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1I31
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BU of 1i31 by Molmil
MU2 ADAPTIN SUBUNIT (AP50) OF AP2 CLATHRIN ADAPTOR, COMPLEXED WITH EGFR INTERNALIZATION PEPTIDE FYRALM AT 2.5 A RESOLUTION
Descriptor: CLATHRIN COAT ASSEMBLY PROTEIN AP50, EPIDERMAL GROWTH FACTOR RECEPTOR
Authors:Modis, Y, Boll, W, Rapoport, I, Kirchhausen, T.
Deposit date:2001-02-12
Release date:2001-02-21
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:MU2 ADAPTIN SUBUNIT (AP50) OF AP2 CLATHRIN ADAPTOR, COMPLEXED WITH EGFR INTERNALIZATION PEPTIDE FYRALM AT 2.5 A RESOLUTION
To be Published
1BXX
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MU2 ADAPTIN SUBUNIT (AP50) OF AP2 ADAPTOR (SECOND DOMAIN), COMPLEXED WITH TGN38 INTERNALIZATION PEPTIDE DYQRLN
Descriptor: PROTEIN (AP50), PROTEIN (TGN38 PEPTIDE)
Authors:Owen, D.J, Evans, P.R.
Deposit date:1998-10-08
Release date:1998-11-25
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:A structural explanation for the recognition of tyrosine-based endocytotic signals.
Science, 282, 1998
2PR9
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BU of 2pr9 by Molmil
Mu2 adaptin subunit (AP50) of AP2 adaptor (second domain), complexed with GABAA receptor-gamma2 subunit-derived internalization peptide DEEYGYECL
Descriptor: AP-2 complex subunit mu-1, GABA(A) receptor subunit gamma-2 peptide
Authors:Vahedi-Faridi, A, Haucke, V, Kittler, J.T, Kukhtina, V, Moss, S.J, Saenger, W, Chen, G.-J, Tretter, V, Smith, K, Yan, Z, McAinsh, K, Arancibia-Carcamo, L.
Deposit date:2007-05-04
Release date:2008-03-18
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.51 Å)
Cite:Regulation of synaptic inhibition by phospho-dependent binding of the AP2 complex to a YECL motif in the GABAA receptor gamma2 subunit.
Proc.Natl.Acad.Sci.Usa, 105, 2008
1BW8
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BU of 1bw8 by Molmil
MU2 ADAPTIN SUBUNIT (AP50) OF AP2 ADAPTOR (SECOND DOMAIN), COMPLEXED WITH EGFR INTERNALIZATION PEPTIDE FYRALM
Descriptor: PROTEIN (INTERNALIZATION SIGNAL FROM EGFR), PROTEIN (MU2 ADAPTIN SUBUNIT)
Authors:Owen, D.J, Evans, P.R.
Deposit date:1998-09-30
Release date:1998-11-25
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:A structural explanation for the recognition of tyrosine-based endocytotic signals.
Science, 282, 1998
4IKN
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BU of 4ikn by Molmil
Crystal structure of adaptor protein complex 3 (AP-3) mu3A subunit C-terminal domain, in complex with a sorting peptide from TGN38
Descriptor: AP-3 complex subunit mu-1, Trans-Golgi network integral membrane protein TGN38
Authors:Mardones, G.A, Kloer, D.P, Burgos, P.V, Bonifacino, J.S, Hurley, J.H.
Deposit date:2012-12-26
Release date:2013-02-20
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.851 Å)
Cite:Structural basis for the recognition of tyrosine-based sorting signals by the mu 3A subunit of the AP-3 adaptor complex.
J.Biol.Chem., 288, 2013
1HES
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BU of 1hes by Molmil
MU2 ADAPTIN SUBUNIT (AP50) OF AP2 ADAPTOR (SECOND DOMAIN), COMPLEXED WITH P-selectin INTERNALIZATION PEPTIDE SHLGTYGVFTNAA
Descriptor: CLATHRIN COAT ASSEMBLY PROTEIN AP50, P-SELECTIN PEPTIDE
Authors:Owen, D.J, Evans, P.R, Green, S.A.
Deposit date:2000-11-24
Release date:2001-05-31
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:A Third Specificity-Determining Site in Mu 2 Adaptin for Sequences Upstream of Yxx Phi Sorting Motifs
Traffic, 2, 2001
1H6E
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BU of 1h6e by Molmil
MU2 ADAPTIN SUBUNIT (AP50) OF AP2 ADAPTOR (SECOND DOMAIN), COMPLEXED WITH CTLA-4 INTERNALIZATION PEPTIDE TTGVYVKMPPT
Descriptor: CLATHRIN COAT ASSEMBLY PROTEIN AP50, CYTOTOXIC T-LYMPHOCYTE PROTEIN 4
Authors:Rowsell, S, Pauptit, R.A.
Deposit date:2001-06-12
Release date:2001-11-28
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:Study of the Interaction of the Medium Chain Mu2 Subunit of the Clathrin-Associated Adapter Protein Complex 2 with Cytotoxic T-Lymphocyte Antigen 4 and Cd28
Biochem.J., 359, 2001
3H85
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BU of 3h85 by Molmil
Molecular basis for the association of PIPKI gamma-p90 with the clathrin adaptor AP-2
Descriptor: AP-2 complex subunit mu-1, NICKEL (II) ION, Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma
Authors:Vahedi-Faridi, A, Kahlfeldt, N, Schaefer, J.G, Haucke, V.
Deposit date:2009-04-28
Release date:2009-11-24
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Molecular basis for association of PIPKI gamma-p90 with clathrin adaptor AP-2.
J.Biol.Chem., 285, 2010
4MDR
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Crystal structure of adaptor protein complex 4 (AP-4) mu4 subunit C-terminal domain D190A mutant, in complex with a sorting peptide from the amyloid precursor protein (APP)
Descriptor: AP-4 complex subunit mu-1, Amyloid beta A4 protein
Authors:Ross, B.H, Lin, Y, Corales, E.A, Burgos, P.V, Mardones, G.A.
Deposit date:2013-08-23
Release date:2014-03-12
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structural and Functional Characterization of Cargo-Binding Sites on the mu 4-Subunit of Adaptor Protein Complex 4.
Plos One, 9, 2014
4O8Q
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BU of 4o8q by Molmil
Crystal structure of bovine MHD domain of the COPI delta subunit at 2.15 A resolution
Descriptor: Coatomer subunit delta, FORMIC ACID
Authors:Lahav, A, Rozenberg, H, Cassel, D, Adir, N.
Deposit date:2013-12-29
Release date:2015-01-07
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structure of the bovine COPI delta subunit mu homology domain at 2.15 angstrom resolution.
Acta Crystallogr.,Sect.D, 71, 2015
5WRM
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BU of 5wrm by Molmil
Mu2 subunit of the clathrin adaptor complex AP2 in complex with IRS-1 Y658 peptide
Descriptor: AP-2 complex subunit mu, Insulin receptor substrate 1
Authors:Yoneyama, Y, Niwa, H, Umehara, T, Yokoyama, S, Hakuno, F, Takahashi, S.
Deposit date:2016-12-02
Release date:2017-12-06
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.597 Å)
Cite:IRS-1 acts as an endocytic regulator of IGF-I receptor to facilitate sustained IGF signaling
Elife, 7, 2018
5WRL
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BU of 5wrl by Molmil
Mu2 subunit of the clathrin adaptor complex AP2 in complex with IRS-1 Y628 peptide
Descriptor: AP-2 complex subunit mu, Insulin receptor substrate 1
Authors:Yoneyama, Y, Niwa, H, Umehara, T, Yokoyama, S, Hakuno, F, Takahashi, S.
Deposit date:2016-12-02
Release date:2017-12-06
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (3.095 Å)
Cite:IRS-1 acts as an endocytic regulator of IGF-I receptor to facilitate sustained IGF signaling
Elife, 7, 2018
5WRK
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BU of 5wrk by Molmil
Mu2 subunit of the clathrin adaptor complex AP2 in complex with IRS-1 Y608 peptide
Descriptor: AP-2 complex subunit mu, Insulin receptor substrate 1, NICKEL (II) ION
Authors:Yoneyama, Y, Niwa, H, Umehara, T, Yokoyama, S, Hakuno, F, Takahashi, S.
Deposit date:2016-12-02
Release date:2017-12-06
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.62 Å)
Cite:IRS-1 acts as an endocytic regulator of IGF-I receptor to facilitate sustained IGF signaling
Elife, 7, 2018
3L81
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BU of 3l81 by Molmil
Crystal structure of adaptor protein complex 4 (AP-4) mu4 subunit C-terminal domain, in complex with a sorting peptide from the amyloid precursor protein (APP)
Descriptor: AP-4 complex subunit mu-1, Amyloid beta A4 protein, GLYCEROL
Authors:Mardones, G.A, Rojas, A.L, Burgos, P.V, Dasilva, L.L.P, Prabhu, Y, Bonifacino, J.S, Hurley, J.H.
Deposit date:2009-12-29
Release date:2010-06-02
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Sorting of the Alzheimer's disease amyloid precursor protein mediated by the AP-4 complex.
Dev.Cell, 18, 2010
5FJW
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BU of 5fjw by Molmil
Yeast delta-COP-I mu-homology domain complexed with Dsl1 WxWx(MSE) peptide
Descriptor: COATOMER SUBUNIT DELTA, PROTEIN TRANSPORT PROTEIN DSL1
Authors:Suckling, R.J, Evans, P.R, Owen, D.J.
Deposit date:2015-10-13
Release date:2015-11-11
Last modified:2016-04-06
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural Basis for the Binding of Tryptophan-Based Motifs by Delta-Cop.
Proc.Natl.Acad.Sci.USA, 112, 2015
5FJZ
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BU of 5fjz by Molmil
Yeast delta-COP-I mu-homology domain complexed with Dsl1 WxWxV peptide
Descriptor: COATOMER SUBUNIT DELTA, PROTEIN TRANSPORT PROTEIN DSL1
Authors:Suckling, R.J, Evans, P.R, Owen, D.J.
Deposit date:2015-10-14
Release date:2015-11-11
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural Basis for the Binding of Tryptophan-Based Motifs by Delta-Cop.
Proc.Natl.Acad.Sci.USA, 112, 2015
5FJX
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BU of 5fjx by Molmil
Yeast delta-COP-I mu-homology domain complexed with Gcs1 WxxF peptide
Descriptor: ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN GCS1, COATOMER SUBUNIT DELTA
Authors:Suckling, R.J, Evans, P.R, Owen, D.J.
Deposit date:2015-10-13
Release date:2015-11-11
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Structural Basis for the Binding of Tryptophan-Based Motifs by Delta-Cop.
Proc.Natl.Acad.Sci.USA, 112, 2015
5FK0
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BU of 5fk0 by Molmil
Yeast delta-COP-I mu-homology domain
Descriptor: CALCIUM ION, COATOMER SUBUNIT DELTA
Authors:Suckling, R.J, Evans, P.R, Owen, D.J.
Deposit date:2015-10-14
Release date:2015-11-11
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural Basis for the Binding of Tryptophan-Based Motifs by Delta-Cop.
Proc.Natl.Acad.Sci.USA, 112, 2015
6BNT
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BU of 6bnt by Molmil
Crystal structure of AP2 mu1 adaptin C-terminal domain with IRS-1 peptide
Descriptor: AP-2 complex subunit mu, Insulin receptor substrate 1
Authors:Kikuchi, S, Choi, E, Yu, H.
Deposit date:2017-11-17
Release date:2018-11-21
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Mitotic regulators and the SHP2-MAPK pathway promote IR endocytosis and feedback regulation of insulin signaling.
Nat Commun, 10, 2019
5C7Z
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BU of 5c7z by Molmil
AP2 Mu2 adaptin C-terminal domain complexed with integrin alpha-4 peptide
Descriptor: AP-2 complex subunit mu, Integrin alpha-4
Authors:Owen, D.J, Evans, P.R, Wilson, T.A.
Deposit date:2015-06-25
Release date:2016-07-06
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.77 Å)
Cite:AP2 Mu2 adaptin C-terminal domain complexed with integrin alpha-4 peptide
To Be Published
7OIT
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BU of 7oit by Molmil
Crystal structure of AP2 Mu2 in complex with FCHO2 WxxPhi motif (P3221 crystal form)
Descriptor: AP-2 complex subunit mu, F-BAR domain only protein 2, GLYCEROL
Authors:Zaccai, N.R, Kelly, B.T, Evans, P.R, Owen, D.J.
Deposit date:2021-05-12
Release date:2022-06-01
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:FCHO controls AP2's initiating role in endocytosis through a PtdIns(4,5)P 2 -dependent switch.
Sci Adv, 8, 2022
7OHZ
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BU of 7ohz by Molmil
Crystal structure of AP2 Mu2 - FCHO2 chimera (His6-tagged)
Descriptor: AP-2 complex subunit mu,F-BAR domain only protein 2
Authors:Zaccai, N.R, Kelly, B.T, Evans, P.R, Owen, D.J.
Deposit date:2021-05-11
Release date:2022-06-01
Method:X-RAY DIFFRACTION (2.27 Å)
Cite:FCHO controls AP2's initiating role in endocytosis through a PtdIns(4,5)P 2 -dependent switch.
Sci Adv, 8, 2022
7OI5
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BU of 7oi5 by Molmil
Crystal structure of AP2 Mu2 - FCHO2 chimera (GST cleaved)
Descriptor: AP-2 complex subunit mu,F-BAR domain only protein 2, GLYCEROL
Authors:Zaccai, N.R, Kelly, B.T, Evans, P.R, Owen, D.J.
Deposit date:2021-05-11
Release date:2022-06-01
Method:X-RAY DIFFRACTION (2.61 Å)
Cite:FCHO controls AP2's initiating role in endocytosis through a PtdIns(4,5)P 2 -dependent switch.
Sci Adv, 8, 2022
7OIQ
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Crystal structure of AP2 Mu2 in complex with FCHO2 WxxPhi motif (C2 crystal form)
Descriptor: AP-2 complex subunit mu, F-BAR domain only protein 2
Authors:Zaccai, N.R, Kelly, B.T, Evans, P.R, Owen, D.J.
Deposit date:2021-05-12
Release date:2022-06-01
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:FCHO controls AP2's initiating role in endocytosis through a PtdIns(4,5)P 2 -dependent switch.
Sci Adv, 8, 2022
7OFP
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BU of 7ofp by Molmil
Apo Structure of Mu2 Adaptin Subunit (Ap50) Of AP2 Clathrin Adaptor
Descriptor: AP-2 complex subunit mu, CITRIC ACID, GLYCEROL
Authors:Zaccai, N.R, Kelly, B.T, Evans, P.R, Owen, D.J.
Deposit date:2021-05-05
Release date:2022-06-01
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:FCHO controls AP2's initiating role in endocytosis through a PtdIns(4,5)P 2 -dependent switch.
Sci Adv, 8, 2022

 

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