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1A0R
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1a0r
HETEROTRIMERIC COMPLEX OF PHOSDUCIN/TRANSDUCIN BETA-GAMMA
Descriptor:TRANSDUCIN, PHOSDUCIN, FARNESYL
Authors:Loew, A., Ho, Y.-K., Blundell, T.L., Bax, B.
Deposit date:1997-12-05
Release date:1998-12-30
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Phosducin induces a structural change in transducin beta gamma.
Structure, 6, 1998
1B9X
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1b9x
STRUCTURAL ANALYSIS OF PHOSDUCIN AND ITS PHOSPHORYLATION-REGULATED INTERACTION WITH TRANSDUCIN
Descriptor:S73E PHOSDUCIN/TRANSDUCIN BETA-GAMMA COMPLEX
Authors:Gaudet, R., Sigler, P.B.
Deposit date:1999-02-16
Release date:1999-02-23
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (3 Å)
Cite:A molecular mechanism for the phosphorylation-dependent regulation of heterotrimeric G proteins by phosducin.
Mol.Cell, 3, 1999
1B9Y
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1b9y
STRUCTURAL ANALYSIS OF PHOSDUCIN AND ITS PHOSPHORYLATION-REGULATED INTERACTION WITH TRANSDUCIN BETA-GAMMA
Descriptor:PHOSDUCIN/TRANSDUCIN BETA-GAMMA COMPLEX
Authors:Gaudet, R., Sigler, P.B.
Deposit date:1999-02-16
Release date:1999-02-23
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (3 Å)
Cite:A molecular mechanism for the phosphorylation-dependent regulation of heterotrimeric G proteins by phosducin.
Mol.Cell, 3, 1999
1GG2
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1gg2
G PROTEIN HETEROTRIMER MUTANT GI_ALPHA_1(G203A) BETA_1 GAMMA_2 WITH GDP BOUND
Descriptor:G PROTEIN GI ALPHA 1, G PROTEIN GI BETA 1, G PROTEIN GI GAMMA 2, GUANOSINE-5'-DIPHOSPHATE
Authors:Wall, M.A., Sprang, S.R.
Deposit date:1996-11-13
Release date:1997-02-12
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The structure of the G protein heterotrimer Gi alpha 1 beta 1 gamma 2.
Cell(Cambridge,Mass.), 83, 1995
1GOT
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1got
HETEROTRIMERIC COMPLEX OF A GT-ALPHA/GI-ALPHA CHIMERA AND THE GT-BETA-GAMMA SUBUNITS
Descriptor:GT-ALPHA/GI-ALPHA CHIMERA, GT-BETA, GT-GAMMA, GUANOSINE-5'-DIPHOSPHATE
Authors:Lambright, D.G., Sondek, J., Bohm, A., Skiba, N.P., Hamm, H.E., Sigler, P.B.
Deposit date:1996-08-07
Release date:1997-03-12
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:The 2.0 A crystal structure of a heterotrimeric G protein.
Nature, 379, 1996
1GP2
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1gp2
G PROTEIN HETEROTRIMER GI_ALPHA_1 BETA_1 GAMMA_2 WITH GDP BOUND
Descriptor:G PROTEIN GI ALPHA 1, G PROTEIN GI BETA 1, G PROTEIN GI GAMMA 2, GUANOSINE-5'-DIPHOSPHATE
Authors:Wall, M.A., Sprang, S.R.
Deposit date:1996-11-13
Release date:1997-02-12
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The structure of the G protein heterotrimer Gi alpha 1 beta 1 gamma 2.
Cell(Cambridge,Mass.), 83, 1995
1OMW
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1omw
CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN G PROTEIN-COUPLED RECEPTOR KINASE 2 AND HETEROTRIMERIC G PROTEIN BETA 1 AND GAMMA 2 SUBUNITS
Descriptor:Beta-adrenergic receptor kinase 1 (E.C.2.7.1.126), Guanine nucleotide-binding protein G(I)/G(S)/G(T) beta subunit 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit
Authors:Lodowski, D.T., Pitcher, J.A., Capel, W.D., Lefkowitz, R.J., Tesmer, J.J.G.
Deposit date:2003-02-26
Release date:2003-06-03
Modification date:2011-07-27
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Keeping G proteins at Bay: A Complex Between G Protein-Coupled Receptor Kinase 2 and G-Beta-Gamma
Science, 300, 2003
1TBG
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1tbg
BETA-GAMMA DIMER OF THE HETEROTRIMERIC G-PROTEIN TRANSDUCIN
Descriptor:TRANSDUCIN
Authors:Sondek, J.S., Bohm, A., Lambright, D.G., Hamm, H.E., Sigler, P.B.
Deposit date:1996-06-15
Release date:1997-04-01
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of a G-protein beta gamma dimer at 2.1A resolution.
Nature, 379, 1996
1XHM
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1xhm
THE CRYSTAL STRUCTURE OF A BIOLOGICALLY ACTIVE PEPTIDE (SIGK) BOUND TO A G PROTEIN BETA:GAMMA HETERODIMER
Descriptor:Guanine nucleotide-binding protein G(I)/G(S)/G(T) beta subunit 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit, SIGK Peptide
Authors:Davis, T.L., Bonacci, T.M., Smrcka, A.V., Sprang, S.R.
Deposit date:2004-09-20
Release date:2005-08-09
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural and Molecular Characterization of a Preferred Protein Interaction Surface on G Protein betagamma Subunits.
Biochemistry, 44, 2005
2BCJ
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2bcj
CRYSTAL STRUCTURE OF G PROTEIN-COUPLED RECEPTOR KINASE 2 IN COMPLEX WITH GALPHA-Q AND GBETAGAMMA SUBUNITS
Descriptor:G-protein coupled receptor kinase 2 (E.C.2.7.1.126), Guanine nucleotide-binding protein G(I)/G(S)/G(T) beta subunit 1 (E.C.3.6.5.1), Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit (E.C.3.6.5.1), Guanine nucleotide-binding protein G(q), alpha subunit (E.C.3.6.5.1)
Authors:Tesmer, J.J.G.
Deposit date:2005-10-19
Release date:2005-12-20
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (3.061 Å)
Cite:Snapshot of Activated G Proteins at the Membrane: The Gq-GRK2-G Complex
Science, 310, 2005
2PBI
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2pbi
THE MULTIFUNCTIONAL NATURE OF GBETA5/RGS9 REVEALED FROM ITS CRYSTAL STRUCTURE
Descriptor:Regulator of G-protein signaling 9, Guanine nucleotide-binding protein subunit beta 5
Authors:Cheever, M.L., Snyder, J.T., Gershburg, S., Siderovski, D.P., Harden, T.K., Sondek, J.
Deposit date:2007-03-28
Release date:2008-01-29
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Crystal structure of the multifunctional Gbeta5-RGS9 complex.
Nat.Struct.Mol.Biol., 15, 2008
2TRC
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2trc
PHOSDUCIN/TRANSDUCIN BETA-GAMMA COMPLEX
Descriptor:TRANSDUCIN, PHOSDUCIN, GADOLINIUM ATOM
Authors:Gaudet, R., Bohm, A., Sigler, P.B.
Deposit date:1997-01-06
Release date:1997-06-05
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure at 2.4 angstroms resolution of the complex of transducin betagamma and its regulator, phosducin.
Cell(Cambridge,Mass.), 87, 1996
3AH8
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3ah8
STRUCTURE OF HETEROTRIMERIC G PROTEIN GALPHA-Q BETA GAMMA IN COMPLEX WITH AN INHIBITOR YM-254890
Descriptor:Guanine nucleotide-binding protein G(i) subunit alpha-1/Guanine nucleotide-binding protein G(q) subunit alpha chimeric protein, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, YM-254890
Authors:Nishimura, A., Kitano, K., Takasaki, J., Taniguchi, M., Mizuno, N., Tago, K., Hakoshima, T., Itoh, H.
Deposit date:2010-04-20
Release date:2010-07-21
Modification date:2010-08-18
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural basis for the specific inhibition of heterotrimeric Gq protein by a small molecule.
Proc.Natl.Acad.Sci.USA, 107, 2010
3CIK
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3cik
HUMAN GRK2 IN COMPLEX WITH GBETAGAMMA SUBUNITS
Descriptor:Beta-adrenergic receptor kinase 1 (E.C.2.7.11.15), Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
Authors:Tesmer, J.J.G., Lodowski, D.T.
Deposit date:2008-03-11
Release date:2009-02-17
Modification date:2012-03-07
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Structure of human G protein-coupled receptor kinase 2 in complex with the kinase inhibitor balanol.
J.Med.Chem., 53, 2010
3KRW
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3krw
HUMAN GRK2 IN COMPLEX WITH GBETGAMMA SUBUNITS AND BALANOL (SOAK)
Descriptor:Beta-adrenergic receptor kinase 1 (E.C.2.7.11.15), Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
Authors:Tesmer, J.J.G., Tesmer, V.M.
Deposit date:2009-11-19
Release date:2010-02-16
Modification date:2010-03-02
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structure of human g protein-coupled receptor kinase 2 in complex with the kinase inhibitor balanol.
J.Med.Chem., 53, 2010
3KRX
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3krx
HUMAN GRK2 IN COMPLEX WITH GBETGAMMA SUBUNITS AND BALANOL (CO-CRYSTAL)
Descriptor:Beta-adrenergic receptor kinase 1 (E.C.2.7.11.15), Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
Authors:Tesmer, J.J.G., Tesmer, V.M.
Deposit date:2009-11-19
Release date:2010-02-16
Modification date:2011-01-05
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structure of human g protein-coupled receptor kinase 2 in complex with the kinase inhibitor balanol.
J.Med.Chem., 53, 2010
3PSC
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3psc
BOVINE GRK2 IN COMPLEX WITH GBETAGAMMA SUBUNITS
Descriptor:Beta-adrenergic receptor kinase 1 (E.C.2.7.11.15), Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
Authors:Thal, D.M., Tesmer, J.J.
Deposit date:2010-12-01
Release date:2011-06-01
Modification date:2011-07-27
Method:X-RAY DIFFRACTION (2.67 Å)
Cite:Molecular Mechanism of Selectivity among G Protein-Coupled Receptor Kinase 2 Inhibitors.
Mol.Pharmacol., 80, 2011
3PVU
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3pvu
BOVINE GRK2 IN COMPLEX WITH GBETAGAMMA SUBUNITS AND A SELECTIVE KINASE INHIBITOR (CMPD101)
Descriptor:Beta-adrenergic receptor kinase 1 (E.C.2.7.11.15), Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
Authors:Thal, D.M., Tesmer, J.J.
Deposit date:2010-12-07
Release date:2011-06-01
Modification date:2011-07-27
Method:X-RAY DIFFRACTION (2.48 Å)
Cite:Molecular Mechanism of Selectivity among G Protein-Coupled Receptor Kinase 2 Inhibitors.
Mol.Pharmacol., 80, 2011
3PVW
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3pvw
BOVINE GRK2 IN COMPLEX WITH GBETAGAMMA SUBUNITS AND A SELECTIVE KINASE INHIBITOR (CMPD103A)
Descriptor:Beta-adrenergic receptor kinase 1 (E.C.2.7.11.15), Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
Authors:Thal, D.M., Tesmer, J.J.
Deposit date:2010-12-07
Release date:2011-06-01
Modification date:2011-07-27
Method:X-RAY DIFFRACTION (2.49 Å)
Cite:Molecular Mechanism of Selectivity among G Protein-Coupled Receptor Kinase 2 Inhibitors.
Mol.Pharmacol., 80, 2011
3SN6
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3sn6
CRYSTAL STRUCTURE OF THE BETA2 ADRENERGIC RECEPTOR-GS PROTEIN COMPLEX
Descriptor:Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Lysozyme, Beta-2 adrenergic receptor (E.C.3.2.1.17), Camelid antibody VHH fragment
Authors:Rasmussen, S.G.F., DeVree, B.T., Zou, Y., Kruse, A.C., Chung, K.Y., Kobilka, T.S., Thian, F.S., Chae, P.S., Pardon, E., Calinski, D., Mathiesen, J.M., Shah, S.T.A., Lyons, J.A., Caffrey, M., Gellman, S.H., Steyaert, J., Skiniotis, G., Weis, W.I., Sunahara, R.K., Kobilka, B.K.
Deposit date:2011-06-28
Release date:2011-07-20
Modification date:2012-08-01
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Crystal structure of the beta2 adrenergic receptor-Gs protein complex
Nature, 477, 2011
3UZS
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3uzs
STRUCTURE OF THE C13.28 RNA APTAMER BOUND TO THE G PROTEIN-COUPLED RECEPTOR KINASE 2-HETEROTRIMERIC G PROTEIN BETA 1 AND GAMMA 2 SUBUNIT COMPLEX
Descriptor:Beta-adrenergic receptor kinase 1 (E.C.2.7.11.15), Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
Authors:Tesmer, J.J.G., Tesmer, V.M.
Deposit date:2011-12-07
Release date:2012-07-11
Modification date:2012-08-29
Method:X-RAY DIFFRACTION (4.52 Å)
Cite:Molecular mechanism for inhibition of g protein-coupled receptor kinase 2 by a selective RNA aptamer.
Structure, 20, 2012
3V5W
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3v5w
HUMAN G PROTEIN-COUPLED RECEPTOR KINASE 2 IN COMPLEX WITH SOLUBLE GBETAGAMMA SUBUNITS AND PAROXETINE
Descriptor:G-protein coupled receptor kinase 2 (E.C.2.7.11.15), Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
Authors:Thal, D.M., Tesmer, J.J.G.
Deposit date:2011-12-17
Release date:2012-09-26
Modification date:2012-12-12
Method:X-RAY DIFFRACTION (2.07 Å)
Cite:Paroxetine is a direct inhibitor of g protein-coupled receptor kinase 2 and increases myocardial contractility.
Acs Chem.Biol., 7, 2012
4KFM
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4kfm
CRYSTAL STRUCTURE OF THE G PROTEIN-GATED INWARD RECTIFIER K+ CHANNEL GIRK2 (KIR3.2) IN COMPLEX WITH THE BETA-GAMMA G PROTEIN SUBUNITS
Descriptor:G protein-activated inward rectifier potassium channel 2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein subunit gamma
Authors:Whorton, M.R., MacKinnon, R.
Deposit date:2013-04-27
Release date:2013-06-12
Modification date:2013-09-11
Method:X-RAY DIFFRACTION (3.45 Å)
Cite:X-ray structure of the mammalian GIRK2-beta gamma G-protein complex.
Nature, 498, 2013
4MK0
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4mk0
CRYSTAL STRUCTURE OF G PROTEIN-COUPLED RECEPTOR KINASE 2 IN COMPLEX WITH A A RATIONALLY DESIGNED PAROXETINE DERIVATIVE
Descriptor:Beta-adrenergic receptor kinase 1 (E.C.2.7.11.15), Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 (E.C.63212), Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 (E.C.62871)
Authors:Homan, K.T., Tesmer, J.J.G.
Deposit date:2013-09-04
Release date:2014-01-22
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural and functional analysis of g protein-coupled receptor kinase inhibition by paroxetine and a rationally designed analog.
Mol.Pharmacol., 85, 2014
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entries available on 2014-10-29
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