1L9K
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DENGUE METHYLTRANSFERASE
Descriptor:RNA-DIRECTED RNA POLYMERASE (E.C.2.7.7.48)
Authors:Egloff, M.P., Benarroch, D., Selisko, B., Romette, J.L., Canard, B.
Deposit date:2002-03-25
Release date:2003-03-25
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:An RNA cap (nucleoside-2'-O-) methyltransferase in the flavivirus RNA polymerase NS5: crystal structure and functional characterization
Embo J., 21, 2002
1R6A
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STRUCTURE OF THE DENGUE VIRUS 2'O METHYLTRANSFERASE IN COMPLEX WITH S-ADENOSYL HOMOCYSTEINE AND RIBAVIRIN 5' TRIPHOSPHATE
Descriptor:Genome polyprotein (E.C.2.7.7.48)
Authors:Benarroch, D., Egloff, M.P., Mulard, L., Romette, J.L., Canard, B.
Deposit date:2003-10-15
Release date:2004-09-21
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:A structural basis for the inhibition of the NS5 dengue virus mRNA 2'-O-methyltransferase domain by ribavirin 5'-triphosphate.
J.Biol.Chem., 279, 2004
2HCN
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CRYSTAL STRUCTURE OF RNA DEPENDENT RNA POLYMERASE DOMAIN FROM WEST NILE VIRUS
Descriptor:RNA-directed RNA polymerase (NS5)
Authors:Egloff, M.P., Malet, H., Marseilles Structural Genomics Program @ AFMB (MSGP)
Deposit date:2006-06-17
Release date:2007-02-06
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Crystal structure of the RNA polymerase domain of the West Nile virus non-structural protein 5
J.Biol.Chem., 282, 2007
2HCS
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CRYSTAL STRUCTURE OF RNA DEPENDANT RNA POLYMERASE DOMAIN OF WEST NILE VIRUS
Descriptor:RNA-directed RNA polymerase (NS5)
Authors:Egloff, M.P., Malet, H., Marseilles Structural Genomics Program @ AFMB (MSGP)
Deposit date:2006-06-18
Release date:2007-02-06
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of the RNA polymerase domain of the West Nile virus non-structural protein 5
J.Biol.Chem., 282, 2007
2HFZ
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CRYSTAL STRUCTURE OF RNA DEPENDENT RNA POLYMERASE DOMAIN FROM WEST NILE VIRUS
Descriptor:RNA-directed RNA polymerase(NS5)
Authors:Egloff, M.P., Malet, H., Marseilles Structural Genomics Program @ AFMB (MSGP)
Deposit date:2006-06-26
Release date:2007-02-06
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal structure of the RNA polymerase domain of the West Nile virus non-structural protein 5
J.Biol.Chem., 282, 2007
2J7U
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DENGUE VIRUS NS5 RNA DEPENDENT RNA POLYMERASE DOMAIN
Descriptor:RNA DEPENDENT RNA POLYMERASE
Authors:Yap, T.L., Xu, T., Chen, Y.L., Malet, H., Egloff, M.P., Canard, B., Vasudevan, S.G., Lescar, J.
Deposit date:2006-10-17
Release date:2007-03-13
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Crystal Structure of the Dengue Virus RNA- Dependent RNA Polymerase Catalytic Domain at 1.85 Angstrom Resolution.
J.Virol., 81, 2007
2J7W
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DENGUE VIRUS NS5 RNA DEPENDENT RNA POLYMERASE DOMAIN COMPLEXED WITH 3'DGTP
Descriptor:POLYPROTEIN
Authors:Yap, T.L., Xu, T., Chen, Y.L., Malet, H., Egloff, M.P., Canard, B., Vasudevan, S.G., Lescar, J.
Deposit date:2006-10-17
Release date:2007-03-13
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal Structure of the Dengue Virus RNA- Dependent RNA Polymerase Catalytic Domain at 1.85 Angstrom Resolution.
J.Virol., 81, 2007
2OXT
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CRYSTAL STRUCTURE OF MEABAN VIRUS NUCLEOSIDE-2'-O-METHYLTRANSFERASE
Descriptor:NUCLEOSIDE-2'-O-METHYLTRANSFERASE
Authors:Mastrangelo, E., Milani, M., Bollati, M., Bolognesi, M.
Deposit date:2007-02-21
Release date:2007-05-15
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural bases for substrate recognition and activity in Meaban virus nucleoside-2'-O-methyltransferase
Protein Sci., 16, 2007
2OY0
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CRYSTAL STRUCTURE OF THE WEST NILE VIRUS METHYLTRANSFERASE
Descriptor:Methyltransferase
Authors:Li, H.M., Zhao, Y.W., Guo, Y., Shi,P.Y.
Deposit date:2007-02-21
Release date:2007-04-03
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure and Function of Flavivirus NS5 Methyltransferase.
J.Virol., 81, 2007
2P1D
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CRYSTAL STRUCTURE OF DENGUE METHYLTRANSFERASE IN COMPLEX WITH GTP AND S-ADENOSYL-L-HOMOCYSTEINE
Descriptor:type II methyltransferase (E.C.2.7.7.48)
Authors:Egloff, M.P., Benarooch, D., Marseilles Structural Genomics Program @ AFMB (MSGP)
Deposit date:2007-03-05
Release date:2007-03-20
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:An RNA cap (nucleoside-2'-O)-methyltransferase in the flavivirus RNA polymerase NS5: crystal structure and functional characterization
EMBO J., 21, 2002
2P3L
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CRYSTAL STRUCTURE OF DENGUE METHYLTRANSFERASE IN COMPLEX WITH GPPPA AND S-ADENOSYL-L-HOMOCYSTEINE
Descriptor:type II methyltransferase (E.C.2.7.7.48)
Authors:Egloff, M.P., Marseilles Structural Genomics Program @ AFMB (MSGP)
Deposit date:2007-03-09
Release date:2007-08-28
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural and functional analysis of methylation and 5'-RNA sequence requirements of short capped RNAs by the methyltransferase domain of dengue virus NS5
J.Mol.Biol., 372, 2007
2P3O
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CRYSTAL STRUCTURE OF DENGUE METHYLTRANSFERASE IN COMPLEX WITH 7MEGPPPA AND S-ADENOSYL-L-HOMOCYSTEINE
Descriptor:type II methyltransferase (E.C.2.7.7.48)
Authors:Egloff, M.P., Marseilles Structural Genomics Program @ AFMB (MSGP)
Deposit date:2007-03-09
Release date:2007-08-28
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.756 Å)
Cite:Structural and functional analysis of methylation and 5'-RNA sequence requirements of short capped RNAs by the methyltransferase domain of dengue virus NS5
J.Mol.Biol., 372, 2007
2P3Q
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CRYSTAL STRUCTURE OF DENGUE METHYLTRANSFERASE IN COMPLEX WITH GPPPG AND S-ADENOSYL-L-HOMOCYSTEINE
Descriptor:type II methyltransferase (E.C.2.7.7.48)
Authors:Egloff, M.P., Marseilles Structural Genomics Program @ AFMB (MSGP)
Deposit date:2007-03-09
Release date:2007-08-28
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Structural and functional analysis of methylation and 5'-RNA sequence requirements of short capped RNAs by the methyltransferase domain of dengue virus NS5
J.Mol.Biol., 372, 2007
2P40
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CRYSTAL STRUCTURE OF DENGUE METHYLTRANSFERASE IN COMPLEX WITH 7MEGPPPG
Descriptor:type II methyltransferase (E.C.2.7.7.48)
Authors:Egloff, M.P., Marseilles Structural Genomics Program @ AFMB (MSGP)
Deposit date:2007-03-11
Release date:2007-08-28
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.701 Å)
Cite:Structural and functional analysis of methylation and 5'-RNA sequence requirements of short capped RNAs by the methyltransferase domain of dengue virus NS5
J.Mol.Biol., 372, 2007
2P41
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CRYSTAL STRUCTURE OF DENGUE METHYLTRANSFERASE IN COMPLEX WITH 7MEGPPPG2'OME AND S-ADENOSYL-L-HOMOCYSTEINE
Descriptor:type II methyltransferase (E.C.2.7.7.48)
Authors:Egloff, M.P., Marseilles Structural Genomics Program @ AFMB (MSGP)
Deposit date:2007-03-11
Release date:2007-08-28
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (1.801 Å)
Cite:Structural and functional analysis of methylation and 5'-RNA sequence requirements of short capped RNAs by the methyltransferase domain of dengue virus NS5
J.Mol.Biol., 372, 2007
2PX2
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CRYSTAL STRUCTURE OF THE MURRAY VALLEY ENCEPHALITIS VIRUS NS5 2'-O METHYLTRANSFERASE DOMAIN IN COMPLEX WITH SAH (MONOCLINIC FORM 1)
Descriptor:Genome polyprotein [Contains: Capsid protein C (Core protein); Envelope protein M (Matrix protein); Major envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Flavivirin protease NS2B regulatory subunit; Flavivirin protease NS3 catalytic subunit; Non-structural protein 4A (NS4A); Non-structural protein 4B (NS4B); RNA-directed RNA polymerase (EC 2.7.7.48) (NS5)] (E.C.2.7.7.48)
Authors:Assenberg, R., Ren, J., Verma, A., Walter, T.S., Alderton, D., Hurrelbrink, R.J., Fuller, S.D., Owens, R.J., Stuart, D.I., Grimes, J.M., Oxford Protein Production Facility (OPPF)
Deposit date:2007-05-14
Release date:2007-05-29
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of the Murray Valley encephalitis virus NS5 methyltransferase domain in complex with cap analogues.
J.Gen.Virol., 88, 2007
2PX4
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CRYSTAL STRUCTURE OF THE MURRAY VALLEY ENCEPHALITIS VIRUS NS5 2'-O METHYLTRANSFERASE DOMAIN IN COMPLEX WITH SAH (MONOCLINIC FORM 2)
Descriptor:Genome polyprotein [Contains: Capsid protein C (Core protein); Envelope protein M (Matrix protein); Major envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Flavivirin protease NS2B regulatory subunit; Flavivirin protease NS3 catalytic subunit; Non-structural protein 4A (NS4A); Non-structural protein 4B (NS4B); RNA-directed RNA polymerase (EC 2.7.7.48) (NS5)] (E.C.2.7.7.48)
Authors:Assenberg, R., Ren, J., Verma, A., Walter, T.S., Alderton, D., Hurrelbrink, R.J., Fuller, S.D., Owens, R.J., Stuart, D.I., Grimes, J.M., Oxford Protein Production Facility (OPPF)
Deposit date:2007-05-14
Release date:2007-05-29
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of the Murray Valley encephalitis virus NS5 methyltransferase domain in complex with cap analogues.
J.Gen.Virol., 88, 2007
2PX5
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CRYSTAL STRUCTURE OF THE MURRAY VALLEY ENCEPHALITIS VIRUS NS5 2'-O METHYLTRANSFERASE DOMAIN IN COMPLEX WITH SAH (ORTHORHOMBIC CRYSTAL FORM)
Descriptor:Genome polyprotein [Contains: Capsid protein C (Core protein); Envelope protein M (Matrix protein); Major envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Flavivirin protease NS2B regulatory subunit; Flavivirin protease NS3 catalytic subunit; Non-structural protein 4A (NS4A); Non-structural protein 4B (NS4B); RNA-directed RNA polymerase (EC 2.7.7.48) (NS5)] (E.C.2.7.7.48)
Authors:Assenberg, R., Ren, J., Verma, A., Walter, T.S., Alderton, D., Hurrelbrink, R.J., Fuller, S.D., Owens, R.J., Stuart, D.I., Grimes, J.M., Oxford Protein Production Facility (OPPF)
Deposit date:2007-05-14
Release date:2007-05-29
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of the Murray Valley encephalitis virus NS5 methyltransferase domain in complex with cap analogues.
J.Gen.Virol., 88, 2007
2PX8
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CRYSTAL STRUCTURE OF THE MURRAY VALLEY ENCEPHALITIS VIRUS NS5 2'-O METHYLTRANSFERASE DOMAIN IN COMPLEX WITH SAH AND 7M-GTP
Descriptor:Genome polyprotein [Contains: Capsid protein C (Core protein); Envelope protein M (Matrix protein); Major envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Flavivirin protease NS2B regulatory subunit; Flavivirin protease NS3 catalytic subunit; Non-structural protein 4A (NS4A); Non-structural protein 4B (NS4B); RNA-directed RNA polymerase (EC 2.7.7.48) (NS5)] (E.C.2.7.7.48)
Authors:Assenberg, R., Ren, J., Verma, A., Walter, T.S., Alderton, D., Hurrelbrink, R.J., Fuller, S.D., Owens, R.J., Stuart, D.I., Grimes, J.M., Oxford Protein Production Facility (OPPF)
Deposit date:2007-05-14
Release date:2007-05-29
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of the Murray Valley encephalitis virus NS5 methyltransferase domain in complex with cap analogues.
J.Gen.Virol., 88, 2007
2PXA
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CRYSTAL STRUCTURE OF THE MURRAY VALLEY ENCEPHALITIS VIRUS NS5 2'-O METHYLTRANSFERASE DOMAIN IN COMPLEX WITH SAH AND GTPG
Descriptor:Genome polyprotein [Contains: Capsid protein C (Core protein); Envelope protein M (Matrix protein); Major envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Flavivirin protease NS2B regulatory subunit; Flavivirin protease NS3 catalytic subunit; Non-structural protein 4A (NS4A); Non-structural protein 4B (NS4B); RNA-directed RNA polymerase (EC 2.7.7.48) (NS5)] (E.C.2.7.7.48)
Authors:Assenberg, R., Ren, J., Verma, A., Walter, T.S., Alderton, D., Hurrelbrink, R.J., Fuller, S.D., Owens, R.J., Stuart, D.I., Grimes, J.M., Oxford Protein Production Facility (OPPF)
Deposit date:2007-05-14
Release date:2007-05-29
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of the Murray Valley encephalitis virus NS5 methyltransferase domain in complex with cap analogues.
J.Gen.Virol., 88, 2007
2PXC
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CRYSTAL STRUCTURE OF THE MURRAY VALLEY ENCEPHALITIS VIRUS NS5 2'-O METHYLTRANSFERASE DOMAIN IN COMPLEX WITH SAM AND GTPA
Descriptor:Genome polyprotein [Contains: Capsid protein C (Core protein); Envelope protein M (Matrix protein); Major envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Flavivirin protease NS2B regulatory subunit; Flavivirin protease NS3 catalytic subunit; Non-structural protein 4A (NS4A); Non-structural protein 4B (NS4B); RNA-directed RNA polymerase (EC 2.7.7.48) (NS5)] (E.C.2.7.7.48)
Authors:Assenberg, R., Ren, J., Verma, A., Walter, T.S., Alderton, D., Hurrelbrink, R.J., Fuller, S.D., Owens, R.J., Stuart, D.I., Grimes, J.M., Oxford Protein Production Facility (OPPF)
Deposit date:2007-05-14
Release date:2007-05-29
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure of the Murray Valley encephalitis virus NS5 methyltransferase domain in complex with cap analogues.
J.Gen.Virol., 88, 2007
3ELD
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WESSELSBRON METHYLTRANSFERASE IN COMPLEX WITH SINEFUNGIN
Descriptor:Methyltransferase (E.C.2.1.1.57)
Authors:Bollati, M., Milani, M., Mastrangelo, E., Ricagno, S., Bolognesi, M.
Deposit date:2008-09-22
Release date:2008-11-18
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Recognition of RNA Cap in the Wesselsbron Virus NS5 Methyltransferase Domain: Implications for RNA-Capping Mechanisms in Flavivirus
J.Mol.Biol., 385, 2009
3ELU
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WESSELSBRON VIRUS METHYLTRANSFERASE IN COMPLEX WITH ADOMET
Descriptor:Methyltransferase (E.C.2.1.1.57)
Authors:Bollati, M., Ricagno, S., Milani, M., Mastrangelo, E., Bolognesi, M.
Deposit date:2008-09-23
Release date:2008-11-18
Modification date:2010-12-08
Method:X-RAY DIFFRACTION (2 Å)
Cite:Recognition of RNA Cap in the Wesselsbron Virus NS5 Methyltransferase Domain: Implications for RNA-Capping Mechanisms in Flavivirus
J.Mol.Biol., 385, 2009
3ELW
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WESSELSBRON VIRUS METHYLTRANSFERASE IN COMPLEX WITH ADOMET AND GPPPG
Descriptor:Methyltransferase (E.C.2.1.1.57)
Authors:Bollati, M., Ricagno, S., Milani, M., Mastrangelo, E., Bolognesi, M.
Deposit date:2008-09-23
Release date:2008-11-18
Modification date:2010-12-08
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Recognition of RNA Cap in the Wesselsbron Virus NS5 Methyltransferase Domain: Implications for RNA-Capping Mechanisms in Flavivirus
J.Mol.Biol., 385, 2009
3ELY
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WESSELSBRON VIRUS METHYLTRANSFERASE IN COMPLEX WITH ADOHCY
Descriptor:Methyltransferase (E.C.2.1.1.57)
Authors:Bollati, M., Milani, M., Ricagno, S., Mastrangelo, E., Bolognesi, M.
Deposit date:2008-09-23
Release date:2008-11-18
Modification date:2010-12-08
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Recognition of RNA Cap in the Wesselsbron Virus NS5 Methyltransferase Domain: Implications for RNA-Capping Mechanisms in Flavivirus
J.Mol.Biol., 385, 2009
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