3IP0
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CRYSTAL STRUCTURE OF E. COLI HPPK IN COMPLEX WITH MGAMPCPP AND 6-HYDROXYMETHYLPTERIN/6-CARBOXYPTERIN
Descriptor:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (E.C.2.7.6.3)
Authors:Blaszczyk, J., Ji, X.
Deposit date:2009-08-15
Release date:2009-08-25
Modification date:2016-10-12
Method:X-RAY DIFFRACTION (0.89 Å)
Cite:Dynamic roles of arginine residues 82 and 92 of Escherichia coli 6-hydroxymethyl-7,8-dihydroptein pyrophosphokinase: Crystallographic studies
Biochemistry, 42, 2003
5ETP
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E. COLI 6-HYDROXYMETHYL-7,8-DIHYDROPTERIN PYROPHOSPHOKINASE COMPLEXED WITH AMPCPP AND INHIBITOR AT 1.05 ANGSTROM RESOLUTION
Descriptor:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (E.C.2.7.6.3)
Authors:Dennis, M.L., Peat, T.S., Swarbrick, J.D.
Deposit date:2015-11-17
Release date:2016-05-04
Modification date:2016-06-22
Method:X-RAY DIFFRACTION (1.05 Å)
Cite:Structural Basis for the Selective Binding of Inhibitors to 6-Hydroxymethyl-7,8-dihydropterin Pyrophosphokinase from Staphylococcus aureus and Escherichia coli.
J.Med.Chem., 59, 2016
5ETO
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E. COLI 6-HYDROXYMETHYL-7,8-DIHYDROPTERIN PYROPHOSPHOKINASE COMPLEXED WITH AMPCPP AND INHIBITOR AT 1.07 ANGSTROM RESOLUTION
Descriptor:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (E.C.2.7.6.3)
Authors:Dennis, M.L., Peat, T.S., Swarbrick, J.D.
Deposit date:2015-11-17
Release date:2016-05-04
Modification date:2016-06-22
Method:X-RAY DIFFRACTION (1.07 Å)
Cite:Structural Basis for the Selective Binding of Inhibitors to 6-Hydroxymethyl-7,8-dihydropterin Pyrophosphokinase from Staphylococcus aureus and Escherichia coli.
J.Med.Chem., 59, 2016
4M5I
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THE IDENTIFICATION, ANALYSIS AND STRUCTURE-BASED DEVELOPMENT OF NOVEL INHIBITORS OF 6-HYDROXYMETHYL-7,8-DIHYDROPTERIN PYROPHOSPHOKINASE
Descriptor:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (E.C.2.7.6.3)
Authors:Yun, M., Hoagland, D., Kumar, G., Waddell, B., Rock, C.O., Lee, R.E., White, S.W.
Deposit date:2013-08-08
Release date:2014-04-02
Modification date:2014-04-16
Method:X-RAY DIFFRACTION (1.08 Å)
Cite:The identification, analysis and structure-based development of novel inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase.
Bioorg.Med.Chem., 22, 2014
5ETK
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E. COLI 6-HYDROXYMETHYL-7,8-DIHYDROPTERIN PYROPHOSPHOKINASE COMPLEXED WITH AMPCPP AND INHIBITOR AT 1.09 ANGSTROM RESOLUTION
Descriptor:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (E.C.2.7.6.3)
Authors:Dennis, M.L., Peat, T.S., Swarbrick, J.D.
Deposit date:2015-11-17
Release date:2016-05-04
Modification date:2016-06-22
Method:X-RAY DIFFRACTION (1.09 Å)
Cite:Structural Basis for the Selective Binding of Inhibitors to 6-Hydroxymethyl-7,8-dihydropterin Pyrophosphokinase from Staphylococcus aureus and Escherichia coli.
J.Med.Chem., 59, 2016
4M5L
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THE IDENTIFICATION, ANALYSIS AND STRUCTURE-BASED DEVELOPMENT OF NOVEL INHIBITORS OF 6-HYDROXYMETHYL-7,8-DIHYDROPTERIN PYROPHOSPHOKINASE
Descriptor:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (E.C.2.7.6.3)
Authors:Yun, M., Hoagland, D., Kumar, G., Waddell, B., Rock, C.O., Lee, R.E., White, S.W.
Deposit date:2013-08-08
Release date:2014-04-02
Modification date:2014-04-16
Method:X-RAY DIFFRACTION (1.094 Å)
Cite:The identification, analysis and structure-based development of novel inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase.
Bioorg.Med.Chem., 22, 2014
3HD2
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CRYSTAL STRUCTURE OF E. COLI HPPK(Q50A) IN COMPLEX WITH MGAMPCPP AND PTERIN
Descriptor:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (E.C.2.7.6.3)
Authors:Blaszczyk, J., Li, Y., Yan, H., Ji, X.
Deposit date:2009-05-06
Release date:2010-05-19
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Role of loop coupling in enzymatic catalysis and conformational dynamics
To be Published
3ILO
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CRYSTAL STRUCTURE OF E. COLI HPPK(D97A) IN COMPLEX WITH MGAMPCPP AND 6-HYDROXYMETHYL-7,8-DIHYDROPTERIN
Descriptor:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (E.C.2.7.6.3)
Authors:Blaszczyk, J., Li, Y., Yan, H., Ji, X.
Deposit date:2009-08-07
Release date:2010-08-11
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Structural and functional roles of residues D95 and D97 in E. coli HPPK
To be Published
4M5H
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THE IDENTIFICATION, ANALYSIS AND STRUCTURE-BASED DEVELOPMENT OF NOVEL INHIBITORS OF 6-HYDROXYMETHYL-7,8-DIHYDROPTERIN PYROPHOSPHOKINASE
Descriptor:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (E.C.2.7.6.3)
Authors:Yun, M., Hoagland, D., Kumar, G., Waddell, B., Rock, C.O., Lee, R.E., White, S.W.
Deposit date:2013-08-08
Release date:2014-04-02
Modification date:2014-04-16
Method:X-RAY DIFFRACTION (1.11 Å)
Cite:The identification, analysis and structure-based development of novel inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase.
Bioorg.Med.Chem., 22, 2014
4M5M
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THE IDENTIFICATION, ANALYSIS AND STRUCTURE-BASED DEVELOPMENT OF NOVEL INHIBITORS OF 6-HYDROXYMETHYL-7,8-DIHYDROPTERIN PYROPHOSPHOKINASE
Descriptor:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (E.C.2.7.6.3)
Authors:Yun, M., Hoagland, D., Kumar, G., Waddell, B., Rock, C.O., Lee, R.E., White, S.W.
Deposit date:2013-08-08
Release date:2014-04-02
Modification date:2014-04-16
Method:X-RAY DIFFRACTION (1.118 Å)
Cite:The identification, analysis and structure-based development of novel inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase.
Bioorg.Med.Chem., 22, 2014
3HSG
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CRYSTAL STRUCTURE OF E. COLI HPPK(Y53A) IN COMPLEX WITH MGAMPCPP
Descriptor:HPPK (E.C.2.7.6.3)
Authors:Blaszczyk, J., Li, Y., Yan, H., Ji, X.
Deposit date:2009-06-10
Release date:2010-06-23
Method:X-RAY DIFFRACTION (1.14 Å)
Cite:Pterin-binding site mutation Y53A, N55A or F123A and activity of E. coli HPPK
To be Published
3HSJ
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CRYSTAL STRUCTURE OF E. COLI HPPK(N55A)
Descriptor:HPPK (E.C.2.7.6.3)
Authors:Blaszczyk, J., Li, Y., Yan, H., Ji, X.
Deposit date:2009-06-10
Release date:2010-06-23
Method:X-RAY DIFFRACTION (1.18 Å)
Cite:Pterin-binding site mutation Y53A, N55A or F123A and activity of E. coli HPPK
To be Published
1HQ2
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CRYSTAL STRUCTURE OF A TERNARY COMPLEX OF E.COLI HPPK(R82A) WITH MGAMPCPP AND 6-HYDROXYMETHYL-7,8-DIHYDROPTERIN AT 1.25 ANGSTROM RESOLUTION
Descriptor:6-HYDROXYMETHYL-7,8-DIHYDROPTERIN PYROPHOSPHOKINASE (E.C.2.7.6.3)
Authors:Blaszczyk, J., Ji, X.
Deposit date:2000-12-13
Release date:2003-04-15
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Dynamic Roles of Arginine Residues 82 and 92 of Escherichia coli 6-Hydroxymethyl-7,8-dihydropterin Pyrophosphokinase: Crystallographic Studies
Biochemistry, 42, 2003
1Q0N
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CRYSTAL STRUCTURE OF A TERNARY COMPLEX OF 6-HYDROXYMETHYL-7,8-DIHYDROPTERIN PYROPHOSPHOKINASE FROM E. COLI WITH MGAMPCPP AND 6-HYDROXYMETHYL-7,8-DIHYDROPTERIN AT 1.25 ANGSTROM RESOLUTION
Descriptor:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (E.C.2.7.6.3)
Authors:Blaszczyk, J., Ji, X.
Deposit date:2003-07-16
Release date:2003-08-26
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Catalytic Center Assembly of Hppk as Revealed by the Crystal Structure of a Ternary Complex at 1.25 A Resolution
Structure, 8, 2000
1TMM
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CRYSTAL STRUCTURE OF TERNARY COMPLEX OF E.COLI HPPK(W89A) WITH MGAMPCPP AND 6-HYDROXYMETHYLPTERIN
Descriptor:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (E.C.2.7.6.3)
Authors:Blaszczyk, J., Li, Y., Wu, Y., Shi, G., Ji, X., Yan, H.
Deposit date:2004-06-10
Release date:2005-06-21
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Is the Critical Role of Loop 3 of Escherichia coli 6-Hydroxymethyl-7,8-dihydropterin Pyrophosphokinase in Catalysis Due to Loop-3 Residues Arginine-84 and Tryptophan-89? Site-Directed Mutagenesis, Biochemical, and Crystallographic Studies.
Biochemistry, 44, 2005
4M5K
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THE IDENTIFICATION, ANALYSIS AND STRUCTURE-BASED DEVELOPMENT OF NOVEL INHIBITORS OF 6-HYDROXYMETHYL-7,8-DIHYDROPTERIN PYROPHOSPHOKINASE
Descriptor:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (E.C.2.7.6.3)
Authors:Yun, M., Hoagland, D., Kumar, G., Waddell, B., Rock, C.O., Lee, R.E., White, S.W.
Deposit date:2013-08-08
Release date:2014-04-02
Modification date:2014-04-16
Method:X-RAY DIFFRACTION (1.296 Å)
Cite:The identification, analysis and structure-based development of novel inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase.
Bioorg.Med.Chem., 22, 2014
3HD1
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CRYSTAL STRUCTURE OF E. COLI HPPK(N10A) IN COMPLEX WITH MGAMPCPP
Descriptor:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (E.C.2.7.6.3)
Authors:Blaszczyk, J., Li, Y., Yan, H., Ji, X.
Deposit date:2009-05-06
Release date:2010-05-19
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Role of loop coupling in enzymatic catalysis and conformational dynamics
To be Published
4M5G
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THE IDENTIFICATION, ANALYSIS AND STRUCTURE-BASED DEVELOPMENT OF NOVEL INHIBITORS OF 6-HYDROXYMETHYL-7,8-DIHYDROPTERIN PYROPHOSPHOKINASE
Descriptor:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (E.C.2.7.6.3)
Authors:Yun, M., Hoagland, D., Kumar, G., Waddell, B., Rock, C.O., Lee, R.E., White, S.W.
Deposit date:2013-08-08
Release date:2014-04-02
Modification date:2014-04-16
Method:X-RAY DIFFRACTION (1.31 Å)
Cite:The identification, analysis and structure-based development of novel inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase.
Bioorg.Med.Chem., 22, 2014
5ETR
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S. AUREUS 6-HYDROXYMETHYL-7,8-DIHYDROPTERIN PYROPHOSPHOKINASE COMPLEXED WITH AMPCPP AND INHIBITOR AT 1.32 ANGSTROM RESOLUTION
Descriptor:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (E.C.2.7.6.3)
Authors:Dennis, M.L., Peat, T.S., Swarbrick, J.D.
Deposit date:2015-11-18
Release date:2016-05-04
Modification date:2016-06-22
Method:X-RAY DIFFRACTION (1.32 Å)
Cite:Structural Basis for the Selective Binding of Inhibitors to 6-Hydroxymethyl-7,8-dihydropterin Pyrophosphokinase from Staphylococcus aureus and Escherichia coli.
J.Med.Chem., 59, 2016
1RTZ
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CRYSTAL STRUCTURE OF E.COLI APO-HPPK(V83G/DEL84-89) AT 1.33 ANGSTROM RESOLUTION
Descriptor:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (E.C.2.7.6.3)
Authors:Blaszczyk, J., Ji, X.
Deposit date:2003-12-10
Release date:2004-02-24
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (1.33 Å)
Cite:Essential Roles of a Dynamic Loop in the Catalysis of 6-Hydroxymethyl-7,8-dihydropterin Pyrophosphokinase.
Biochemistry, 43, 2004
1RB0
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CRYSTAL STRUCTURE OF A BINARY COMPLEX OF E. COLI HPPK WITH 6-HYDROXYMETHYLPTERIN-DIPHOSPHATE AT 1.35 ANGSTROM RESOLUTION
Descriptor:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (E.C.2.7.6.3)
Authors:Blaszczyk, J., Ji, X.
Deposit date:2003-10-31
Release date:2004-11-09
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Reaction trajectory of pyrophosphoryl transfer catalyzed by 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase.
Structure, 12, 2004
3KUH
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CRYSTAL STRUCTURE OF E. COLI HPPK(H115A) IN COMPLEX WITH AMPCPP AND HP
Descriptor:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (E.C.2.7.6.3)
Authors:Blaszczyk, J., Li, Y., Yan, H., Ji, X.
Deposit date:2009-11-27
Release date:2010-11-24
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Roles of residues E77 and H115 in E. coli HPPK
To be Published
1RU1
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CRYSTAL STRUCTURE OF A TERNARY COMPLEX OF E. COLI HPPK(V83G/DEL84-89) WITH MGAMPCPP AND 6-HYDROXYMETHYL-7,8-DIHYDROPTERIN AT 1.40 ANGSTROM RESOLUTION (MONOCLINIC FORM)
Descriptor:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (E.C.2.7.6.3)
Authors:Blaszczyk, J., Ji, X.
Deposit date:2003-12-10
Release date:2004-02-24
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Essential Roles of a Dynamic Loop in the Catalysis of 6-Hydroxymethyl-7,8-dihydropterin Pyrophosphokinase.
Biochemistry, 43, 2004
3HSZ
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CRYSTAL STRUCTURE OF E. COLI HPPK(F123A)
Descriptor:HPPK (E.C.2.7.6.3)
Authors:Blaszczyk, J., Li, Y., Yan, H., Ji, X.
Deposit date:2009-06-11
Release date:2010-06-23
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Pterin-binding site mutation Y53A, N55A or F123A and activity of E. coli HPPK
To be Published
3HT0
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CRYSTAL STRUCTURE OF E. COLI HPPK(F123A) IN COMPLEX WITH MGAMPCPP
Descriptor:HPPK (E.C.2.7.6.3)
Authors:Blaszczyk, J., Li, Y., Yan, H., Ji, X.
Deposit date:2009-06-11
Release date:2010-06-23
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Pterin-binding site mutation Y53A, N55A or F123A and activity of E. coli HPPK
To be Published
<123>
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