6D0S
| RabGAP domain of human TBC1D22B | Descriptor: | SULFATE ION, TBC1 domain family member 22B, UNKNOWN ATOM OR ION | Authors: | Tong, Y, Tempel, W, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Park, H, Structural Genomics Consortium (SGC) | Deposit date: | 2018-04-10 | Release date: | 2018-06-06 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | RabGAP domain of human TBC1D22B To be Published
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3HZJ
| Crystal structure of the RabGAP domain of the RABGAP1L protein | Descriptor: | RAB GTPase-activating protein 1-like, UNKNOWN ATOM OR ION | Authors: | Nedyalkova, L, Tempel, W, Tong, Y, Zhong, N, MacKenzie, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC) | Deposit date: | 2009-06-23 | Release date: | 2009-07-14 | Last modified: | 2017-11-01 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Crystal structure of the RabGAP domain of the RABGAP1L protein To be Published
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4Z6Y
| Structure of the TBC1D7-TSC1 complex | Descriptor: | Hamartin, TBC1 domain family member 7 | Authors: | Gai, Z, Wu, G. | Deposit date: | 2015-04-06 | Release date: | 2016-04-20 | Method: | X-RAY DIFFRACTION (2.81 Å) | Cite: | Structure of the TBC1D7-TSC1 complex To Be Published
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1FKM
| CRYSTAL STRUCTURE OF THE YPT/RAB-GAP DOMAIN OF GYP1P | Descriptor: | PROTEIN (GYP1P) | Authors: | Rak, A, Fedorov, R, Alexandrov, K, Albert, S, Goody, R.S, Gallwitz, D, Scheidig, A.J. | Deposit date: | 2000-08-09 | Release date: | 2001-02-09 | Last modified: | 2022-12-21 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Crystal structure of the GAP domain of Gyp1p: first insights into interaction with Ypt/Rab proteins. EMBO J., 19, 2000
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4NC6
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5EJC
| Crystal structural of the TSC1-TBC1D7 complex | Descriptor: | Hamartin, TBC1 domain family member 7 | Authors: | Wang, Z, Qin, J, Gong, W, Xu, W. | Deposit date: | 2015-11-01 | Release date: | 2016-03-02 | Last modified: | 2019-11-27 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Structural Basis of the Interaction between Tuberous Sclerosis Complex 1 (TSC1) and Tre2-Bub2-Cdc16 Domain Family Member 7 (TBC1D7). J.Biol.Chem., 291, 2016
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5HJN
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5HJQ
| Crystal structure of the TBC domain of Skywalker/TBC1D24 from Drosophila melanogaster in complex with inositol(1,4,5)triphosphate | Descriptor: | D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE, LD10117p | Authors: | Fischer, B, Paesmans, J, Versees, W. | Deposit date: | 2016-01-13 | Release date: | 2016-09-21 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Skywalker-TBC1D24 has a lipid-binding pocket mutated in epilepsy and required for synaptic function. Nat.Struct.Mol.Biol., 23, 2016
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5TUB
| Crystal Structure of the Shark TBC1D15 GAP Domain | Descriptor: | Shark TBC1D15 GTPase-activating Protein | Authors: | Chen, Y.-N, Wang, W, Cheng, D, Ge, Y, Gu, X, Zhou, X.E, Ye, F, Xu, H.E, Lv, Z. | Deposit date: | 2016-11-05 | Release date: | 2017-02-22 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | Crystal structure of TBC1D15 GTPase-activating protein (GAP) domain and its activity on Rab GTPases. Protein Sci., 26, 2017
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5TUC
| Crystal Structure of the Sus TBC1D15 GAP Domain | Descriptor: | Sus TBC1D15 GAP Domain | Authors: | Chen, Y.-N, Wang, W, Cheng, D, Ge, Y, Gu, X, Zhou, X.E, Ye, F, Xu, H.E, Lv, Z. | Deposit date: | 2016-11-05 | Release date: | 2017-02-22 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Crystal structure of TBC1D15 GTPase-activating protein (GAP) domain and its activity on Rab GTPases. Protein Sci., 26, 2017
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4HL4
| Crystal structure of the human TBC1D20 RabGAP domain | Descriptor: | ACETATE ION, BERYLLIUM TRIFLUORIDE ION, TBC1 domain family member 20 | Authors: | Gazdag, E.M, Gavriljuk, K, Itzen, A, Koetting, C, Gerwert, K, Goody, R.S. | Deposit date: | 2012-10-16 | Release date: | 2013-01-16 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Catalytic mechanism of a mammalian Rab-RabGAP complex in atomic detail. Proc.Natl.Acad.Sci.USA, 109, 2012
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2QFZ
| Crystal structure of human TBC1 domain family member 22A | Descriptor: | TBC1 domain family member 22A, UNKNOWN ATOM OR ION | Authors: | Tong, Y, Tempel, W, Dimov, S, Dong, A, Landry, R, Arrowsmith, C.H, Edwards, A.M, Sundstrom, M, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC) | Deposit date: | 2007-06-28 | Release date: | 2007-07-10 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystal structure of human TBC1 domain family member 22A. To be Published
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2QQ8
| Crystal structure of the putative RabGAP domain of human TBC1 domain family member 14 | Descriptor: | TBC1 domain family member 14, UNKNOWN ATOM OR ION | Authors: | Tong, Y, Tempel, W, Dimov, S, Landry, R, Arrowsmith, C.H, Edwards, A.M, Sundstrom, M, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC) | Deposit date: | 2007-07-26 | Release date: | 2007-08-07 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal structure of the putative RabGAP domain of human TBC1 domain family member 14. To be Published
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3QWL
| Crystal structure of human TBC1 domain family member 7 | Descriptor: | TBC1 domain family member 7, UNKNOWN ATOM OR ION | Authors: | Guan, X, Tempel, W, Tong, Y, Wernimont, A.K, Landry, R, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Park, H, Structural Genomics Consortium (SGC) | Deposit date: | 2011-02-28 | Release date: | 2011-06-01 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Crystal structure of human TBC1 domain family member 7 to be published
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3QYB
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3QYE
| Crystal Structure of Human TBC1D1 RabGAP domain | Descriptor: | TBC1 domain family member 1 | Authors: | Park, S.Y, Shoelson, S.E. | Deposit date: | 2011-03-03 | Release date: | 2011-03-23 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal structures of human TBC1D1 and TBC1D4 (AS160) RabGTPase-activating protein (RabGAP) domains reveal critical elements for GLUT4 translocation. J.Biol.Chem., 286, 2011
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7DL2
| Cryo-EM structure of human TSC complex | Descriptor: | Hamartin, Isoform 7 of Tuberin, TBC1 domain family member 7, ... | Authors: | Yang, H, Yu, Z, Chen, X, Li, J, Li, N, Cheng, J, Gao, N, Yuan, H, Ye, D, Guan, K, Xu, Y. | Deposit date: | 2020-11-25 | Release date: | 2020-12-16 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (4.4 Å) | Cite: | Structural insights into TSC complex assembly and GAP activity on Rheb. Nat Commun, 12, 2021
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6JL7
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2G77
| Crystal Structure of Gyp1 TBC domain in complex with Rab33 GTPase bound to GDP and AlF3 | Descriptor: | ALUMINUM FLUORIDE, GTPase-activating protein GYP1, GUANOSINE-5'-DIPHOSPHATE, ... | Authors: | Pan, X, Eathiraj, S, Munson, M, Lambright, D.G. | Deposit date: | 2006-02-27 | Release date: | 2006-07-25 | Last modified: | 2021-10-20 | Method: | X-RAY DIFFRACTION (2.26 Å) | Cite: | TBC-domain GAPs for Rab GTPases accelerate GTP hydrolysis by a dual-finger mechanism. Nature, 442, 2006
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4HLQ
| Crystal structure of human rab1b bound to GDP and BEF3 in complex with the GAP domain of TBC1D20 from homo sapiens | Descriptor: | BERYLLIUM TRIFLUORIDE ION, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Gazdag, E.M, Gavriljuk, K, Itzen, A, Koetting, C, Gerwert, K, Goody, R.S. | Deposit date: | 2012-10-17 | Release date: | 2013-01-16 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Catalytic mechanism of a mammalian Rab-RabGAP complex in atomic detail. Proc.Natl.Acad.Sci.USA, 109, 2012
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