PDB: 27 resultsInfo pagesStatus searchChemie searchBIRD

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6VGG	Crystal structure of the DNA binding domains of human transcription factor ERG, human Runx2 bound to core binding factor beta (Cbfb), and mithramycin, in complex with 16mer DNA CAGAGGATGTGGCTTC Descriptor: Core-binding factor subunit beta, DNA (5'-D(P*CP*AP*GP*AP*GP*GP*AP*TP*GP*TP*GP*GP*CP*TP*TP*C)-3'), DNA (5'-D(P*GP*AP*AP*GP*CP*CP*AP*CP*AP*TP*CP*CP*TP*CP*TP*G)-3'), ... Authors: Hou, C, Rohr, J, Tsodikov, O.V. Deposit date: 2020-01-08 Release date: 2020-11-25 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (4.31 Å) Cite: Allosteric interference in oncogenic FLI1 and ERG transactions by mithramycins. Structure, 29, 2021
6VGD	Crystal structure of the DNA binding domain (DBD) of human FLI1 and the complex of the DBD of human Runx2 with core binding factor beta (Cbfb), in complex with 16mer DNA CAGAGGATGTGGCTTC Descriptor: Core-binding factor subunit beta, DNA (5'-D(P*CP*AP*GP*AP*GP*GP*AP*TP*GP*TP*GP*GP*CP*TP*TP*C)-3'), DNA (5'-D(P*GP*AP*AP*GP*CP*CP*AP*CP*AP*TP*CP*CP*TP*CP*TP*G)-3'), ... Authors: Hou, C, Tsodikov, O.V. Deposit date: 2020-01-07 Release date: 2020-11-25 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (4.2 Å) Cite: Allosteric interference in oncogenic FLI1 and ERG transactions by mithramycins. Structure, 29, 2021
6VGE	Crystal structure of the DNA binding domains of human transcription factor ERG, human Runx2 bound to core binding factor beta (Cbfb), in complex with 16mer DNA CAGAGGATGTGGCTTC Descriptor: Core-binding factor subunit beta, DNA (5'-D(P*CP*AP*GP*AP*GP*GP*AP*TP*GP*TP*GP*GP*CP*TP*TP*C)-3'), DNA (5'-D(P*GP*AP*AP*GP*CP*CP*AP*CP*AP*TP*CP*CP*TP*CP*TP*G)-3'), ... Authors: Hou, C, Tsodikov, O.V. Deposit date: 2020-01-07 Release date: 2020-11-25 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (4.25 Å) Cite: Allosteric interference in oncogenic FLI1 and ERG transactions by mithramycins. Structure, 29, 2021
6VG8	Crystal structure of the DNA binding domains of human FLI1 and Runx2 in complex with 16-mer DNA CAGAGGATGTGGCTTC Descriptor: DNA (5'-D(P*CP*AP*GP*AP*GP*GP*AP*TP*GP*TP*GP*GP*CP*TP*TP*C)-3'), DNA (5'-D(P*GP*AP*AP*GP*CP*CP*AP*CP*AP*TP*CP*CP*TP*CP*TP*G)-3'), Friend leukemia integration 1 transcription factor, ... Authors: Hou, C, Tsodikov, O.V. Deposit date: 2020-01-07 Release date: 2020-11-25 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (4.31 Å) Cite: Allosteric interference in oncogenic FLI1 and ERG transactions by mithramycins. Structure, 29, 2021
3WTW	Crystal structure of the complex comprised of ETS1(K167A), RUNX1, CBFBETA, and the tcralpha gene enhancer DNA Descriptor: Core-binding factor subunit beta, DNA (5'-D(*AP*GP*AP*GP*GP*AP*TP*GP*TP*GP*GP*CP*TP*TP*C)-3'), DNA (5'-D(*GP*AP*AP*GP*CP*CP*AP*CP*AP*TP*CP*CP*TP*CP*T)-3'), ... Authors: Shiina, M, Hamada, K, Ogata, K. Deposit date: 2014-04-21 Release date: 2014-08-20 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.9 Å) Cite: A novel allosteric mechanism on protein-DNA interactions underlying the phosphorylation-dependent regulation of Ets1 target gene expressions. J.Mol.Biol., 427, 2015
3WTY	Crystal structure of the complex comprised of ETS1(G333P), RUNX1, CBFBETA, and the tcralpha gene enhancer DNA Descriptor: Core-binding factor subunit beta, DNA (5'-D(*AP*GP*AP*GP*GP*AP*TP*GP*TP*GP*GP*CP*TP*TP*C)-3'), DNA (5'-D(*GP*AP*AP*GP*CP*CP*AP*CP*AP*TP*CP*CP*TP*CP*T)-3'), ... Authors: Shiina, M, Hamada, K, Ogata, K. Deposit date: 2014-04-21 Release date: 2014-08-13 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.7 Å) Cite: A novel allosteric mechanism on protein-DNA interactions underlying the phosphorylation-dependent regulation of Ets1 target gene expressions. J.Mol.Biol., 427, 2015
3WTX	Crystal structure of the complex comprised of ETS1(Y329A), RUNX1, CBFBETA, and the tcralpha gene enhancer DNA Descriptor: Core-binding factor subunit beta, DNA (5'-D(*AP*GP*AP*GP*GP*AP*TP*GP*TP*GP*GP*CP*TP*TP*C)-3'), DNA (5'-D(*GP*AP*AP*GP*CP*CP*AP*CP*AP*TP*CP*CP*TP*CP*T)-3'), ... Authors: Shiina, M, Hamada, K, Ogata, K. Deposit date: 2014-04-21 Release date: 2014-08-13 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.8 Å) Cite: A novel allosteric mechanism on protein-DNA interactions underlying the phosphorylation-dependent regulation of Ets1 target gene expressions. J.Mol.Biol., 427, 2015
3WTV	Crystal structure of the complex comprised of ETS1(V170G), RUNX1, CBFBETA, and the tcralpha gene enhancer DNA Descriptor: Core-binding factor subunit beta, DNA (5'-D(*AP*GP*AP*GP*GP*AP*TP*GP*TP*GP*GP*CP*TP*TP*C)-3'), DNA (5'-D(*GP*AP*AP*GP*CP*CP*AP*CP*AP*TP*CP*CP*TP*CP*T)-3'), ... Authors: Shiina, M, Hamada, K, Ogata, K. Deposit date: 2014-04-21 Release date: 2014-08-20 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.7 Å) Cite: A novel allosteric mechanism on protein-DNA interactions underlying the phosphorylation-dependent regulation of Ets1 target gene expressions. J.Mol.Biol., 427, 2015
3WTT	Crystal structure of the complex comprised of phosphorylated ETS1, RUNX1, CBFBETA, and the tcralpha gene enhancer DNA Descriptor: 5'-D(*AP*GP*AP*GP*GP*AP*TP*GP*TP*GP*GP*CP*TP*TP*C)-3', 5'-D(*GP*AP*AP*GP*CP*CP*AP*CP*AP*TP*CP*CP*TP*CP*T)-3', Core-binding factor subunit beta, ... Authors: Shiina, M, Hamada, K, Ogata, K. Deposit date: 2014-04-21 Release date: 2014-08-13 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.35 Å) Cite: A novel allosteric mechanism on protein-DNA interactions underlying the phosphorylation-dependent regulation of Ets1 target gene expressions. J.Mol.Biol., 427, 2015
3WTS	Crystal structure of the complex comprised of ETS1, RUNX1, CBFBETA, and the tcralpha gene enhancer DNA Descriptor: 5'-D(*AP*GP*AP*GP*GP*AP*TP*GP*TP*GP*GP*CP*TP*TP*C)-3', 5'-D(*GP*AP*AP*GP*CP*CP*AP*CP*AP*TP*CP*CP*TP*CP*T)-3', Core-binding factor subunit beta, ... Authors: Shiina, M, Hamada, K, Ogata, K. Deposit date: 2014-04-21 Release date: 2014-08-13 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.35 Å) Cite: A novel allosteric mechanism on protein-DNA interactions underlying the phosphorylation-dependent regulation of Ets1 target gene expressions. J.Mol.Biol., 427, 2015
3WTU	Crystal structure of the complex comprised of ETS1 (V170A), RUNX1, CBFBETA, and the tcralpha gene enhancer DNA Descriptor: Core-binding factor subunit beta, DNA (5'-D(*AP*GP*AP*GP*GP*AP*TP*GP*TP*GP*GP*CP*TP*TP*C)-3'), DNA (5'-D(*GP*AP*AP*GP*CP*CP*AP*CP*AP*TP*CP*CP*TP*CP*T)-3'), ... Authors: Shiina, M, Hamada, K, Ogata, K. Deposit date: 2014-04-21 Release date: 2014-08-13 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.7 Å) Cite: A novel allosteric mechanism on protein-DNA interactions underlying the phosphorylation-dependent regulation of Ets1 target gene expressions. J.Mol.Biol., 427, 2015
3WU1	Crystal structure of the ETS1-RUNX1-DNA ternary complex Descriptor: DNA (5'-D(*CP*AP*GP*AP*GP*GP*AP*TP*GP*TP*GP*GP*CP*TP*TP*C)-3'), DNA (5'-D(*GP*GP*AP*AP*GP*CP*CP*AP*CP*AP*TP*CP*CP*TP*CP*T)-3'), Protein C-ets-1, ... Authors: Tahirov, T.H, Ogata, K. Deposit date: 2014-04-21 Release date: 2014-08-20 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.4 Å) Cite: A novel allosteric mechanism on protein-DNA interactions underlying the phosphorylation-dependent regulation of Ets1 target gene expressions. J.Mol.Biol., 427, 2015
4L18	Crystal structure of Runx1 and Ets1 bound to TCR alpha promoter (crystal form 3) Descriptor: 5'-D(*CP*AP*GP*AP*GP*GP*AP*TP*GP*TP*GP*GP*CP*TP*TP*C)-3', 5'-D(*GP*GP*AP*AP*GP*CP*CP*AP*CP*AP*TP*CP*CP*TP*CP*T)-3', GLYCEROL, ... Authors: Tahirov, T.H. Deposit date: 2013-06-02 Release date: 2014-03-26 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structural basis of Ets1 activation by Runx1. Leukemia, 28, 2014
4L0Y	Crystal structure of Runx1 and Ets1 bound to TCR alpha promoter (crystal form 1) Descriptor: 5'-D(*CP*AP*GP*AP*GP*GP*AP*TP*GP*TP*GP*GP*CP*TP*TP*C)-3', 5'-D(*GP*GP*AP*AP*GP*CP*CP*AP*CP*AP*TP*CP*CP*TP*CP*T)-3', Protein C-ets-1, ... Authors: Tahirov, T.H. Deposit date: 2013-06-01 Release date: 2014-03-26 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Structural basis of Ets1 activation by Runx1. Leukemia, 28, 2014
4L0Z	Crystal structure of Runx1 and Ets1 bound to TCR alpha promoter (crystal form 2) Descriptor: 5'-D(*CP*AP*GP*AP*GP*GP*AP*TP*GP*TP*GP*GP*CP*TP*TP*C)-3', 5'-D(*GP*GP*AP*AP*GP*CP*CP*AP*CP*AP*TP*CP*CP*TP*CP*T)-3', Protein C-ets-1, ... Authors: Tahirov, T.H. Deposit date: 2013-06-01 Release date: 2014-03-26 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Structural basis of Ets1 activation by Runx1. Leukemia, 28, 2014
2J6W	R164N mutant of the RUNX1 Runt domain Descriptor: CHLORIDE ION, RUNT-RELATED TRANSCRIPTION FACTOR 1 Authors: Grembecka, J, Zhe, L, Lukasik, S.M, Liu, Y, Bielnicka, I, Bushweller, J.H, Speck, N.A. Deposit date: 2006-10-04 Release date: 2007-10-09 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.6 Å) Cite: A Mutation in the S-Switch Region of the Runt Domain Alters the Dynamics of an Allosteric Network Responsible for Cbfbeta Regulation. J.Mol.Biol., 364, 2006
1LJM	DNA recognition is mediated by conformational transition and by DNA bending Descriptor: CHLORIDE ION, RUNX1 transcription factor Authors: Bartfeld, D, Shimon, L, Couture, G.C, Rabinovich, D, Frolow, F, Levanon, D, Groner, Y, Shakked, Z. Deposit date: 2002-04-22 Release date: 2002-11-06 Last modified: 2023-08-16 Method: X-RAY DIFFRACTION (2.5 Å) Cite: DNA Recognition by the RUNX1 Transcription Factor Is Mediated by an Allosteric Transition in the RUNT Domain and by DNA Bending. Structure, 10
1EAQ	The RUNX1 Runt domain at 1.25A resolution: A structural switch and specifically bound chloride ions modulate DNA binding Descriptor: CHLORIDE ION, RUNT-RELATED TRANSCRIPTION FACTOR 1 Authors: Backstrom, S, Wolf-Watz, M, Grundstrom, C, Hard, T, Grundstrom, T, Sauer, U.H. Deposit date: 2001-07-14 Release date: 2002-09-12 Method: X-RAY DIFFRACTION (1.25 Å) Cite: The Runx1 Runt Domain at 1.25 A Resolution: A Structural Switch and Specifically Bound Chloride Ions Modulate DNA Binding J.Mol.Biol., 322, 2002
1EAO	THE RUNX1 Runt domain at 1.4A resolution: a structural switch and specifically bound chloride ions modulate DNA binding Descriptor: BROMIDE ION, RUNT-RELATED TRANSCRIPTION FACTOR 1 Authors: Backstrom, S, Wolf-Watz, M, Grundstrom, C, Hard, T.H, Grundstrom, T, Sauer, U.H. Deposit date: 2001-07-14 Release date: 2002-09-12 Method: X-RAY DIFFRACTION (1.4 Å) Cite: The Runx1 Runt Domain at 1.25A Resolution: A Structural Switch and Specifically Bound Chloride Ions Modulate DNA Binding J.Mol.Biol., 322, 2002
1EAN	THE RUNX1 Runt domain at 1.70A resolution: A structural switch and specifically bound chloride ions modulate DNA binding Descriptor: CHLORIDE ION, RUNT-RELATED TRANSCRIPTION FACTOR 1 Authors: Backstrom, S, Wolf-Watz, M, Grundstrom, C, Hard, T, Grundstrom, T, Sauer, U.H. Deposit date: 2001-07-13 Release date: 2002-09-12 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (1.7 Å) Cite: The Runx1 Runt Domain at 1.25 A Resolution: A Structural Switch and Specifically Bound Chloride Ions Modulate DNA Binding J.Mol.Biol., 322, 2002
1H9D	Aml1/cbf-beta/dna complex Descriptor: CORE-BINDING FACTOR ALPHA SUBUNIT1, CORE-BINDING FACTOR CBF-BETA, DNA (5'-(*CP*AP*AP*CP*CP*GP*CP*AP*AP*C)-3'), ... Authors: Bravo, J, Warren, A.J. Deposit date: 2001-03-07 Release date: 2001-03-31 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.6 Å) Cite: The Leukemia-Associated Aml1 (Runx1)-Cbfbeta Complex Functions as a DNA-Induced Molecular Clamp Nat.Struct.Biol., 8, 2001
1HJB	CRYSTAL STRUCTURE OF RUNX-1/AML1/CBFALPHA RUNT DOMAIN AND C/EBPBETA BZIP HOMODIMER BOUND TO A DNA FRAGMENT FROM THE CSF-1R PROMOTER Descriptor: CCAAT/ENHANCER BINDING PROTEIN BETA, DNA (5'-(*CP*CP*GP*CP*AP*AP*CP*CP*AP*CP* AP*GP*AP*GP*TP*TP*TP*GP*GP*AP*AP*AP*TP*CP*TP*T)-3'), DNA (5'-(*GP*AP*AP*GP*AP*TP*TP*TP*CP*CP* AP*AP*AP*CP*TP*CP*TP*GP*TP*GP*GP*TP*TP*GP*CP*G)-3'), ... Authors: Tahirov, T.H, Ogata, K. Deposit date: 2001-01-11 Release date: 2001-03-09 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (3 Å) Cite: Structural Analyses of DNA Recognition by the Aml1/Runx-1 Runt Domain and its Allosteric Control by Cbfbeta Cell(Cambridge,Mass.), 104, 2001
1HJC	CRYSTAL STRUCTURE OF RUNX-1/AML1/CBFALPHA RUNT DOMAIN BOUND TO A DNA FRAGMENT FROM THE CSF-1R PROMOTER Descriptor: DNA (5'-(*GP*AP*AP*CP*TP*CP*TP*GP*TP*GP*GP* TP*TP*GP*CP*G)-3'), DNA (5'-(CP*CP*GP*CP*AP*AP*CP*CP*AP*CP*AP* GP*AP*GP*TP*T)-3'), RUNT-RELATED TRANSCRIPTION FACTOR 1 Authors: Tahirov, T.H, Ogata, K. Deposit date: 2001-01-11 Release date: 2001-03-09 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.65 Å) Cite: Structural Analyses of DNA Recognition by the Aml1/Runx-1 Runt Domain and its Allosteric Control by Cbfbeta Cell(Cambridge,Mass.), 104, 2001
1IO4	CRYSTAL STRUCTURE OF RUNX-1/AML1/CBFALPHA RUNT DOMAIN-CBFBETA CORE DOMAIN HETERODIMER AND C/EBPBETA BZIP HOMODIMER BOUND TO A DNA FRAGMENT FROM THE CSF-1R PROMOTER Descriptor: CAAT/ENHANCER BINDING PROTEIN BETA, CORE-BINDING FACTOR, BETA SUBUNIT, ... Authors: Tahirov, T.H, Ogata, K. Deposit date: 2001-01-10 Release date: 2001-03-12 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (3 Å) Cite: Structural analyses of DNA recognition by the AML1/Runx-1 Runt domain and its allosteric control by CBFbeta. Cell(Cambridge,Mass.), 104, 2001
1E50	AML1/CBFbeta complex Descriptor: CORE-BINDING FACTOR ALPHA SUBUNIT, CORE-BINDING FACTOR CBF-BETA Authors: Warren, A.J, Bravo, J, Williams, R.L, Rabbits, T.H. Deposit date: 2000-07-13 Release date: 2001-07-12 Last modified: 2018-01-24 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Structural Basis for the Heterodimeric Interaction between the Acute Leukaemia-Associated Transcription Factors Aml1 and Cbfbeta Embo J., 19, 2000

 

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