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1AS0
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1as0
GTP-GAMMA-S BOUND G42V GIA1
Descriptor:GIA1, 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE
Authors:Raw, A.S., Coleman, D.E., Gilman, A.G., Sprang, S.R.
Deposit date:1997-08-11
Release date:1997-11-12
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural and biochemical characterization of the GTPgammaS-, GDP.Pi-, and GDP-bound forms of a GTPase-deficient Gly42 --> Val mutant of Gialpha1.
Biochemistry, 36, 1997
1AS2
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1as2
GDP+PI BOUND G42V GIA1
Descriptor:GIA1, GUANOSINE-5'-DIPHOSPHATE
Authors:Raw, A.S., Coleman, D.E., Gilman, A.G., Sprang, S.R.
Deposit date:1997-08-11
Release date:1997-11-12
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural and biochemical characterization of the GTPgammaS-, GDP.Pi-, and GDP-bound forms of a GTPase-deficient Gly42 --> Val mutant of Gialpha1.
Biochemistry, 36, 1997
1AS3
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1as3
GDP BOUND G42V GIA1
Descriptor:GIA1, GUANOSINE-5'-DIPHOSPHATE
Authors:Raw, A.S., Coleman, D.E., Gilman, A.G., Sprang, S.R.
Deposit date:1997-08-11
Release date:1997-11-12
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural and biochemical characterization of the GTPgammaS-, GDP.Pi-, and GDP-bound forms of a GTPase-deficient Gly42 --> Val mutant of Gialpha1.
Biochemistry, 36, 1997
1AZT
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1azt
GS-ALPHA COMPLEXED WITH GTP-GAMMA-S
Descriptor:GS-ALPHA, 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE
Authors:Tesmer, J.J.G., Sprang, S.R.
Deposit date:1997-11-20
Release date:1998-02-25
Modification date:2013-08-07
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of the adenylyl cyclase activator Gsalpha
Science, 278, 1997
1BH2
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1bh2
A326S MUTANT OF AN INHIBITORY ALPHA SUBUNIT
Descriptor:GUANINE NUCLEOTIDE-BINDING PROTEIN, 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE
Authors:Mixon, M.B., Posner, B.A., Wall, M.A., Gilman, A.G., Sprang, S.R.
Deposit date:1998-06-12
Release date:1998-11-04
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The A326S mutant of Gialpha1 as an approximation of the receptor-bound state.
J.Biol.Chem., 273, 1998
1BOF
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1bof
GI-ALPHA-1 BOUND TO GDP AND MAGNESIUM
Descriptor:GI ALPHA 1, GUANOSINE-5'-DIPHOSPHATE
Authors:Coleman, D.E., Sprang, S.R.
Deposit date:1998-08-04
Release date:1999-01-06
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structures of the G protein Gi alpha 1 complexed with GDP and Mg2+: a crystallographic titration experiment.
Biochemistry, 37, 1998
1CIP
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1cip
GI-ALPHA-1 SUBUNIT OF GUANINE NUCLEOTIDE-BINDING PROTEIN COMPLEXED WITH A GTP ANALOGUE
Descriptor:GUANINE NUCLEOTIDE-BINDING PROTEIN ALPHA-1 SUBUNIT
Authors:Coleman, D., Sprang, S.
Deposit date:1999-04-05
Release date:1999-04-09
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structure of Gialpha1.GppNHp, autoinhibition in a galpha protein-substrate complex.
J.Biol.Chem., 274, 1999
1GDD
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1gdd
TERTIARY AND QUATERNARY STRUCTURAL CHANGES IN GIA1 INDUCED BY GTP HYDROLYSIS
Descriptor:GI ALPHA 1, GUANOSINE-5'-DIPHOSPHATE
Authors:Mixon, M.B., Sprang, S.R.
Deposit date:1995-07-25
Release date:1995-11-27
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Tertiary and quaternary structural changes in Gi alpha 1 induced by GTP hydrolysis.
Science, 270, 1995
1GFI
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1gfi
STRUCTURES OF ACTIVE CONFORMATIONS OF GI ALPHA 1 AND THE MECHANISM OF GTP HYDROLYSIS
Descriptor:GUANINE NUCLEOTIDE-BINDING PROTEIN G(I), ALPHA-1 SUBUNIT (G(I)-ALPHA-1) (ACTIVE FORM) COMPLEXED WITH GDP-ALF4
Authors:Coleman, D.E., Berghuis, A.M., Sprang, S.R.
Deposit date:1994-11-11
Release date:1995-03-31
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structures of active conformations of Gi alpha 1 and the mechanism of GTP hydrolysis.
Science, 265, 1994
1GIA
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1gia
STRUCTURE OF ACTIVE CONFORMATIONS OF GIA1 AND THE MECHANISM OF GTP HYDROLYSIS
Descriptor:GI ALPHA 1 (ACTIVE FORM WITH BOUND GTP-GAMMA-S)
Authors:Berghuis, A.M., Coleman, D.E., Sprang, S.R.
Deposit date:1994-07-20
Release date:1994-09-30
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structures of active conformations of Gi alpha 1 and the mechanism of GTP hydrolysis.
Science, 265, 1994
1GIL
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1gil
STRUCTURE OF ACTIVE CONFORMATIONS OF GIA1 AND THE MECHANISM OF GTP HYDROLYSIS
Descriptor:G I ALPHA1 (GUANINE NUCLEOTIDE-BINDING PROTEIN G(I), ALPHA-1 SUBUNIT) MUTANT WITH GLN 204 REPLACED BY LEU (Q204L) COMPLEXED WITH GTP-GAMMA-S AND MAGNESIUM
Authors:Coleman, D.E., Berghuis, A.M., Sprang, S.R.
Deposit date:1995-01-02
Release date:1995-02-14
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structures of active conformations of Gi alpha 1 and the mechanism of GTP hydrolysis.
Science, 265, 1994
1GIT
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1git
STRUCTURE OF GTP-BINDING PROTEIN
Descriptor:G PROTEIN GI ALPHA 1, GUANOSINE-5'-DIPHOSPHATE
Authors:Berghuis, A.M., Lee, E., Sprang, S.R.
Deposit date:1996-10-16
Release date:1997-02-12
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure of the GDP-Pi complex of Gly203-->Ala gialpha1: a mimic of the ternary product complex of galpha-catalyzed GTP hydrolysis.
Structure, 4, 1996
1SVK
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1svk
STRUCTURE OF THE K180P MUTANT OF GI ALPHA SUBUNIT BOUND TO ALF4 AND GDP
Descriptor:Guanine nucleotide-binding protein G(i), alpha-1 subunit (E.C.3.6.1.46)
Authors:Thomas, C.J., Du, X., Li, P., Wang, Y., Ross, E.M., Sprang, S.R.
Deposit date:2004-03-29
Release date:2004-06-01
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Uncoupling conformational change from GTP hydrolysis in a heterotrimeric G protein {alpha}-subunit.
Proc.Natl.Acad.Sci.USA, 101, 2004
1SVS
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1svs
STRUCTURE OF THE K180P MUTANT OF GI ALPHA SUBUNIT BOUND TO GPPNHP.
Descriptor:Guanine nucleotide-binding protein G(i), alpha-1 subunit
Authors:Thomas, C.J., Du, X., Li, P., Wang, Y., Ross, E.M., Sprang, S.R.
Deposit date:2004-03-29
Release date:2004-06-01
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Uncoupling conformational change from GTP hydrolysis in a heterotrimeric G protein {alpha}-subunit.
Proc.Natl.Acad.Sci.USA, 101, 2004
1TAD
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1tad
GTPASE MECHANISM OF GPROTEINS FROM THE 1.7-ANGSTROM CRYSTAL STRUCTURE OF TRANSDUCIN ALPHA-GDP-ALF4-
Descriptor:TRANSDUCIN-ALPHA (GT-ALPHA-GDP-ALF, T-ALPHA-GDP-ALF) COMPLEXED WITH GDP AND ALUMINUM FLUORIDE
Authors:Sondek, J., Lambright, D.G., Noel, J.P., Hamm, H.E., Sigler, P.B.
Deposit date:1995-01-05
Release date:1995-05-08
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:GTPase mechanism of Gproteins from the 1.7-A crystal structure of transducin alpha-GDP-AIF-4.
Nature, 372, 1994
1TAG
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1tag
STRUCTURAL DETERMINANTS FOR ACTIVATION OF THE ALPHA-SUBUNIT OF A HETEROTRIMERIC G PROTEIN
Descriptor:TRANSDUCIN-ALPHA COMPLEXED WITH GDP AND MAGNESIUM (GT-ALPHA-GDP, T-ALPHA-GDP)
Authors:Lambright, D.G., Noel, J.P., Hamm, H.E., Sigler, P.B.
Deposit date:1994-11-23
Release date:1995-02-07
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural determinants for activation of the alpha-subunit of a heterotrimeric G protein.
Nature, 369, 1994
1TND
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1tnd
THE 2.2 ANGSTROMS CRYSTAL STRUCTURE OF TRANSDUCIN-ALPHA COMPLEXED WITH GTP GAMMA S
Descriptor:TRANSDUCIN (ALPHA SUBUNIT) COMPLEXED WITH THE NONHYDROLYZABLE GTP ANALOGUE GTP GAMMA S
Authors:Noel, J.P., Hamm, H.E., Sigler, P.B.
Deposit date:1994-03-31
Release date:1994-07-31
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The 2.2 A crystal structure of transducin-alpha complexed with GTP gamma S.
Nature, 366, 1993
1Y3A
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1y3a
STRUCTURE OF G-ALPHA-I1 BOUND TO A GDP-SELECTIVE PEPTIDE PROVIDES INSIGHT INTO GUANINE NUCLEOTIDE EXCHANGE
Descriptor:Guanine nucleotide-binding protein G(i), alpha-1 subunit, KB752 peptide
Authors:Johnston, C.A., Willard, F.S., Jezyk, M.R., Fredericks, Z., Bodor, E.T., Jones, M.B., Blaesius, R., Harden, T.K., Sondek, J., Watts, V.J., Ramer, J.K., Siderovski, D.P.
Deposit date:2004-11-24
Release date:2005-07-12
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of G-Alpha-I1 bound to a GDP-selective peptide provides insight into guanine nucleotide exchange
Structure, 7, 2005
1ZCA
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1zca
CRYSTAL STRUCTURE OF G ALPHA 12 IN COMPLEX WITH GDP, MG2+ AND ALF4-
Descriptor:Galphai/12
Authors:Nance, M.R., Tesmer, J.J.G.
Deposit date:2005-04-11
Release date:2005-11-15
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:A new approach to producing functional G alpha subunits yields the activated and deactivated structures of G alpha(12/13) proteins.
Biochemistry, 45, 2006
1ZCB
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1zcb
CRYSTAL STRUCTURE OF G ALPHA 13 IN COMPLEX WITH GDP
Descriptor:G alpha i/13
Authors:Nance, M.R., Tesmer, J.J.G.
Deposit date:2005-04-11
Release date:2005-11-15
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:A new approach to producing functional G alpha subunits yields the activated and deactivated structures of G alpha(12/13) proteins.
Biochemistry, 45, 2006
2G83
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2g83
STRUCTURE OF ACTIVATED G-ALPHA-I1 BOUND TO A NUCLEOTIDE-STATE-SELECTIVE PEPTIDE: MINIMAL DETERMINANTS FOR RECOGNIZING THE ACTIVE FORM OF A G PROTEIN ALPHA SUBUNIT
Descriptor:KB-1753 phage display peptide, Guanine nucleotide-binding protein G(i), alpha-1 subunit
Authors:Johnston, C.A., Ramer, J.K., Blaesius, R., Kuhlman, B., Arshavsky, V.Y., Siderovski, D.P.
Deposit date:2006-03-01
Release date:2006-10-10
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Minimal Determinants for Binding Activated Galpha from the Structure of a Galpha(i1)-Peptide Dimer.
Biochemistry, 45, 2006
2XTZ
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2xtz
CRYSTAL STRUCTURE OF THE G ALPHA PROTEIN ATGPA1 FROM ARABIDOPSIS THALIANA
Descriptor:GUANINE NUCLEOTIDE-BINDING PROTEIN ALPHA-1 SUBUNIT (E.C.3.6.5.1)
Authors:Jones, J.C., Duffy, J.W., Machius, M., Temple, B.R.S., Dohlman, H.G., Jones, A.M.
Deposit date:2010-10-13
Release date:2011-02-16
Modification date:2011-04-13
Method:X-RAY DIFFRACTION (2.34 Å)
Cite:The Crystal Structure of a Self-Activating G Protein Alpha Subunit Reveals its Distinct Mechanism of Signal Initiation
Sci.Signal., 159, 2011
2ZJY
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2zjy
STRUCTURE OF THE K349P MUTANT OF GI ALPHA 1 SUBUNIT BOUND TO ALF4 AND GDP
Descriptor:Guanine nucleotide-binding protein G(i), alpha-1 subunit (E.C.3.6.5.1)
Authors:Morikawa, T., Muroya, A., Sugio, S., Wakamatsu, K., Kohno, T.
Deposit date:2008-03-11
Release date:2009-03-24
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:How GPCRs activate G proteins: Structural changes form C-terminal tail to GDP binding pocket
To be Published
2ZJZ
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2zjz
STRUCTURE OF THE K349P MUTANT OF GI ALPHA 1 SUBUNIT BOUND TO GDP
Descriptor:Guanine nucleotide-binding protein G(i), alpha-1 subunit (E.C.3.6.5.1)
Authors:Morikawa, T., Muroya, A., Sugio, S., Wakamatsu, K., Kohno, T.
Deposit date:2008-03-11
Release date:2009-03-24
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:How GPCRs activate G proteins: Structural changes from C-terminal tail to GDP binding pocket
To be Published
3D7M
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3d7m
CRYSTAL STRUCTURE OF THE G PROTEIN FAST-EXCHANGE DOUBLE MUTANT I56C/Q333C
Descriptor:Guanine nucleotide-binding protein G(i), alpha-1 subunit
Authors:Funk, M.A., Preininger, A.M., Oldham, W.M., Meier, S.M., Hamm, H.E., Iverson, T.M.
Deposit date:2008-05-21
Release date:2009-03-03
Modification date:2009-09-22
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Helix dipole movement and conformational variability contribute to allosteric GDP release in Galphai subunits.
Biochemistry, 48, 2009
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entries available on 2014-12-17
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