5FI8
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CRYSTAL STRUCTURE OF PLASMODIUM FALCIPARUM DIHYDROOROTATE DEHYDROGENASE BOUNDED WITH DSM422 (TETRAHYDRO-2-NAPHTHYL AND 2-INDANYL TRIAZOLOPYRIMIDINE)
Descriptor:Dihydroorotate dehydrogenase (quinone), mitochondrial (E.C.1.3.5.2)
Authors:Deng, X., Kokkonda, S., Tomchick, D., Phillips, M.
Deposit date:2015-12-22
Release date:2016-05-18
Modification date:2016-06-22
Method:X-RAY DIFFRACTION (2.32 Å)
Cite:Tetrahydro-2-naphthyl and 2-Indanyl Triazolopyrimidines Targeting Plasmodium falciparum Dihydroorotate Dehydrogenase Display Potent and Selective Antimalarial Activity.
J.Med.Chem., 59, 2016
4ZL1
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CRYSTAL STRUCTURE OF HUMAN DIHYDROOROTATE DEHYDROGENASE (DHODH) WITH 18X AT 1.86 A RESOLUTION
Descriptor:Dihydroorotate dehydrogenase (quinone), mitochondrial (E.C.1.3.5.2)
Authors:Huang, J., Wu, D., Ouyang, P., Lu, W., Pu, J.
Deposit date:2015-05-01
Release date:2016-05-04
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Crystal structure of human dihydroorotate dehydrogenase (DHODH) with 18XYW at 1.86 A resolution
To Be Published
4ZMG
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CRYSTAL STRUCTURE OF HUMAN DIHYDROOROTATE DEHYDROGENASE (DHODH) WITH DH03A338
Descriptor:Dihydroorotate dehydrogenase (quinone), mitochondrial (E.C.1.3.5.2)
Authors:Ren, X.L., Zhu, J.S., Zhu, L.L., Li, H.L.
Deposit date:2015-05-04
Release date:2016-05-04
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of Human Dihydroorotate Dehydrogenase (DHODH) with DH03A338
To Be Published
4YLW
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CRYSTAL STRUCTURE OF HUMAN DIHYDROOROTATE DEHYDROGENASE (DHODH) WITH NO.33 COMPOUND
Descriptor:Dihydroorotate dehydrogenase (quinone), mitochondrial (E.C.1.3.5.2)
Authors:Wu, D., Ouyang, P., Lu, W., Huang, J.
Deposit date:2015-03-06
Release date:2016-03-09
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:Crystal structure of human dihydroorotate dehydrogenase (DHODH) with No.33 compound
To Be Published
4RR4
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CRYSTAL STRUCTURE OF HUMAN DIHYDROOROTATE DEHYDROGENASE (DHODH) WITH DH03A367
Descriptor:Dihydroorotate dehydrogenase (quinone), mitochondrial (E.C.1.3.5.2)
Authors:Zhu, L., Ren, X., Zhu, J., Li, H.
Deposit date:2014-11-06
Release date:2015-11-25
Method:X-RAY DIFFRACTION (2.38 Å)
Cite:Crystal structure of human dihydroorotate dehydrogenase (DHODH) with DH03A367
TO BE PUBLISHED
4RK8
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CRYSTAL STRUCTURE OF HUMAN DIHYDROOROTATE DEHYDROGENASE (DHODH) WITH DH03A356
Descriptor:Dihydroorotate dehydrogenase (quinone), mitochondrial (E.C.1.3.5.2)
Authors:Zhu, L., Ren, X., Zhu, J., Li, H.
Deposit date:2014-10-12
Release date:2015-11-11
Method:X-RAY DIFFRACTION (2.22 Å)
Cite:Crystal structure of human dihydroorotate dehydrogenase (DHODH) with DH03A356
TO BE PUBLISHED
4RKA
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CRYSTAL STRUCTURE OF HUMAN DIHYDROOROTATE DEHYDROGENASE (DHODH) WITH DH03A347
Descriptor:Dihydroorotate dehydrogenase (quinone), mitochondrial (E.C.1.3.5.2)
Authors:Zhu, L., Ren, X., Zhu, J., Li, H.
Deposit date:2014-10-12
Release date:2015-11-11
Method:X-RAY DIFFRACTION (2.71 Å)
Cite:Crystal structure of human dihydroorotate dehydrogenase (DHODH) with DH03A347
TO BE PUBLISHED
4RLI
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CRYSTAL STRUCTURE OF HUMAN DIHYDROOROTATE DEHYDROGENASE (DHODH) WITH DH03A048
Descriptor:Dihydroorotate dehydrogenase (quinone), mitochondrial (E.C.1.3.5.2)
Authors:Zhu, L., Ren, X., Zhu, J., Li, H.
Deposit date:2014-10-17
Release date:2015-11-04
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of human dihydroorotate dehydrogenase (DHODH) with DH03A048
TO BE PUBLISHED
5DEL
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CRYSTAL STRUCTURE OF PLASMODIUM FALCIPARUM DIHYDROOROTATE DEHYDROGENASE BOUND WITH INHIBITOR DSM59
Descriptor:Dihydroorotate dehydrogenase (quinone), mitochondrial (E.C.1.3.5.2)
Authors:Phillips, M., Deng, X.
Deposit date:2015-08-25
Release date:2015-10-07
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The X-ray structure of Plasmodium falciparum dihydroorotate dehydrogenase bound to a potent and selective N-phenylbenzamide inhibitor reveals novel binding-site interactions.
Acta Crystallogr.,Sect.F, 71, 2015
4RX0
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CRYSTAL STRUCTURE OF PLASMODIUM FALCIPARUM DIHYDROOROTATE DEHYDROGENASE BOUND WITH INHIBITOR DSM265
Descriptor:Dihydroorotate dehydrogenase (quinone), mitochondrial (E.C.1.3.5.2)
Authors:Deng, X., Phillips, M., Tomchick, D.
Deposit date:2014-12-08
Release date:2015-07-29
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria.
Sci Transl Med, 7, 2015
5BOO
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CRYSTAL STRUCTURE OF PLASMODIUM FALCIPARUM DIHYDROOROTATE DEHYDROGENASE BOUND WITH INHIBITOR DSM265
Descriptor:Dihydroorotate dehydrogenase (quinone), mitochondrial (E.C.1.3.5.2)
Authors:Phillips, M., Deng, X., Tomchick, D.
Deposit date:2015-05-27
Release date:2015-07-29
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria.
Sci Transl Med, 7, 2015
4WZH
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DIHYDROOROTATE DEHYDROGENASE FROM LEISHMANIA VIANNIA BRAZILIENSIS
Descriptor:Dihydroorotate dehydrogenase (E.C.1.3.98.1)
Authors:Reis, R.A.G., Lorenzato, E., Silva, V.C., Nonato, M.C.
Deposit date:2014-11-19
Release date:2015-05-13
Modification date:2015-05-20
Method:X-RAY DIFFRACTION (2.12 Å)
Cite:Recombinant production, crystallization and crystal structure determination of dihydroorotate dehydrogenase from Leishmania (Viannia) braziliensis.
Acta Crystallogr.,Sect.F, 71, 2015
4LS0
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CRYSTAL STRUCTURE OF HUMAN DIHYDROOROTATE DEHYDROGENASE (DHODH) WITH DH01B0033
Descriptor:Dihydroorotate dehydrogenase (quinone), mitochondrial (E.C.1.3.5.2)
Authors:Zhu, L., Li, H., Ren, X., Zhu, J.
Deposit date:2013-07-21
Release date:2014-07-23
Method:X-RAY DIFFRACTION (2.07 Å)
Cite:Crystal structure of human dihydroorotate dehydrogenase (DHODH) with DHO1B0033
To be Published
4LS1
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CRYSTAL STRUCTURE OF HUMAN DIHYDROOROTATE DEHYDROGENASE (DHODH) WITH DH03A312
Descriptor:Dihydroorotate dehydrogenase (quinone), mitochondrial (E.C.1.3.5.2)
Authors:Zhu, L., Li, H., Ren, X., Zhu, J.
Deposit date:2013-07-21
Release date:2014-07-23
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of human dihydroorotate dehydrogenase (DHODH) with DH03A312
To be Published
4LS2
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CRYSTAL STRUCTURE OF HUMAN DIHYDROOROTATE DEHYDROGENASE (DHODH) WITH DH03A313
Descriptor:Dihydroorotate dehydrogenase (quinone), mitochondrial (E.C.1.3.5.2)
Authors:Zhu, L., Li, H., Ren, X., Zhu, J.
Deposit date:2013-07-21
Release date:2014-07-23
Method:X-RAY DIFFRACTION (2.27 Å)
Cite:Crystal structure of human dihydroorotate dehydrogenase (DHODH) with DH03A313
To be Published
4OQV
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HIGH RESOLUTION CRYSTAL STRUCTURE OF HUMAN DIHYDROOROTATE DEHYDROGENASE BOUND WITH DSM338 (N-[3,5-DIFLUORO-4-(TRIFLUOROMETHYL)PHENYL]-5-METHYL-2-(TRIFLUOROMETHYL)[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7-AMINE)
Descriptor:Dihydroorotate dehydrogenase (quinone), mitochondrial (E.C.1.3.5.2)
Authors:Deng, X., Phillips, M.A.
Deposit date:2014-02-10
Release date:2014-06-04
Modification date:2014-07-09
Method:X-RAY DIFFRACTION (1.23 Å)
Cite:Fluorine Modulates Species Selectivity in the Triazolopyrimidine Class of Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors.
J.Med.Chem., 57, 2014
4ORI
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RAT DIHYDROOROTATE DEHYDROGENASE BOUND WITH DSM338 (N-[3,5-DIFLUORO-4-(TRIFLUOROMETHYL)PHENYL]-5-METHYL-2-(TRIFLUOROMETHYL)[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7-AMINE)
Descriptor:Dihydroorotate dehydrogenase (quinone), mitochondrial (E.C.1.3.5.2)
Authors:Deng, X., Phillips, M.A.
Deposit date:2014-02-11
Release date:2014-06-04
Modification date:2014-07-09
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Fluorine Modulates Species Selectivity in the Triazolopyrimidine Class of Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors.
J.Med.Chem., 57, 2014
4ORM
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CRYSTAL STRUCTURE OF PLASMODIUM FALCIPARUM DIHYDROOROTATE DEHYDROGENASE BOUND WITH INHIBITOR DSM338 (N-[3,5-DIFLUORO-4-(TRIFLUOROMETHYL)PHENYL]-5-METHYL-2-(TRIFLUOROMETHYL)[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7-AMINE)
Descriptor:Dihydroorotate dehydrogenase (quinone), mitochondrial (E.C.1.3.5.2)
Authors:Deng, X., Phillips, M.A.
Deposit date:2014-02-11
Release date:2014-06-04
Modification date:2014-07-09
Method:X-RAY DIFFRACTION (2.07 Å)
Cite:Fluorine Modulates Species Selectivity in the Triazolopyrimidine Class of Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors.
J.Med.Chem., 57, 2014
4CQ8
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PLASMODIUM FALCIPARUM DIHYDROOROTATE DEHYDROGENASE (DHODH) IN COMPLEX WITH GENZ-669178
Descriptor:DIHYDROOROTATE DEHYDROGENASE
Authors:Rowland, P.
Deposit date:2014-02-12
Release date:2014-04-30
Modification date:2014-08-13
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:In Vitro Resistance Selections for Plasmodium Falciparum Dihydroorotate Dehydrogenase Inhibitors Give Mutants with Multiple Point Mutations in the Drug-Binding Site and Altered Growth.
J.Biol.Chem., 289, 2014
4CQ9
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PLASMODIUM FALCIPARUM DIHYDROOROTATE DEHYDROGENASE (DHODH) IN COMPLEX WITH IDI-6253
Descriptor:DIHYDROOROTATE DEHYDROGENASE
Authors:Rowland, P.
Deposit date:2014-02-12
Release date:2014-04-30
Modification date:2014-08-13
Method:X-RAY DIFFRACTION (2.72 Å)
Cite:In Vitro Resistance Selections for Plasmodium Falciparum Dihydroorotate Dehydrogenase Inhibitors Give Mutants with Multiple Point Mutations in the Drug-Binding Site and Altered Growth.
J.Biol.Chem., 289, 2014
4CQA
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PLASMODIUM FALCIPARUM DIHYDROOROTATE DEHYDROGENASE (DHODH) IN COMPLEX WITH IDI-6273
Descriptor:DIHYDROOROTATE DEHYDROGENASE (E.C.1.3.3.1)
Authors:Rowland, P.
Deposit date:2014-02-12
Release date:2014-04-30
Modification date:2014-08-13
Method:X-RAY DIFFRACTION (2.82 Å)
Cite:In Vitro Resistance Selections for Plasmodium Falciparum Dihydroorotate Dehydrogenase Inhibitors Give Mutants with Multiple Point Mutations in the Drug-Binding Site and Altered Growth.
J.Biol.Chem., 289, 2014
3W83
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STRUCTURE OF TRYPANOSOMA CRUZI DIHYDROOROTATE DEHYDROGENASE IN COMPLEX WITH MII-6-097
Descriptor:Dihydroorotate dehydrogenase (fumarate) (E.C.1.3.98.1)
Authors:Inaoka, D.K., Iida, M., Tabuchi, T., Lee, N., Hashimoto, S., Matsuoka, S., Kuranaga, T., Shiba, T., Sakamoto, K., Suzuki, S., Balogun, E.O., Nara, T., Aoki, T., Inoue, M., Honma, T., Tanaka, A., Harada, S., Kita, K.
Deposit date:2013-03-12
Release date:2014-04-09
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with MII-6-097
To be Published
3W87
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STRUCTURE OF TRYPANOSOMA CRUZI DIHYDROOROTATE DEHYDROGENASE IN COMPLEX WITH SH-1-103
Descriptor:Dihydroorotate dehydrogenase (fumarate) (E.C.1.3.98.1)
Authors:Inaoka, D.K., Hashimoto, S., Rocha, J.R., Iida, M., Tabuchi, T., Lee, N., Matsuoka, S., Kuranaga, T., Shiba, T., Balogun, E.O., Sakamoto, K., Suzuki, S., Montanari, C.A., Nara, T., Aoki, T., Inoue, M., Honma, T., Tanaka, A., Harada, S., Kita, K.
Deposit date:2013-03-12
Release date:2014-04-09
Method:X-RAY DIFFRACTION (1.43 Å)
Cite:Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with SH-1-103
To be Published
4JS3
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CRYSTAL STRUCTURE OF HUMAN DIHYDROOROTATE DEHYDROGENASE (DHODH) WITH 057
Descriptor:Dihydroorotate dehydrogenase (quinone), mitochondrial (E.C.1.3.5.2)
Authors:Zhu, L., Li, H., Zhu, J., Ren, X.
Deposit date:2013-03-22
Release date:2014-03-26
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of human dihydroorotate dehydrogenase (DHODH) with 057
TO BE PUBLISHED
4JTS
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CRYSTAL STRUCTURE OF HUMAN DIHYDROOROTATE DEHYDROGENASE (DHODH) WITH 072
Descriptor:Dihydroorotate dehydrogenase (quinone), mitochondrial (E.C.1.3.5.2)
Authors:Zhu, L., Zhu, J., Ren, X., Li, H.
Deposit date:2013-03-24
Release date:2014-03-26
Method:X-RAY DIFFRACTION (2.206 Å)
Cite:Crystal structure of human dihydroorotate dehydrogenase (DHODH) with 057
To be Published
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