5JI5
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CRYSTAL STRUCTURE OF A HISTONE DEACETYLASE SUPERFAMILY PROTEIN FROM BURKHOLDERIA PHYMATUMPHYMATUM
Descriptor:BuphA.10154.a.B1
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2016-04-21
Release date:2016-05-04
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal Structure of a Histone Deacetylase superfamily protein from Burkholderia phymatumphymatum
to be published
5IKK
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STRUCTURE OF THE HISTONE DEACETYLASE CLR3
Descriptor:Histone deacetylase clr3 (E.C.3.5.1.98)
Authors:Brugger, C., Schalch, T.
Deposit date:2016-03-03
Release date:2016-04-20
Modification date:2016-05-04
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:SHREC Silences Heterochromatin via Distinct Remodeling and Deacetylation Modules.
Mol.Cell, 62, 2016
5ICN
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HDAC1:MTA1 IN COMPLEX WITH INOSITOL-6-PHOSPHATE AND A NOVEL PEPTIDE INHIBITOR BASED ON HISTONE H4
Descriptor:Metastasis-associated protein MTA1, Histone deacetylase 1 (E.C.3.5.1.98), GLY-ALA-ACL-ARG-HIS
Authors:Millard, C.J., Robertson, N.S., Watson, P.J., Jameson, A.G., Schwabe, J.W.R.
Deposit date:2016-02-23
Release date:2016-05-11
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Insights into the activation mechanism of class I HDAC complexes by inositol phosphates.
Nat Commun, 7, 2016
5DC8
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CRYSTAL STRUCTURE OF H142A-Y306F HDAC8 IN COMPLEX WITH A TETRAPEPTIDE SUBSTRATE
Descriptor:Histone deacetylase 8 (E.C.3.5.1.98), Fluor-de-Lys tetrapeptide assay substrate
Authors:Decroos, C., Lee, M.S., Christianson, D.W.
Deposit date:2015-08-23
Release date:2016-02-03
Modification date:2016-02-17
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:General Base-General Acid Catalysis in Human Histone Deacetylase 8.
Biochemistry, 55, 2016
5DC7
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CRYSTAL STRUCTURE OF D176A-Y306F HDAC8 IN COMPLEX WITH A TETRAPEPTIDE SUBSTRATE
Descriptor:Histone deacetylase 8 (E.C.3.5.1.98), Fluor-de-Lys tetrapeptide assay substrate
Authors:Decroos, C., Lee, M.S., Christianson, D.W.
Deposit date:2015-08-23
Release date:2016-02-03
Modification date:2016-02-17
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:General Base-General Acid Catalysis in Human Histone Deacetylase 8.
Biochemistry, 55, 2016
5DC6
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CRYSTAL STRUCTURE OF D176N-Y306F HDAC8 IN COMPLEX WITH A TETRAPEPTIDE SUBSTRATE
Descriptor:Histone deacetylase 8 (E.C.3.5.1.98), Fluor-de-Lys tetrapeptide assay substrate
Authors:Decroos, C., Lee, M.S., Christianson, D.W.
Deposit date:2015-08-23
Release date:2016-02-03
Modification date:2016-02-17
Method:X-RAY DIFFRACTION (1.553 Å)
Cite:General Base-General Acid Catalysis in Human Histone Deacetylase 8.
Biochemistry, 55, 2016
5DC5
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CRYSTAL STRUCTURE OF D176N HDAC8 IN COMPLEX WITH M344
Descriptor:Histone deacetylase 8 (E.C.3.5.1.98)
Authors:Decroos, C., Lee, M.S., Christianson, D.W.
Deposit date:2015-08-23
Release date:2016-02-03
Modification date:2016-02-17
Method:X-RAY DIFFRACTION (1.94 Å)
Cite:General Base-General Acid Catalysis in Human Histone Deacetylase 8.
Biochemistry, 55, 2016
5D1D
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CRYSTAL STRUCTURE OF P91L-Y306F HDAC8 IN COMPLEX WITH A TETRAPEPTIDE SUBSTRATE
Descriptor:Histone deacetylase 8 (E.C.3.5.1.98), HDAC8 Fluor de Lys tetrapeptide substrate
Authors:Decroos, C., Christianson, N.H., Gullett, L.E., Bowman, C.M., Christianson, K.E., Deardorff, M.A., Christianson, D.W.
Deposit date:2015-08-04
Release date:2015-10-21
Modification date:2015-11-11
Method:X-RAY DIFFRACTION (2.011 Å)
Cite:Biochemical and Structural Characterization of HDAC8 Mutants Associated with Cornelia de Lange Syndrome Spectrum Disorders.
Biochemistry, 54, 2015
5D1C
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CRYSTAL STRUCTURE OF D233G-Y306F HDAC8 IN COMPLEX WITH A TETRAPEPTIDE SUBSTRATE
Descriptor:Histone deacetylase 8 (E.C.3.5.1.98), HDAC8 Fluor de Lys tetrapeptide substrate
Authors:Decroos, C., Christianson, N.H., Gullett, L.E., Bowman, C.M., Christianson, K.E., Deardorff, M.A., Christianson, D.W.
Deposit date:2015-08-04
Release date:2015-10-21
Modification date:2015-11-11
Method:X-RAY DIFFRACTION (1.422 Å)
Cite:Biochemical and Structural Characterization of HDAC8 Mutants Associated with Cornelia de Lange Syndrome Spectrum Disorders.
Biochemistry, 54, 2015
5D1B
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CRYSTAL STRUCTURE OF G117E HDAC8 IN COMPLEX WITH TSA
Descriptor:Histone deacetylase 8 (E.C.3.5.1.98)
Authors:Decroos, C., Christianson, N.H., Gullett, L.E., Bowman, C.M., Christianson, K.E., Deardorff, M.A., Christianson, D.W.
Deposit date:2015-08-04
Release date:2015-10-21
Modification date:2015-11-11
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Biochemical and Structural Characterization of HDAC8 Mutants Associated with Cornelia de Lange Syndrome Spectrum Disorders.
Biochemistry, 54, 2015
5A2S
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POTENT, SELECTIVE AND CNS-PENETRANT TETRASUBSTITUTED CYCLOPROPANE CLASS IIA HISTONE DEACETYLASE (HDAC) INHIBITORS
Descriptor:HISTONE DEACETYLASE 4 (E.C.3.5.1.98)
Authors:Luckhurst, C.A., Breccia, P., Stott, A.J., Aziz, O., Birch, H., Burli, R.W., Hughes, S., Jarvis, R.E., Lamers, M., Leonard, P., Matthews, K.L., McAllister, G., Pollack, S., Saville-Stones, E., Wishart, G., Yates, D., Dominguez, C.
Deposit date:2015-05-22
Release date:2016-02-10
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Potent, Selective, and Cns-Penetrant Tetrasubstituted Cyclopropane Class Iia Histone Deacetylase (Hdac) Inhibitors.
Acs Med.Chem.Lett., 7, 2016
4RN2
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CRYSTAL STRUCTURE OF S39D HDAC8 IN COMPLEX WITH A LARGAZOLE ANALOGUE.
Descriptor:Histone deacetylase 8 (E.C.3.5.1.98)
Authors:Decroos, C., Christianson, D.W.
Deposit date:2014-10-22
Release date:2015-04-08
Modification date:2015-04-22
Method:X-RAY DIFFRACTION (2.39 Å)
Cite:Variable Active Site Loop Conformations Accommodate the Binding of Macrocyclic Largazole Analogues to HDAC8.
Biochemistry, 54, 2015
4RN1
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CRYSTAL STRUCTURE OF S39D HDAC8 IN COMPLEX WITH A LARGAZOLE ANALOGUE.
Descriptor:Histone deacetylase 8 (E.C.3.5.1.98)
Authors:Decroos, C., Christianson, D.W.
Deposit date:2014-10-22
Release date:2015-04-08
Modification date:2015-04-22
Method:X-RAY DIFFRACTION (2.18 Å)
Cite:Variable Active Site Loop Conformations Accommodate the Binding of Macrocyclic Largazole Analogues to HDAC8.
Biochemistry, 54, 2015
4RN0
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CRYSTAL STRUCTURE OF S39D HDAC8 IN COMPLEX WITH A LARGAZOLE ANALOGUE.
Descriptor:Histone deacetylase 8 (E.C.3.5.1.98)
Authors:Decroos, C., Christianson, D.W.
Deposit date:2014-10-22
Release date:2015-04-08
Modification date:2015-04-22
Method:X-RAY DIFFRACTION (1.761 Å)
Cite:Variable Active Site Loop Conformations Accommodate the Binding of Macrocyclic Largazole Analogues to HDAC8.
Biochemistry, 54, 2015
4QA7
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CRYSTAL STRUCTURE OF H334R/Y306F HDAC8 IN COMPLEX WITH A TETRAPEPTIDE SUBSTRATE
Descriptor:Histone deacetylase 8 (E.C.3.5.1.98), tetrapeptide substrate
Authors:Decroos, C., Bowman, C.B., Moser, J.-A.S., Christianson, K.E., Deardorff, M.A., Christianson, D.W.
Deposit date:2014-05-02
Release date:2014-08-06
Modification date:2014-10-01
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:Compromised Structure and Function of HDAC8 Mutants Identified in Cornelia de Lange Syndrome Spectrum Disorders.
Acs Chem.Biol., 9, 2014
4QA6
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CRYSTAL STRUCTURE OF I243N/Y306F HDAC8 IN COMPLEX WITH A TETRAPEPTIDE SUBSTRATE
Descriptor:Histone deacetylase 8 (E.C.3.5.1.98), tetrapeptide substrate
Authors:Decroos, C., Bowman, C.B., Moser, J.-A.S., Christianson, K.E., Deardorff, M.A., Christianson, D.W.
Deposit date:2014-05-02
Release date:2014-08-06
Modification date:2014-10-01
Method:X-RAY DIFFRACTION (2.053 Å)
Cite:Compromised Structure and Function of HDAC8 Mutants Identified in Cornelia de Lange Syndrome Spectrum Disorders.
Acs Chem.Biol., 9, 2014
4QA5
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CRYSTAL STRUCTURE OF A188T/Y306F HDAC8 IN COMPLEX WITH A TETRAPEPTIDE SUBSTRATE
Descriptor:Histone deacetylase 8 (E.C.3.5.1.98), tetrapeptide substrate
Authors:Decroos, C., Bowman, C.B., Moser, J.-A.S., Christianson, K.E., Deardorff, M.A., Christianson, D.W.
Deposit date:2014-05-02
Release date:2014-08-06
Modification date:2014-10-01
Method:X-RAY DIFFRACTION (1.76 Å)
Cite:Compromised Structure and Function of HDAC8 Mutants Identified in Cornelia de Lange Syndrome Spectrum Disorders.
Acs Chem.Biol., 9, 2014
4QA4
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CRYSTAL STRUCTURE OF H334R HDAC8 IN COMPLEX WITH M344
Descriptor:Histone deacetylase 8 (E.C.3.5.1.98)
Authors:Decroos, C., Bowman, C.B., Moser, J.-A.S., Christianson, K.E., Deardorff, M.A., Christianson, D.W.
Deposit date:2014-05-02
Release date:2014-08-06
Modification date:2014-10-01
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Compromised Structure and Function of HDAC8 Mutants Identified in Cornelia de Lange Syndrome Spectrum Disorders.
Acs Chem.Biol., 9, 2014
4QA3
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CRYSTAL STRUCTURE OF T311M HDAC8 IN COMPLEX WITH TRICHOSTATIN A (TSA)
Descriptor:Histone deacetylase 8 (E.C.3.5.1.98)
Authors:Decroos, C., Bowman, C.B., Moser, J.-A.S., Christianson, K.E., Deardorff, M.A., Christianson, D.W.
Deposit date:2014-05-02
Release date:2014-08-06
Modification date:2014-10-01
Method:X-RAY DIFFRACTION (2.876 Å)
Cite:Compromised Structure and Function of HDAC8 Mutants Identified in Cornelia de Lange Syndrome Spectrum Disorders.
Acs Chem.Biol., 9, 2014
4QA2
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CRYSTAL STRUCTURE OF I243N HDAC8 IN COMPLEX WITH SAHA
Descriptor:Histone deacetylase 8 (E.C.3.5.1.98)
Authors:Decroos, C., Bowman, C.B., Moser, J.-A.S., Christianson, K.E., Deardorff, M.A., Christianson, D.W.
Deposit date:2014-05-02
Release date:2014-08-06
Modification date:2014-10-01
Method:X-RAY DIFFRACTION (2.377 Å)
Cite:Compromised Structure and Function of HDAC8 Mutants Identified in Cornelia de Lange Syndrome Spectrum Disorders.
Acs Chem.Biol., 9, 2014
4QA1
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CRYSTAL STRUCTURE OF A188T HDAC8 IN COMPLEX WITH M344
Descriptor:Histone deacetylase 8 (E.C.3.5.1.98)
Authors:Decroos, C., Bowman, C.B., Moser, J.-A.S., Christianson, K.E., Deardorff, M.A., Christianson, D.W.
Deposit date:2014-05-02
Release date:2014-08-06
Modification date:2014-10-01
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:Compromised Structure and Function of HDAC8 Mutants Identified in Cornelia de Lange Syndrome Spectrum Disorders.
Acs Chem.Biol., 9, 2014
4QA0
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CRYSTAL STRUCTURE OF C153F HDAC8 IN COMPLEX WITH SAHA
Descriptor:Histone deacetylase 8 (E.C.3.5.1.98)
Authors:Decroos, C., Bowman, C.B., Moser, J.-A.S., Christianson, K.E., Deardorff, M.A., Christianson, D.W.
Deposit date:2014-05-02
Release date:2014-08-06
Modification date:2014-10-01
Method:X-RAY DIFFRACTION (2.242 Å)
Cite:Compromised Structure and Function of HDAC8 Mutants Identified in Cornelia de Lange Syndrome Spectrum Disorders.
Acs Chem.Biol., 9, 2014
4LY1
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STRUCTURE OF HUMAN HDAC2 IN COMPLEX WITH INHIBITOR 4-(ACETYLAMINO)-N-[2-AMINO-5-(THIOPHEN-2-YL)PHENYL]BENZAMIDE
Descriptor:Histone deacetylase 2 (E.C.3.5.1.98)
Authors:Fong, R., Lupardus, P.J.
Deposit date:2013-07-30
Release date:2013-08-21
Modification date:2013-10-02
Method:X-RAY DIFFRACTION (1.57 Å)
Cite:Histone Deacetylase (HDAC) Inhibitor Kinetic Rate Constants Correlate with Cellular Histone Acetylation but Not Transcription and Cell Viability.
J.Biol.Chem., 288, 2013
4LXZ
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STRUCTURE OF HUMAN HDAC2 IN COMPLEX WITH SAHA (VORINOSTAT)
Descriptor:Histone deacetylase 2 (E.C.3.5.1.98)
Authors:Fong, R., Lupardus, P.J.
Deposit date:2013-07-30
Release date:2013-08-21
Modification date:2013-10-02
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Histone Deacetylase (HDAC) Inhibitor Kinetic Rate Constants Correlate with Cellular Histone Acetylation but Not Transcription and Cell Viability.
J.Biol.Chem., 288, 2013
4CBY
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DESIGN, SYNTHESIS, AND BIOLOGICAL EVALUATION OF POTENT AND SELECTIVE CLASS IIA HDAC INHIBITORS AS A POTENTIAL THERAPY FOR HUNTINGTONS DISEASE
Descriptor:HISTONE DEACETYLASE 4 (E.C.3.5.1.98)
Authors:Burli, R.W., Luckhurst, C.A., Aziz, O., Matthews, K.L., Yates, D., Lyons, K.A., Beconi, M., McAllister, G., Breccia, P., Stott, A.J., Penrose, S.D., Wall, M., Lamers, M., Leonard, P., Mueller, I., Richardson, C.M., Jarvis, R., Stones, L., Hughes, S., Wishart, G., Haughan, A.F., OConnell, C., Mead, T., McNeil, H., Vann, J., Mangette, J., Maillard, M., Beaumont, V., Munoz-Sanjuan, I., Dominguez, C.
Deposit date:2013-10-17
Release date:2013-12-11
Modification date:2014-01-15
Method:X-RAY DIFFRACTION (2.72 Å)
Cite:Design, Synthesis, and Biological Evaluation of Potent and Selective Class Iia Histone Deacetylase (Hdac) Inhibitors as a Potential Therapy for Huntington'S Disease.
J.Med.Chem., 56, 2013
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