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6D0S
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BU of 6d0s by Molmil
RabGAP domain of human TBC1D22B
Descriptor: SULFATE ION, TBC1 domain family member 22B, UNKNOWN ATOM OR ION
Authors:Tong, Y, Tempel, W, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Park, H, Structural Genomics Consortium (SGC)
Deposit date:2018-04-10
Release date:2018-06-06
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:RabGAP domain of human TBC1D22B
To be Published
3HZJ
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BU of 3hzj by Molmil
Crystal structure of the RabGAP domain of the RABGAP1L protein
Descriptor: RAB GTPase-activating protein 1-like, UNKNOWN ATOM OR ION
Authors:Nedyalkova, L, Tempel, W, Tong, Y, Zhong, N, MacKenzie, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC)
Deposit date:2009-06-23
Release date:2009-07-14
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of the RabGAP domain of the RABGAP1L protein
To be Published
4Z6Y
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BU of 4z6y by Molmil
Structure of the TBC1D7-TSC1 complex
Descriptor: Hamartin, TBC1 domain family member 7
Authors:Gai, Z, Wu, G.
Deposit date:2015-04-06
Release date:2016-04-20
Method:X-RAY DIFFRACTION (2.81 Å)
Cite:Structure of the TBC1D7-TSC1 complex
To Be Published
1FKM
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BU of 1fkm by Molmil
CRYSTAL STRUCTURE OF THE YPT/RAB-GAP DOMAIN OF GYP1P
Descriptor: PROTEIN (GYP1P)
Authors:Rak, A, Fedorov, R, Alexandrov, K, Albert, S, Goody, R.S, Gallwitz, D, Scheidig, A.J.
Deposit date:2000-08-09
Release date:2001-02-09
Last modified:2022-12-21
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of the GAP domain of Gyp1p: first insights into interaction with Ypt/Rab proteins.
EMBO J., 19, 2000
4NC6
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BU of 4nc6 by Molmil
Tbc domain of human rab gtpase-activating protein 1
Descriptor: ACETATE ION, CHLORIDE ION, Rab GTPase-activating protein 1
Authors:Janowski, R, Boutin, M, Coll, M.
Deposit date:2013-10-24
Release date:2015-08-19
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Tbc domain of human rab gtpase-activating protein 1
To be Published
5EJC
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BU of 5ejc by Molmil
Crystal structural of the TSC1-TBC1D7 complex
Descriptor: Hamartin, TBC1 domain family member 7
Authors:Wang, Z, Qin, J, Gong, W, Xu, W.
Deposit date:2015-11-01
Release date:2016-03-02
Last modified:2019-11-27
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structural Basis of the Interaction between Tuberous Sclerosis Complex 1 (TSC1) and Tre2-Bub2-Cdc16 Domain Family Member 7 (TBC1D7).
J.Biol.Chem., 291, 2016
5HJN
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BU of 5hjn by Molmil
Crystal structure of the TBC domain of Skywalker/TBC1D24 from Drosophila melanogaster
Descriptor: LD10117p, SULFATE ION
Authors:Fischer, B, Paesmans, J, Versees, W.
Deposit date:2016-01-13
Release date:2016-09-21
Last modified:2019-10-16
Method:X-RAY DIFFRACTION (2.501 Å)
Cite:Skywalker-TBC1D24 has a lipid-binding pocket mutated in epilepsy and required for synaptic function.
Nat.Struct.Mol.Biol., 23, 2016
5HJQ
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BU of 5hjq by Molmil
Crystal structure of the TBC domain of Skywalker/TBC1D24 from Drosophila melanogaster in complex with inositol(1,4,5)triphosphate
Descriptor: D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE, LD10117p
Authors:Fischer, B, Paesmans, J, Versees, W.
Deposit date:2016-01-13
Release date:2016-09-21
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Skywalker-TBC1D24 has a lipid-binding pocket mutated in epilepsy and required for synaptic function.
Nat.Struct.Mol.Biol., 23, 2016
5TUB
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BU of 5tub by Molmil
Crystal Structure of the Shark TBC1D15 GAP Domain
Descriptor: Shark TBC1D15 GTPase-activating Protein
Authors:Chen, Y.-N, Wang, W, Cheng, D, Ge, Y, Gu, X, Zhou, X.E, Ye, F, Xu, H.E, Lv, Z.
Deposit date:2016-11-05
Release date:2017-02-22
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Crystal structure of TBC1D15 GTPase-activating protein (GAP) domain and its activity on Rab GTPases.
Protein Sci., 26, 2017
5TUC
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BU of 5tuc by Molmil
Crystal Structure of the Sus TBC1D15 GAP Domain
Descriptor: Sus TBC1D15 GAP Domain
Authors:Chen, Y.-N, Wang, W, Cheng, D, Ge, Y, Gu, X, Zhou, X.E, Ye, F, Xu, H.E, Lv, Z.
Deposit date:2016-11-05
Release date:2017-02-22
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of TBC1D15 GTPase-activating protein (GAP) domain and its activity on Rab GTPases.
Protein Sci., 26, 2017
4HL4
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BU of 4hl4 by Molmil
Crystal structure of the human TBC1D20 RabGAP domain
Descriptor: ACETATE ION, BERYLLIUM TRIFLUORIDE ION, TBC1 domain family member 20
Authors:Gazdag, E.M, Gavriljuk, K, Itzen, A, Koetting, C, Gerwert, K, Goody, R.S.
Deposit date:2012-10-16
Release date:2013-01-16
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Catalytic mechanism of a mammalian Rab-RabGAP complex in atomic detail.
Proc.Natl.Acad.Sci.USA, 109, 2012
2QFZ
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BU of 2qfz by Molmil
Crystal structure of human TBC1 domain family member 22A
Descriptor: TBC1 domain family member 22A, UNKNOWN ATOM OR ION
Authors:Tong, Y, Tempel, W, Dimov, S, Dong, A, Landry, R, Arrowsmith, C.H, Edwards, A.M, Sundstrom, M, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC)
Deposit date:2007-06-28
Release date:2007-07-10
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of human TBC1 domain family member 22A.
To be Published
2QQ8
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BU of 2qq8 by Molmil
Crystal structure of the putative RabGAP domain of human TBC1 domain family member 14
Descriptor: TBC1 domain family member 14, UNKNOWN ATOM OR ION
Authors:Tong, Y, Tempel, W, Dimov, S, Landry, R, Arrowsmith, C.H, Edwards, A.M, Sundstrom, M, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC)
Deposit date:2007-07-26
Release date:2007-08-07
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of the putative RabGAP domain of human TBC1 domain family member 14.
To be Published
3QWL
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BU of 3qwl by Molmil
Crystal structure of human TBC1 domain family member 7
Descriptor: TBC1 domain family member 7, UNKNOWN ATOM OR ION
Authors:Guan, X, Tempel, W, Tong, Y, Wernimont, A.K, Landry, R, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Park, H, Structural Genomics Consortium (SGC)
Deposit date:2011-02-28
Release date:2011-06-01
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of human TBC1 domain family member 7
to be published
3QYB
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BU of 3qyb by Molmil
X-ray Crystal Structure of Human TBC1D4 (AS160) RabGAP domain
Descriptor: TBC1 domain family member 4
Authors:Park, S.Y, Shoelson, S.E.
Deposit date:2011-03-03
Release date:2011-03-23
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Crystal structures of human TBC1D1 and TBC1D4 (AS160) RabGTPase-activating protein (RabGAP) domains reveal critical elements for GLUT4 translocation.
J.Biol.Chem., 286, 2011
3QYE
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BU of 3qye by Molmil
Crystal Structure of Human TBC1D1 RabGAP domain
Descriptor: TBC1 domain family member 1
Authors:Park, S.Y, Shoelson, S.E.
Deposit date:2011-03-03
Release date:2011-03-23
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structures of human TBC1D1 and TBC1D4 (AS160) RabGTPase-activating protein (RabGAP) domains reveal critical elements for GLUT4 translocation.
J.Biol.Chem., 286, 2011
7DL2
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BU of 7dl2 by Molmil
Cryo-EM structure of human TSC complex
Descriptor: Hamartin, Isoform 7 of Tuberin, TBC1 domain family member 7, ...
Authors:Yang, H, Yu, Z, Chen, X, Li, J, Li, N, Cheng, J, Gao, N, Yuan, H, Ye, D, Guan, K, Xu, Y.
Deposit date:2020-11-25
Release date:2020-12-16
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (4.4 Å)
Cite:Structural insights into TSC complex assembly and GAP activity on Rheb.
Nat Commun, 12, 2021
6JL7
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BU of 6jl7 by Molmil
crystal structure of TBC1D23 N terminal domain
Descriptor: TBC1 domain family member 23
Authors:Sun, Q, Hu, W, Jia, D.
Deposit date:2019-03-04
Release date:2020-03-04
Last modified:2021-09-15
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of TBC1D23 N-terminus reveals a novel role for rhodanese domain.
Plos Biol., 18, 2020
2G77
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BU of 2g77 by Molmil
Crystal Structure of Gyp1 TBC domain in complex with Rab33 GTPase bound to GDP and AlF3
Descriptor: ALUMINUM FLUORIDE, GTPase-activating protein GYP1, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Pan, X, Eathiraj, S, Munson, M, Lambright, D.G.
Deposit date:2006-02-27
Release date:2006-07-25
Last modified:2021-10-20
Method:X-RAY DIFFRACTION (2.26 Å)
Cite:TBC-domain GAPs for Rab GTPases accelerate GTP hydrolysis by a dual-finger mechanism.
Nature, 442, 2006
4HLQ
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BU of 4hlq by Molmil
Crystal structure of human rab1b bound to GDP and BEF3 in complex with the GAP domain of TBC1D20 from homo sapiens
Descriptor: BERYLLIUM TRIFLUORIDE ION, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Gazdag, E.M, Gavriljuk, K, Itzen, A, Koetting, C, Gerwert, K, Goody, R.S.
Deposit date:2012-10-17
Release date:2013-01-16
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Catalytic mechanism of a mammalian Rab-RabGAP complex in atomic detail.
Proc.Natl.Acad.Sci.USA, 109, 2012

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