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5GWD
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BU of 5gwd by Molmil
Structure of Myroilysin
Descriptor: Myroilysin, ZINC ION
Authors:Xu, D, Ran, T, Wang, W.
Deposit date:2016-09-10
Release date:2017-02-15
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Myroilysin Is a New Bacterial Member of the M12A Family of Metzincin Metallopeptidases and Is Activated by a Cysteine Switch Mechanism.
J. Biol. Chem., 292, 2017
1AST
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BU of 1ast by Molmil
STRUCTURE OF ASTACIN AND IMPLICATIONS FOR ACTIVATION OF ASTACINS AND ZINC-LIGATION OF COLLAGENASES
Descriptor: ASTACIN, ZINC ION
Authors:Bode, W, Gomis-Rueth, F.X, Stoecker, W.
Deposit date:1993-04-21
Release date:1994-07-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure of astacin and implications for activation of astacins and zinc-ligation of collagenases.
Nature, 358, 1992
5CZW
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BU of 5czw by Molmil
Crystal structure of myroilysin
Descriptor: Myroilysin, ZINC ION
Authors:Zhou, J, Ran, T, Xu, D, Wang, W.
Deposit date:2015-08-01
Release date:2016-08-03
Last modified:2017-04-26
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Myroilysin is a New Bacterial Member of the M12A Family of Metzincin Metallopeptidases and Activated by a Cysteine-switch Mechanism
J. Biol. Chem., 292, 2017
3VTG
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BU of 3vtg by Molmil
High choriolytic enzyme 1 (HCE-1), a hatching enzyme zinc-protease from Oryzias latipes (Medaka fish)
Descriptor: High choriolytic enzyme 1, ZINC ION
Authors:Kudo, N, Yasumasu, S, Iuchi, I, Tanokura, M.
Deposit date:2012-05-30
Release date:2013-06-05
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.34 Å)
Cite:Crystal Structure of High choriolytic enzyme 1 (HCE-1), a hatching enzyme from Oryzias latipes (Medaka fish)
To be Published
6BSL
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BU of 6bsl by Molmil
BMP1 complexed with a reverse hydroxymate - compound 22
Descriptor: 1,2-ETHANEDIOL, Bone morphogenetic protein 1, N-(2-ethoxy-4-{5-[({[(2R)-2-{(1R)-1-[formyl(hydroxy)amino]propyl}heptanoyl]amino}methyl)carbamoyl]furan-2-yl}benzene-1-carbonyl)-L-aspartic acid, ...
Authors:Gampe, R, Shewchuk, L.
Deposit date:2017-12-04
Release date:2018-08-08
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Reverse Hydroxamate Inhibitors of Bone Morphogenetic Protein 1.
ACS Med Chem Lett, 9, 2018
6BTQ
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BU of 6btq by Molmil
BMP1 complexed with a hydroxamate - compound 2
Descriptor: 1,2-ETHANEDIOL, Bone morphogenetic protein 1, N~2~-[(2H-1,3-benzodioxol-5-yl)methyl]-N-hydroxy-N~2~-[(4-methoxyphenyl)sulfonyl]-3-thiophen-2-yl-D-alaninamide, ...
Authors:Gampe, R, Shewchuk, L.
Deposit date:2017-12-07
Release date:2018-08-08
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Reverse Hydroxamate Inhibitors of Bone Morphogenetic Protein 1.
ACS Med Chem Lett, 9, 2018
1QJI
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BU of 1qji by Molmil
Structure of astacin with a transition-state analogue inhibitor
Descriptor: ASTACIN, CARBOBENZOXY-PRO-LYS-PHE-Y(PO2)-ALA-PRO-OME, ZINC ION
Authors:Grams, F, Bode, W, Stocker, W.
Deposit date:1999-06-24
Release date:2000-01-21
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.14 Å)
Cite:Structure of Astacin with a Transition-State Analogue Inhibitor
Nat.Struct.Biol., 3, 1996
1QJJ
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BU of 1qjj by Molmil
Structure of astacin with a hydroxamic acid inhibitor
Descriptor: ASTACIN, PRO-LEU-GLY-HYDROXAMIC ACID, ZINC ION
Authors:Grams, F, Bode, W, Stocker, W.
Deposit date:1999-06-24
Release date:2000-01-24
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Structure of Astacin with a Transition-State Analogue Inhibitor
Nat.Struct.Biol., 3, 1996
3LQB
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BU of 3lqb by Molmil
Crystal structure of the hatching enzyme ZHE1 from the zebrafish Danio rerio
Descriptor: 1,2-ETHANEDIOL, LOC792177 protein, SULFATE ION, ...
Authors:Tanokura, M, Okada, A, Nagata, K, Yasumasu, S, Ohtsuka, J, Iuchi, I.
Deposit date:2010-02-08
Release date:2010-09-08
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Crystal structure of zebrafish hatching enzyme 1 from the zebrafish Danio rerio
J.Mol.Biol., 402, 2010
3LQ0
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BU of 3lq0 by Molmil
Zymogen structure of crayfish astacin metallopeptidase
Descriptor: GLYCEROL, ProAstacin, SULFATE ION, ...
Authors:Guevara, T, Yiallouros, I, Kappelhoff, R, Bissdorf, S, Stocker, W, Gomis-Ruth, F.X.
Deposit date:2010-02-08
Release date:2010-02-23
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Proenzyme structure and activation of astacin metallopeptidase
J.Biol.Chem., 285, 2010
3EDG
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BU of 3edg by Molmil
Crystal structure of bone morphogenetic protein 1 protease domain
Descriptor: ACETYL GROUP, Bone morphogenetic protein 1, ZINC ION
Authors:Mac Sweeney, A.
Deposit date:2008-09-03
Release date:2008-09-16
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.27 Å)
Cite:Structural basis for the substrate specificity of bone morphogenetic protein 1/tolloid-like metalloproteases
To be Published
3EDI
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BU of 3edi by Molmil
Crystal structure of tolloid-like protease 1 (TLL-1) protease domain
Descriptor: ACETYL GROUP, DIMETHYL SULFOXIDE, SULFATE ION, ...
Authors:Mac Sweeney, A.
Deposit date:2008-09-03
Release date:2008-09-16
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Structural basis for the substrate specificity of bone morphogenetic protein 1/tolloid-like metalloproteases
To be Published
3EDH
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BU of 3edh by Molmil
Crystal structure of bone morphogenetic protein 1 protease domain in complex with partially bound DMSO
Descriptor: ACETYL GROUP, Bone morphogenetic protein 1, DIMETHYL SULFOXIDE, ...
Authors:Mac Sweeney, A.
Deposit date:2008-09-03
Release date:2008-09-16
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Structural basis for the substrate specificity of bone morphogenetic protein 1/tolloid-like metalloproteases
To be Published
1IAE
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BU of 1iae by Molmil
CRYSTAL STRUCTURES, SPECTROSCOPIC FEATURES, AND CATALYTIC PROPERTIES OF COBALT(II), COPPER(II), NICKEL(II), AND MERCURY(II) DERIVATIVES OF THE ZINC ENDOPEPTIDASE ASTACIN. A CORRELATION OF STRUCTURE AND PROTEOLYTIC ACTIVITY
Descriptor: ASTACIN, NICKEL (II) ION
Authors:Grams, F, Stoecker, W, Bode, W.
Deposit date:1994-05-09
Release date:1994-08-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:Crystal structures, spectroscopic features, and catalytic properties of cobalt(II), copper(II), nickel(II), and mercury(II) derivatives of the zinc endopeptidase astacin. A correlation of structure and proteolytic activity.
J.Biol.Chem., 269, 1994
1IAD
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BU of 1iad by Molmil
REFINED 1.8 ANGSTROMS X-RAY CRYSTAL STRUCTURE OF ASTACIN, A ZINC-ENDOPEPTIDASE FROM THE CRAYFISH ASTACUS ASTACUS L. STRUCTURE DETERMINATION, REFINEMENT, MOLECULAR STRUCTURE AND COMPARISON TO THERMOLYSIN
Descriptor: ASTACIN
Authors:Gomis-Rueth, F.-X, Stoecker, W, Bode, W.
Deposit date:1994-05-09
Release date:1994-08-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Refined 1.8 A X-ray crystal structure of astacin, a zinc-endopeptidase from the crayfish Astacus astacus L. Structure determination, refinement, molecular structure and comparison with thermolysin.
J.Mol.Biol., 229, 1993
1IAB
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BU of 1iab by Molmil
CRYSTAL STRUCTURES, SPECTROSCOPIC FEATURES, AND CATALYTIC PROPERTIES OF COBALT(II), COPPER(II), NICKEL(II), AND MERCURY(II) DERIVATIVES OF THE ZINC ENDOPEPTIDASE ASTACIN. A CORRELATION OF STRUCTURE AND PROTEOLYTIC ACTIVITY
Descriptor: ASTACIN, COBALT (II) ION
Authors:Gomis-Rueth, F.-X, Stoecker, W, Bode, W.
Deposit date:1994-05-09
Release date:1994-08-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:Crystal structures, spectroscopic features, and catalytic properties of cobalt(II), copper(II), nickel(II), and mercury(II) derivatives of the zinc endopeptidase astacin. A correlation of structure and proteolytic activity.
J.Biol.Chem., 269, 1994
1IAA
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BU of 1iaa by Molmil
CRYSTAL STRUCTURES, SPECTROSCOPIC FEATURES, AND CATALYTIC PROPERTIES OF COBALT(II), COPPER(II), NICKEL(II), AND MERCURY(II) DERIVATIVES OF THE ZINC ENDOPEPTIDASE ASTACIN. A CORRELATION OF STRUCTURE AND PROTEOLYTIC ACTIVITY
Descriptor: ASTACIN, COPPER (II) ION
Authors:Gomis-Rueth, F.-X, Stoecker, W, Bode, W.
Deposit date:1994-05-09
Release date:1994-08-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structures, spectroscopic features, and catalytic properties of cobalt(II), copper(II), nickel(II), and mercury(II) derivatives of the zinc endopeptidase astacin. A correlation of structure and proteolytic activity.
J.Biol.Chem., 269, 1994
1IAC
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BU of 1iac by Molmil
REFINED 1.8 ANGSTROMS X-RAY CRYSTAL STRUCTURE OF ASTACIN, A ZINC-ENDOPEPTIDASE FROM THE CRAYFISH ASTACUS ASTACUS L. STRUCTURE DETERMINATION, REFINEMENT, MOLECULAR STRUCTURE AND COMPARISON WITH THERMOLYSIN
Descriptor: ASTACIN, MERCURY (II) ION
Authors:Gomis-Rueth, F.-X, Stoecker, W, Bode, W.
Deposit date:1994-05-09
Release date:1994-08-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Refined 1.8 A X-ray crystal structure of astacin, a zinc-endopeptidase from the crayfish Astacus astacus L. Structure determination, refinement, molecular structure and comparison with thermolysin.
J.Mol.Biol., 229, 1993
5ZJK
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BU of 5zjk by Molmil
Structure of myroilysin
Descriptor: Myroilysin, PHOSPHATE ION, ZINC ION
Authors:Li, W.D, Ran, T.T, Xu, D.Q, Wang, W.W.
Deposit date:2018-03-20
Release date:2019-03-20
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structure of mature myroilysin and implication for its activation mechanism.
Int.J.Biol.Macromol., 2019
6BTN
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BU of 6btn by Molmil
BMP1 complexed with a reverse hydroxymate - compound 1
Descriptor: (3S)-6-cyclohexyl-3-{3-[(dimethylamino)methyl]-1,2,4-oxadiazol-5-yl}-N-hydroxyhexanamide, 1,2-ETHANEDIOL, Bone morphogenetic protein 1, ...
Authors:Gampe, R, Shewchuk, L.
Deposit date:2017-12-07
Release date:2018-08-08
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Reverse Hydroxamate Inhibitors of Bone Morphogenetic Protein 1.
ACS Med Chem Lett, 9, 2018
6BSM
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BU of 6bsm by Molmil
BMP1 complexed with a reverse hydroxamate - compound 4
Descriptor: Bone morphogenetic protein 1, N-({[(2R)-2-{[hydroxy(hydroxymethyl)amino]methyl}heptanoyl]amino}methyl)-7-methoxy-1-benzofuran-2-carboxamide, ZINC ION
Authors:Gampe, R, Shewchuk, L.
Deposit date:2017-12-04
Release date:2018-08-08
Method:X-RAY DIFFRACTION (2.33 Å)
Cite:Reverse Hydroxamate Inhibitors of Bone Morphogenetic Protein 1.
ACS Med Chem Lett, 9, 2018
6BTO
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BU of 6bto by Molmil
BMP1 complexed with (2~{S})-2-[[(1~{R},3~{S},4~{S})-2-[(2~{R})-2-[2-(oxidanylamino)-2-oxidanylidene-ethyl]heptanoyl]-2-azabicyclo[2.2.1]heptan-3-yl]carbonylamino]-2-phenyl-ethanoic acid
Descriptor: (2~{S})-2-[[(1~{R},3~{S},4~{S})-2-[(2~{R})-2-[2-(oxidanylamino)-2-oxidanylidene-ethyl]heptanoyl]-2-azabicyclo[2.2.1]heptan-3-yl]carbonylamino]-2-phenyl-ethanoic acid, 1,2-ETHANEDIOL, Bone morphogenetic protein 1, ...
Authors:Gampe, R, Shewchuk, L.
Deposit date:2017-12-07
Release date:2018-08-08
Last modified:2019-04-24
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Reverse Hydroxamate Inhibitors of Bone Morphogenetic Protein 1.
ACS Med Chem Lett, 9, 2018
6BTP
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BU of 6btp by Molmil
BMP1 complexed with a hydroxamate
Descriptor: (1R,3S,4S)-2-{(2R)-2-[2-(hydroxyamino)-2-oxoethyl]heptanoyl}-N-(3-methoxypyrazin-2-yl)-2-azabicyclo[2.2.1]heptane-3-carboxamide, Bone morphogenetic protein 1, THIOCYANATE ION, ...
Authors:Gampe, R, Shewchuk, L.
Deposit date:2017-12-07
Release date:2018-08-08
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Reverse Hydroxamate Inhibitors of Bone Morphogenetic Protein 1.
ACS Med Chem Lett, 9, 2018
6SAZ
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BU of 6saz by Molmil
Cleaved human fetuin-b in complex with crayfish astacin
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Astacin, ...
Authors:Gomis-Ruth, F.X, Guevara, T, Cuppari, A, Korschgen, H, Schmitz, C, Kuske, M, Yiallouros, I, Floehr, J, Jahnen-Dechent, W, Stocker, W.
Deposit date:2019-07-18
Release date:2019-10-23
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (3 Å)
Cite:The C-terminal region of human plasma fetuin-B is dispensable for the raised-elephant-trunk mechanism of inhibition of astacin metallopeptidases.
Sci Rep, 9, 2019
8A28
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BU of 8a28 by Molmil
Structure of the astacin zymogen of LAST-MAM from Limulus polyphemus
Descriptor: DI(HYDROXYETHYL)ETHER, GLYCEROL, MAGNESIUM ION, ...
Authors:Guevara, T, Rodriguez Banqueri, A.
Deposit date:2022-06-02
Release date:2022-10-19
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Zymogenic latency in an ∼250-million-year-old astacin metallopeptidase.
Acta Crystallogr D Struct Biol, 78, 2022

 

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