1C3P
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CRYSTAL STRUCTURE OF AN HDAC HOMOLOG FROM AQUIFEX AEOLICUS
Descriptor:PROTEIN (HDLP (HISTONE DEACETYLASE-LIKE PROTEIN))
Authors:Finnin, M.S., Donigian, J.R., Pavletich, N.P.
Deposit date:1999-07-28
Release date:1999-09-15
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structures of a histone deacetylase homologue bound to the TSA and SAHA inhibitors.
Nature, 401, 1999
1C3R
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CRYSTAL STRUCTURE OF AN HDAC HOMOLOG COMPLEXED WITH TRICHOSTATIN A
Descriptor:HDLP (HISTONE DEACETYLASE-LIKE PROTEIN)
Authors:Finnin, M.S., Donigian, J.R., Pavletich, N.P.
Deposit date:1999-07-28
Release date:1999-09-15
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structures of a histone deacetylase homologue bound to the TSA and SAHA inhibitors.
Nature, 401, 1999
1C3S
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CRYSTAL STRUCTURE OF AN HDAC HOMOLOG COMPLEXED WITH SAHA
Descriptor:HDLP (HISTONE DEACETYLASE-LIKE PROTEIN)
Authors:Finnin, M.S., Donigian, J.R., Pavletich, N.P.
Deposit date:1999-07-28
Release date:1999-09-15
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structures of a histone deacetylase homologue bound to the TSA and SAHA inhibitors.
Nature, 401, 1999
1T64
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CRYSTAL STRUCTURE OF HUMAN HDAC8 COMPLEXED WITH TRICHOSTATIN A
Descriptor:Histone deacetylase 8
Authors:Somoza, J.R., Skene, R.J., Katz, B.A., Mol, C., Ho, J.D., Jennings, A.J., Luong, C., Arvai, A., Buggy, J.J., Chi, E., Tang, J., Sang, B.-C., Verner, E., Wynands, R., Leahy, E.M., Dougan, D.R., Snell, G., Navre, M., Knuth, M.W., Swanson, R.V., McRee, D.E., Tari, L.W.
Deposit date:2004-05-05
Release date:2004-07-27
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural Snapshots of Human HDAC8 Provide Insights into the Class I Histone Deacetylases
Structure, 12, 2004
1T67
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CRYSTAL STRUCTURE OF HUMAN HDAC8 COMPLEXED WITH MS-344
Descriptor:Histone deacetylase 8
Authors:Somoza, J.R., Skene, R.J., Katz, B.A., Mol, C., Ho, J.D., Jennings, A.J., Luong, C., Arvai, A., Buggy, J.J., Chi, E., Tang, J., Sang, B.-C., Verner, E., Wynands, R., Leahy, E.M., Dougan, D.R., Snell, G., Navre, M., Knuth, M.W., Swanson, R.V., McRee, D.E., Tari, L.W.
Deposit date:2004-05-05
Release date:2004-07-27
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:Structural Snapshots of Human HDAC8 Provide Insights into the Class I Histone Deacetylases
Structure, 12, 2004
1T69
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CRYSTAL STRUCTURE OF HUMAN HDAC8 COMPLEXED WITH SAHA
Descriptor:Histone deacetylase 8
Authors:Somoza, J.R., Skene, R.J., Katz, B.A., Mol, C., Ho, J.D., Jennings, A.J., Luong, C., Arvai, A., Buggy, J.J., Chi, E., Tang, J., Sang, B.-C., Verner, E., Wynands, R., Leahy, E.M., Dougan, D.R., Snell, G., Navre, M., Knuth, M.W., Swanson, R.V., McRee, D.E., Tari, L.W.
Deposit date:2004-05-05
Release date:2004-07-27
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.91 Å)
Cite:Structural Snapshots of Human HDAC8 Provide Insights into the Class I Histone Deacetylases
Structure, 12, 2004
1VKG
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CRYSTAL STRUCTURE OF HUMAN HDAC8 COMPLEXED WITH CRA-19156
Descriptor:Histone deacetylase 8
Authors:Somoza, J.R., Skene, R.J., Katz, B.A., Mol, C., Ho, J.D., Jennings, A.J., Luong, C., Arvai, A., Buggy, J.J., Chi, E., Tang, J., Sang, B.-C., Verner, E., Wynands, R., Leahy, E.M., Dougan, D.R., Snell, G., Navre, M., Knuth, M.W., Swanson, R.V., McRee, D.E., Tari, L.W.
Deposit date:2004-05-13
Release date:2004-07-27
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural Snapshots of Human HDAC8 Provide Insights into the Class I Histone Deacetylases
Structure, 12, 2004
1W22
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CRYSTAL STRUCTURE OF INHIBITED HUMAN HDAC8
Descriptor:HISTONE DEACETYLASE 8
Authors:Vannini, A., Volpari, C., Caroli Casavola, E., Di Marco, S.
Deposit date:2004-06-25
Release date:2004-09-24
Modification date:2013-01-30
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal Structure of a Eukaryotic Zn-Dependent Histone Deacetylase,Human Hdac8,Complexed with a Hydroxamic Acid Inhibitor
Proc.Natl.Acad.Sci.USA, 101, 2004
2V5W
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CRYSTAL STRUCTURE OF HDAC8-SUBSTRATE COMPLEX
Descriptor:HISTONE DEACETYLASE 8, GLYCYL-GLYCYL-GLYCINE, PEPTIDIC SUBSTRATE
Authors:Di Marco, S., Vannini, A., Volpari, C., Gallinari, P., Jones, P., Mattu, M., Carfi, A., Defrancesco, R., Steinkuhler, C.
Deposit date:2007-07-10
Release date:2007-09-04
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Substrate Binding to Histone Deacetylases as Revealed by Crystal Structure of Hdac8-Substrate Complex
Embo Rep., 8, 2007
2V5X
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CRYSTAL STRUCTURE OF HDAC8-INHIBITOR COMPLEX
Descriptor:HISTONE DEACETYLASE 8
Authors:Di Marco, S., Vannini, A., Volpari, C., Gallinari, P., Jones, P., Mattu, M., Carfi, A., Defrancesco, R., Steinkuhler, C.
Deposit date:2007-07-10
Release date:2007-09-04
Modification date:2012-09-12
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Substrate Binding to Histone Deacetylases as Revealed by Crystal Structure of Hdac8-Substrate Complex
Embo Rep., 8, 2007
2VQJ
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STRUCTURE OF HDAC4 CATALYTIC DOMAIN BOUND TO A TRIFLUOROMETHYLKETONE INHBITOR
Descriptor:HISTONE DEACETYLASE 4
Authors:Bottomley, M.J., Lo Surdo, P., Di Giovine, P., Cirillo, A., Scarpelli, R., Ferrigno, F., Jones, P., Neddermann, P., De Francesco, R., Steinkuhler, C., Gallinari, P., Carfi, A.
Deposit date:2008-03-17
Release date:2008-07-08
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural and Functional Analysis of the Human Hdac4 Catalytic Domain Reveals a Regulatory Zinc-Binding Domain.
J.Biol.Chem., 283, 2008
2VQM
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STRUCTURE OF HDAC4 CATALYTIC DOMAIN BOUND TO A HYDROXAMIC ACID INHBITOR
Descriptor:HISTONE DEACETYLASE 4
Authors:Bottomley, M.J., Lo Surdo, P., Di Giovine, P., Cirillo, A., Scarpelli, R., Ferrigno, F., Jones, P., Neddermann, P., De Francesco, R., Steinkuhler, C., Gallinari, P., Carfi, A.
Deposit date:2008-03-17
Release date:2008-07-08
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural and Functional Analysis of the Human Hdac4 Catalytic Domain Reveals a Regulatory Zinc-Binding Domain.
J.Biol.Chem., 283, 2008
2VQO
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STRUCTURE OF HDAC4 CATALYTIC DOMAIN WITH A GAIN-OF-FUNCTION MUATION BOUND TO A TRIFLUOROMETHYLKETONE INHBITOR
Descriptor:HISTONE DEACETYLASE 4
Authors:Bottomley, M.J., Lo Surdo, P., Di Giovine, P., Cirillo, A., Scarpelli, R., Ferrigno, F., Jones, P., Neddermann, P., De Francesco, R., Steinkuhler, C., Gallinari, P., Carfi, A.
Deposit date:2008-03-18
Release date:2008-07-08
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structural and Functional Analysis of the Human Hdac4 Catalytic Domain Reveals a Regulatory Zinc-Binding Domain.
J.Biol.Chem., 283, 2008
2VQQ
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STRUCTURE OF HDAC4 CATALYTIC DOMAIN (A DOUBLE CYSTEINE-TO-ALANINE MUTANT) BOUND TO A TRIFLUOROMETHYLKETONE INHBITOR
Descriptor:HISTONE DEACETYLASE 4
Authors:Bottomley, M.J., Lo Surdo, P., Di Giovine, P., Cirillo, A., Scarpelli, R., Ferrigno, F., Jones, P., Neddermann, P., De Francesco, R., Steinkuhler, C., Gallinari, P., Carfi, A.
Deposit date:2008-03-18
Release date:2008-07-08
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural and Functional Analysis of the Human Hdac4 Catalytic Domain Reveals a Regulatory Zinc-Binding Domain.
J.Biol.Chem., 283, 2008
2VQV
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STRUCTURE OF HDAC4 CATALYTIC DOMAIN WITH A GAIN-OF-FUNCTION MUTATION BOUND TO A HYDROXAMIC ACID INHIBITOR
Descriptor:HISTONE DEACETYLASE 4
Authors:Bottomley, M.J., Lo Surdo, P., Di Giovine, P., Cirillo, A., Scarpelli, R., Ferrigno, F., Jones, P., Neddermann, P., De Francesco, R., Steinkuhler, C., Gallinari, P., Carfi, A.
Deposit date:2008-03-19
Release date:2008-07-22
Modification date:2009-11-10
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Structural and Functional Analysis of the Human Hdac4 Catalytic Domain Reveals a Regulatory Structural Zinc-Binding Domain.
J.Biol.Chem., 283, 2008
2VQW
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STRUCTURE OF INHIBITOR-FREE HDAC4 CATALYTIC DOMAIN (WITH GAIN-OF-FUNCTION MUTATION HIS332TYR)
Descriptor:HISTONE DEACETYLASE 4 (E.C.3.5.1.98)
Authors:Bottomley, M.J., Lo Surdo, P., Di Giovine, P., Cirillo, A., Scarpelli, R., Ferrigno, F., Jones, P., Neddermann, P., De Francesco, R., Steinkuhler, C., Gallinari, P., Carfi, A.
Deposit date:2008-03-19
Release date:2008-08-05
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural and Functional Analysis of the Human Hdac4 Catalytic Domain Reveals a Regulatory Structural Zinc-Binding Domain.
J.Biol.Chem., 283, 2008
3C0Y
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CRYSTAL STRUCTURE OF CATALYTIC DOMAIN OF HUMAN HISTONE DEACETYLASE HDAC7
Descriptor:Histone deacetylase 7a
Authors:Min, J.R., Schuetz, A., Allali-Hassani, A., Loppnau, P., Kwiatkowski, N.P., Mazitschek, R., Weigelt, J., Sundstrom, M., Arrowsmith, C.H., Edwards, A.M., Vedadi, M., Bochkarev, A., Plotnikov, A.N., Structural Genomics Consortium (SGC)
Deposit date:2008-01-21
Release date:2008-02-19
Modification date:2009-10-27
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Human HDAC7 harbors a class IIa histone deacetylase-specific zinc binding motif and cryptic deacetylase activity.
J.Biol.Chem., 283, 2008
3C0Z
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CRYSTAL STRUCTURE OF CATALYTIC DOMAIN OF HUMAN HISTONE DEACETYLASE HDAC7 IN COMPLEX WITH SAHA
Descriptor:Histone deacetylase 7a
Authors:Min, J., Schuetz, A., Loppnau, P., Weigelt, J., Sundstrom, M., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Plotnikov, A.N., Structural Genomics Consortium (SGC)
Deposit date:2008-01-21
Release date:2008-02-19
Modification date:2009-10-27
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Human HDAC7 harbors a class IIa histone deacetylase-specific zinc binding motif and cryptic deacetylase activity.
J.Biol.Chem., 283, 2008
3C10
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CRYSTAL STRUCTURE OF CATALYTIC DOMAIN OF HUMAN HISTONE DEACETYLASE HDAC7 IN COMPLEX WITH TRICHOSTATIN A (TSA)
Descriptor:Histone deacetylase 7a
Authors:Min, J., Schuetz, A., Loppnau, P., Weigelt, J., Sundstrom, M., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Plotnikov, A.N., Structural Genomics Consortium (SGC)
Deposit date:2008-01-21
Release date:2008-02-19
Modification date:2009-10-27
Method:X-RAY DIFFRACTION (2 Å)
Cite:Human HDAC7 harbors a class IIa histone deacetylase-specific zinc binding motif and cryptic deacetylase activity.
J.Biol.Chem., 283, 2008
3EW8
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CRYSTAL STRUCTURE ANALYSIS OF HUMAN HDAC8 D101L VARIANT
Descriptor:Histone deacetylase 8 (E.C.3.5.1.98)
Authors:Dowling, D.P., Gantt, S.L., Gattis, S.G., Fierke, C.A., Christianson, D.W.
Deposit date:2008-10-14
Release date:2008-12-30
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural studies of human histone deacetylase 8 and its site-specific variants complexed with substrate and inhibitors.
Biochemistry, 47, 2008
3EWF
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CRYSTAL STRUCTURE ANALYSIS OF HUMAN HDAC8 H143A VARIANT COMPLEXED WITH SUBSTRATE.
Descriptor:Histone deacetylase 8 (E.C.3.5.1.98)
Authors:Dowling, D.P., Gantt, S.L., Gattis, S.G., Fierke, C.A., Christianon, D.W.
Deposit date:2008-10-14
Release date:2008-12-30
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural studies of human histone deacetylase 8 and its site-specific variants complexed with substrate and inhibitors.
Biochemistry, 47, 2008
3EZP
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CRYSTAL STRUCTURE ANALYSIS OF HUMAN HDAC8 D101N VARIANT
Descriptor:Histone deacetylase 8 (E.C.3.5.1.98)
Authors:Dowling, D.P., Gantt, S.L., Gattis, S.G., Fierke, C.A., Christianon, D.W.
Deposit date:2008-10-23
Release date:2008-12-30
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Structural studies of human histone deacetylase 8 and its site-specific variants complexed with substrate and inhibitors.
Biochemistry, 47, 2008
3EZT
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CRYSTAL STRUCTURE ANALYSIS OF HUMAN HDAC8 D101E VARIANT
Descriptor:Histone deacetylase 8 (E.C.3.5.1.98)
Authors:Dowling, D.P., Gantt, S.L., Gattis, S.G., Fierke, C.A., Christianon, D.W.
Deposit date:2008-10-23
Release date:2008-12-30
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Structural studies of human histone deacetylase 8 and its site-specific variants complexed with substrate and inhibitors.
Biochemistry, 47, 2008
3F06
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CRYSTAL STRUCTURE ANALYSIS OF HUMAN HDAC8 D101A VARIANT.
Descriptor:Histone deacetylase 8 (E.C.3.5.1.98)
Authors:Dowling, D.P., Gantt, S.L., Gattis, S.G., Fierke, C.A., Christianson, D.W.
Deposit date:2008-10-24
Release date:2008-12-30
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Structural studies of human histone deacetylase 8 and its site-specific variants complexed with substrate and inhibitors.
Biochemistry, 47, 2008
3F07
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CRYSTAL STRUCTURE ANALYSIS OF HUMAN HDAC8 COMPLEXED WITH APHA IN A NEW MONOCLINIC CRYSTAL FORM
Descriptor:Histone deacetylase 8 (E.C.3.5.1.98)
Authors:Dowling, D.P., Gantt, S.L., Gattis, S.G., Fierke, C.A., Christianson, D.W.
Deposit date:2008-10-24
Release date:2008-12-30
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Structural studies of human histone deacetylase 8 and its site-specific variants complexed with substrate and inhibitors.
Biochemistry, 47, 2008
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