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1TND	THE 2.2 ANGSTROMS CRYSTAL STRUCTURE OF TRANSDUCIN-ALPHA COMPLEXED WITH GTP GAMMA S Descriptor: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, CACODYLATE ION, MAGNESIUM ION, ... Authors: Noel, J.P, Hamm, H.E, Sigler, P.B. Deposit date: 1994-03-31 Release date: 1994-07-31 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.2 Å) Cite: The 2.2 A crystal structure of transducin-alpha complexed with GTP gamma S. Nature, 366, 1993
1GIA	STRUCTURE OF ACTIVE CONFORMATIONS OF GIA1 AND THE MECHANISM OF GTP HYDROLYSIS Descriptor: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, G PROTEIN GI ALPHA 1, MAGNESIUM ION Authors: Berghuis, A.M, Coleman, D.E, Sprang, S.R. Deposit date: 1994-07-20 Release date: 1994-09-30 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2 Å) Cite: Structures of active conformations of Gi alpha 1 and the mechanism of GTP hydrolysis. Science, 265, 1994
1GFI	STRUCTURES OF ACTIVE CONFORMATIONS OF GI ALPHA 1 AND THE MECHANISM OF GTP HYDROLYSIS Descriptor: GUANINE NUCLEOTIDE-BINDING PROTEIN G, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... Authors: Coleman, D.E, Berghuis, A.M, Sprang, S.R. Deposit date: 1994-11-11 Release date: 1995-03-31 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Structures of active conformations of Gi alpha 1 and the mechanism of GTP hydrolysis. Science, 265, 1994
1TAG	STRUCTURAL DETERMINANTS FOR ACTIVATION OF THE ALPHA-SUBUNIT OF A HETEROTRIMERIC G PROTEIN Descriptor: GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, TRANSDUCIN-ALPHA Authors: Lambright, D.G, Noel, J.P, Hamm, H.E, Sigler, P.B. Deposit date: 1994-11-23 Release date: 1995-02-07 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Structural determinants for activation of the alpha-subunit of a heterotrimeric G protein. Nature, 369, 1994
1GIL	STRUCTURE OF ACTIVE CONFORMATIONS OF GIA1 AND THE MECHANISM OF GTP HYDROLYSIS Descriptor: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, G PROTEIN GI ALPHA 1, MAGNESIUM ION Authors: Coleman, D.E, Berghuis, A.M, Sprang, S.R. Deposit date: 1995-01-02 Release date: 1995-02-14 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structures of active conformations of Gi alpha 1 and the mechanism of GTP hydrolysis. Science, 265, 1994
1TAD	GTPASE MECHANISM OF GPROTEINS FROM THE 1.7-ANGSTROM CRYSTAL STRUCTURE OF TRANSDUCIN ALPHA-GDP-ALF4- Descriptor: CACODYLATE ION, CALCIUM ION, GUANOSINE-5'-DIPHOSPHATE, ... Authors: Sondek, J, Lambright, D.G, Noel, J.P, Hamm, H.E, Sigler, P.B. Deposit date: 1995-01-05 Release date: 1995-05-08 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.7 Å) Cite: GTPase mechanism of Gproteins from the 1.7-A crystal structure of transducin alpha-GDP-AIF-4. Nature, 372, 1994
1GDD	TERTIARY AND QUATERNARY STRUCTURAL CHANGES IN GIA1 INDUCED BY GTP HYDROLYSIS Descriptor: GI ALPHA 1, GUANOSINE-5'-DIPHOSPHATE, SULFATE ION Authors: Mixon, M.B, Sprang, S.R. Deposit date: 1995-07-25 Release date: 1995-11-27 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Tertiary and quaternary structural changes in Gi alpha 1 induced by GTP hydrolysis. Science, 270, 1995
1GOT	HETEROTRIMERIC COMPLEX OF A GT-ALPHA/GI-ALPHA CHIMERA AND THE GT-BETA-GAMMA SUBUNITS Descriptor: GT-ALPHA/GI-ALPHA CHIMERA, GT-BETA, GT-GAMMA, ... Authors: Lambright, D.G, Sondek, J, Bohm, A, Skiba, N.P, Hamm, H.E, Sigler, P.B. Deposit date: 1996-08-07 Release date: 1997-03-12 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (2 Å) Cite: The 2.0 A crystal structure of a heterotrimeric G protein. Nature, 379, 1996
1GIT	STRUCTURE OF GTP-BINDING PROTEIN Descriptor: G PROTEIN GI ALPHA 1, GUANOSINE-5'-DIPHOSPHATE, PHOSPHATE ION Authors: Berghuis, A.M, Lee, E, Sprang, S.R. Deposit date: 1996-10-16 Release date: 1997-02-12 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Structure of the GDP-Pi complex of Gly203-->Ala gialpha1: a mimic of the ternary product complex of galpha-catalyzed GTP hydrolysis. Structure, 4, 1996
1GG2	G PROTEIN HETEROTRIMER MUTANT GI_ALPHA_1(G203A) BETA_1 GAMMA_2 WITH GDP BOUND Descriptor: G PROTEIN GI ALPHA 1, G PROTEIN GI BETA 1, G PROTEIN GI GAMMA 2, ... Authors: Wall, M.A, Sprang, S.R. Deposit date: 1996-11-13 Release date: 1997-02-12 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.4 Å) Cite: The structure of the G protein heterotrimer Gi alpha 1 beta 1 gamma 2. Cell(Cambridge,Mass.), 83, 1995
1GP2	G PROTEIN HETEROTRIMER GI_ALPHA_1 BETA_1 GAMMA_2 WITH GDP BOUND Descriptor: G PROTEIN GI ALPHA 1, G PROTEIN GI BETA 1, G PROTEIN GI GAMMA 2, ... Authors: Wall, M.A, Sprang, S.R. Deposit date: 1996-11-13 Release date: 1997-02-12 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.3 Å) Cite: The structure of the G protein heterotrimer Gi alpha 1 beta 1 gamma 2. Cell(Cambridge,Mass.), 83, 1995
1AGR	COMPLEX OF ALF4-ACTIVATED GI-ALPHA-1 WITH RGS4 Descriptor: CITRIC ACID, GUANINE NUCLEOTIDE-BINDING PROTEIN G(I), GUANOSINE-5'-DIPHOSPHATE, ... Authors: Tesmer, J.J.G, Sprang, S.R. Deposit date: 1997-03-25 Release date: 1997-06-16 Last modified: 2023-08-02 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Structure of RGS4 bound to AlF4--activated G(i alpha1): stabilization of the transition state for GTP hydrolysis. Cell(Cambridge,Mass.), 89, 1997
1AS2	GDP+PI BOUND G42V GIA1 Descriptor: GIA1, GUANOSINE-5'-DIPHOSPHATE, PHOSPHATE ION Authors: Raw, A.S, Coleman, D.E, Gilman, A.G, Sprang, S.R. Deposit date: 1997-08-11 Release date: 1997-11-12 Last modified: 2023-08-02 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Structural and biochemical characterization of the GTPgammaS-, GDP.Pi-, and GDP-bound forms of a GTPase-deficient Gly42 --> Val mutant of Gialpha1. Biochemistry, 36, 1997
1AS0	GTP-GAMMA-S BOUND G42V GIA1 Descriptor: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, GIA1, MAGNESIUM ION, ... Authors: Raw, A.S, Coleman, D.E, Gilman, A.G, Sprang, S.R. Deposit date: 1997-08-11 Release date: 1997-11-12 Last modified: 2023-08-02 Method: X-RAY DIFFRACTION (2 Å) Cite: Structural and biochemical characterization of the GTPgammaS-, GDP.Pi-, and GDP-bound forms of a GTPase-deficient Gly42 --> Val mutant of Gialpha1. Biochemistry, 36, 1997
1AS3	GDP BOUND G42V GIA1 Descriptor: GIA1, GUANOSINE-5'-DIPHOSPHATE, SULFATE ION Authors: Raw, A.S, Coleman, D.E, Gilman, A.G, Sprang, S.R. Deposit date: 1997-08-11 Release date: 1997-11-12 Last modified: 2023-08-02 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Structural and biochemical characterization of the GTPgammaS-, GDP.Pi-, and GDP-bound forms of a GTPase-deficient Gly42 --> Val mutant of Gialpha1. Biochemistry, 36, 1997
1AZS	COMPLEX OF GS-ALPHA WITH THE CATALYTIC DOMAINS OF MAMMALIAN ADENYLYL CYCLASE Descriptor: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, GS-ALPHA, IIC2, ... Authors: Tesmer, J.J.G, Sprang, S.R. Deposit date: 1997-11-20 Release date: 1998-02-25 Last modified: 2023-08-02 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Crystal structure of the catalytic domains of adenylyl cyclase in a complex with Gsalpha.GTPgammaS. Science, 278, 1997
1AZT	GS-ALPHA COMPLEXED WITH GTP-GAMMA-S Descriptor: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, GS-ALPHA, MAGNESIUM ION, ... Authors: Tesmer, J.J.G, Sprang, S.R. Deposit date: 1997-11-20 Release date: 1998-02-25 Last modified: 2023-08-02 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Crystal structure of the adenylyl cyclase activator Gsalpha Science, 278, 1997
1BH2	A326S MUTANT OF AN INHIBITORY ALPHA SUBUNIT Descriptor: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, GUANINE NUCLEOTIDE-BINDING PROTEIN, MAGNESIUM ION Authors: Mixon, M.B, Posner, B.A, Wall, M.A, Gilman, A.G, Sprang, S.R. Deposit date: 1998-06-12 Release date: 1998-11-04 Last modified: 2023-08-02 Method: X-RAY DIFFRACTION (2.1 Å) Cite: The A326S mutant of Gialpha1 as an approximation of the receptor-bound state. J.Biol.Chem., 273, 1998
1BOF	GI-ALPHA-1 BOUND TO GDP AND MAGNESIUM Descriptor: GI ALPHA 1, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... Authors: Coleman, D.E, Sprang, S.R. Deposit date: 1998-08-04 Release date: 1999-01-06 Last modified: 2023-08-09 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Crystal structures of the G protein Gi alpha 1 complexed with GDP and Mg2+: a crystallographic titration experiment. Biochemistry, 37, 1998
1CIP	GI-ALPHA-1 SUBUNIT OF GUANINE NUCLEOTIDE-BINDING PROTEIN COMPLEXED WITH A GTP ANALOGUE Descriptor: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, PROTEIN (GUANINE NUCLEOTIDE-BINDING PROTEIN ALPHA-1 SUBUNIT) Authors: Coleman, D, Sprang, S. Deposit date: 1999-04-05 Release date: 1999-04-09 Last modified: 2023-08-09 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Structure of Gialpha1.GppNHp, autoinhibition in a galpha protein-substrate complex. J.Biol.Chem., 274, 1999
1CJT	COMPLEX OF GS-ALPHA WITH THE CATALYTIC DOMAINS OF MAMMALIAN ADENYLYL CYCLASE: COMPLEX WITH BETA-L-2',3'-DIDEOXYATP, MN, AND MG Descriptor: 2',3'-DIDEOXYADENOSINE-5'-TRIPHOSPHATE, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, ... Authors: Tesmer, J.J.G, Sprang, S.R. Deposit date: 1999-04-16 Release date: 1999-08-31 Last modified: 2023-08-02 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Two-metal-Ion catalysis in adenylyl cyclase. Science, 285, 1999
1CJK	COMPLEX OF GS-ALPHA WITH THE CATALYTIC DOMAINS OF MAMMALIAN ADENYLYL CYCLASE: COMPLEX WITH ADENOSINE 5'-(ALPHA THIO)-TRIPHOSPHATE (RP), MG, AND MN Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, ADENOSINE-5'-RP-ALPHA-THIO-TRIPHOSPHATE, ... Authors: Tesmer, J.J.G, Sprang, S.R. Deposit date: 1999-04-16 Release date: 1999-08-31 Last modified: 2023-08-09 Method: X-RAY DIFFRACTION (3 Å) Cite: Two-metal-Ion catalysis in adenylyl cyclase. Science, 285, 1999
1CJU	COMPLEX OF GS-ALPHA WITH THE CATALYTIC DOMAINS OF MAMMALIAN ADENYLYL CYCLASE: COMPLEX WITH BETA-L-2',3'-DIDEOXYATP AND MG Descriptor: 2',3'-DIDEOXYADENOSINE-5'-TRIPHOSPHATE, 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, ADENYLATE CYCLASE, ... Authors: Tesmer, J.J.G, Sprang, S.R. Deposit date: 1999-04-16 Release date: 1999-08-31 Last modified: 2023-08-02 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Two-metal-Ion catalysis in adenylyl cyclase. Science, 285, 1999
1CJV	COMPLEX OF GS-ALPHA WITH THE CATALYTIC DOMAINS OF MAMMALIAN ADENYLYL CYCLASE: COMPLEX WITH BETA-L-2',3'-DIDEOXYATP, MG, AND ZN Descriptor: 2',3'-DIDEOXYADENOSINE-5'-TRIPHOSPHATE, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, ... Authors: Tesmer, J.J.G, Sprang, S.R. Deposit date: 1999-04-19 Release date: 1999-08-31 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (3 Å) Cite: Two-metal-Ion catalysis in adenylyl cyclase. Science, 285, 1999
1CS4	COMPLEX OF GS-ALPHA WITH THE CATALYTIC DOMAINS OF MAMMALIAN ADENYLYL CYCLASE: COMPLEX WITH 2'-DEOXY-ADENOSINE 3'-MONOPHOSPHATE, PYROPHOSPHATE AND MG Descriptor: 2'-DEOXY-ADENOSINE 3'-MONOPHOSPHATE, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, ... Authors: Tesmer, J.J.G, Dessauer, C.A, Sunahara, R.K, Johnson, R.A, Gilman, A.G, Sprang, S.R. Deposit date: 1999-08-16 Release date: 2001-01-10 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Molecular basis for P-site inhibition of adenylyl cyclase. Biochemistry, 39, 2000

 

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