1D3G
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HUMAN DIHYDROOROTATE DEHYDROGENASE COMPLEXED WITH BREQUINAR ANALOG
Descriptor:DIHYDROOROTATE DEHYDROGENASE (1.3.3.1)
Authors:Liu, S., Neidhardt, E.A., Grossman, T.H., Ocain, T., Clardy, J.
Deposit date:1999-09-29
Release date:2000-09-13
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structures of human dihydroorotate dehydrogenase in complex with antiproliferative agents.
Structure Fold.Des., 8, 2000
1D3H
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HUMAN DIHYDROOROTATE DEHYDROGENASE COMPLEXED WITH ANTIPROLIFERATIVE AGENT A771726
Descriptor:DIHYDROOROTATE DEHYDROGENASE (1.3.3.1)
Authors:Liu, S., Neidhardt, E.A., Grossman, T.H., Ocain, T., Clardy, J.
Deposit date:1999-09-29
Release date:2000-08-13
Modification date:2012-07-18
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structures of human dihydroorotate dehydrogenase in complex with antiproliferative agents.
Structure Fold.Des., 8, 2000
1F76
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ESCHERICHIA COLI DIHYDROOROTATE DEHYDROGENASE
Descriptor:DIHYDROOROTATE DEHYDROGENASE (E.C.1.3.3.1)
Authors:Norager, S., Jensen, K.F., Bjornberg, O., Larsen, S.
Deposit date:2000-06-26
Release date:2002-10-16
Modification date:2014-03-12
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:E. coli Dihydroorotate Dehydrogenase Reveals Structural and Functional Distinction between different classes of dihydroorotate dehydrogenases
Structure, 10, 2002
1GT8
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DIHYDROPYRIMIDINE DEHYDROGENASE (DPD) FROM PIG, TERNARY COMPLEX WITH NADPH AND URACIL-4-ACETIC ACID
Descriptor:DIHYDROPYRIMIDINE DEHYDROGENASE (E.C.1.3.1.2)
Authors:Dobritzsch, D., Ricagno, S., Schneider, G., Schnackerz, K.D., Lindqvist, Y.
Deposit date:2002-01-14
Release date:2002-04-11
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Crystal Structure of the Productive Ternary Complex of Dihydropyrimidine Dehydrogenase with Nadph and 5-Iodouracil. Implications for Mechanism of Inhibition and Electron Transfer
J.Biol.Chem., 277, 2002
1GTE
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DIHYDROPYRIMIDINE DEHYDROGENASE (DPD) FROM PIG, BINARY COMPLEX WITH 5-IODOURACIL
Descriptor:DIHYDROPYRIMIDINE DEHYDROGENASE (E.C.1.3.1.2)
Authors:Dobritzsch, D., Ricagno, S., Schneider, G., Schnackerz, K.D., Lindqvist, Y.
Deposit date:2002-01-15
Release date:2002-04-11
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Crystal Structure of the Productive Ternary Complex of Dihydropyrimidine Dehydrogenase with Nadph and 5-Iodouracil. Implications for Mechanism of Inhibition and Electron Transfer
J.Biol.Chem., 277, 2002
1GTH
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DIHYDROPYRIMIDINE DEHYDROGENASE (DPD) FROM PIG, TERNARY COMPLEX WITH NADPH AND 5-IODOURACIL
Descriptor:DIHYDROPYRIMIDINE DEHYDROGENASE (E.C.1.3.1.2)
Authors:Dobritzsch, D., Ricagno, S., Schneider, G., Schnackerz, K.D., Lindqvist, Y.
Deposit date:2002-01-15
Release date:2002-04-11
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Crystal Structure of the Productive Ternary Complex of Dihydropyrimidine Dehydrogenase with Nadph and 5-Iodouracil. Implications for Mechanism of Inhibition and Electron Transfer
J.Biol.Chem., 277, 2002
1H7W
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DIHYDROPYRIMIDINE DEHYDROGENASE (DPD) FROM PIG
Descriptor:DIHYDROPYRIMIDINE DEHYDROGENASE (E.C.1.3.1.2)
Authors:Dobritzsch, D., Schneider, G., Schnackerz, K.D., Lindqvist, Y.
Deposit date:2001-01-19
Release date:2001-02-23
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal Structure of Dihydropyrimidine Dehydrogenase, a Major Determinant of the Pharmacokinetics of the Anti-Cancer Drug 5-Fluorouracil
Embo J., 20, 2001
1H7X
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DIHYDROPYRIMIDINE DEHYDROGENASE (DPD) FROM PIG, TERNARY COMPLEX OF A MUTANT ENZYME (C671A), NADPH AND 5-FLUOROURACIL
Descriptor:DIHYDROPYRIMIDINE DEHYDROGENASE (E.C.1.3.1.2)
Authors:Dobritzsch, D., Schneider, G., Schnackerz, K.D., Lindqvist, Y.
Deposit date:2001-01-19
Release date:2001-02-23
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Crystal Structure of Dihydropyrimidine Dehydrogenase, a Major Determinant of the Pharmacokinetics of the Anti-Cancer Drug 5-Fluorouracil
Embo J., 20, 2001
1TV5
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PLASMODIUM FALCIPARUM DIHYDROOROTATE DEHYDROGENASE WITH A BOUND INHIBITOR
Descriptor:Dihydroorotate dehydrogenase homolog, mitochondrial (E.C.1.3.3.1,E.C.1.3.99.11)
Authors:Hurt, D.E., Widom, J., Clardy, J.
Deposit date:2004-06-27
Release date:2005-09-06
Modification date:2012-07-18
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure of Plasmodium falciparum dihydroorotate dehydrogenase with a bound inhibitor.
Acta Crystallogr.,Sect.D, 62, 2006
1UUM
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RAT DIHYDROOROTATE DEHYDROGENASE (DHOD)IN COMPLEX WITH ATOVAQUONE
Descriptor:DIHYDROOROTATE DEHYDROGENASE (E.C.1.3.99.11)
Authors:Hansen, M., Le Nours, J., Johansson, E., Antal, T., Ullrich, A., Loffler, M., Larsen, S.
Deposit date:2004-01-06
Release date:2004-04-01
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Inhibitor Binding in a Class 2 Dihydroorotate Dehydrogenase Causes Variations in the Membrane-Associated N-Terminal Domain
Protein Sci., 13, 2004
1UUO
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RAT DIHYDROOROTATE DEHYDROGENASE (DHOD)IN COMPLEX WITH BREQUINAR
Descriptor:DIHYDROOROTATE DEHYDROGENASE (E.C.1.3.99.11)
Authors:Hansen, M., Le Nours, J., Johansson, E., Antal, T., Ullrich, A., Loffler, M., Larsen, S.
Deposit date:2004-01-08
Release date:2004-04-01
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.44 Å)
Cite:Inhibitor Binding in a Class 2 Dihydroorotate Dehydrogenase Causes Variations in the Membrane-Associated N-Terminal Domain
Protein Sci., 13, 2004
2B0M
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HUMAN DIHYDROOROTATE DEHYDROGENASE BOUND TO A NOVEL INHIBITOR
Descriptor:Dihydroorotate dehydrogenase, mitochondrial (E.C.1.3.3.1)
Authors:Hurt, D.E., Sutton, A.E., Clardy, J.
Deposit date:2005-09-14
Release date:2005-09-27
Modification date:2009-03-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Brequinar derivatives and species-specific drug design for dihydroorotate dehydrogenase.
Bioorg.Med.Chem.Lett., 16, 2006
2B4G
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DIHYDROOROTATE DEHYDROGENASE
Descriptor:dihydroorotate dehydrogenase (E.C.1.3.99.11)
Authors:Arakaki, T.L., Merritt, E.A., Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:2005-09-23
Release date:2005-10-11
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Characterization of Trypanosoma brucei dihydroorotate dehydrogenase as a possible drug target; structural, kinetic and RNAi studies
Mol.Microbiol., 68, 2008
2BXV
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DUAL BINDING MODE OF A NOVEL SERIES OF DHODH INHIBITORS
Descriptor:DIHYDROOROTATE DEHYDROGENASE (E.C.1.3.3.1)
Authors:Baumgartner, R., Walloschek, M., Karlik, M., Gotschlich, A., Tasler, S., Mies, J., Leban, J.
Deposit date:2005-07-27
Release date:2006-08-16
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Dual Binding Mode of a Novel Series of Dhodh Inhibitors.
J.Med.Chem., 49, 2006
2DJL
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CRYSTAL STRUCTURE OF TRYPANOSOMA CRUZI DIHYDROOROTATE DEHYDROGENASE IN COMPLEX WITH SUCCINATE
Descriptor:dihydroorotate dehydrogenase (E.C.1.3.3.1)
Authors:Inaoka, D.K., Shimizu, H., Sakamoto, K., Shiba, T., Kurisu, G., Nara, T., Aoki, T., Harada, S., Kita, K.
Deposit date:2006-04-04
Release date:2007-06-26
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (1.38 Å)
Cite:Crystal structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with succinate
To be Published
2DJX
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CRYSTAL STRUCTURE OF NATIVE TRYPANOSOMA CRUZI DIHYDROOROTATE DEHYDROGENASE
Descriptor:Dihydroorotate Dehydrogenase (E.C.1.3.3.1)
Authors:Inaoka, D.K., Shimizu, H., Sakamoto, K., Shiba, T., Kurisu, G., Nara, T., Aoki, T., Harada, S., Kita, K.
Deposit date:2006-04-05
Release date:2007-06-26
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (1.58 Å)
Cite:Crystal structure of native Trypanosoma cruzi dihydroorotate dehydrogenase
To be Published
2E68
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CRYSTAL STRUCTURE OF TRYPANOSOMA CRUZI DIHYDROOROTATE DEHYDROGENASE IN COMPLEX WITH DIHYDROOROTATE
Descriptor:Dihydroorotate dehydrogenase (E.C.1.3.3.1)
Authors:Inaoka, D.K., Shimizu, H., Sakamoto, K., Shiba, T., Kurisu, G., Nara, T., Aoki, T., Harada, S., Kita, K.
Deposit date:2006-12-26
Release date:2008-01-15
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (1.38 Å)
Cite:Crystal structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with dihydroorotate
To be Published
2E6A
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CRYSTAL STRUCTURE OF TRYPANOSOMA CRUZI DIHYDROOROTATE DEHYDROGENASE IN COMPLEX WITH OROTATE
Descriptor:Dihydroorotate dehydrogenase (E.C.1.3.3.1)
Authors:Inaoka, D.K., Shimizu, H., Sakamoto, K., Shiba, T., Kurisu, G., Nara, T., Aoki, T., Harada, S., Kita, K.
Deposit date:2006-12-26
Release date:2008-01-15
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (1.64 Å)
Cite:Crystal structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with orotate
To be Published
2E6D
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CRYSTAL STRUCTURE OF TRYPANOSOMA CRUZI DIHYDROOROTATE DEHYDROGENASE IN COMPLEX WITH FUMARATE
Descriptor:Dihydroorotate dehydrogenase (E.C.1.3.3.1)
Authors:Inaoka, D.K., Shimizu, H., Sakamoto, K., Shiba, T., Kurisu, G., Nara, T., Aoki, T., Harada, S., Kita, K.
Deposit date:2006-12-26
Release date:2008-01-15
Modification date:2012-02-15
Method:X-RAY DIFFRACTION (1.94 Å)
Cite:Structures of Trypanosoma cruzi dihydroorotate dehydrogenase complexed with substrates and products: atomic resolution insights into mechanisms of dihydroorotate oxidation and fumarate reduction
Biochemistry, 47, 2008
2E6F
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CRYSTAL STRUCTURE OF TRYPANOSOMA CRUZI DIHYDROOROTATE DEHYDROGENASE IN COMPLEX WITH OXONATE
Descriptor:Dihydroorotate dehydrogenase (E.C.1.3.3.1)
Authors:Inaoka, D.K., Shimizu, H., Sakamoto, K., Shiba, T., Kurisu, G., Nara, T., Aoki, T., Harada, S., Kita, K.
Deposit date:2006-12-26
Release date:2008-01-15
Modification date:2014-04-16
Method:X-RAY DIFFRACTION (1.26 Å)
Cite:Crystal structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with oxonate
To be Published
2FPT
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DUAL BINDING MODE OF A NOVEL SERIES OF DHODH INHIBITORS
Descriptor:Dihydroorotate dehydrogenase, mitochondrial (E.C.1.3.3.1)
Authors:Baumgartner, R., Walloschek, M., Kralik, M., Gotschlich, A., Tasler, S., Leban, J.
Deposit date:2006-01-17
Release date:2007-01-23
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Dual binding mode of a novel series of DHODH inhibitors.
J.Med.Chem., 49, 2006
2FPV
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DUAL BINDING MODE OF A NOVEL SERIES OF DHODH INHIBITORS
Descriptor:Dihydroorotate dehydrogenase, mitochondrial (E.C.1.3.3.1)
Authors:Baumgartner, R., Leban, J.
Deposit date:2006-01-17
Release date:2007-01-23
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Dual binding mode of a novel series of DHODH inhibitors.
J.Med.Chem., 49, 2006
2FPY
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DUAL BINDING MODE OF A NOVEL SERIES OF DHODH INHIBITORS
Descriptor:Dihydroorotate dehydrogenase, mitochondrial (E.C.1.3.3.1)
Authors:Baumgartner, R., Leban, J.
Deposit date:2006-01-17
Release date:2007-01-23
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Dual binding mode of a novel series of DHODH inhibitors.
J.Med.Chem., 49, 2006
2FQI
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DUAL BINDING MODES OF A NOVEL SERIES OF DHODH INHIBITORS
Descriptor:Dihydroorotate dehydrogenase, mitochondrial (E.C.1.3.3.1)
Authors:Baumgartner, R., Leban, J.
Deposit date:2006-01-18
Release date:2007-01-23
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Dual binding mode of a novel series of DHODH inhibitors.
J.Med.Chem., 49, 2006
2PRH
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THE STRUCTURES OF APO- AND INHIBITOR BOUND HUMAN DIHYDROOROTATE DEHYDROGENASE REVEAL CONFORMATIONAL FLEXIBILITY WITHIN THE INHIBITOR BINDING SITE
Descriptor:Dihydroorotate dehydrogenase, mitochondrial (E.C.1.3.99.11)
Authors:Walse, B., Dufe, V.T., Al-Karadaghi, S.
Deposit date:2007-05-04
Release date:2008-05-20
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The structures of human dihydroorotate dehydrogenase with and without inhibitor reveal conformational flexibility in the inhibitor and substrate binding sites
Biochemistry, 47, 2008
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