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1E2H
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1e2h
THE NUCLEOSIDE BINDING SITE OF HERPES SIMPLEX TYPE 1 THYMIDINE KINASE ANALYZED BY X-RAY CRYSTALLOGRAPHY
Descriptor:THYMIDINE KINASE (E.C.2.7.1.21)
Authors:Vogt, J., Scapozza, L., Schulz, G.E.
Deposit date:2000-05-23
Release date:2000-11-06
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Nucleoside Binding Site of Herpes Simplex Type 1 Thymidine Kinase Analyzed by X-Ray Crystallography
Proteins: Struct.,Funct., Genet., 41, 2000
1E2I
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1e2i
THE NUCLEOSIDE BINDING SITE OF HERPES SIMPLEX TYPE 1 THYMIDINE KINASE ANALYZED BY X-RAY CRYSTALLOGRAPHY
Descriptor:THYMIDINE KINASE (E.C.2.7.1.21)
Authors:Vogt, J., Scapozza, L., Schulz, G.E.
Deposit date:2000-05-23
Release date:2000-11-06
Modification date:2009-11-03
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Nucleoside Binding Site of Herpes Simplex Type 1 Thymidine Kinase Analyzed by X-Ray Crystallography
Proteins, 41, 2000
1E2J
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1e2j
THE NUCLEOSIDE BINDING SITE OF HERPES SIMPLEX TYPE 1 THYMIDINE KINASE ANALYZED BY X-RAY CRYSTALLOGRAPHY
Descriptor:THYMIDINE KINASE (E.C.2.7.1.21)
Authors:Vogt, J., Scapozza, L., Schulz, G.E.
Deposit date:2000-05-23
Release date:2000-11-06
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Nucleoside Binding Site of Herpes Simplex Type 1 Thymidine Kinase Analyzed by X-Ray Crystallography
Proteins: Struct.,Funct., Genet., 41, 2000
1E2K
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1e2k
KINETICS AND CRYSTAL STRUCTURE OF THE WILD-TYPE AND THE ENGINEERED Y101F MUTANT OF HERPES SIMPLEX VIRUS TYPE 1 THYMIDINE KINASE INTERACTING WITH (NORTH)-METHANOCARBA-THYMIDINE
Descriptor:THYMIDINE KINASE (E.C.2.7.1.21)
Authors:Vogt, J., Scapozza, L., Schulz, G.E.
Deposit date:2000-05-23
Release date:2000-08-19
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Kinetics and Crystal Structure of the Wild-Type and the Engineered Y101F Mutant of Herpes Simplex Virus Type 1 Thymidine Kinase Interacting with (North)-Methanocarba-Thymidine
Biochemistry, 39, 2000
1E2L
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1e2l
KINETICS AND CRYSTAL STRUCTURE OF THE WILD-TYPE AND THE ENGINEERED Y101F MUTANT OF HERPES SIMPLEX VIRUS TYPE 1 THYMIDINE KINASE INTERACTING WITH (NORTH)-METHANOCARBA-THYMIDINE
Descriptor:THYMIDINE KINASE (E.C.2.7.1.21)
Authors:Vogt, J., Scapozza, L., Schulz, G.E.
Deposit date:2000-05-23
Release date:2000-08-18
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Kinetics and Crystal Structure of the Wild-Type and the Engineered Y101F Mutant of Herpes Simplex Virus Type 1 Thymidine Kinase Interacting with (North)-Methanocarba-Thymidine
Biochemistry, 39, 2000
1E2M
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1e2m
HPT + HMTT
Descriptor:THYMIDINE KINASE (E.C.2.7.1.21)
Authors:Vogt, J., Scapozza, L., Schulz, G.E.
Deposit date:2000-05-23
Release date:2001-03-31
Modification date:2009-06-16
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The Effect of Substrate Binding on the Conformation and Structural Stability of Herpes Simplex Virus Type 1 Thymidine Kinase
Protein Sci., 10, 2001
1E2N
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1e2n
HPT + HMTT
Descriptor:THYMIDINE KINASE (E.C.2.7.1.21)
Authors:Vogt, J., Scapozza, L., Schulz, G.E.
Deposit date:2000-05-23
Release date:2001-03-31
Modification date:2009-06-16
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The Effect of Substrate Binding on the Conformation and Structural Stability of Herpes Simplex Virus Type 1 Thymidine Kinase
Protein Sci., 10, 2001
1E2P
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1e2p
THYMIDINE KINASE, DHBT
Descriptor:THYMIDINE KINASE (E.C.2.7.1.21)
Authors:Schulz, G.E., Kessler, U.
Deposit date:2000-05-23
Release date:2001-04-26
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:The Effect of Substrate Binding on the Conformation and Structural Stability of Herpes Simplex Virus Type 1 Thymidine Kinase
Protein Sci., 10, 2001
1KI2
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1ki2
CRYSTAL STRUCTURE OF THYMIDINE KINASE FROM HERPES SIMPLEX VIRUS TYPE I COMPLEXED WITH GANCICLOVIR
Descriptor:THYMIDINE KINASE, 9-(1,3-DIHYDROXY-PROPOXYMETHANE)GUANINE
Authors:Champness, J.N., Bennett, M.S., Wien, F., Brown, D.G., Visse, R., Sandhu, G., Davies, A., Rizkallah, P.J., Melitz, C., Summers, W.C., Sanderson, M.R.
Deposit date:1998-05-15
Release date:1998-12-02
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Exploring the active site of herpes simplex virus type-1 thymidine kinase by X-ray crystallography of complexes with aciclovir and other ligands.
Proteins, 32, 1998
1KI3
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1ki3
CRYSTAL STRUCTURE OF THYMIDINE KINASE FROM HERPES SIMPLEX VIRUS TYPE I COMPLEXED WITH PENCICLOVIR
Descriptor:THYMIDINE KINASE, 9-(4-HYDROXY-3-(HYDROXYMETHYL)BUT-1-YL)GUANINE
Authors:Champness, J.N., Bennett, M.S., Wien, F., Visse, R., Jarvest, R.L., Summers, W.C., Sanderson, M.R.
Deposit date:1998-05-15
Release date:1999-05-18
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.37 Å)
Cite:Exploring the active site of herpes simplex virus type-1 thymidine kinase by X-ray crystallography of complexes with aciclovir and other ligands.
Proteins, 32, 1998
1KI4
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1ki4
CRYSTAL STRUCTURE OF THYMIDINE KINASE FROM HERPES SIMPLEX VIRUS TYPE I COMPLEXED WITH 5-BROMOTHIENYLDEOXYURIDINE
Descriptor:THYMIDINE KINASE, 5-BROMOTHIENYLDEOXYURIDINE
Authors:Champness, J.N., Bennett, M.S., Wien, F., Visse, R., Summers, W.C., Sanderson, M.R.
Deposit date:1998-05-18
Release date:1998-12-02
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.34 Å)
Cite:Exploring the active site of herpes simplex virus type-1 thymidine kinase by X-ray crystallography of complexes with aciclovir and other ligands.
Proteins, 32, 1998
1KI7
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1ki7
CRYSTAL STRUCTURE OF THYMIDINE KINASE FROM HERPES SIMPLEX VIRUS TYPE I COMPLEXED WITH 5-IODODEOXYURIDINE
Descriptor:THYMIDINE KINASE, 5-IODODEOXYURIDINE
Authors:Champness, J.N., Bennett, M.S., Wien, F., Visse, R., Summers, W.C., Sanderson, M.R.
Deposit date:1998-05-15
Release date:1998-12-02
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Exploring the active site of herpes simplex virus type-1 thymidine kinase by X-ray crystallography of complexes with aciclovir and other ligands.
Proteins, 32, 1998
1KI8
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1ki8
CRYSTAL STRUCTURE OF THYMIDINE KINASE FROM HERPES SIMPLEX VIRUS TYPE I COMPLEXED WITH 5-BROMOVINYLDEOXYURIDINE
Descriptor:THYMIDINE KINASE, 5-BROMOVINYLDEOXYURIDINE
Authors:Champness, J.N., Bennett, M.S., Wien, F., Visse, R., Summers, W.C., Sanderson, M.R.
Deposit date:1998-05-15
Release date:1998-12-02
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Exploring the active site of herpes simplex virus type-1 thymidine kinase by X-ray crystallography of complexes with aciclovir and other ligands.
Proteins, 32, 1998
1KIM
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1kim
CRYSTAL STRUCTURE OF THYMIDINE KINASE FROM HERPES SIMPLEX VIRUS TYPE I COMPLEXED WITH DEOXYTHYMIDINE
Descriptor:THYMIDINE KINASE, THYMIDINE
Authors:Champness, J.N., Bennett, M.S., Wien, F., Brown, D.G., Visse, R., Sandhu, G., Davies, A., Rizkallah, P.J., Melitz, C., Summers, W.C., Sanderson, M.R.
Deposit date:1997-11-12
Release date:1998-05-20
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.14 Å)
Cite:Exploring the active site of herpes simplex virus type-1 thymidine kinase by X-ray crystallography of complexes with aciclovir and other ligands.
Proteins, 32, 1998
1OF1
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1of1
KINETICS AND CRYSTAL STRUCTURE OF THE HERPES SIMPLEX VIRUS TYPE 1 THYMIDINE KINASE INTERACTING WITH (SOUTH)-METHANOCARBA-THYMIDINE
Descriptor:THYMIDINE KINASE (E.C.2.7.1.21)
Authors:Claus, M.T., Schelling, P., Folkers, G., Marquez, V.E., Scapozza, L., Schulz, G.E.
Deposit date:2003-04-03
Release date:2004-06-03
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Biochemical and Structural Characterization of (South)-Methanocarbathymidine that Specifically Inhibits Growth of Herpes Simplex Virus Type 1 Thymidine Kinase-Transduced Osteosarcoma Cells
J.Biol.Chem., 279, 2004
1OSN
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1osn
CRYSTAL STRUCTURE OF VARICELLA ZOSTER VIRUS THYMIDINE KINASE IN COMPLEX WITH BVDU-MP AND ADP
Descriptor:Thymidine kinase(E.C.2.7.1.21)
Authors:Bird, L.E., Ren, J., Wright, A., Leslie, K.D., Degreve, B., Balzarini, J., Stammers, D.K.
Deposit date:2003-03-20
Release date:2003-06-10
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Crystal structure of varicella zoster virus thymidine kinase
J.Biol.Chem., 278, 2003
1P6X
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1p6x
CRYSTAL STRUCTURE OF EHV4-TK COMPLEXED WITH THY AND SO4
Descriptor:Thymidine kinase (E.C.2.7.1.21)
Authors:Gardberg, A., Shuvalova, L., Monnerjahn, C., Konrad, M., Lavie, A.
Deposit date:2003-04-30
Release date:2003-11-04
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis for the dual thymidine and thymidylate kinase activity of herpes thymidine kinases.
Structure, 11, 2003
1P72
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1p72
CRYSTAL STRUCTURE OF EHV4-TK COMPLEXED WITH THY AND ADP
Descriptor:Thymidine kinase (E.C.2.7.1.21)
Authors:Gardberg, A., Shuvalova, L., Monnerjahn, C., Konrad, M., Lavie, A.
Deposit date:2003-04-30
Release date:2003-11-04
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural basis for the dual thymidine and thymidylate kinase activity of herpes thymidine kinases.
Structure, 11, 2003
1P73
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1p73
CRYSTAL STRUCTURE OF EHV4-TK COMPLEXED WITH TP4A
Descriptor:Thymidine kinase (E.C.2.7.1.21)
Authors:Gardberg, A., Shuvalova, L., Monnerjahn, C., Konrad, M., Lavie, A.
Deposit date:2003-04-30
Release date:2003-11-04
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural basis for the dual thymidine and thymidylate kinase activity of herpes thymidine kinases.
Structure, 11, 2003
1P75
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1p75
CRYSTAL STRUCTURE OF EHV4-TK COMPLEXED WITH TP5A
Descriptor:Thymidine kinase (E.C.2.7.1.21)
Authors:Gardberg, A., Shuvalova, L., Monnerjahn, C., Konrad, M., Lavie, A.
Deposit date:2003-04-30
Release date:2003-11-04
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (3.02 Å)
Cite:Structural basis for the dual thymidine and thymidylate kinase activity of herpes thymidine kinases.
Structure, 11, 2003
1P7C
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1p7c
CRYSTAL STRUCTURE OF HSV1-TK COMPLEXED WITH TP5A
Descriptor:Thymidine kinase (E.C.2.7.1.21)
Authors:Gardberg, A., Shuvalova, L., Monnerjahn, C., Konrad, M., Lavie, A.
Deposit date:2003-05-01
Release date:2003-11-04
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural basis for the dual thymidine and thymidylate kinase activity of herpes thymidine kinases.
Structure, 11, 2003
1QHI
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1qhi
HERPES SIMPLEX VIRUS TYPE-I THYMIDINE KINASE COMPLEXED WITH A NOVEL NON-SUBSTRATE INHIBITOR, 9-(4-HYDROXYBUTYL)-N2-PHENYLGUANINE
Descriptor:PROTEIN (THYMIDINE KINASE) (2.7.1.21)
Authors:Bennett, M.S., Wien, F., Champness, J.N., Batuwangala, T., Rutherford, T., Summers, W.C., Sun, H., Wright, G., Sanderson, M.R.
Deposit date:1999-05-12
Release date:1999-07-09
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure to 1.9 A resolution of a complex with herpes simplex virus type-1 thymidine kinase of a novel, non-substrate inhibitor: X-ray crystallographic comparison with binding of aciclovir.
FEBS Lett., 443, 1999
1VTK
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1vtk
THYMIDINE KINASE FROM HERPES SIMPLEX VIRUS TYPE 1 IN COMPLEX WITH ADP AND DEOXYTHYMIDINE-MONOPHOSPHATE
Descriptor:THYMIDINE KINASE, ADENOSINE-5'-DIPHOSPHATE, THYMIDINE-5'-PHOSPHATE
Authors:Wild, K., Schulz, G.E.
Deposit date:1997-04-01
Release date:1997-10-22
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:The structures of thymidine kinase from herpes simplex virus type 1 in complex with substrates and a substrate analogue.
Protein Sci., 6, 1997
2KI5
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2ki5
HERPES SIMPLEX TYPE-1 THYMIDINE KINASE IN COMPLEX WITH THE DRUG ACICLOVIR AT 1.9A RESOLUTION
Descriptor:THYMIDINE KINASE
Authors:Bennett, M.S., Wien, F., Champness, J.N., Batuwangala, T., Rutherford, T., Summers, W.C., Sun, H., Wright, G., Sanderson, M.R.
Deposit date:1999-02-12
Release date:1999-03-04
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure to 1.9 A resolution of a complex with herpes simplex virus type-1 thymidine kinase of a novel, non-substrate inhibitor: X-ray crystallographic comparison with binding of aciclovir.
FEBS Lett., 443, 1999
2VTK
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2vtk
THYMIDINE KINASE FROM HERPES SIMPLEX VIRUS TYPE 1 IN COMPLEX WITH ADP AND DEOXYTHYMIDINE
Descriptor:THYMIDINE KINASE, ADENOSINE-5'-DIPHOSPHATE, THYMIDINE
Authors:Wild, K., Schulz, G.E.
Deposit date:1997-04-01
Release date:1997-10-22
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:The structures of thymidine kinase from herpes simplex virus type 1 in complex with substrates and a substrate analogue.
Protein Sci., 6, 1997
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