1BY1
 
 | | DBL homology domain from beta-PIX | | Descriptor: | PROTEIN (PIX) | | Authors: | Aghazadeh, B, Zhu, K, Kubiseski, T.J, Liu, G.A, Pawson, T, Zheng, Y, Rosen, M.K. | | Deposit date: | 1998-10-22 | | Release date: | 1999-10-24 | | Last modified: | 2023-12-27 | | Method: | SOLUTION NMR | | Cite: | Structure and Mutagenesis of the Dbl Homology Domain
Nat.Struct.Biol., 5, 1998
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1DBH
 | | DBL AND PLECKSTRIN HOMOLOGY DOMAINS FROM HSOS1 | | Descriptor: | PROTEIN (HUMAN SOS 1) | | Authors: | Soisson, S.M, Kuriyan, J. | | Deposit date: | 1998-12-17 | | Release date: | 1998-12-23 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Crystal structure of the Dbl and pleckstrin homology domains from the human Son of sevenless protein.
Cell(Cambridge,Mass.), 95, 1998
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1F5X
 | | NMR STRUCTURE OF THE Y174 AUTOINHIBITED DBL HOMOLOGY DOMAIN | | Descriptor: | RHO-GEF VAV | | Authors: | Aghazadeh, B, Rosen, M.K, Lowry, W.E, Huang, X.Y. | | Deposit date: | 2000-06-18 | | Release date: | 2000-09-15 | | Last modified: | 2022-02-16 | | Method: | SOLUTION NMR | | Cite: | Structural basis for relief of autoinhibition of the Dbl homology domain of proto-oncogene Vav by tyrosine phosphorylation.
Cell(Cambridge,Mass.), 102, 2000
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1FOE
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1KI1
 | | Guanine Nucleotide Exchange Region of Intersectin in Complex with Cdc42 | | Descriptor: | G25K GTP-binding protein, placental isoform, SULFATE ION, ... | | Authors: | Snyder, J.T, Pruitt, W.M, Der, C.J, Sondek, J. | | Deposit date: | 2001-12-02 | | Release date: | 2002-05-29 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Structural basis for the selective activation of Rho GTPases by Dbl exchange factors.
Nat.Struct.Biol., 9, 2002
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1KZ7
 | | Crystal Structure of the DH/PH Fragment of Murine Dbs in Complex with the Placental Isoform of Human Cdc42 | | Descriptor: | CDC42 HOMOLOG, GUANINE NUCLEOTIDE EXCHANGE FACTOR DBS | | Authors: | Rossman, K.L, Worthylake, D.K, Snyder, J.T, Siderovski, D.P, Campbell, S.L, Sondek, J. | | Deposit date: | 2002-02-06 | | Release date: | 2002-03-20 | | Last modified: | 2021-10-27 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | A crystallographic view of interactions between Dbs and Cdc42: PH domain-assisted guanine nucleotide exchange.
EMBO J., 21, 2002
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1KZG
 | | DbsCdc42(Y889F) | | Descriptor: | CDC42 HOMOLOG, GUANINE NUCLEOTIDE EXCHANGE FACTOR DBS | | Authors: | Rossman, K.L, Worthylake, D.K, Snyder, J.T, Siderovski, D.P, Campbell, S.L, Sondek, J. | | Deposit date: | 2002-02-06 | | Release date: | 2002-03-20 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | A crystallographic view of interactions between Dbs and Cdc42: PH domain-assisted guanine nucleotide exchange.
EMBO J., 21, 2002
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1LB1
 | | Crystal Structure of the Dbl and Pleckstrin homology domains of Dbs in complex with RhoA | | Descriptor: | Guanine nucleotide exchange factor DBS, Transforming protein RhoA | | Authors: | Snyder, J.T, Worthylake, D.K, Rossman, K.L, Betts, L, Pruitt, W.M, Siderovski, D.P, Der, C.J, Sondek, J. | | Deposit date: | 2002-04-01 | | Release date: | 2002-05-29 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (2.81 Å) | | Cite: | Structural basis for the selective activation of Rho GTPases by Dbl exchange factors.
Nat.Struct.Biol., 9, 2002
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1NTY
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1RJ2
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1TXD
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1X86
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1XCG
 | | Crystal Structure of Human RhoA in complex with DH/PH fragment of PDZRHOGEF | | Descriptor: | Rho guanine nucleotide exchange factor 11, Transforming protein RhoA | | Authors: | Derewenda, U, Oleksy, A, Stevenson, A.S, Korczynska, J, Dauter, Z, Somlyo, A.P, Otlewski, J, Somlyo, A.V, Derewenda, Z.S. | | Deposit date: | 2004-09-01 | | Release date: | 2004-12-14 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | The crystal structure of RhoA in complex with the DH/PH fragment of PDZRhoGEF, an activator of the Ca(2+) sensitization pathway in smooth muscle
Structure, 12, 2004
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1XD4
 | | Crystal structure of the DH-PH-cat module of Son of Sevenless (SOS) | | Descriptor: | Son of sevenless protein homolog 1 | | Authors: | Sondermann, H, Soisson, S.M, Boykevisch, S, Yang, S.S, Bar-Sagi, D, Kuriyan, J. | | Deposit date: | 2004-09-03 | | Release date: | 2004-11-02 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (3.64 Å) | | Cite: | Structural analysis of autoinhibition in the ras activator son of sevenless.
Cell(Cambridge,Mass.), 119, 2004
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1XDV
 | | Experimentally Phased Structure of Human the Son of Sevenless protein at 4.1 Ang. | | Descriptor: | Son of sevenless protein homolog 1 | | Authors: | Sondermann, H, Soisson, S.M, Boykevisch, S, Yang, S.S, Bar-Sagi, D, Kuriyan, J. | | Deposit date: | 2004-09-08 | | Release date: | 2004-11-02 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (4.1 Å) | | Cite: | Structural analysis of autoinhibition in the ras activator son of sevenless.
Cell(Cambridge,Mass.), 119, 2004
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2DFK
 | | Crystal structure of the CDC42-Collybistin II complex | | Descriptor: | GLYCEROL, SULFATE ION, cell division cycle 42 isoform 1, ... | | Authors: | Xiang, S, Kim, E.Y, Connelly, J.J, Nassar, N, Kirsch, J, Winking, J, Schwarz, G, Schindelin, H. | | Deposit date: | 2006-03-02 | | Release date: | 2006-05-02 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.15 Å) | | Cite: | The Crystal Structure of Cdc42 in Complex with Collybistin II, a Gephyrin-interacting Guanine Nucleotide Exchange Factor.
J.Mol.Biol., 359, 2006
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2DX1
 | | Crystal structure of RhoGEF protein Asef | | Descriptor: | Rho guanine nucleotide exchange factor 4 | | Authors: | Murayama, K, Kato-Murayama, M, Terada, T, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2006-08-22 | | Release date: | 2007-01-02 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.36 Å) | | Cite: | Crystal structure of the rac activator, Asef, reveals its autoinhibitory mechanism
J.Biol.Chem., 282, 2007
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2KR9
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2NZ8
 | | N-terminal DHPH cassette of Trio in complex with nucleotide-free Rac1 | | Descriptor: | ras-related C3 botulinum toxin substrate 1 isoform Rac1, triple functional domain protein | | Authors: | Chhatriwala, M.K, Betts, L, Worthylake, D.K, Sondek, J. | | Deposit date: | 2006-11-22 | | Release date: | 2007-04-10 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | The DH and PH Domains of Trio Coordinately Engage Rho GTPases for their Efficient Activation
J.Mol.Biol., 368, 2007
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2PZ1
 | | Crystal Structure of Auto-inhibited Asef | | Descriptor: | Rho guanine nucleotide exchange factor 4 | | Authors: | Betts, L, Sondek, J, Rossman, K.L. | | Deposit date: | 2007-05-17 | | Release date: | 2007-08-21 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2.25 Å) | | Cite: | Release of autoinhibition of ASEF by APC leads to CDC42 activation and tumor suppression.
Nat.Struct.Mol.Biol., 14, 2007
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2RGN
 | | Crystal Structure of p63RhoGEF complex with Galpha-q and RhoA | | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, Guanine nucleotide-binding protein G(i) subunit alpha-1,Guanine nucleotide-binding protein G(q) subunit alpha, MAGNESIUM ION, ... | | Authors: | Shankaranarayanan, A, Nance, M.R, Tesmer, J.J.G. | | Deposit date: | 2007-10-04 | | Release date: | 2008-01-15 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (3.5 Å) | | Cite: | Structure of Galphaq-p63RhoGEF-RhoA complex reveals a pathway for the activation of RhoA by GPCRs.
Science, 318, 2007
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2VRW
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2Z0Q
 | | Crystal structure of DH-PH domain of RhoGEF3(Xpln) | | Descriptor: | Rho guanine nucleotide exchange factor 3, SULFATE ION | | Authors: | Murayama, K, Kato-Murayama, M, Terada, T, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2007-05-07 | | Release date: | 2008-05-13 | | Last modified: | 2012-12-12 | | Method: | X-RAY DIFFRACTION (1.79 Å) | | Cite: | Structure of the Rho-specific guanine nucleotide-exchange factor Xpln
Acta Crystallogr.,Sect.F, 68, 2012
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3BJI
 | | Structural Basis of Promiscuous Guanine Nucleotide Exchange by the T-Cell Essential Vav1 | | Descriptor: | Proto-oncogene vav, Ras-related C3 botulinum toxin substrate 1 precursor, ZINC ION | | Authors: | Chrencik, J.E, Brooun, A, Kuhn, P, Accelerated Technologies Center for Gene to 3D Structure (ATCG3D) | | Deposit date: | 2007-12-04 | | Release date: | 2008-07-15 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Structural basis of guanine nucleotide exchange mediated by the T-cell essential Vav1.
J.Mol.Biol., 380, 2008
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3EO2
 | | Crystal structure of the RhoGEF domain of human neuroepithelial cell-transforming gene 1 protein | | Descriptor: | Neuroepithelial cell-transforming gene 1 protein, UNKNOWN ATOM OR ION | | Authors: | Nedyalkova, L, Tong, Y, Tempel, W, MacKenzie, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC) | | Deposit date: | 2008-09-26 | | Release date: | 2008-10-07 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Crystal structure of the RhoGEF domain of human neuroepithelial cell-transforming gene 1 protein
To be Published
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