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6LZI
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BU of 6lzi by Molmil
Aquifex aeolicus MutL ATPase domain complexed with ADP
Descriptor: ADENOSINE-5'-DIPHOSPHATE, DI(HYDROXYETHYL)ETHER, DNA mismatch repair protein MutL, ...
Authors:Fukui, K, Izuhara, K, Yano, T.
Deposit date:2020-02-19
Release date:2020-07-01
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.69105685 Å)
Cite:A Lynch syndrome-associated mutation at a Bergerat ATP-binding fold destabilizes the structure of the DNA mismatch repair endonuclease MutL.
J.Biol.Chem., 295, 2020
6LZJ
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BU of 6lzj by Molmil
Aquifex aeolicus MutL ATPase domain complexed with AMPPCP
Descriptor: DNA mismatch repair protein MutL, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER
Authors:Fukui, K, Izuhara, K, Yano, T.
Deposit date:2020-02-19
Release date:2020-07-01
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.72835565 Å)
Cite:A Lynch syndrome-associated mutation at a Bergerat ATP-binding fold destabilizes the structure of the DNA mismatch repair endonuclease MutL.
J.Biol.Chem., 295, 2020
1B63
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BU of 1b63 by Molmil
MUTL COMPLEXED WITH ADPNP
Descriptor: 1,2-ETHANEDIOL, MAGNESIUM ION, MUTL, ...
Authors:Yang, W.
Deposit date:1999-01-20
Release date:1999-06-08
Last modified:2023-08-02
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Transformation of MutL by ATP binding and hydrolysis: a switch in DNA mismatch repair.
Cell(Cambridge,Mass.), 97, 1999
1H7S
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BU of 1h7s by Molmil
N-terminal 40kDa fragment of human PMS2
Descriptor: PMS1 PROTEIN HOMOLOG 2
Authors:Guarne, A, Junop, M.S, Yang, W.
Deposit date:2001-07-10
Release date:2001-11-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structure and Function of the N-Terminal 40 kDa Fragment of Human Pms2: A Monomeric Ghl ATPase
Embo J., 20, 2001
1NHI
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BU of 1nhi by Molmil
Crystal structure of N-terminal 40KD MutL (LN40) complex with ADPnP and one potassium
Descriptor: 1,2-ETHANEDIOL, DNA mismatch repair protein mutL, MAGNESIUM ION, ...
Authors:Hu, X, Machius, M, Yang, W.
Deposit date:2002-12-19
Release date:2003-06-10
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2 Å)
Cite:Monovalent cation dependence and preference of GHKL ATPases and kinases
FEBS Lett., 544, 2003
7RCB
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BU of 7rcb by Molmil
Crystal Structure of a PMS2 VUS
Descriptor: Mismatch repair endonuclease PMS2
Authors:D'Arcy, B.M, Prakash, A.
Deposit date:2021-07-07
Release date:2022-03-02
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2 Å)
Cite:PMS2 variant results in loss of ATPase activity without compromising mismatch repair.
Mol Genet Genomic Med, 10, 2022
7RCK
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BU of 7rck by Molmil
Crystal Structure of PMS2 with Substrate
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Mismatch repair endonuclease PMS2
Authors:D'Arcy, B.M, Prakash, A.
Deposit date:2021-07-07
Release date:2022-03-02
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.04 Å)
Cite:PMS2 variant results in loss of ATPase activity without compromising mismatch repair.
Mol Genet Genomic Med, 10, 2022
1B62
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BU of 1b62 by Molmil
MUTL COMPLEXED WITH ADP
Descriptor: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, PROTEIN (MUTL)
Authors:Wei, Y.
Deposit date:1999-01-11
Release date:1999-04-28
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Transformation of MutL by ATP binding and hydrolysis: a switch in DNA mismatch repair.
Cell(Cambridge,Mass.), 97, 1999
7RCI
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BU of 7rci by Molmil
Crystal Structure of a PMS2 VUS with Substrate
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Mismatch repair endonuclease PMS2
Authors:D'Arcy, B.M, Prakash, A.
Deposit date:2021-07-07
Release date:2022-03-02
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.12 Å)
Cite:PMS2 variant results in loss of ATPase activity without compromising mismatch repair.
Mol Genet Genomic Med, 10, 2022
1NHJ
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BU of 1nhj by Molmil
Crystal structure of N-terminal 40KD MutL/A100P mutant protein complex with ADPnP and one sodium
Descriptor: DNA mismatch repair protein mutL, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
Authors:Hu, X, Machius, M, Yang, W.
Deposit date:2002-12-19
Release date:2003-06-10
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Monovalent cation dependence and preference of GHKL ATPases and kinases
FEBS Lett., 544, 2003
4P7A
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BU of 4p7a by Molmil
Crystal Structure of human MLH1
Descriptor: ADENOSINE-5'-DIPHOSPHATE, DNA mismatch repair protein Mlh1, MAGNESIUM ION, ...
Authors:Tempel, W, Lam, R, Zeng, H, Walker, J.R, Loppnau, P, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Wu, H, Structural Genomics Consortium (SGC)
Deposit date:2014-03-26
Release date:2014-04-09
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure of the human MLH1 N-terminus: implications for predisposition to Lynch syndrome.
Acta Crystallogr.,Sect.F, 71, 2015
1NHH
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BU of 1nhh by Molmil
Crystal structure of N-terminal 40KD MutL protein (LN40) complex with ADPnP and one Rubidium
Descriptor: 1,2-ETHANEDIOL, DNA mismatch repair protein mutL, MAGNESIUM ION, ...
Authors:Hu, X, Machius, M, Yang, W.
Deposit date:2002-12-19
Release date:2003-06-10
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Monovalent cation dependence and preference of GHKL ATPases and kinases
FEBS Lett., 544, 2003
3H4L
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BU of 3h4l by Molmil
Crystal Structure of N terminal domain of a DNA repair protein
Descriptor: DNA mismatch repair protein PMS1, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
Authors:Arana, M.E, Holmes, S.F, Fortune, J.M, Moon, A.F, Pedersen, L.C, Kunkel, T.A.
Deposit date:2009-04-20
Release date:2010-03-02
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Functional residues on the surface of the N-terminal domain of yeast Pms1.
Dna Repair, 9, 2010
6MFQ
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BU of 6mfq by Molmil
Crystal structure of a PMS2 variant
Descriptor: Mismatch repair endonuclease PMS2
Authors:D'Arcy, B.M, Prakash, A.
Deposit date:2018-09-11
Release date:2019-02-06
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Biochemical and structural characterization of two variants of uncertain significance in the PMS2 gene.
Hum. Mutat., 40, 2019
1EA6
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BU of 1ea6 by Molmil
N-terminal 40kDa fragment of NhPMS2 complexed with ADP
Descriptor: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, PMS1 PROTEIN HOMOLOG 2
Authors:Guarne, A, Junop, M.S, Yang, W.
Deposit date:2001-07-10
Release date:2001-11-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structure and Function of the N-Terminal 40 kDa Fragment of Human Pms2: A Monomeric Ghl ATPase
Embo J., 20, 2001
1H7U
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BU of 1h7u by Molmil
hPMS2-ATPgS
Descriptor: MAGNESIUM ION, MISMATCH REPAIR ENDONUCLEASE PMS2, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER
Authors:Guarne, A, Junop, M.S, Yang, W.
Deposit date:2001-07-10
Release date:2001-11-27
Last modified:2013-01-30
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structure and Function of the N-Terminal 40 kDa Fragment of Human Pms2: A Monomeric Ghl ATPase
Embo J., 20, 2001
1BKN
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BU of 1bkn by Molmil
CRYSTAL STRUCTURE OF AN N-TERMINAL 40KD FRAGMENT OF E. COLI DNA MISMATCH REPAIR PROTEIN MUTL
Descriptor: MUTL
Authors:Yang, W, Ban, C.
Deposit date:1998-07-09
Release date:1999-05-11
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal structure and ATPase activity of MutL: implications for DNA repair and mutagenesis.
Cell(Cambridge,Mass.), 95, 1998
6LZK
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BU of 6lzk by Molmil
Aquifex aeolicus MutL ATPase domain with K252N mutation
Descriptor: DI(HYDROXYETHYL)ETHER, DNA mismatch repair protein MutL, SODIUM ION
Authors:Fukui, K, Izuhara, K, Yano, T.
Deposit date:2020-02-19
Release date:2020-07-01
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (3.15949631 Å)
Cite:A Lynch syndrome-associated mutation at a Bergerat ATP-binding fold destabilizes the structure of the DNA mismatch repair endonuclease MutL.
J.Biol.Chem., 295, 2020
5X9Y
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BU of 5x9y by Molmil
Crystal structure of the ATPase domain from bacterial mismatch repair endonuclease Aquifex aeolicus MutL.
Descriptor: DI(HYDROXYETHYL)ETHER, DNA mismatch repair protein MutL
Authors:Fukui, K, Yano, T.
Deposit date:2017-03-10
Release date:2017-08-30
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (3.443 Å)
Cite:Crystal structure and DNA-binding property of the ATPase domain of bacterial mismatch repair endonuclease MutL from Aquifex aeolicus
Biochim. Biophys. Acta, 1865, 2017
7P8V
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BU of 7p8v by Molmil
The structure of E. coli MutL bound to a 3' resected DNA end
Descriptor: DNA mismatch repair protein MutL, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
Authors:Borsellini, A, Lamers, M.H.
Deposit date:2021-07-23
Release date:2022-06-29
Last modified:2022-08-31
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:MutL binds to 3' resected DNA ends and blocks DNA polymerase access.
Nucleic Acids Res., 50, 2022
7AIB
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BU of 7aib by Molmil
MutS-MutL in clamp state
Descriptor: DNA (30-MER), DNA mismatch repair protein MutL, DNA mismatch repair protein MutS, ...
Authors:Fernandez-Leiro, R, Bhairosing-Kok, D, Sixma, T.K, Lamers, M.H.
Deposit date:2020-09-26
Release date:2021-03-31
Last modified:2021-04-28
Method:ELECTRON MICROSCOPY (4.7 Å)
Cite:The selection process of licensing a DNA mismatch for repair.
Nat.Struct.Mol.Biol., 28, 2021
5AKB
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BU of 5akb by Molmil
MutS in complex with the N-terminal domain of MutL - crystal form 1
Descriptor: DNA MISMATCH REPAIR PROTEIN MUTL, DNA MISMATCH REPAIR PROTEIN MUTS, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
Authors:Groothuizen, F.S, Winkler, I, Cristovao, M, Fish, A, Winterwerp, H.H.K, Reumer, A, Marx, A.D, Hermans, N, Nicholls, R.A, Murshudov, G.N, Lebbink, J.H.G, Friedhoff, P, Sixma, T.K.
Deposit date:2015-03-03
Release date:2015-07-22
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (4.71 Å)
Cite:MutS/MutL crystal structure reveals that the MutS sliding clamp loads MutL onto DNA.
Elife, 4, 2015
7AIC
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BU of 7aic by Molmil
MutS-MutL in clamp state (kinked clamp domain)
Descriptor: DNA (30-MER), DNA mismatch repair protein MutL, DNA mismatch repair protein MutS, ...
Authors:Fernandez-Leiro, R, Bhairosing-Kok, D, Sixma, T.K, Lamers, M.H.
Deposit date:2020-09-26
Release date:2021-03-31
Last modified:2021-04-28
Method:ELECTRON MICROSCOPY (5 Å)
Cite:The selection process of licensing a DNA mismatch for repair.
Nat.Struct.Mol.Biol., 28, 2021
5AKC
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BU of 5akc by Molmil
MutS in complex with the N-terminal domain of MutL - crystal form 2
Descriptor: DNA MISMATCH REPAIR PROTEIN MUTL, DNA MISMATCH REPAIR PROTEIN MUTS, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
Authors:Groothuizen, F.S, Winkler, I, Cristovao, M, Fish, A, Winterwerp, H.H.K, Reumer, A, Marx, A.D, Hermans, N, Nicholls, R.A, Murshudov, G.N, Lebbink, J.H.G, Friedhoff, P, Sixma, T.K.
Deposit date:2015-03-03
Release date:2015-07-22
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (6.6 Å)
Cite:MutS/MutL crystal structure reveals that the MutS sliding clamp loads MutL onto DNA.
Elife, 4, 2015
5AKD
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BU of 5akd by Molmil
MutS in complex with the N-terminal domain of MutL - crystal form 3
Descriptor: DNA MISMATCH REPAIR PROTEIN MUTL, DNA MISMATCH REPAIR PROTEIN MUTS, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
Authors:Groothuizen, F.S, Winkler, I, Cristovao, M, Fish, A, Winterwerp, H.H.K, Reumer, A, Marx, A.D, Hermans, N, Nicholls, R.A, Murshudov, G.N, Lebbink, J.H.G, Friedhoff, P, Sixma, T.K.
Deposit date:2015-03-03
Release date:2015-07-22
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (7.6 Å)
Cite:MutS/MutL crystal structure reveals that the MutS sliding clamp loads MutL onto DNA.
Elife, 4, 2015

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