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4CQF
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4cqf
CRYSTAL STRUCTURE OF SCHISTOSOMA MANSONI HDAC8 COMPLEXED WITH A MERCAPTOACETAMIDE INHIBITOR
Descriptor:HISTONE DEACETYLASE 8
Authors:Marek, M., Romier, C.
Deposit date:2014-02-14
Release date:2014-04-02
Modification date:2014-10-08
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Molecular Basis for the Anti-Parasitic Activity of a Mercaptoacetamide Derivative that Inhibits Histone Deacetylase 8 (Hdac8) from the Human Pathogen Schistosoma Mansoni
J.Mol.Biol., 426, 2014
4CBT
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4cbt
DESIGN, SYNTHESIS, AND BIOLOGICAL EVALUATION OF POTENT AND SELECTIVE CLASS IIA HDAC INHIBITORS AS A POTENTIAL THERAPY FOR HUNTINGTONS DISEASE
Descriptor:HISTONE DEACETYLASE 4 (E.C.3.5.1.98)
Authors:Burli, R.W., Luckhurst, C.A., Aziz, O., Matthews, K.L., Yates, D., Lyons, K.A., Beconi, M., McAllister, G., Breccia, P., Stott, A.J., Penrose, S.D., Wall, M., Lamers, M., Leonard, P., Mueller, I., Richardson, C.M., Jarvis, R., Stones, L., Hughes, S., Wishart, G., Haughan, A.F., OConnell, C., Mead, T., McNeil, H., Vann, J., Mangette, J., Maillard, M., Beaumont, V., Munoz-Sanjuan, I., Dominguez, C.
Deposit date:2013-10-16
Release date:2013-12-11
Modification date:2014-01-15
Method:X-RAY DIFFRACTION (3.03 Å)
Cite:Design, Synthesis, and Biological Evaluation of Potent and Selective Class Iia Histone Deacetylase (Hdac) Inhibitors as a Potential Therapy for Huntington'S Disease.
J.Med.Chem., 56, 2013
4CBY
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4cby
DESIGN, SYNTHESIS, AND BIOLOGICAL EVALUATION OF POTENT AND SELECTIVE CLASS IIA HDAC INHIBITORS AS A POTENTIAL THERAPY FOR HUNTINGTONS DISEASE
Descriptor:HISTONE DEACETYLASE 4 (E.C.3.5.1.98)
Authors:Burli, R.W., Luckhurst, C.A., Aziz, O., Matthews, K.L., Yates, D., Lyons, K.A., Beconi, M., McAllister, G., Breccia, P., Stott, A.J., Penrose, S.D., Wall, M., Lamers, M., Leonard, P., Mueller, I., Richardson, C.M., Jarvis, R., Stones, L., Hughes, S., Wishart, G., Haughan, A.F., OConnell, C., Mead, T., McNeil, H., Vann, J., Mangette, J., Maillard, M., Beaumont, V., Munoz-Sanjuan, I., Dominguez, C.
Deposit date:2013-10-17
Release date:2013-12-11
Modification date:2014-01-15
Method:X-RAY DIFFRACTION (2.72 Å)
Cite:Design, Synthesis, and Biological Evaluation of Potent and Selective Class Iia Histone Deacetylase (Hdac) Inhibitors as a Potential Therapy for Huntington'S Disease.
J.Med.Chem., 56, 2013
4LXZ
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4lxz
STRUCTURE OF HUMAN HDAC2 IN COMPLEX WITH SAHA (VORINOSTAT)
Descriptor:Histone deacetylase 2 (E.C.3.5.1.98)
Authors:Fong, R., Lupardus, P.J.
Deposit date:2013-07-30
Release date:2013-08-21
Modification date:2013-10-02
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Histone Deacetylase (HDAC) Inhibitor Kinetic Rate Constants Correlate with Cellular Histone Acetylation but Not Transcription and Cell Viability.
J.Biol.Chem., 288, 2013
4LY1
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4ly1
STRUCTURE OF HUMAN HDAC2 IN COMPLEX WITH INHIBITOR 4-(ACETYLAMINO)-N-[2-AMINO-5-(THIOPHEN-2-YL)PHENYL]BENZAMIDE
Descriptor:Histone deacetylase 2 (E.C.3.5.1.98)
Authors:Fong, R., Lupardus, P.J.
Deposit date:2013-07-30
Release date:2013-08-21
Modification date:2013-10-02
Method:X-RAY DIFFRACTION (1.57 Å)
Cite:Histone Deacetylase (HDAC) Inhibitor Kinetic Rate Constants Correlate with Cellular Histone Acetylation but Not Transcription and Cell Viability.
J.Biol.Chem., 288, 2013
4BZ5
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4bz5
CRYSTAL STRUCTURE OF SCHISTOSOMA MANSONI HDAC8
Descriptor:HISTONE DEACETYLASE 8
Authors:Marek, M., Romier, C.
Deposit date:2013-07-24
Release date:2013-08-14
Modification date:2013-10-16
Method:X-RAY DIFFRACTION (1.785 Å)
Cite:Structural Basis for the Inhibition of Histone Deacetylase 8 (Hdac8), a Key Epigenetic Player in the Blood Fluke Schistosoma Mansoni.
Plos Pathog., 9, 2013
4BZ6
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4bz6
CRYSTAL STRUCTURE OF SCHISTOSOMA MANSONI HDAC8 COMPLEXED WITH SAHA
Descriptor:HISTONE DEACETYLASE 8
Authors:Marek, M., Romier, C.
Deposit date:2013-07-24
Release date:2013-08-14
Modification date:2013-10-16
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural Basis for the Inhibition of Histone Deacetylase 8 (Hdac8), a Key Epigenetic Player in the Blood Fluke Schistosoma Mansoni.
Plos Pathog., 9, 2013
4BZ7
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4bz7
CRYSTAL STRUCTURE OF SCHISTOSOMA MANSONI HDAC8 COMPLEXED WITH M344
Descriptor:HISTONE DEACETYLASE 8
Authors:Marek, M., Romier, C.
Deposit date:2013-07-24
Release date:2013-08-14
Modification date:2013-10-16
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structural Basis for the Inhibition of Histone Deacetylase 8 (Hdac8), a Key Epigenetic Player in the Blood Fluke Schistosoma Mansoni.
Plos Pathog., 9, 2013
4BZ8
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4bz8
CRYSTAL STRUCTURE OF SCHISTOSOMA MANSONI HDAC8 COMPLEXED WITH J1038
Descriptor:HISTONE DEACETYLASE 8
Authors:Marek, M., Romier, C.
Deposit date:2013-07-24
Release date:2013-08-14
Modification date:2013-10-16
Method:X-RAY DIFFRACTION (2.21 Å)
Cite:Structural Basis for the Inhibition of Histone Deacetylase 8 (Hdac8), a Key Epigenetic Player in the Blood Fluke Schistosoma Mansoni.
Plos Pathog., 9, 2013
4BZ9
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4bz9
CRYSTAL STRUCTURE OF SCHISTOSOMA MANSONI HDAC8 COMPLEXED WITH J1075
Descriptor:HISTONE DEACETYLASE 8
Authors:Marek, M., Romier, C.
Deposit date:2013-07-24
Release date:2013-08-14
Modification date:2013-10-16
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural Basis for the Inhibition of Histone Deacetylase 8 (Hdac8), a Key Epigenetic Player in the Blood Fluke Schistosoma Mansoni.
Plos Pathog., 9, 2013
4BKX
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4bkx
THE STRUCTURE OF HDAC1 IN COMPLEX WITH THE DIMERIC ELM2-SANT DOMAIN OF MTA1 FROM THE NURD COMPLEX
Descriptor:METASTASIS-ASSOCIATED PROTEIN MTA1, HISTONE DEACETYLASE 1 (E.C.3.5.1.98)
Authors:Millard, C.J., Watson, P.J., Celardo, I., Gordiyenko, Y., Cowley, S.M., Robinson, C.V., Fairall, L., Schwabe, J.W.R.
Deposit date:2013-04-30
Release date:2013-07-03
Modification date:2013-07-31
Method:X-RAY DIFFRACTION (3 Å)
Cite:Class I Hdacs Share a Common Mechanism of Regulation by Inositol Phosphates.
Mol.Cell, 51, 2013
3ZNR
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3znr
HDAC7 BOUND WITH INHIBITOR TMP269
Descriptor:HISTONE DEACETYLASE 7 (E.C.3.5.1.98)
Authors:Lobera, m., madauss, k., pohlhaus, d., trump, r., nolan, m.
Deposit date:2013-02-15
Release date:2013-03-27
Modification date:2013-05-01
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Selective Class Iia Histone Deacetylase Inhibition Via a Non-Chelating Zinc Binding Group
Nat.Chem.Biol., 9, 2013
3ZNS
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3zns
HDAC7 BOUND WITH TFMO INHIBITOR TMP942
Descriptor:HISTONE DEACETYLASE 7 (E.C.3.5.1.98)
Authors:Lobera, M., Madauss, K.P., Pohlhaus, D.T., Trump, R.P., Nolan, M.A.
Deposit date:2013-02-15
Release date:2013-03-27
Modification date:2013-05-01
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Selective Class Iia Histone Deacetylase Inhibition Via a Non-Chelating Zinc Binding Group
Nat.Chem.Biol., 9, 2013
4A69
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4a69
STRUCTURE OF HDAC3 BOUND TO COREPRESSOR AND INOSITOL TETRAPHOSPHATE
Descriptor:HISTONE DEACETYLASE 3, (E.C.3.5.1.98), NUCLEAR RECEPTOR COREPRESSOR 2
Authors:Watson, P.J., Fairall, L., Santos, G.M., Schwabe, J.W.R.
Deposit date:2011-11-01
Release date:2012-01-11
Modification date:2012-01-25
Method:X-RAY DIFFRACTION (2.06 Å)
Cite:Structure of Hdac3 Bound to Co-Repressor and Inositol Tetraphosphate.
Nature, 481, 2012
3RQD
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3rqd
IDEAL THIOLATE-ZINC COORDINATION GEOMETRY IN DEPSIPEPTIDE BINDING TO HISTONE DEACETYLASE 8
Descriptor:Histone deacetylase 8 (E.C.3.5.1.98)
Authors:Cole, K.E, Dowling, D.P., Christianson, D.W.
Deposit date:2011-04-28
Release date:2011-08-24
Modification date:2012-03-21
Method:X-RAY DIFFRACTION (2.143 Å)
Cite:Structural basis of the antiproliferative activity of largazole, a depsipeptide inhibitor of the histone deacetylases.
J.Am.Chem.Soc., 133, 2011
3SFF
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3sff
CRYSTAL STRUCTURE OF HUMAN HDAC8 INHIBITOR COMPLEX, AN AMINO ACID DERIVED INHIBITOR
Descriptor:Histone deacetylase 8 (E.C.3.5.1.98)
Authors:Stams, T., Vash, B.
Deposit date:2011-06-13
Release date:2011-07-20
Modification date:2011-08-03
Method:X-RAY DIFFRACTION (2 Å)
Cite:Human HDAC isoform selectivity achieved via exploitation of the acetate release channel with structurally unique small molecule inhibitors.
Bioorg.Med.Chem., 19, 2011
3SFH
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3sfh
CRYSTAL STRUCTURE OF HUMAN HDAC8 INHIBITOR COMPLEX, AN AMINO ACID DERIVED INHIBITOR
Descriptor:Histone deacetylase 8 (E.C.3.5.1.98)
Authors:Stams, T., Vash, B.
Deposit date:2011-06-13
Release date:2011-07-20
Modification date:2011-08-03
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Human HDAC isoform selectivity achieved via exploitation of the acetate release channel with structurally unique small molecule inhibitors.
Bioorg.Med.Chem., 19, 2011
3Q9B
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3q9b
CRYSTAL STRUCTURE OF APAH COMPLEXED WITH M344
Descriptor:Acetylpolyamine amidohydrolase
Authors:Lombardi, P.M., Christianson, D.W.
Deposit date:2011-01-07
Release date:2011-03-02
Modification date:2011-03-30
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structure of prokaryotic polyamine deacetylase reveals evolutionary functional relationships with eukaryotic histone deacetylases .
Biochemistry, 50, 2011
3Q9C
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3q9c
CRYSTAL STRUCTURE OF H159A APAH COMPLEXED WITH N8-ACETYLSPERMIDINE
Descriptor:Acetylpolyamine amidohydrolase
Authors:Lombardi, P.M., Christianson, D.W.
Deposit date:2011-01-07
Release date:2011-03-02
Modification date:2011-03-30
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure of prokaryotic polyamine deacetylase reveals evolutionary functional relationships with eukaryotic histone deacetylases .
Biochemistry, 50, 2011
3Q9E
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3q9e
CRYSTAL STRUCTURE OF H159A APAH COMPLEXED WITH ACETYLSPERMINE
Descriptor:Acetylpolyamine amidohydrolase
Authors:Lombardi, P.M., Christianson, D.W.
Deposit date:2011-01-07
Release date:2011-03-02
Modification date:2011-03-30
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of prokaryotic polyamine deacetylase reveals evolutionary functional relationships with eukaryotic histone deacetylases .
Biochemistry, 50, 2011
3Q9F
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3q9f
CRYSTAL STRUCTURE OF APAH COMPLEXED WITH CAPS
Descriptor:Acetylpolyamine amidohydrolase
Authors:Lombardi, P.M., Christianson, D.W.
Deposit date:2011-01-07
Release date:2011-03-02
Modification date:2011-03-30
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Structure of prokaryotic polyamine deacetylase reveals evolutionary functional relationships with eukaryotic histone deacetylases .
Biochemistry, 50, 2011
3MZ3
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3mz3
CRYSTAL STRUCTURE OF CO2+ HDAC8 COMPLEXED WITH M344
Descriptor:histone deacetylase 8 (E.C.3.5.1.98)
Authors:Dowling, D.P., Gattis, S.G., Fierke, C.A., Christianson, D.W.
Deposit date:2010-05-11
Release date:2010-06-23
Modification date:2011-03-02
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structures of metal-substituted human histone deacetylase 8 provide mechanistic inferences on biological function.
Biochemistry, 49, 2010
3MZ4
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3mz4
CRYSTAL STRUCTURE OF D101L MN2+ HDAC8 COMPLEXED WITH M344
Descriptor:Histone deacetylase 8 (E.C.3.5.1.98)
Authors:Dowling, D.P., Gattis, S.G., Fierke, C.A., Christianson, D.W.
Deposit date:2010-05-11
Release date:2010-06-23
Modification date:2011-03-02
Method:X-RAY DIFFRACTION (1.845 Å)
Cite:Structures of metal-substituted human histone deacetylase 8 provide mechanistic inferences on biological function.
Biochemistry, 49, 2010
3MZ6
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3mz6
CRYSTAL STRUCTURE OF D101L FE2+ HDAC8 COMPLEXED WITH M344
Descriptor:Histone deacetylase 8 (E.C.3.5.1.98)
Authors:Dowling, D.P., Gattis, S.G., Fierke, C.A., Christianson, D.W.
Deposit date:2010-05-11
Release date:2010-06-23
Modification date:2011-03-02
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structures of metal-substituted human histone deacetylase 8 provide mechanistic inferences on biological function.
Biochemistry, 49, 2010
3MZ7
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3mz7
CRYSTAL STRUCTURE OF D101L CO2+ HDAC8 COMPLEXED WITH M344
Descriptor:Histone deacetylase 8 (E.C.3.5.1.98)
Authors:Dowling, D.P., Gattis, S.G., Fierke, C.A., Christianson, D.W.
Deposit date:2010-05-11
Release date:2010-06-23
Modification date:2011-03-02
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structures of metal-substituted human histone deacetylase 8 provide mechanistic inferences on biological function.
Biochemistry, 49, 2010
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entries available on 2014-10-22
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