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1C3P
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1c3p
CRYSTAL STRUCTURE OF AN HDAC HOMOLOG FROM AQUIFEX AEOLICUS
Descriptor:PROTEIN (HDLP (HISTONE DEACETYLASE-LIKE PROTEIN))
Authors:Finnin, M.S., Donigian, J.R., Pavletich, N.P.
Deposit date:1999-07-28
Release date:1999-09-15
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structures of a histone deacetylase homologue bound to the TSA and SAHA inhibitors.
Nature, 401, 1999
1C3R
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1c3r
CRYSTAL STRUCTURE OF AN HDAC HOMOLOG COMPLEXED WITH TRICHOSTATIN A
Descriptor:HDLP (HISTONE DEACETYLASE-LIKE PROTEIN)
Authors:Finnin, M.S., Donigian, J.R., Pavletich, N.P.
Deposit date:1999-07-28
Release date:1999-09-15
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structures of a histone deacetylase homologue bound to the TSA and SAHA inhibitors.
Nature, 401, 1999
1C3S
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1c3s
CRYSTAL STRUCTURE OF AN HDAC HOMOLOG COMPLEXED WITH SAHA
Descriptor:HDLP (HISTONE DEACETYLASE-LIKE PROTEIN)
Authors:Finnin, M.S., Donigian, J.R., Pavletich, N.P.
Deposit date:1999-07-28
Release date:1999-09-15
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structures of a histone deacetylase homologue bound to the TSA and SAHA inhibitors.
Nature, 401, 1999
1T64
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1t64
CRYSTAL STRUCTURE OF HUMAN HDAC8 COMPLEXED WITH TRICHOSTATIN A
Descriptor:Histone deacetylase 8
Authors:Somoza, J.R., Skene, R.J., Katz, B.A., Mol, C., Ho, J.D., Jennings, A.J., Luong, C., Arvai, A., Buggy, J.J., Chi, E., Tang, J., Sang, B.-C., Verner, E., Wynands, R., Leahy, E.M., Dougan, D.R., Snell, G., Navre, M., Knuth, M.W., Swanson, R.V., McRee, D.E., Tari, L.W.
Deposit date:2004-05-05
Release date:2004-07-27
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural Snapshots of Human HDAC8 Provide Insights into the Class I Histone Deacetylases
Structure, 12, 2004
1T67
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1t67
CRYSTAL STRUCTURE OF HUMAN HDAC8 COMPLEXED WITH MS-344
Descriptor:Histone deacetylase 8
Authors:Somoza, J.R., Skene, R.J., Katz, B.A., Mol, C., Ho, J.D., Jennings, A.J., Luong, C., Arvai, A., Buggy, J.J., Chi, E., Tang, J., Sang, B.-C., Verner, E., Wynands, R., Leahy, E.M., Dougan, D.R., Snell, G., Navre, M., Knuth, M.W., Swanson, R.V., McRee, D.E., Tari, L.W.
Deposit date:2004-05-05
Release date:2004-07-27
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:Structural Snapshots of Human HDAC8 Provide Insights into the Class I Histone Deacetylases
Structure, 12, 2004
1T69
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1t69
CRYSTAL STRUCTURE OF HUMAN HDAC8 COMPLEXED WITH SAHA
Descriptor:Histone deacetylase 8
Authors:Somoza, J.R., Skene, R.J., Katz, B.A., Mol, C., Ho, J.D., Jennings, A.J., Luong, C., Arvai, A., Buggy, J.J., Chi, E., Tang, J., Sang, B.-C., Verner, E., Wynands, R., Leahy, E.M., Dougan, D.R., Snell, G., Navre, M., Knuth, M.W., Swanson, R.V., McRee, D.E., Tari, L.W.
Deposit date:2004-05-05
Release date:2004-07-27
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.91 Å)
Cite:Structural Snapshots of Human HDAC8 Provide Insights into the Class I Histone Deacetylases
Structure, 12, 2004
1VKG
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1vkg
CRYSTAL STRUCTURE OF HUMAN HDAC8 COMPLEXED WITH CRA-19156
Descriptor:Histone deacetylase 8
Authors:Somoza, J.R., Skene, R.J., Katz, B.A., Mol, C., Ho, J.D., Jennings, A.J., Luong, C., Arvai, A., Buggy, J.J., Chi, E., Tang, J., Sang, B.-C., Verner, E., Wynands, R., Leahy, E.M., Dougan, D.R., Snell, G., Navre, M., Knuth, M.W., Swanson, R.V., McRee, D.E., Tari, L.W.
Deposit date:2004-05-13
Release date:2004-07-27
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural Snapshots of Human HDAC8 Provide Insights into the Class I Histone Deacetylases
Structure, 12, 2004
1W22
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1w22
CRYSTAL STRUCTURE OF INHIBITED HUMAN HDAC8
Descriptor:HISTONE DEACETYLASE 8
Authors:Vannini, A., Volpari, C., Caroli Casavola, E., Di Marco, S.
Deposit date:2004-06-25
Release date:2004-09-24
Modification date:2013-01-30
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal Structure of a Eukaryotic Zn-Dependent Histone Deacetylase,Human Hdac8,Complexed with a Hydroxamic Acid Inhibitor
Proc.Natl.Acad.Sci.USA, 101, 2004
1ZZ0
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1zz0
CRYSTAL STRUCTURE OF A HDAC-LIKE PROTEIN WITH ACETATE BOUND
Descriptor:Histone deacetylase-like amidohydrolase (E.C.3.5.1.-)
Authors:Nielsen, T.K., Hildmann, C., Dickmanns, A., Schwienhorst, A., Ficner, R.
Deposit date:2005-06-13
Release date:2005-11-29
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystal structure of a bacterial class 2 histone deacetylase homologue
J.Mol.Biol., 354, 2005
1ZZ1
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1zz1
CRYSTAL STRUCTURE OF A HDAC-LIKE PROTEIN WITH SAHA BOUND
Descriptor:Histone deacetylase-like amidohydrolase (E.C.3.5.1.-)
Authors:Nielsen, T.K., Hildmann, C., Dickmanns, A., Schwienhorst, A., Ficner, R.
Deposit date:2005-06-13
Release date:2005-11-29
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (1.57 Å)
Cite:Crystal structure of a bacterial class 2 histone deacetylase homologue
J.Mol.Biol., 354, 2005
1ZZ3
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1zz3
CRYSTAL STRUCTURE OF A HDAC-LIKE PROTEIN WITH CYPX BOUND
Descriptor:Histone deacetylase-like amidohydrolase (E.C.3.5.1.-)
Authors:Nielsen, T.K., Hildmann, C., Dickmanns, A., Schwienhorst, A., Ficner, R.
Deposit date:2005-06-13
Release date:2005-11-29
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (1.76 Å)
Cite:Crystal structure of a bacterial class 2 histone deacetylase homologue
J.Mol.Biol., 354, 2005
2GH6
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2gh6
CRYSTAL STRUCTURE OF A HDAC-LIKE PROTEIN WITH 9,9,9-TRIFLUORO-8-OXO-N-PHENYLNONAN AMIDE BOUND
Descriptor:Histone deacetylase-like amidohydrolase (E.C.3.5.1.-)
Authors:Nielsen, T.K., Hildmann, C., Riester, D., Wegener, D., Schwienhorst, A., Ficner, R.
Deposit date:2006-03-26
Release date:2007-03-20
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.203 Å)
Cite:Complex structure of a bacterial class 2 histone deacetylase homologue with a trifluoromethylketone inhibitor.
Acta Crystallogr.,Sect.F, 63, 2007
2V5W
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2v5w
CRYSTAL STRUCTURE OF HDAC8-SUBSTRATE COMPLEX
Descriptor:HISTONE DEACETYLASE 8, GLYCYL-GLYCYL-GLYCINE, PEPTIDIC SUBSTRATE
Authors:Di Marco, S., Vannini, A., Volpari, C., Gallinari, P., Jones, P., Mattu, M., Carfi, A., Defrancesco, R., Steinkuhler, C.
Deposit date:2007-07-10
Release date:2007-09-04
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Substrate Binding to Histone Deacetylases as Revealed by Crystal Structure of Hdac8-Substrate Complex
Embo Rep., 8, 2007
2V5X
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2v5x
CRYSTAL STRUCTURE OF HDAC8-INHIBITOR COMPLEX
Descriptor:HISTONE DEACETYLASE 8
Authors:Di Marco, S., Vannini, A., Volpari, C., Gallinari, P., Jones, P., Mattu, M., Carfi, A., Defrancesco, R., Steinkuhler, C.
Deposit date:2007-07-10
Release date:2007-09-04
Modification date:2012-09-12
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Substrate Binding to Histone Deacetylases as Revealed by Crystal Structure of Hdac8-Substrate Complex
Embo Rep., 8, 2007
2VCG
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2vcg
CRYSTAL STRUCTURE OF A HDAC-LIKE PROTEIN HDAH FROM BORDETELLA SP. WITH THE BOUND INHIBITOR ST-17
Descriptor:HISTONE DEACETYLASE-LIKE AMIDOHYDROLASE (E.C.3.5.1.-)
Authors:Dickmanns, A., Strasser, A., Ficner, R.
Deposit date:2007-09-24
Release date:2008-01-08
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Phenylalanine-Containing Hydroxamic Acids as Selective Inhibitors of Class Iib Histone Deacetylases (Hdacs).
Bioorg.Med.Chem., 16, 2008
3C0Y
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3c0y
CRYSTAL STRUCTURE OF CATALYTIC DOMAIN OF HUMAN HISTONE DEACETYLASE HDAC7
Descriptor:Histone deacetylase 7a
Authors:Min, J.R., Schuetz, A., Allali-Hassani, A., Loppnau, P., Kwiatkowski, N.P., Mazitschek, R., Weigelt, J., Sundstrom, M., Arrowsmith, C.H., Edwards, A.M., Vedadi, M., Bochkarev, A., Plotnikov, A.N., Structural Genomics Consortium (SGC)
Deposit date:2008-01-21
Release date:2008-02-19
Modification date:2009-10-27
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Human HDAC7 harbors a class IIa histone deacetylase-specific zinc binding motif and cryptic deacetylase activity.
J.Biol.Chem., 283, 2008
3C0Z
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3c0z
CRYSTAL STRUCTURE OF CATALYTIC DOMAIN OF HUMAN HISTONE DEACETYLASE HDAC7 IN COMPLEX WITH SAHA
Descriptor:Histone deacetylase 7a
Authors:Min, J., Schuetz, A., Loppnau, P., Weigelt, J., Sundstrom, M., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Plotnikov, A.N., Structural Genomics Consortium (SGC)
Deposit date:2008-01-21
Release date:2008-02-19
Modification date:2009-10-27
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Human HDAC7 harbors a class IIa histone deacetylase-specific zinc binding motif and cryptic deacetylase activity.
J.Biol.Chem., 283, 2008
3C10
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3c10
CRYSTAL STRUCTURE OF CATALYTIC DOMAIN OF HUMAN HISTONE DEACETYLASE HDAC7 IN COMPLEX WITH TRICHOSTATIN A (TSA)
Descriptor:Histone deacetylase 7a
Authors:Min, J., Schuetz, A., Loppnau, P., Weigelt, J., Sundstrom, M., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Plotnikov, A.N., Structural Genomics Consortium (SGC)
Deposit date:2008-01-21
Release date:2008-02-19
Modification date:2009-10-27
Method:X-RAY DIFFRACTION (2 Å)
Cite:Human HDAC7 harbors a class IIa histone deacetylase-specific zinc binding motif and cryptic deacetylase activity.
J.Biol.Chem., 283, 2008
3EW8
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3ew8
CRYSTAL STRUCTURE ANALYSIS OF HUMAN HDAC8 D101L VARIANT
Descriptor:Histone deacetylase 8 (E.C.3.5.1.98)
Authors:Dowling, D.P., Gantt, S.L., Gattis, S.G., Fierke, C.A., Christianson, D.W.
Deposit date:2008-10-14
Release date:2008-12-30
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural studies of human histone deacetylase 8 and its site-specific variants complexed with substrate and inhibitors.
Biochemistry, 47, 2008
3EWF
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3ewf
CRYSTAL STRUCTURE ANALYSIS OF HUMAN HDAC8 H143A VARIANT COMPLEXED WITH SUBSTRATE.
Descriptor:Histone deacetylase 8 (E.C.3.5.1.98)
Authors:Dowling, D.P., Gantt, S.L., Gattis, S.G., Fierke, C.A., Christianon, D.W.
Deposit date:2008-10-14
Release date:2008-12-30
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural studies of human histone deacetylase 8 and its site-specific variants complexed with substrate and inhibitors.
Biochemistry, 47, 2008
3EZP
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3ezp
CRYSTAL STRUCTURE ANALYSIS OF HUMAN HDAC8 D101N VARIANT
Descriptor:Histone deacetylase 8 (E.C.3.5.1.98)
Authors:Dowling, D.P., Gantt, S.L., Gattis, S.G., Fierke, C.A., Christianon, D.W.
Deposit date:2008-10-23
Release date:2008-12-30
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Structural studies of human histone deacetylase 8 and its site-specific variants complexed with substrate and inhibitors.
Biochemistry, 47, 2008
3EZT
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3ezt
CRYSTAL STRUCTURE ANALYSIS OF HUMAN HDAC8 D101E VARIANT
Descriptor:Histone deacetylase 8 (E.C.3.5.1.98)
Authors:Dowling, D.P., Gantt, S.L., Gattis, S.G., Fierke, C.A., Christianon, D.W.
Deposit date:2008-10-23
Release date:2008-12-30
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Structural studies of human histone deacetylase 8 and its site-specific variants complexed with substrate and inhibitors.
Biochemistry, 47, 2008
3F06
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3f06
CRYSTAL STRUCTURE ANALYSIS OF HUMAN HDAC8 D101A VARIANT.
Descriptor:Histone deacetylase 8 (E.C.3.5.1.98)
Authors:Dowling, D.P., Gantt, S.L., Gattis, S.G., Fierke, C.A., Christianson, D.W.
Deposit date:2008-10-24
Release date:2008-12-30
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Structural studies of human histone deacetylase 8 and its site-specific variants complexed with substrate and inhibitors.
Biochemistry, 47, 2008
3F07
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3f07
CRYSTAL STRUCTURE ANALYSIS OF HUMAN HDAC8 COMPLEXED WITH APHA IN A NEW MONOCLINIC CRYSTAL FORM
Descriptor:Histone deacetylase 8 (E.C.3.5.1.98)
Authors:Dowling, D.P., Gantt, S.L., Gattis, S.G., Fierke, C.A., Christianson, D.W.
Deposit date:2008-10-24
Release date:2008-12-30
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Structural studies of human histone deacetylase 8 and its site-specific variants complexed with substrate and inhibitors.
Biochemistry, 47, 2008
3F0R
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3f0r
CRYSTAL STRUCTURE ANALYSIS OF HUMAN HDAC8 COMPLEXED WITH TRICHOSTATIN A IN A NEW MONOCLINIC CRYSTAL FORM
Descriptor:Histone deacetylase 8 (E.C.3.5.1.98)
Authors:Dowling, D.P., Gantt, S.L., Gattis, S.G., Fierke, C.A., Christianson, D.W.
Deposit date:2008-10-25
Release date:2008-12-30
Method:X-RAY DIFFRACTION (2.54 Å)
Cite:Structural studies of human histone deacetylase 8 and its site-specific variants complexed with substrate and inhibitors.
Biochemistry, 47, 2008
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105097
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