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7RH2
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IRF4 Transcription factor mutant -K59R
Descriptor: DNA (5'-D(*CP*AP*AP*CP*TP*GP*AP*AP*AP*CP*CP*GP*AP*GP*AP*AP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*TP*TP*CP*TP*CP*GP*GP*TP*TP*TP*CP*AP*GP*TP*TP*G)-3'), ICSAT transcription factor
Authors:Williams, S.J, Sundararaj, S, Casarotto, M.G.
Deposit date:2021-07-16
Release date:2022-05-25
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.47 Å)
Cite:The molecular basis for the development of adult T-cell leukemia/lymphoma in patients with an IRF4 K59R mutation.
Protein Sci., 31, 2022
6TD4
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IRF4 DNA-binding domain surface entropy mutant apo structure
Descriptor: CHLORIDE ION, Interferon regulatory factor 4
Authors:Tucker, J.A, Martin, M.P, Wang, L.Z, Jennings, C, Heath, R.
Deposit date:2019-11-07
Release date:2020-11-18
Last modified:2021-06-23
Method:X-RAY DIFFRACTION (1.71 Å)
Cite:Cancer-associated mutations in the IRF4 DNA-binding domain confer no disadvantage in DNA-binding affinity and may increase transcriptional activity
To Be Published
2IRF
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CRYSTAL STRUCTURE OF AN IRF-2/DNA COMPLEX.
Descriptor: DNA (5'-D(*TP*TP*CP*AP*CP*TP*TP*TP*CP*AP*CP*(5IU)P*T)-3'), DNA (5'-D(P*AP*AP*GP*TP*GP*AP*AP*AP*GP*(5IU)P*GP*A)-3'), INTERFERON REGULATORY FACTOR 2, ...
Authors:Fujii, Y, Shimizu, T, Kusumoto, M, Kyogoku, Y, Taniguchi, T, Hakoshima, T.
Deposit date:1999-05-30
Release date:1999-10-08
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of an IRF-DNA complex reveals novel DNA recognition and cooperative binding to a tandem repeat of core sequences.
EMBO J., 18, 1999
7JM4
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IRF Transcription Factor
Descriptor: Interferon regulatory factor 4, Interferon-Stimulated Response Elements
Authors:Sundararaj, S, Williams, S.J, Casarotto, M.G.
Deposit date:2020-07-31
Release date:2021-03-24
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Structural determinants of the IRF4/DNA homodimeric complex.
Nucleic Acids Res., 49, 2021
2DLL
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Solution structure of the IRF domain of human interferon regulator factors 4
Descriptor: Interferon regulatory factor 4
Authors:Zhang, H.P, Kurosaki, C, Yoshida, M, Hayashi, F, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2006-04-20
Release date:2006-10-20
Last modified:2022-03-09
Method:SOLUTION NMR
Cite:Solution structure of the IRF domain of human interferon regulator factors 4
To be published
4HLY
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The complex crystal structure of the DNA binding domain of vIRF-1 from the oncogenic KSHV with DNA
Descriptor: 5'-D(*GP*CP*GP*TP*CP*GP*AP*GP*AP*CP*GP*C)-3', K9
Authors:Hew, K, Venkatachalam, R.
Deposit date:2012-10-17
Release date:2013-03-13
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (1.48 Å)
Cite:The crystal structure of the DNA-binding domain of vIRF-1 from the oncogenic KSHV reveals a conserved fold for DNA binding and reinforces its role as a transcription factor.
Nucleic Acids Res., 41, 2013
4HLX
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The crystal structure of the DNA binding domain of vIRF-1 from the oncogenic KSHV
Descriptor: K9
Authors:Hew, K, Venkatachalam, R.
Deposit date:2012-10-17
Release date:2013-03-13
Last modified:2014-02-05
Method:X-RAY DIFFRACTION (2.379 Å)
Cite:The crystal structure of the DNA-binding domain of vIRF-1 from the oncogenic KSHV reveals a conserved fold for DNA binding and reinforces its role as a transcription factor.
Nucleic Acids Res., 41, 2013
3QU3
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Crystal structure of IRF-7 DBD apo form
Descriptor: 1,2-ETHANEDIOL, Interferon regulatory factor 7, SODIUM ION
Authors:De Ioannes, P.E, Escalante, C.R, Aggarwal, A.K.
Deposit date:2011-02-23
Release date:2011-06-01
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Structures of apo IRF-3 and IRF-7 DNA binding domains: effect of loop L1 on DNA binding.
Nucleic Acids Res., 39, 2011
3QU6
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Crystal structure of IRF-3 DBD free form
Descriptor: CHLORIDE ION, IRF3 protein, SODIUM ION, ...
Authors:De Ioannes, P.E, Escalante, C.R, Aggarwal, A.K.
Deposit date:2011-02-23
Release date:2011-06-01
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structures of apo IRF-3 and IRF-7 DNA binding domains: effect of loop L1 on DNA binding.
Nucleic Acids Res., 39, 2011
7O56
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X-ray Structure of Interferon Regulatory Factor 4 DNA binding domain bound to an interferon-stimulated response element solved by Phosphorus and Sulphur SAD methods
Descriptor: DNA (5'-D(P*AP*AP*TP*AP*AP*AP*AP*GP*AP*AP*AP*CP*CP*GP*AP*AP*AP*GP*TP*AP*A)-3'), DNA (5'-D(P*TP*TP*TP*AP*CP*TP*TP*TP*CP*GP*GP*TP*TP*TP*CP*TP*TP*TP*TP*AP*T)-3'), Interferon regulatory factor 4
Authors:El Omari, K, Agnarelli, A, Duman, R, Wagner, A, Mancini, E.J.
Deposit date:2021-04-07
Release date:2021-05-12
Last modified:2021-10-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Phosphorus and sulfur SAD phasing of the nucleic acid-bound DNA-binding domain of interferon regulatory factor 4.
Acta Crystallogr.,Sect.F, 77, 2021
7OGS
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X-ray Structure of Interferon Regulatory Factor 4 DNA binding domain bound to an interferon-stimulated response element
Descriptor: DNA (5'-D(P*AP*TP*AP*AP*CP*TP*GP*AP*AP*AP*CP*CP*GP*AP*AP*AP*GP*TP*AP*C)-3'), DNA (5'-D(P*TP*GP*TP*AP*CP*TP*TP*TP*CP*GP*GP*TP*TP*TP*CP*AP*GP*TP*TP*A)-3'), Interferon regulatory factor 4
Authors:Agnarelli, A, El Omari, K, Alt, A.O, Mancini, E.J.
Deposit date:2021-05-07
Release date:2022-06-01
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.37 Å)
Cite:X-ray Structure of Interferon Regulatory Factor 4 DNA binding domain bound to interferon-stimulated response element
To Be Published
7OOT
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X-ray Structure of Interferon Regulatory Factor 4 DNA binding domain bound to an interferon-stimulated response element
Descriptor: DNA (5'-D(P*AP*GP*CP*TP*TP*TP*CP*TP*CP*GP*GP*TP*TP*TP*CP*AP*GP*TP*TP*G)-3'), DNA (5'-D(P*TP*CP*AP*AP*CP*TP*GP*AP*AP*AP*CP*CP*GP*AP*GP*AP*AP*AP*GP*C)-3'), Interferon regulatory factor 4, ...
Authors:Agnarelli, A, El Omari, K, Alt, A.O, Mancini, E.J.
Deposit date:2021-05-28
Release date:2022-06-08
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:X-ray Structure of Interferon Regulatory Factor 4 DNA binding domain bound to interferon-stimulated response element
To Be Published
1IRG
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INTERFERON REGULATORY FACTOR-2 DNA BINDING DOMAIN, NMR, 20 STRUCTURES
Descriptor: INTERFERON REGULATORY FACTOR-2
Authors:Furui, J, Uegaki, K, Yamazaki, T, Shirakawa, M, Swindells, M.B, Harada, H, Taniguchi, T, Kyogoku, Y.
Deposit date:1997-11-25
Release date:1998-03-18
Last modified:2017-11-29
Method:SOLUTION NMR
Cite:Solution structure of the IRF-2 DNA-binding domain: a novel subgroup of the winged helix-turn-helix family.
Structure, 6, 1998
1IF1
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INTERFERON REGULATORY FACTOR 1 (IRF-1) COMPLEX WITH DNA
Descriptor: DNA (26-MER), PROTEIN (INTERFERON REGULATORY FACTOR 1)
Authors:Escalante, C.R, Yie, J, Thanos, D, Aggarwal, A.
Deposit date:1997-09-12
Release date:1998-02-25
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structure of IRF-1 with bound DNA reveals determinants of interferon regulation.
Nature, 391, 1998
1IRF
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INTERFERON REGULATORY FACTOR-2 DNA BINDING DOMAIN, NMR, MINIMIZED AVERAGE STRUCTURE
Descriptor: INTERFERON REGULATORY FACTOR-2
Authors:Furui, J, Uegaki, K, Yamazaki, T, Shirakawa, M, Swindells, M.B, Harada, H, Taniguchi, T, Kyogoku, Y.
Deposit date:1997-11-24
Release date:1998-01-28
Last modified:2017-11-29
Method:SOLUTION NMR
Cite:Solution structure of the IRF-2 DNA-binding domain: a novel subgroup of the winged helix-turn-helix family.
Structure, 6, 1998
2O6G
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Crystal structure of IRF-3 bound to the interferon-b enhancer
Descriptor: Interferon regulatory factor 3, interferon-b enhancer
Authors:Panne, D.
Deposit date:2006-12-07
Release date:2007-07-24
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:An Atomic Model of the Interferon-beta Enhanceosome.
Cell(Cambridge,Mass.), 129, 2007
2PI0
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BU of 2pi0 by Molmil
Crystal Structure of IRF-3 bound to the PRDIII-I regulatory element of the human interferon-B enhancer
Descriptor: Interferon regulatory factor 3, PRDIII-I region of human interferon-B promoter strand 1, PRDIII-I region of human interferon-B promoter strand 2
Authors:Escalante, C.R, Nistal-Villan, E, Leyi, S, Garcia-Sastre, A, Aggarwal, A.K.
Deposit date:2007-04-12
Release date:2007-10-30
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:Structure of IRF-3 bound to the PRDIII-I regulatory element of the human interferon-beta enhancer.
Mol.Cell, 26, 2007
8JKS
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BU of 8jks by Molmil
T95R mutant IRF4 DNA-binding domain bound to an DNA containing GAGA motif
Descriptor: GAGA-Forward, GAGA-Reverse, Interferon regulatory factor 4
Authors:Wang, G, Feng, X, Ding, J.
Deposit date:2023-06-01
Release date:2023-09-20
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Molecular basis for the functional roles of the multimorphic T95R mutation of IRF4 causing human autosomal dominant combined immunodeficiency.
Structure, 31, 2023
8JKL
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IRF4 DNA-binding domain bound to an DNA containing GATA motif
Descriptor: GATA-Forward, GATA-Reverse, Interferon regulatory factor 4
Authors:Wang, G, Feng, X, Ding, J.
Deposit date:2023-06-01
Release date:2023-09-20
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.94 Å)
Cite:Molecular basis for the functional roles of the multimorphic T95R mutation of IRF4 causing human autosomal dominant combined immunodeficiency.
Structure, 31, 2023
8JKQ
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T95R mutant IRF4 DNA-binding domain bound to an DNA containing GACA motif
Descriptor: GACA-Forward, GACA-Reverse, Interferon regulatory factor 4
Authors:Wang, G, Feng, X, Ding, J.
Deposit date:2023-06-01
Release date:2023-09-20
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (3.09 Å)
Cite:Molecular basis for the functional roles of the multimorphic T95R mutation of IRF4 causing human autosomal dominant combined immunodeficiency.
Structure, 31, 2023
8JKN
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T95R mutant IRF4 DNA-binding domain bound to an DNA containing GAAA motif
Descriptor: GAAA-Forward, GAAA-Reverse, Interferon regulatory factor 4
Authors:Wang, G, Feng, X, Ding, J.
Deposit date:2023-06-01
Release date:2023-09-20
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.92 Å)
Cite:Molecular basis for the functional roles of the multimorphic T95R mutation of IRF4 causing human autosomal dominant combined immunodeficiency.
Structure, 31, 2023
8JKO
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T95R mutant IRF4 DNA-binding domain bound to an DNA containing GATA motif
Descriptor: GATA-Forward, GATA-Reverse, Interferon regulatory factor 4
Authors:Wang, G, Feng, X, Ding, J.
Deposit date:2023-06-01
Release date:2023-09-20
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Molecular basis for the functional roles of the multimorphic T95R mutation of IRF4 causing human autosomal dominant combined immunodeficiency.
Structure, 31, 2023
1T2K
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Structure Of The DNA Binding Domains Of IRF3, ATF-2 and Jun Bound To DNA
Descriptor: 31-MER, Cyclic-AMP-dependent transcription factor ATF-2, Interferon regulatory factor 3, ...
Authors:Panne, D, Maniatis, T, Harrison, S.C.
Deposit date:2004-04-21
Release date:2004-11-16
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal structure of ATF-2/c-Jun and IRF-3 bound to the interferon-beta enhancer.
Embo J., 23, 2004
2O61
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Crystal Structure of NFkB, IRF7, IRF3 bound to the interferon-b enhancer
Descriptor: 34-MER, 36-MER, Nuclear factor NF-kappa-B p105 subunit, ...
Authors:Panne, D.
Deposit date:2006-12-06
Release date:2007-07-24
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:An Atomic Model of the Interferon-beta Enhanceosome.
Cell(Cambridge,Mass.), 129, 2007

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