PDB: 67 resultsInfo pagesStatus searchChemie searchBIRD

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4GMU	Structure of rat cytosolic PEPCK Ld_1g in complex with oxalate and GTP Descriptor: GUANOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, OXALATE ION, ... Authors: Johnson, T.A, Holyoak, T. Deposit date: 2012-08-16 Release date: 2013-07-03 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.2 Å) Cite: The {Omega}-loop lid domain of phosphoenolpyruvate carboxykinase is essential for catalytic function. Biochemistry, 51, 2012
3MOE	The structure of rat cytosolic PEPCK mutant A467G in complex with Beta-Sulfopyruvate and GTP Descriptor: 1,2-ETHANEDIOL, GUANOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, ... Authors: Johnson, T.A, Holyoak, T. Deposit date: 2010-04-22 Release date: 2010-06-02 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (1.25 Å) Cite: Increasing the conformational entropy of the Omega-loop lid domain in phosphoenolpyruvate carboxykinase impairs catalysis and decreases catalytic fidelity . Biochemistry, 49, 2010
3DTB	The structure of rat cytosolic PEPCK in complex with phosphoglycolate and GDP Descriptor: 2-PHOSPHOGLYCOLIC ACID, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, BICARBONATE ION, ... Authors: Sullivan, S.M, Holyoak, T. Deposit date: 2008-07-14 Release date: 2008-08-26 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (1.3 Å) Cite: Enzymes with lid-gated active sites must operate by an induced fit mechanism instead of conformational selection. Proc.Natl.Acad.Sci.Usa, 105, 2008
4GNQ	Structure of rat cytosolic PEPCK Ld_3g in complex with oxalate and GTP Descriptor: GUANOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, OXALATE ION, ... Authors: Johnson, T.A, Holyoak, T. Deposit date: 2012-08-17 Release date: 2013-07-03 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.4 Å) Cite: The {Omega}-loop lid domain of phosphoenolpyruvate carboxykinase is essential for catalytic function. Biochemistry, 51, 2012
4YW9	Structure of rat cytosolic pepck in complex with 3-mercaptopicolinic acid and GTP Descriptor: 3-sulfanylpyridine-2-carboxylic acid, GUANOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, ... Authors: Balan, M.D, Johnson, T.A, Mcleod, M.J, Lotosky, W.R, Holyoak, T. Deposit date: 2015-03-20 Release date: 2015-09-23 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Inhibition and Allosteric Regulation of Monomeric Phosphoenolpyruvate Carboxykinase by 3-Mercaptopicolinic Acid. Biochemistry, 54, 2015
3DT4	The structure of rat cytosolic PEPCK in complex with oxalate and GTP Descriptor: GUANOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, OXALATE ION, ... Authors: Sullivan, S.M, Holyoak, T. Deposit date: 2008-07-14 Release date: 2008-08-26 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (1.45 Å) Cite: Enzymes with lid-gated active sites must operate by an induced fit mechanism instead of conformational selection. Proc.Natl.Acad.Sci.Usa, 105, 2008
6P5O	The structure of rat cytosolic PEPCK in complex with 3-(carboxymethylthiol)-picolinic acid Descriptor: 3-[(carboxymethyl)sulfanyl]pyridine-2-carboxylic acid, MANGANESE (II) ION, Phosphoenolpyruvate carboxykinase, ... Authors: Mcleod, M.J, Holyoak, T. Deposit date: 2019-05-30 Release date: 2019-09-18 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.49 Å) Cite: Characterization of 3-[(Carboxymethyl)thio]picolinic Acid: A Novel Inhibitor of Phosphoenolpyruvate Carboxykinase. Biochemistry, 58, 2019
5FH2	The structure of rat cytosolic PEPCK variant E89Q in complex with GTP Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, GUANOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, ... Authors: Johnson, T.A, Holyoak, T. Deposit date: 2015-12-21 Release date: 2016-11-09 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.49 Å) Cite: Utilization of Substrate Intrinsic Binding Energy for Conformational Change and Catalytic Function in Phosphoenolpyruvate Carboxykinase. Biochemistry, 55, 2016
5FH4	The structure of rat cytosolic PEPCK variant E89D in complex with beta-sulfopyruvate and GTP Descriptor: 1,2-ETHANEDIOL, GUANOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, ... Authors: Johnson, T.A, Holyoak, T. Deposit date: 2015-12-21 Release date: 2016-11-09 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.49 Å) Cite: Utilization of Substrate Intrinsic Binding Energy for Conformational Change and Catalytic Function in Phosphoenolpyruvate Carboxykinase. Biochemistry, 55, 2016
4GNM	Structure of rat cytosolic PEPCK Ld_2g in complex with oxalate and GTP Descriptor: GUANOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, OXALATE ION, ... Authors: Johnson, T.A, Holyoak, T. Deposit date: 2012-08-17 Release date: 2013-07-03 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.5 Å) Cite: The {Omega}-loop lid domain of phosphoenolpyruvate carboxykinase is essential for catalytic function. Biochemistry, 51, 2012
4GNO	Structure of rat cytosolic PEPCK Ld_3g in complex with Beta-Sulfopyruvate and GTP Descriptor: GUANOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, PENTAETHYLENE GLYCOL, ... Authors: Johnson, T.A, Holyoak, T. Deposit date: 2012-08-17 Release date: 2013-07-03 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.5 Å) Cite: The {Omega}-loop lid domain of phosphoenolpyruvate carboxykinase is essential for catalytic function. Biochemistry, 51, 2012
4YWB	Structure of rat cytosolic pepck in complex with 3-mercaptopicolinic acid and oxalic acid Descriptor: 3-sulfanylpyridine-2-carboxylic acid, CHLORIDE ION, MANGANESE (II) ION, ... Authors: Balan, M.D, Johnson, T.A, Lotosky, W.R, Mcleod, M.J, Holyoak, T. Deposit date: 2015-03-20 Release date: 2015-09-23 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Inhibition and Allosteric Regulation of Monomeric Phosphoenolpyruvate Carboxykinase by 3-Mercaptopicolinic Acid. Biochemistry, 54, 2015
3DT2	The structure of rat cytosolic PEPCK in complex with oxalate and GTP Descriptor: GUANOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, OXALATE ION, ... Authors: Sullivan, S.M, Holyoak, T. Deposit date: 2008-07-14 Release date: 2008-08-26 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Enzymes with lid-gated active sites must operate by an induced fit mechanism instead of conformational selection. Proc.Natl.Acad.Sci.Usa, 105, 2008
3DT7	The structure of rat cytosolic PEPCK in complex with beta-sulfopyruvate and GTP Descriptor: 2-ETHOXYETHANOL, GUANOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, ... Authors: Sullivan, S.M, Holyoak, T. Deposit date: 2008-07-14 Release date: 2008-08-26 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Enzymes with lid-gated active sites must operate by an induced fit mechanism instead of conformational selection. Proc.Natl.Acad.Sci.Usa, 105, 2008
4YW8	Structure of rat cytosolic pepck in complex with 3-mercaptopicolinic acid Descriptor: 1,2-ETHANEDIOL, 3-sulfanylpyridine-2-carboxylic acid, MANGANESE (II) ION, ... Authors: Balan, M.D, Johnson, T.A, Mcleod, M.J, Lotosky, W.R, Holyoak, T. Deposit date: 2015-03-20 Release date: 2015-09-23 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.55 Å) Cite: Inhibition and Allosteric Regulation of Monomeric Phosphoenolpyruvate Carboxykinase by 3-Mercaptopicolinic Acid. Biochemistry, 54, 2015
5FH5	The structure of rat cytosolic PEPCK variant E89Q in complex with phosphoglycolate and GDP Descriptor: 2-PHOSPHOGLYCOLIC ACID, GUANOSINE-5'-DIPHOSPHATE, MANGANESE (II) ION, ... Authors: Johnson, T.A, Holyoak, T. Deposit date: 2015-12-21 Release date: 2016-11-09 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.55 Å) Cite: Utilization of Substrate Intrinsic Binding Energy for Conformational Change and Catalytic Function in Phosphoenolpyruvate Carboxykinase. Biochemistry, 55, 2016
5FH1	The structure of rat cytosolic PEPCK variant E89D in complex with GTP Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, GUANOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, ... Authors: Johnson, T.A, Holyoak, T. Deposit date: 2015-12-21 Release date: 2016-12-28 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.55 Å) Cite: Utilization of Substrate Intrinsic Binding Energy for Conformational Change and Catalytic Function in Phosphoenolpyruvate Carboxykinase. Biochemistry, 55, 2016
4WPT	Crystal Structure of Mtb PEPCK in complex with PEP Descriptor: GLYCEROL, PHOSPHATE ION, PHOSPHOENOLPYRUVATE, ... Authors: Kim, H.L, Krieger, I.V, Sacchettini, J.C. Deposit date: 2014-10-21 Release date: 2015-11-04 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Crystal Structure of Mtb PEPCK in complex with PEP To Be Published
5FH3	The structure of rat cytosolic PEPCK variant E89A in complex with oxalic acid and GTP Descriptor: GUANOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, OXALATE ION, ... Authors: Johnson, T.A, Holyoak, T. Deposit date: 2015-12-21 Release date: 2016-11-09 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Utilization of Substrate Intrinsic Binding Energy for Conformational Change and Catalytic Function in Phosphoenolpyruvate Carboxykinase. Biochemistry, 55, 2016
5FH0	The structure of rat cytosolic PEPCK variant E89A complex with GTP Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, GUANOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, ... Authors: Johnson, T.A, Holyoak, T. Deposit date: 2015-12-21 Release date: 2016-11-09 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Utilization of Substrate Intrinsic Binding Energy for Conformational Change and Catalytic Function in Phosphoenolpyruvate Carboxykinase. Biochemistry, 55, 2016
4WL8	Crystal Structure of Mtb PEPCK in complex with non-hydrolyzable analog of GTP Descriptor: GLYCEROL, MANGANESE (II) ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... Authors: Kim, H.L, Sacchettini, J.C. Deposit date: 2014-10-06 Release date: 2015-10-21 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.61 Å) Cite: Crystal Structure of Mtb PEPCK in complex with non-hydrolyzable analog of GTP to be published
2QF2	Rat cytosolic PEPCK in complex with oxaloacetic acid and GDP. Descriptor: GUANOSINE-5'-DIPHOSPHATE, MANGANESE (II) ION, OXALOACETATE ION, ... Authors: Sullivan, S.M, Holyoak, T. Deposit date: 2007-06-26 Release date: 2007-08-28 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.65 Å) Cite: Structures of rat cytosolic PEPCK: insight into the mechanism of phosphorylation and decarboxylation of oxaloacetic acid. Biochemistry, 46, 2007
4WPV	Crystal Structure of E83A mutant of Mtb PEPCK in complex with Zn2+ and phosphate ion Descriptor: GLYCEROL, PHOSPHATE ION, Phosphoenolpyruvate carboxykinase [GTP], ... Authors: Kim, H.L, Sacchettini, J.C. Deposit date: 2014-10-21 Release date: 2015-11-04 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.672 Å) Cite: Crystal Structure of E83A from Mtb PEPCK in complex with Zn2+ and phosphate ion To Be Published
4GNL	Structure of rat cytosolic PEPCK Ld_2g in complex with PEP and GDP Descriptor: GUANOSINE-5'-DIPHOSPHATE, MANGANESE (II) ION, PHOSPHOENOLPYRUVATE, ... Authors: Johnson, T.A, Holyoak, T. Deposit date: 2012-08-17 Release date: 2013-07-03 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.7 Å) Cite: The {Omega}-loop lid domain of phosphoenolpyruvate carboxykinase is essential for catalytic function. Biochemistry, 51, 2012
2FAF	The structure of chicken mitochondrial PEPCK. Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, MANGANESE (II) ION, PENTAETHYLENE GLYCOL, ... Authors: Holyoak, T, Sullivan, S.M, Nowak, T. Deposit date: 2005-12-07 Release date: 2006-06-27 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Structural Insights into the Mechanism of PEPCK Catalysis Biochemistry, 45, 2006

 

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