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1KHE
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BU of 1khe by Molmil
PEPCK complex with nonhydrolyzable GTP analog, MAD data
Descriptor: MANGANESE (II) ION, PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER, Phosphoenolpyruvate Carboxykinase, ...
Authors:Dunten, P, Belunis, C, Crowther, R, Hollfelder, K, Kammlott, U, Levin, W, Michel, H, Ramsey, G.B, Swain, A, Weber, D, Wertheimer, S.J.
Deposit date:2001-11-29
Release date:2002-02-27
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of human cytosolic phosphoenolpyruvate carboxykinase reveals a new GTP-binding site.
J.Mol.Biol., 316, 2002
1KHB
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PEPCK complex with nonhydrolyzable GTP analog, native data
Descriptor: 1,2-ETHANEDIOL, ACETATE ION, MANGANESE (II) ION, ...
Authors:Dunten, P, Belunis, C, Crowther, R, Hollfelder, K, Kammlott, U, Levin, W, Michel, H, Ramsey, G.B, Swain, A, Weber, D, Wertheimer, S.J.
Deposit date:2001-11-29
Release date:2002-02-27
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.854 Å)
Cite:Crystal structure of human cytosolic phosphoenolpyruvate carboxykinase reveals a new GTP-binding site.
J.Mol.Biol., 316, 2002
1KHG
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PEPCK
Descriptor: 1,2-ETHANEDIOL, MANGANESE (II) ION, Phosphoenolpyruvate carboxykinase, ...
Authors:Dunten, P, Belunis, C, Crowther, R, Hollfelder, K, Kammlott, U, Levin, W, Michel, H, Ramsey, G.B, Swain, A, Weber, D, Wertheimer, S.J.
Deposit date:2001-11-29
Release date:2002-02-27
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.34 Å)
Cite:Crystal structure of human cytosolic phosphoenolpyruvate carboxykinase reveals a new GTP-binding site.
J.Mol.Biol., 316, 2002
1KHF
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PEPCK complex with PEP
Descriptor: 1,2-ETHANEDIOL, MANGANESE (II) ION, PHOSPHOENOLPYRUVATE, ...
Authors:Dunten, P, Belunis, C, Crowther, R, Hollfelder, K, Kammlott, U, Levin, W, Michel, H, Ramsey, G.B, Swain, A, Weber, D, Wertheimer, S.J.
Deposit date:2001-11-29
Release date:2002-02-27
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:Crystal structure of human cytosolic phosphoenolpyruvate carboxykinase reveals a new GTP-binding site.
J.Mol.Biol., 316, 2002
1M51
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BU of 1m51 by Molmil
PEPCK complex with a GTP-competitive inhibitor
Descriptor: 1,2-ETHANEDIOL, ACETATE ION, MANGANESE (II) ION, ...
Authors:Foley, L.H, Wang, P, Dunten, P, Wertheimer, S.J.
Deposit date:2002-07-06
Release date:2003-09-30
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:X-ray Structures of two xanthine inhibitors bound to PEPCK and N-3 modifications of substituted 1,8-Dibenzylxanthines
Bioorg.Med.Chem.Lett., 13, 2003
1NHX
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BU of 1nhx by Molmil
PEPCK COMPLEX WITH A GTP-COMPETITIVE INHIBITOR
Descriptor: 1,2-ETHANEDIOL, MANGANESE (II) ION, N-{4-[1-(2-FLUOROBENZYL)-3-BUTYL-2,6-DIOXO-2,3,6,7-TETRAHYDRO-1H-PURIN-8-YLMETHYL]-PHENYL}-ACETAMIDE, ...
Authors:Foley, L.H, Wang, P, Dunten, P, Ramsey, G, Gubler, M.-L, Wertheimer, S.J.
Deposit date:2002-12-19
Release date:2003-09-30
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:X-RAY STRUCTURES OF TWO XANTHINE INHIBITORS BOUND TO PEPCK and N-3 modifications of substituted 1,8-Dibenzylxanthines
Bioorg.Med.Chem.Lett., 13, 2003
2FAH
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BU of 2fah by Molmil
The structure of mitochondrial PEPCK, Complex with Mn and GDP
Descriptor: GUANOSINE-5'-DIPHOSPHATE, MALONIC ACID, MANGANESE (II) ION, ...
Authors:Holyoak, T, Sullivan, S.M, Nowak, T.
Deposit date:2005-12-07
Release date:2006-06-27
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:Structural Insights into the Mechanism of PEPCK Catalysis
Biochemistry, 45, 2006
2FAF
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BU of 2faf by Molmil
The structure of chicken mitochondrial PEPCK.
Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, MANGANESE (II) ION, PENTAETHYLENE GLYCOL, ...
Authors:Holyoak, T, Sullivan, S.M, Nowak, T.
Deposit date:2005-12-07
Release date:2006-06-27
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural Insights into the Mechanism of PEPCK Catalysis
Biochemistry, 45, 2006
2GMV
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BU of 2gmv by Molmil
PEPCK complex with a GTP-competitive inhibitor
Descriptor: MANGANESE (II) ION, N-(4-{[3-BUTYL-1-(2-FLUOROBENZYL)-2,6-DIOXO-2,3,6,7-TETRAHYDRO-1H-PURIN-8-YL]METHYL}PHENYL)-1-METHYL-1H-IMIDAZOLE-4-SULFONAMIDE, PHOSPHOENOLPYRUVATE, ...
Authors:Dunten, P.
Deposit date:2006-04-07
Release date:2007-05-29
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:C-8 Modifications of 3-alkyl-1,8-dibenzylxanthines as inhibitors of human cytosolic phosphoenolpyruvate carboxykinase.
Bioorg.Med.Chem.Lett., 17, 2007
2QF2
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BU of 2qf2 by Molmil
Rat cytosolic PEPCK in complex with oxaloacetic acid and GDP.
Descriptor: GUANOSINE-5'-DIPHOSPHATE, MANGANESE (II) ION, OXALOACETATE ION, ...
Authors:Sullivan, S.M, Holyoak, T.
Deposit date:2007-06-26
Release date:2007-08-28
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structures of rat cytosolic PEPCK: insight into the mechanism of phosphorylation and decarboxylation of oxaloacetic acid.
Biochemistry, 46, 2007
2QF1
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BU of 2qf1 by Molmil
Rat cytosolic PEPCK in complex with oxaloacetic acid.
Descriptor: MANGANESE (II) ION, OXALOACETATE ION, Phosphoenolpyruvate carboxykinase, ...
Authors:Sullivan, S.M, Holyoak, T.
Deposit date:2007-06-26
Release date:2007-08-21
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structures of rat cytosolic PEPCK: insight into the mechanism of phosphorylation and decarboxylation of oxaloacetic acid.
Biochemistry, 46, 2007
2QEY
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BU of 2qey by Molmil
Rat cytosolic PEPCK in complex with GTP
Descriptor: 1,2-ETHANEDIOL, GUANOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, ...
Authors:Sullivan, S.M, Holyoak, T.
Deposit date:2007-06-26
Release date:2007-08-21
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structures of rat cytosolic PEPCK: insight into the mechanism of phosphorylation and decarboxylation of oxaloacetic acid.
Biochemistry, 46, 2007
2QEW
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BU of 2qew by Molmil
Rat cytosolic PEPCK, in complex with manganese ion.
Descriptor: MANGANESE (II) ION, Phosphoenolpyruvate carboxykinase, cytosolic [GTP], ...
Authors:Sullivan, S.M, Holyoak, T.
Deposit date:2007-06-26
Release date:2007-08-21
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structures of rat cytosolic PEPCK: insight into the mechanism of phosphorylation and decarboxylation of oxaloacetic acid.
Biochemistry, 46, 2007
2QZY
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BU of 2qzy by Molmil
The structure of chicken mitochondrial PEPCK in complex with PEP
Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, MANGANESE (II) ION, PHOSPHOENOLPYRUVATE, ...
Authors:Holyoak, T, Sullivan, S.M, Nowak, T.
Deposit date:2007-08-17
Release date:2007-09-04
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural Insights into the Mechanism of PEPCK Catalysis
Biochemistry, 45, 2006
2RKD
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BU of 2rkd by Molmil
The Structure of rat cytosolic PEPCK in complex with 3-phosphonopropionate
Descriptor: 3-PHOSPHONOPROPANOIC ACID, MANGANESE (II) ION, Phosphoenolpyruvate carboxykinase, ...
Authors:Sullivan, S.M, Stiffin, R.M, Carlson, G.M, Holyoak, T.
Deposit date:2007-10-16
Release date:2008-01-29
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Differential Inhibition of Cytosolic PEPCK by Substrate Analogues. Kinetic and Structural Characterization of Inhibitor Recognition.
Biochemistry, 47, 2008
2RK8
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BU of 2rk8 by Molmil
The Structure of rat cytosolic PEPCK in complex with phosphonoformate
Descriptor: DI(HYDROXYETHYL)ETHER, FORMIC ACID, MANGANESE (II) ION, ...
Authors:Sullivan, S.M, Stiffin, R.M, Carlson, G.M, Holyoak, T.
Deposit date:2007-10-16
Release date:2008-01-29
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2 Å)
Cite:Differential Inhibition of Cytosolic PEPCK by Substrate Analogues. Kinetic and Structural Characterization of Inhibitor Recognition.
Biochemistry, 47, 2008
2RKA
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BU of 2rka by Molmil
The Structure of rat cytosolic PEPCK in complex with phosphoglycolate
Descriptor: 2-PHOSPHOGLYCOLIC ACID, MANGANESE (II) ION, Phosphoenolpyruvate carboxykinase, ...
Authors:Sullivan, S.M, Stiffin, R.M, Carlson, G.M, Holyoak, T.
Deposit date:2007-10-16
Release date:2008-01-29
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Differential Inhibition of Cytosolic PEPCK by Substrate Analogues. Kinetic and Structural Characterization of Inhibitor Recognition.
Biochemistry, 47, 2008
2RK7
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BU of 2rk7 by Molmil
The Structure of rat cytosolic PEPCK in complex with oxalate
Descriptor: MANGANESE (II) ION, OXALATE ION, Phosphoenolpyruvate carboxykinase, ...
Authors:Sullivan, S.M, Stiffin, R.M, Carlson, G.M, Holyoak, T.
Deposit date:2007-10-16
Release date:2008-01-29
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Differential Inhibition of Cytosolic PEPCK by Substrate Analogues. Kinetic and Structural Characterization of Inhibitor Recognition.
Biochemistry, 47, 2008
2RKE
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BU of 2rke by Molmil
The Structure of rat cytosolic PEPCK in complex with sulfoacetate.
Descriptor: MANGANESE (II) ION, Phosphoenolpyruvate carboxykinase, cytosolic [GTP], ...
Authors:Sullivan, S.M, Stiffin, R.M, Carlson, G.M, Holyoak, T.
Deposit date:2007-10-16
Release date:2008-01-29
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Differential Inhibition of Cytosolic PEPCK by Substrate Analogues. Kinetic and Structural Characterization of Inhibitor Recognition.
Biochemistry, 47, 2008
2ZCI
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BU of 2zci by Molmil
Structure of a GTP-dependent bacterial PEP-carboxykinase from Corynebacterium glutamicum
Descriptor: Phosphoenolpyruvate carboxykinase [GTP]
Authors:Aich, S, Prasad, L, Delbaere, L.T.J.
Deposit date:2007-11-09
Release date:2008-04-15
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure of a GTP-dependent bacterial PEP-carboxykinase from Corynebacterium glutamicum.
Int.J.Biochem.Cell Biol., 40, 2008
3DT4
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BU of 3dt4 by Molmil
The structure of rat cytosolic PEPCK in complex with oxalate and GTP
Descriptor: GUANOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, OXALATE ION, ...
Authors:Sullivan, S.M, Holyoak, T.
Deposit date:2008-07-14
Release date:2008-08-26
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Enzymes with lid-gated active sites must operate by an induced fit mechanism instead of conformational selection.
Proc.Natl.Acad.Sci.Usa, 105, 2008
3DTB
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BU of 3dtb by Molmil
The structure of rat cytosolic PEPCK in complex with phosphoglycolate and GDP
Descriptor: 2-PHOSPHOGLYCOLIC ACID, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, BICARBONATE ION, ...
Authors:Sullivan, S.M, Holyoak, T.
Deposit date:2008-07-14
Release date:2008-08-26
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Enzymes with lid-gated active sites must operate by an induced fit mechanism instead of conformational selection.
Proc.Natl.Acad.Sci.Usa, 105, 2008
3DT2
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BU of 3dt2 by Molmil
The structure of rat cytosolic PEPCK in complex with oxalate and GTP
Descriptor: GUANOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, OXALATE ION, ...
Authors:Sullivan, S.M, Holyoak, T.
Deposit date:2008-07-14
Release date:2008-08-26
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Enzymes with lid-gated active sites must operate by an induced fit mechanism instead of conformational selection.
Proc.Natl.Acad.Sci.Usa, 105, 2008
3DT7
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BU of 3dt7 by Molmil
The structure of rat cytosolic PEPCK in complex with beta-sulfopyruvate and GTP
Descriptor: 2-ETHOXYETHANOL, GUANOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, ...
Authors:Sullivan, S.M, Holyoak, T.
Deposit date:2008-07-14
Release date:2008-08-26
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Enzymes with lid-gated active sites must operate by an induced fit mechanism instead of conformational selection.
Proc.Natl.Acad.Sci.Usa, 105, 2008
3MOE
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BU of 3moe by Molmil
The structure of rat cytosolic PEPCK mutant A467G in complex with Beta-Sulfopyruvate and GTP
Descriptor: 1,2-ETHANEDIOL, GUANOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, ...
Authors:Johnson, T.A, Holyoak, T.
Deposit date:2010-04-22
Release date:2010-06-02
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Increasing the conformational entropy of the Omega-loop lid domain in phosphoenolpyruvate carboxykinase impairs catalysis and decreases catalytic fidelity .
Biochemistry, 49, 2010

 

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