosine phosphatase (LMW-PTP) with a small molecule inhibitor SPAA-2
Descriptor: 2-[(1,3-benzothiazol-2-yl)amino]-2-oxoethane-1-sulfonic acid, Low molecular weight phosphotyrosine protein phosphatase
Authors:Wang, J, Zhang, Z.Y.
Deposit date:2022-05-02
Release date:2022-10-19
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structure-Based Design of Active-Site-Directed, Highly Potent, Selective, and Orally Bioavailable Low-Molecular-Weight Protein Tyrosine Phosphatase Inhibitors.
J.Med.Chem., 65, 2022
7PUA
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BU of 7pua by Molmil
Middle assembly intermediate of the Trypanosoma brucei mitoribosomal small subunit
Descriptor: 30S Ribosomal protein S17, putative, 30S ribosomal protein S8, ...
Authors:Lenarcic, T, Leibundgut, M, Saurer, M, Ramrath, D.J.F, Fluegel, T, Boehringer, D, Ban, N.
Deposit date:2021-09-29
Release date:2022-03-02
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Mitoribosomal small subunit maturation involves formation of initiation-like complexes.
Proc.Natl.Acad.Sci.USA, 119, 2022
7KH8
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BU of 7kh8 by Molmil
Human LMPTP in complex with inhibitor
Descriptor: 3-[(2,6-dichlorophenyl)methyl]-8-(2-methylphenyl)-3H-purin-6-amine, Low molecular weight phosphotyrosine protein phosphatase, NITRATE ION
Authors:Stanford, S.M, Diaz, M.A, Ardecky, R.J, Zou, J, Roosild, T, Holmes, Z.J, Hedrick, M.P, Rodiles, S, Santelli, E, Chung, T.D.Y, Jackson, M.R, Bottini, N, Pinkerton, A.B.
Deposit date:2020-10-20
Release date:2021-05-19
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Discovery of Orally Bioavailable Purine-Based Inhibitors of the Low-Molecular-Weight Protein Tyrosine Phosphatase.
J.Med.Chem., 64, 2021
7DHD
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BU of 7dhd by Molmil
Vibrio vulnificus Wzb
Descriptor: CHLORIDE ION, Protein-tyrosine-phosphatase
Authors:Ma, Q, Wang, X.
Deposit date:2020-11-14
Release date:2021-01-20
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.71 Å)
Cite:Wzb of Vibrio vulnificus represents a new group of low-molecular-weight protein tyrosine phosphatases with a unique insertion in the W-loop.
J.Biol.Chem., 296, 2021
7DHF
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BU of 7dhf by Molmil
Vibrio vulnificus Wzb in complex with benzylphosphonate
Descriptor: GLYCEROL, PHOSPHATE ION, Protein-tyrosine-phosphatase
Authors:Ma, Q, Wang, X.
Deposit date:2020-11-14
Release date:2021-01-20
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.211 Å)
Cite:Wzb of Vibrio vulnificus represents a new group of low-molecular-weight protein tyrosine phosphatases with a unique insertion in the W-loop.
J.Biol.Chem., 296, 2021
7DHE
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BU of 7dhe by Molmil
Vibrio vulnificus Wzb in complex with benzylphosphonate
Descriptor: Protein-tyrosine-phosphatase, benzylphosphonic acid
Authors:Ma, Q, Wang, X.
Deposit date:2020-11-14
Release date:2021-01-20
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.79 Å)
Cite:Wzb of Vibrio vulnificus represents a new group of low-molecular-weight protein tyrosine phosphatases with a unique insertion in the W-loop.
J.Biol.Chem., 296, 2021
7BTG
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BU of 7btg by Molmil
Crystal structure of DARP, drosophila arginine phosphatase
Descriptor: CHLORIDE ION, GEO10716p1, PHOSPHATE ION
Authors:Lee, H.S, Mo, Y, Ku, B, Kim, S.J.
Deposit date:2020-04-01
Release date:2021-01-13
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.188 Å)
Cite:Structural and Biochemical Characterization of the Two Drosophila Low Molecular Weight-Protein Tyrosine Phosphatases DARP and Primo-1.
Mol.Cells, 43, 2020
7CUY
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BU of 7cuy by Molmil
Crystal structure of Primo-1
Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Low molecular weight phosphotyrosine protein phosphatase 1
Authors:Lee, H.S, Kim, S.J, Ku, B.
Deposit date:2020-08-25
Release date:2021-01-13
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.081 Å)
Cite:Structural and Biochemical Characterization of the Two Drosophila Low Molecular Weight-Protein Tyrosine Phosphatases DARP and Primo-1.
Mol.Cells, 43, 2020
6U1P
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BU of 6u1p by Molmil
Crystal structure of VpsU (VC0916) from Vibrio cholerae
Descriptor: GLYCEROL, Low molecular weight phosphotyrosine protein phosphatase
Authors:Tripathi, S.M, Schwechheimer, C, Herbert, K, Osorio, J, Yildiz, F.H, Rubin, S.M.
Deposit date:2019-08-16
Release date:2020-08-19
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.201 Å)
Cite:A tyrosine phosphoregulatory system controls exopolysaccharide biosynthesis and biofilm formation in Vibrio cholerae.
Plos Pathog., 16, 2020
6Y2V
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BU of 6y2v by Molmil
Crystal structure of the double mutant L13R I16K of Low Molecular Weight Protein Tyrosine Phosphatase (LMW-PTP)
Descriptor: Low molecular weight phosphotyrosine protein phosphatase, PHOSPHATE ION, TRIETHYLENE GLYCOL
Authors:Levy, C.
Deposit date:2020-02-17
Release date:2020-07-22
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Computational and structure-guided design of phosphoinositide substrate specificity into the tyrosine specific LMW-PTP enzyme.
Plos One, 15, 2020
6Y2W
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BU of 6y2w by Molmil
Crystal structure of the single mutant I16K of Low Molecular Weight Protein Tyrosine Phosphatase (LMW-PTP)
Descriptor: ACETATE ION, Low molecular weight phosphotyrosine protein phosphatase
Authors:Levy, C.
Deposit date:2020-02-17
Release date:2020-07-22
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.77 Å)
Cite:Computational and structure-guided design of phosphoinositide substrate specificity into the tyrosine specific LMW-PTP enzyme.
Plos One, 15, 2020
6SGB
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BU of 6sgb by Molmil
mt-SSU assemblosome of Trypanosoma brucei
Descriptor: 9S rRNA, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
Authors:Saurer, M, Ramrath, D.J.F, Niemann, M, Calderaro, S, Prange, C, Mattei, S, Scaiola, A, Leitner, A, Bieri, P, Horn, E.K, Leibundgut, M, Boehringer, D, Schneider, A, Ban, N.
Deposit date:2019-08-03
Release date:2019-09-25
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Mitoribosomal small subunit biogenesis in trypanosomes involves an extensive assembly machinery.
Science, 365, 2019
6SGA
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BU of 6sga by Molmil
Body domain of the mt-SSU assemblosome from Trypanosoma brucei
Descriptor: 9S rRNA, MAGNESIUM ION, PHOSPHATE ION, ...
Authors:Saurer, M, Ramrath, D.J.F, Niemann, M, Calderaro, S, Prange, C, Mattei, S, Scaiola, A, Leitner, A, Bieri, P, Horn, E.K, Leibundgut, M, Boehringer, D, Schneider, A, Ban, N.
Deposit date:2019-08-03
Release date:2019-09-18
Last modified:2019-09-25
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Mitoribosomal small subunit biogenesis in trypanosomes involves an extensive assembly machinery.
Science, 365, 2019
5Z3M
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BU of 5z3m by Molmil
Crystal structure of Low Molecular Weight Phosphotyrosine phosphatase (VcLMWPTP-2) from Vibrio choleraeO395
Descriptor: 3[N-MORPHOLINO]PROPANE SULFONIC ACID, GLYCEROL, Phosphotyrosine protein phosphatase, ...
Authors:Chatterjee, S, Nath, S, Sen, U.
Deposit date:2018-01-08
Release date:2018-09-19
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Vibrio cholerae LMWPTP-2 display unique surface charge and grooves around the active site: Indicative of distinctive substrate specificity and scope to design specific inhibitor.
Biochim Biophys Acta Proteins Proteom, 1867, 2019
5O7B
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BU of 5o7b by Molmil
CRYSTAL STRUCTURE OF THE SLR0328 TYROSINE PHOSPHATASE WZB FROM SYNECHOCYSTIS SP. PCC 6803
Descriptor: Putative low molecular weight protein-tyrosine-phosphatase slr0328
Authors:Leite, J.P, Gales, L.
Deposit date:2017-06-08
Release date:2018-06-20
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.281 Å)
Cite:The role of the tyrosine kinase Wzc (Sll0923) and the phosphatase Wzb (Slr0328) in the production of extracellular polymeric substances (EPS) by Synechocystis PCC 6803.
Microbiologyopen, 2019
5JNU
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BU of 5jnu by Molmil
Crystal structure of mouse Low-Molecular Weight Protein Tyrosine Phosphatase type A (LMPTP-A) complexed with phosphate
Descriptor: Low molecular weight phosphotyrosine protein phosphatase, PHOSPHATE ION
Authors:Stanford, S.M, Aleshin, A.E, Liddington, R.C, Bankston, L, Cadwell, G, Bottini, N.
Deposit date:2016-04-30
Release date:2017-03-29
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.535 Å)
Cite:Diabetes reversal by inhibition of the low-molecular-weight tyrosine phosphatase.
Nat. Chem. Biol., 13, 2017
5JNW
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BU of 5jnw by Molmil
Crystal structure of bovine low molecular weight protein tyrosine phosphatase (LMPTP) mutant (W49Y N50E) complexed with vanadate and uncompetitive inhibitor
Descriptor: 2-(4-{[3-(piperidin-1-yl)propyl]amino}quinolin-2-yl)benzonitrile, Low molecular weight phosphotyrosine protein phosphatase, VANADATE ION
Authors:Stanford, S.M, Aleshin, A.E, Liddington, R.C, Bankston, L, Cadwell, G, Bottini, N.
Deposit date:2016-04-30
Release date:2017-03-29
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Diabetes reversal by inhibition of the low-molecular-weight tyrosine phosphatase.
Nat. Chem. Biol., 13, 2017
5JNS
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BU of 5jns by Molmil
Crystal structure of human low molecular weight protein tyrosine phosphatase (LMPTP) type A complexed with phosphate
Descriptor: DIMETHYL SULFOXIDE, Low molecular weight phosphotyrosine protein phosphatase, PHOSPHATE ION
Authors:Stanford, S.M, Aleshin, A.E, Liddington, R.C, Bankston, L, Cadwell, G, Bottini, N.
Deposit date:2016-04-30
Release date:2017-03-29
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Diabetes reversal by inhibition of the low-molecular-weight tyrosine phosphatase.
Nat. Chem. Biol., 13, 2017
5JNV
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BU of 5jnv by Molmil
Crystal structure of bovine low molecular weight protein tyrosine phosphatase (LMPTP) mutant (W49Y N50E) complexed with HEPES
Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, DIMETHYL SULFOXIDE, Low molecular weight phosphotyrosine protein phosphatase
Authors:Stanford, S.M, Aleshin, A.E, Liddington, R.C, Bankston, L, Cadwell, G, Bottini, N.
Deposit date:2016-04-30
Release date:2017-03-29
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Diabetes reversal by inhibition of the low-molecular-weight tyrosine phosphatase.
Nat. Chem. Biol., 13, 2017
5JNT
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BU of 5jnt by Molmil
Crystal structure of human low molecular weight protein tyrosine phosphatase (LMPTP) type A complexed with MES
Descriptor: 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, DIMETHYL SULFOXIDE, ...
Authors:Stanford, S.M, Aleshin, A.E, Liddington, R.C, Bankston, L, Cadwell, G, Bottini, N.
Deposit date:2016-04-30
Release date:2017-03-29
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Diabetes reversal by inhibition of the low-molecular-weight tyrosine phosphatase.
Nat. Chem. Biol., 13, 2017
5JNR
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BU of 5jnr by Molmil
Crystal structure of human low molecular weight protein tyrosine phosphatase (LMPTP) type A
Descriptor: Low molecular weight phosphotyrosine protein phosphatase
Authors:Stanford, S.M, Aleshin, A.E, Liddington, R.C, Bankston, L, Cadwell, G, Bottini, N.
Deposit date:2016-04-30
Release date:2017-03-29
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2 Å)
Cite:Diabetes reversal by inhibition of the low-molecular-weight tyrosine phosphatase.
Nat. Chem. Biol., 13, 2017
5KQL
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BU of 5kql by Molmil
Co-crystal structure of LMW-PTP in complex with 2-oxo-1-phenyl-2-(phenylamino)ethanesulfonic acid
Descriptor: (1~{S})-2-oxidanylidene-1-phenyl-2-phenylazanyl-ethanesulfonic acid, Low molecular weight phosphotyrosine protein phosphatase
Authors:Wang, J, Zhang, Z.-Y, Yu, Z.-H.
Deposit date:2016-07-06
Release date:2016-10-12
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Inhibition of low molecular weight protein tyrosine phosphatase by an induced-fit mechanism.
J.Med.Chem., 2016
5KQP
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BU of 5kqp by Molmil
Crystal structure of Apo-form LMW-PTP
Descriptor: Low molecular weight phosphotyrosine protein phosphatase
Authors:Wang, J, Zhang, Z.-Y, Yu, Z.-H.
Deposit date:2016-07-06
Release date:2016-10-12
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.052 Å)
Cite:Inhibition of low molecular weight protein tyrosine phosphatase by an induced-fit mechanism.
J.Med.Chem., 2016

 

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