3JBT
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ATOMIC STRUCTURE OF THE APAF-1 APOPTOSOME
Descriptor:Apoptotic protease-activating factor 1, Cytochrome c
Authors:Zhou, M., Li, Y., Hu, Q., Bai, X., Huang, W., Yan, C., Scheres, S.H.W., Shi, Y.
Deposit date:2015-10-15
Release date:2015-11-18
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Atomic structure of the apoptosome: mechanism of cytochrome c- and dATP-mediated activation of Apaf-1
Genes Dev., 2015
2N83
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P75NTR DD:RIP2 CARD
Descriptor:Tumor necrosis factor receptor superfamily member 16, Receptor-interacting serine/threonine-protein kinase 2 (E.C.2.7.11.1, 2.7.10.2)
Authors:Lin, Z., Ibanez, C.F.
Deposit date:2015-10-02
Release date:2015-12-23
Method:SOLUTION NMR
Cite:Structural basis of death domain signaling in the p75 neurotrophin receptor
Elife, 4, 2015
2N7Z
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SOLUTION STRUCTURE OF RIP2 CARD
Descriptor:Receptor-interacting serine/threonine-protein kinase 2 (E.C.2.7.11.1, 2.7.10.2)
Authors:Lin, Z., Ibanez, C.F.
Deposit date:2015-09-28
Release date:2015-12-23
Modification date:2016-01-13
Method:SOLUTION NMR
Cite:Structural basis of death domain signaling in the p75 neurotrophin receptor
Elife, 4, 2015
5AJ2
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CRYO ELECTRON TOMOGRAPHY OF THE NAIP5-NLRC4 INFLAMMASOME
Descriptor:NLR FAMILY CARD DOMAIN-CONTAINING PROTEIN 4
Authors:Diebolder, C.A., Halff, E.F., Koster, A.J., Huizinga, E.G., Koning, R.I.
Deposit date:2015-02-20
Release date:2015-11-11
Method:ELECTRON MICROSCOPY (40 Å)
Cite:Cryo Electron Tomography of the Naip5-Nlrc4 Inflammasome -Implications for Nlr Activation
To be Published
4RHW
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CRYSTAL STRUCTURE OF APAF-1 CARD AND CASPASE-9 CARD COMPLEX
Descriptor:Apoptotic protease-activating factor 1, Caspase-9 (E.C.3.4.22.62)
Authors:Hu, Q., Wu, D., Yan, C., Shi, Y.
Deposit date:2014-10-03
Release date:2014-10-15
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Molecular determinants of caspase-9 activation by the Apaf-1 apoptosome
Proc.Natl.Acad.Sci.USA, 2014
4UZ0
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CRYSTAL STRUCTURE OF APOPTOSIS REPRESSOR WITH CARD (ARC)
Descriptor:NUCLEOLAR PROTEIN 3
Authors:Kim, S.H., Jeong, J.H., Jang, T.H., Kim, Y.G., Park, H.H.
Deposit date:2014-09-04
Release date:2015-07-01
Method:X-RAY DIFFRACTION (2.399 Å)
Cite:Crystal Structure of Caspase Recruiting Domain (Card) of Apoptosis Repressor with Card (Arc) and its Implication in Inhibition of Apoptosis.
Sci.Rep., 5, 2015
4M9S
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CRYSTAL STRUCTURE OF CED-4 BOUND CED-3 FRAGMENT
Descriptor:Cell death protein 4
Authors:Huang, W.J., Jinag, T.Y., Choi, W.Y., Wang, J.W., Shi, Y.G.
Deposit date:2013-08-15
Release date:2013-10-23
Method:X-RAY DIFFRACTION (3.207 Å)
Cite:Mechanistic insights into CED-4-mediated activation of CED-3.
Genes Dev., 27, 2013
4M9X
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CRYSTAL STRUCTURE OF CED-4 BOUND CED-3 FRAGMENT
Descriptor:Cell death protein 4, CED-3 fragment
Authors:Huang, W.J., Jinag, T.Y., Choi, W.Y., Wang, J.W., Shi, Y.G.
Deposit date:2013-08-15
Release date:2013-10-23
Method:X-RAY DIFFRACTION (3.344 Å)
Cite:Mechanistic insights into CED-4-mediated activation of CED-3.
Genes Dev., 27, 2013
4M9Y
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CRYSTAL STRUCTURE OF CED-4 BOUND CED-3 FRAGMENT
Descriptor:Cell death protein 4, CED-3 fragment
Authors:Huang, W.J., Jinag, T.Y., Choi, W.Y., Wang, J.W., Shi, Y.G.
Deposit date:2013-08-15
Release date:2013-10-23
Method:X-RAY DIFFRACTION (4.2 Å)
Cite:Mechanistic insights into CED-4-mediated activation of CED-3.
Genes Dev., 27, 2013
4M9Z
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CRYSTAL STRUCTURE OF CED-4 BOUND CED-3 FRAGMENT
Descriptor:Cell death protein 4, CED-3 fragment
Authors:Huang, W.J., Jinag, T.Y., Choi, W.Y., Wang, J.W., Shi, Y.G.
Deposit date:2013-08-15
Release date:2013-10-23
Method:X-RAY DIFFRACTION (3.405 Å)
Cite:Mechanistic insights into CED-4-mediated activation of CED-3.
Genes Dev., 27, 2013
2MB9
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HUMAN BCL10 CARD
Descriptor:B-cell lymphoma/leukemia 10
Authors:Zheng, C., Bracken, C., Wu, H.
Deposit date:2013-07-26
Release date:2013-10-16
Method:SOLUTION NMR
Cite:Structural Architecture of the CARMA1/Bcl10/MALT1 Signalosome: Nucleation-Induced Filamentous Assembly.
Mol.Cell, 51, 2013
4LWD
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HUMAN CARMA1 CARD DOMAIN
Descriptor:Caspase recruitment domain-containing protein 11
Authors:Zheng, C., Wu, H.
Deposit date:2013-07-26
Release date:2013-10-16
Method:X-RAY DIFFRACTION (1.792 Å)
Cite:Structural Architecture of the CARMA1/Bcl10/MALT1 Signalosome: Nucleation-Induced Filamentous Assembly.
Mol.Cell, 51, 2013
4KXF
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CRYSTAL STRUCTURE OF NLRC4 REVEALS ITS AUTOINHIBITION MECHANISM
Descriptor:NLR family CARD domain-containing protein 4
Authors:Chai, J., Hu, Z.
Deposit date:2013-05-25
Release date:2013-07-24
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Crystal structure of NLRC4 reveals its autoinhibition mechanism
Science, 341, 2013
4JUP
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DIMERIC STRUCTURE OF CARMA1 CARD
Descriptor:Caspase recruitment domain-containing protein 11
Authors:Park, H.H.
Deposit date:2013-03-25
Release date:2014-02-05
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Novel Disulfide Bond-Mediated Dimerization of the CARD Domain Was Revealed by the Crystal Structure of CARMA1 CARD
Plos One, 8, 2013
4JQW
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CRYSTAL STRUCTURE OF A COMPLEX OF NOD1 CARD AND UBIQUITIN
Descriptor:Nucleotide-binding oligomerization domain-containing protein 1, Polyubiquitin-C
Authors:Ver Heul, A.M., Gakhar, L., Piper, R.C., Ramaswamy, S.
Deposit date:2013-03-20
Release date:2014-03-26
Modification date:2014-12-24
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal structure of a complex of NOD1 CARD and ubiquitin
Plos One, 9, 2014
4IRL
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X-RAY STRUCTURE OF THE CARD DOMAIN OF ZEBRAFISH GBP-NLRP1 LIKE PROTEIN
Descriptor:Maltose-binding periplasmic protein, Novel protein similar to vertebrate guanylate binding protein family
Authors:Jin, T., Huang, M., Smith, P., Xiao, T.
Deposit date:2013-01-15
Release date:2013-08-07
Modification date:2014-11-26
Method:X-RAY DIFFRACTION (1.47 Å)
Cite:Structure of the caspase-recruitment domain from a zebrafish guanylate-binding protein.
Acta Crystallogr.,Sect.F, 69, 2013
4IKM
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X-RAY STRUCTURE OF CARD8 CARD DOMAIN
Descriptor:Maltose-binding periplasmic protein, Caspase recruitment domain-containing protein 8
Authors:Jin, T., Huang, M., Smith, P., Jiang, J., Xiao, T.
Deposit date:2012-12-26
Release date:2013-05-08
Modification date:2013-06-05
Method:X-RAY DIFFRACTION (2.4606 Å)
Cite:The structure of the CARD8 caspase-recruitment domain suggests its association with the FIIND domain and procaspases through adjacent surfaces.
Acta Crystallogr.,Sect.F, 69, 2013
3J2T
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AN IMPROVED MODEL OF THE HUMAN APOPTOSOME
Descriptor:Apoptotic protease-activating factor 1, Cytochrome c
Authors:Yuan, S., Topf, M., Akey, C.W.
Deposit date:2012-12-23
Release date:2013-04-10
Modification date:2013-04-17
Method:ELECTRON MICROSCOPY (9.5 Å)
Cite:Changes in apaf-1 conformation that drive apoptosome assembly.
Biochemistry, 52, 2013
4IFP
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X-RAY CRYSTAL STRUCTURE OF HUMAN NLRP1 CARD DOMAIN
Descriptor:Maltose-binding periplasmic protein, NACHT, LRR and PYD domains-containing protein 1
Authors:Jin, T., Curry, J., Smith, P., Jiang, J., Xiao, T.
Deposit date:2012-12-14
Release date:2013-04-03
Modification date:2013-07-03
Method:X-RAY DIFFRACTION (1.9948 Å)
Cite:Structure of the NLRP1 caspase recruitment domain suggests potential mechanisms for its association with procaspase-1.
Proteins, 81, 2013
4I16
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CRYSTAL STRUCTURE OF CARMA1 CARD
Descriptor:Caspase recruitment domain-containing protein 11
Authors:Li, S., Yang, X., Shen, Y.
Deposit date:2012-11-20
Release date:2012-12-26
Method:X-RAY DIFFRACTION (1.751 Å)
Cite:Structural insights into the assembly of CARMA1 and BCL10
Plos One, 7, 2012
4E9M
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NOD1 CARD DOMAIN WITH THREE DISULFIDE-CLINCHED, DOMAIN-SWAPPED DIMERS IN THE ASYMMETRIC UNIT
Descriptor:Nucleotide-binding oligomerization domain-containing protein 1
Authors:Berry, E.A., Huang, L.S., Walker-Kopp, N.
Deposit date:2012-03-21
Release date:2012-04-04
Modification date:2013-02-06
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Crystal structure of nod1 card domain with three disulfide-clinched, domain-swapped dimers in the asymmetric unit
To be Published
3T6P
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IAP ANTAGONIST-INDUCED CONFORMATIONAL CHANGE IN CIAP1 PROMOTES E3 LIGASE ACTIVATION VIA DIMERIZATION
Descriptor:Baculoviral IAP repeat-containing protein 2
Authors:Dueber, E.C., Schoeffler, A.J., Lingel, A., Elliott, M., Fedorova, A.V., Giannetti, A.M., Zobel, K., Maurer, B., Varfolomeev, E., Wu, P., Wallweber, H., Hymowitz, S., Deshayes, K., Vucic, D., Fairbrother, W.J.
Deposit date:2011-07-28
Release date:2011-11-02
Method:X-RAY DIFFRACTION (1.897 Å)
Cite:Antagonists induce a conformational change in cIAP1 that promotes autoubiquitination.
Science, 334, 2011
3SHF
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CRYSTAL STRUCTURE OF THE R265S MUTANT OF FULL-LENGTH MURINE APAF-1
Descriptor:Apoptotic peptidase activating factor 1
Authors:Eschenburg, S., Reubold, T.F.
Deposit date:2011-06-16
Release date:2011-08-24
Method:X-RAY DIFFRACTION (3.55 Å)
Cite:Crystal structure of full-length Apaf-1: how the death signal is relayed in the mitochondrial pathway of apoptosis.
Structure, 19, 2011
3SFZ
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CRYSTAL STRUCTURE OF FULL-LENGTH MURINE APAF-1
Descriptor:Apoptotic peptidase activating factor 1
Authors:Eschenburg, S., Reubold, T.F.
Deposit date:2011-06-14
Release date:2011-08-24
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal structure of full-length Apaf-1: how the death signal is relayed in the mitochondrial pathway of apoptosis.
Structure, 19, 2011
2L9M
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STRUCTURE OF CIAP1 CARD
Descriptor:Baculoviral IAP repeat-containing protein 2
Authors:Day, C.L., Rautureau, G.J.P., Hinds, M.G.
Deposit date:2011-02-21
Release date:2011-08-17
Method:SOLUTION NMR
Cite:CARD-mediated autoinhibition of cIAP1's E3 ligase activity suppresses cell proliferation and migration.
Mol.Cell, 42, 2011
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