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1D3G
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1d3g
HUMAN DIHYDROOROTATE DEHYDROGENASE COMPLEXED WITH BREQUINAR ANALOG
Descriptor:DIHYDROOROTATE DEHYDROGENASE (1.3.3.1)
Authors:Liu, S., Neidhardt, E.A., Grossman, T.H., Ocain, T., Clardy, J.
Deposit date:1999-09-29
Release date:2000-09-13
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structures of human dihydroorotate dehydrogenase in complex with antiproliferative agents.
Structure Fold.Des., 8, 2000
1D3H
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1d3h
HUMAN DIHYDROOROTATE DEHYDROGENASE COMPLEXED WITH ANTIPROLIFERATIVE AGENT A771726
Descriptor:DIHYDROOROTATE DEHYDROGENASE (1.3.3.1)
Authors:Liu, S., Neidhardt, E.A., Grossman, T.H., Ocain, T., Clardy, J.
Deposit date:1999-09-29
Release date:2000-08-13
Modification date:2012-07-18
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structures of human dihydroorotate dehydrogenase in complex with antiproliferative agents.
Structure Fold.Des., 8, 2000
1DOR
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1dor
DIHYDROOROTATE DEHYDROGENASE A FROM LACTOCOCCUS LACTIS
Descriptor:DIHYDROOROTATE DEHYDROGENASE A, FLAVIN MONONUCLEOTIDE
Authors:Rowland, P., Larsen, S.
Deposit date:1997-01-14
Release date:1997-04-21
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:The crystal structure of the flavin containing enzyme dihydroorotate dehydrogenase A from Lactococcus lactis.
Structure, 5, 1997
1F76
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1f76
ESCHERICHIA COLI DIHYDROOROTATE DEHYDROGENASE
Descriptor:DIHYDROOROTATE DEHYDROGENASE (E.C.1.3.3.1)
Authors:Norager, S., Jensen, K.F., Bjornberg, O., Larsen, S.
Deposit date:2000-06-26
Release date:2002-10-16
Modification date:2014-03-12
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:E. coli Dihydroorotate Dehydrogenase Reveals Structural and Functional Distinction between different classes of dihydroorotate dehydrogenases
Structure, 10, 2002
1JQV
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1jqv
THE K213E MUTANT OF LACTOCOCCUS LACTIS DIHYDROOROTATE DEHYDROGENASE A
Descriptor:Dihydroorotate dehydrogenase A(E.C.1.3.3.1)/ FLAVIN MONONUCLEOTIDE/OROTIC ACID
Authors:Norager, S., Arent, S., Bjornberg, O., Ottosen, M., Lo Leggio, L., Jensen, K.F., Larsen, S.
Deposit date:2001-08-09
Release date:2003-09-09
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Lactococcus lactis dihydroorotate dehydrogenase A mutants reveal important facets of the enzymatic function
J.Biol.Chem., 278, 2003
1JQX
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1jqx
THE R57A MUTANT OF LACTOCOCCUS LACTIS DIHYDROOROTATE DEHYDROGENASE A
Descriptor:dihydroorotate dehydrogenase A/ FLAVIN MONONUCLEOTIDE/OROTIC ACID
Authors:Norager, S., Arent, S., Bjornberg, O., Ottosen, M., Lo Leggio, L., Jensen, K.F., Larsen, S.
Deposit date:2001-08-09
Release date:2003-09-09
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Lactococcus lactis dihydroorotate dehydrogenase A mutants reveal important facets of the enzymatic function
J.Biol.Chem., 278, 2003
1JRB
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1jrb
THE P56A MUTANT OF LACTOCOCCUS LACTIS DIHYDROOROTATE DEHYDROGENASE A
Descriptor:dihydroorotate dehydrogenase A(E.C.1.3.3.1)/ FLAVIN MONONUCLEOTIDE/OROTIC ACID
Authors:Norager, S., Arent, S., Bjornberg, O., Ottosen, M., Lo Leggio, L., Jensen, K.F., Larsen, S.
Deposit date:2001-08-13
Release date:2003-09-09
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Lactococcus lactis dihydroorotate dehydrogenase A mutants reveal important facets of the enzymatic function
J.Biol.Chem., 278, 2003
1JRC
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1jrc
THE N67A MUTANT OF LACTOCOCCUS LACTIS DIHYDROOROTATE DEHYDROGENASE A
Descriptor:dihydroorotate dehydrogenase A(E.C.1.3.3.1)/FLAVIN MONONUCLEOTIDE/OROTIC ACID
Authors:Norager, S., Arent, S., Bjornberg, O., Ottosen, M., Lo Leggio, L., Jensen, K.F., Larsen, S.
Deposit date:2001-08-13
Release date:2003-09-09
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Lactococcus lactis dihydroorotate dehydrogenase A mutants reveal important facets of the enzymatic function
J.Biol.Chem., 278, 2003
1JUB
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1jub
THE K136E MUTANT OF LACTOCOCCUS LACTIS DIHYDROOROTATE DEHYDROGENASE A
Descriptor:dihydroorotate dehydrogenase A(E.C.1.3.3.1)/ FLAVIN MONONUCLEOTIDE
Authors:Norager, S., Arent, S., Bjornberg, O., Ottosen, M., Lo Leggio, L., Jensen, K.F., Larsen, S.
Deposit date:2001-08-24
Release date:2003-09-09
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Lactococcus lactis dihydroorotate dehydrogenase A mutants reveal important facets of the enzymatic function
J.Biol.Chem., 278, 2003
1JUE
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1jue
1.8 A RESOLUTION STRUCTURE OF NATIVE LACTOCOCCUS LACTIS DIHYDROOROTATE DEHYDROGENASE A
Descriptor:dihydroorotate dehydrogenase A(E.C.1.3.3.1)/ FLAVIN MONONUCLEOTIDE
Authors:Norager, S., Arent, S., Bjornberg, O., Ottosen, M., Lo Leggio, L., Jensen, K.F., Larsen, S.
Deposit date:2001-08-24
Release date:2003-09-09
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Lactococcus lactis dihydroorotate dehydrogenase A mutants reveal important facets of the enzymatic function
J.Biol.Chem., 278, 2003
1OVD
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1ovd
THE K136E MUTANT OF LACTOCOCCUS LACTIS DIHYDROOROTATE DEHYDROGENASE A IN COMPLEX WITH OROTATE
Descriptor:DIHYDROOROTATE DEHYDROGENASE A (E.C.1.3.3.1)
Authors:Norager, S., Arent, S., Bjornberg, O., Ottosen, M., Lo Leggio, L., Jensen, K.F., Larsen, S.
Deposit date:2003-03-26
Release date:2003-08-19
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Lactococcus lactis dihydroorotate dehydrogenase A mutants reveal important facets of the enzymatic function.
J.Biol.Chem., 278, 2003
1TV5
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1tv5
PLASMODIUM FALCIPARUM DIHYDROOROTATE DEHYDROGENASE WITH A BOUND INHIBITOR
Descriptor:Dihydroorotate dehydrogenase homolog, mitochondrial (E.C.1.3.3.1,E.C.1.3.99.11)
Authors:Hurt, D.E., Widom, J., Clardy, J.
Deposit date:2004-06-27
Release date:2005-09-06
Modification date:2012-07-18
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure of Plasmodium falciparum dihydroorotate dehydrogenase with a bound inhibitor.
Acta Crystallogr.,Sect.D, 62, 2006
1UUM
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1uum
RAT DIHYDROOROTATE DEHYDROGENASE (DHOD)IN COMPLEX WITH ATOVAQUONE
Descriptor:DIHYDROOROTATE DEHYDROGENASE (E.C.1.3.99.11)
Authors:Hansen, M., Le Nours, J., Johansson, E., Antal, T., Ullrich, A., Loffler, M., Larsen, S.
Deposit date:2004-01-06
Release date:2004-04-01
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Inhibitor Binding in a Class 2 Dihydroorotate Dehydrogenase Causes Variations in the Membrane-Associated N-Terminal Domain
Protein Sci., 13, 2004
1UUO
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1uuo
RAT DIHYDROOROTATE DEHYDROGENASE (DHOD)IN COMPLEX WITH BREQUINAR
Descriptor:DIHYDROOROTATE DEHYDROGENASE (E.C.1.3.99.11)
Authors:Hansen, M., Le Nours, J., Johansson, E., Antal, T., Ullrich, A., Loffler, M., Larsen, S.
Deposit date:2004-01-08
Release date:2004-04-01
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.44 Å)
Cite:Inhibitor Binding in a Class 2 Dihydroorotate Dehydrogenase Causes Variations in the Membrane-Associated N-Terminal Domain
Protein Sci., 13, 2004
2B0M
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2b0m
HUMAN DIHYDROOROTATE DEHYDROGENASE BOUND TO A NOVEL INHIBITOR
Descriptor:Dihydroorotate dehydrogenase, mitochondrial (E.C.1.3.3.1)
Authors:Hurt, D.E., Sutton, A.E., Clardy, J.
Deposit date:2005-09-14
Release date:2005-09-27
Modification date:2009-03-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Brequinar derivatives and species-specific drug design for dihydroorotate dehydrogenase.
Bioorg.Med.Chem.Lett., 16, 2006
2B4G
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2b4g
DIHYDROOROTATE DEHYDROGENASE
Descriptor:dihydroorotate dehydrogenase (E.C.1.3.99.11)
Authors:Arakaki, T.L., Merritt, E.A., Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:2005-09-23
Release date:2005-10-11
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Characterization of Trypanosoma brucei dihydroorotate dehydrogenase as a possible drug target; structural, kinetic and RNAi studies
Mol.Microbiol., 68, 2008
2BSL
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2bsl
CRYSTAL STRUCTURE OF L. LACTIS DIHYDROOROTATE DEHYDROGENSE A IN COMPLEX WITH 3,4-DIHYDROXYBENZOATE
Descriptor:DIHYDROOROTATE DEHYDROGENASE A (E.C.1.3.99.11)
Authors:Wolfe, A.E., Hansen, M., Gattis, S.G., Hu, Y.-C., Johansson, E., Arent, S., Larsen, S., Palfey, B.A.
Deposit date:2005-05-23
Release date:2006-08-29
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Interaction of Benzoate Pyrimidine Analogues with Class 1A Dihydroorotate Dehydrogenase from Lactococcus Lactis.
Biochemistry, 46, 2007
2BX7
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2bx7
CRYSTAL STRUCTURE OF L. LACTIS DIHYDROOROTATE DEHYDROGENSE A IN COMPLEX WITH 3,5-DIHYDROXYBENZOATE
Descriptor:DIHYDROOROTATE DEHYDROGENASE (E.C.1.3.3.1)
Authors:Wolfe, A.E., Hansen, M., Gattis, S.G., Hu, Y.-C., Johansson, E., Arent, S., Larsen, S., Palfey, B.A.
Deposit date:2005-07-25
Release date:2006-08-29
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.04 Å)
Cite:Interaction of Benzoate Pyrimidine Analogues with Class 1A Dihydroorotate Dehydrogenase from Lactococcus Lactis.
Biochemistry, 46, 2007
2BXV
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2bxv
DUAL BINDING MODE OF A NOVEL SERIES OF DHODH INHIBITORS
Descriptor:DIHYDROOROTATE DEHYDROGENASE (E.C.1.3.3.1)
Authors:Baumgartner, R., Walloschek, M., Karlik, M., Gotschlich, A., Tasler, S., Mies, J., Leban, J.
Deposit date:2005-07-27
Release date:2006-08-16
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Dual Binding Mode of a Novel Series of Dhodh Inhibitors.
J.Med.Chem., 49, 2006
2DJL
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2djl
CRYSTAL STRUCTURE OF TRYPANOSOMA CRUZI DIHYDROOROTATE DEHYDROGENASE IN COMPLEX WITH SUCCINATE
Descriptor:dihydroorotate dehydrogenase (E.C.1.3.3.1)
Authors:Inaoka, D.K., Shimizu, H., Sakamoto, K., Shiba, T., Kurisu, G., Nara, T., Aoki, T., Harada, S., Kita, K.
Deposit date:2006-04-04
Release date:2007-06-26
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (1.38 Å)
Cite:Crystal structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with succinate
To be Published
2DJX
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2djx
CRYSTAL STRUCTURE OF NATIVE TRYPANOSOMA CRUZI DIHYDROOROTATE DEHYDROGENASE
Descriptor:Dihydroorotate Dehydrogenase (E.C.1.3.3.1)
Authors:Inaoka, D.K., Shimizu, H., Sakamoto, K., Shiba, T., Kurisu, G., Nara, T., Aoki, T., Harada, S., Kita, K.
Deposit date:2006-04-05
Release date:2007-06-26
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (1.58 Å)
Cite:Crystal structure of native Trypanosoma cruzi dihydroorotate dehydrogenase
To be Published
2DOR
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2dor
DIHYDROOROTATE DEHYDROGENASE A FROM LACTOCOCCUS LACTIS COMPLEXED WITH OROTATE
Descriptor:DIHYDROOROTATE DEHYDROGENASE A, FLAVIN MONONUCLEOTIDE, OROTIC ACID
Authors:Rowland, P., Larsen, S.
Deposit date:1998-05-11
Release date:1998-08-12
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:The crystal structure of Lactococcus lactis dihydroorotate dehydrogenase A complexed with the enzyme reaction product throws light on its enzymatic function.
Protein Sci., 7, 1998
2E68
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2e68
CRYSTAL STRUCTURE OF TRYPANOSOMA CRUZI DIHYDROOROTATE DEHYDROGENASE IN COMPLEX WITH DIHYDROOROTATE
Descriptor:Dihydroorotate dehydrogenase (E.C.1.3.3.1)
Authors:Inaoka, D.K., Shimizu, H., Sakamoto, K., Shiba, T., Kurisu, G., Nara, T., Aoki, T., Harada, S., Kita, K.
Deposit date:2006-12-26
Release date:2008-01-15
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (1.38 Å)
Cite:Crystal structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with dihydroorotate
To be Published
2E6A
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2e6a
CRYSTAL STRUCTURE OF TRYPANOSOMA CRUZI DIHYDROOROTATE DEHYDROGENASE IN COMPLEX WITH OROTATE
Descriptor:Dihydroorotate dehydrogenase (E.C.1.3.3.1)
Authors:Inaoka, D.K., Shimizu, H., Sakamoto, K., Shiba, T., Kurisu, G., Nara, T., Aoki, T., Harada, S., Kita, K.
Deposit date:2006-12-26
Release date:2008-01-15
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (1.64 Å)
Cite:Crystal structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with orotate
To be Published
2E6D
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2e6d
CRYSTAL STRUCTURE OF TRYPANOSOMA CRUZI DIHYDROOROTATE DEHYDROGENASE IN COMPLEX WITH FUMARATE
Descriptor:Dihydroorotate dehydrogenase (E.C.1.3.3.1)
Authors:Inaoka, D.K., Shimizu, H., Sakamoto, K., Shiba, T., Kurisu, G., Nara, T., Aoki, T., Harada, S., Kita, K.
Deposit date:2006-12-26
Release date:2008-01-15
Modification date:2012-02-15
Method:X-RAY DIFFRACTION (1.94 Å)
Cite:Structures of Trypanosoma cruzi dihydroorotate dehydrogenase complexed with substrates and products: atomic resolution insights into mechanisms of dihydroorotate oxidation and fumarate reduction
Biochemistry, 47, 2008
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