Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

5JS8
DownloadVisualize
BU of 5js8 by Molmil
Structural Model of a Protein alpha subunit in complex with GDP obtained with SAXS and NMR residual couplings
Descriptor: Guanine nucleotide-binding protein G(i) subunit alpha-1
Authors:Goricanec, D, Stehle, R, Grigoriu, S, Wagner, G, Hagn, F.
Deposit date:2016-05-07
Release date:2016-06-29
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Conformational dynamics of a G-protein alpha subunit is tightly regulated by nucleotide binding.
Proc.Natl.Acad.Sci.USA, 113, 2016
1AZT
DownloadVisualize
BU of 1azt by Molmil
GS-ALPHA COMPLEXED WITH GTP-GAMMA-S
Descriptor: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, GS-ALPHA, MAGNESIUM ION, ...
Authors:Tesmer, J.J.G, Sprang, S.R.
Deposit date:1997-11-20
Release date:1998-02-25
Last modified:2023-08-02
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of the adenylyl cyclase activator Gsalpha
Science, 278, 1997
6AU6
DownloadVisualize
BU of 6au6 by Molmil
Crystal structure of GDP-bound human GNAS R201C mutant
Descriptor: CHLORIDE ION, GLYCEROL, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Hu, Q, Shokat, K.M.
Deposit date:2017-08-30
Release date:2018-05-09
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Disease-Causing Mutations in the G Protein G alpha s Subvert the Roles of GDP and GTP.
Cell, 173, 2018
1ZCB
DownloadVisualize
BU of 1zcb by Molmil
Crystal structure of G alpha 13 in complex with GDP
Descriptor: G alpha i/13, GUANOSINE-5'-DIPHOSPHATE
Authors:Nance, M.R, Tesmer, J.J.G.
Deposit date:2005-04-11
Release date:2005-11-15
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2 Å)
Cite:A new approach to producing functional G alpha subunits yields the activated and deactivated structures of G alpha(12/13) proteins.
Biochemistry, 45, 2006
5KDL
DownloadVisualize
BU of 5kdl by Molmil
Crystal structure of the 4 alanine insertion variant of the Gi alpha1 subunit bound to GTPgammaS
Descriptor: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, Guanine nucleotide-binding protein G(i) subunit alpha-1, MAGNESIUM ION
Authors:Kaya, A.I, Lokits, A.D, Gilbert, J, Iverson, T.M, Meiler, J, Hamm, H.E.
Deposit date:2016-06-08
Release date:2016-08-03
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.665 Å)
Cite:A Conserved Hydrophobic Core in G alpha i1 Regulates G Protein Activation and Release from Activated Receptor.
J.Biol.Chem., 291, 2016
5JS7
DownloadVisualize
BU of 5js7 by Molmil
Structural model of a apo G-protein alpha subunit determined with NMR residual dipolar couplings and SAXS
Descriptor: Guanine nucleotide-binding protein G(i) subunit alpha-1
Authors:Goricanec, D, Stehle, R, Grigoriu, S, Wagner, G, Hagn, F.
Deposit date:2016-05-07
Release date:2016-06-29
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Conformational dynamics of a G-protein alpha subunit is tightly regulated by nucleotide binding.
Proc.Natl.Acad.Sci.USA, 113, 2016
1ZCA
DownloadVisualize
BU of 1zca by Molmil
Crystal structure of G alpha 12 in complex with GDP, Mg2+ and AlF4-
Descriptor: G alpha i/12, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Nance, M.R, Tesmer, J.J.G.
Deposit date:2005-04-11
Release date:2005-11-15
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:A new approach to producing functional G alpha subunits yields the activated and deactivated structures of G alpha(12/13) proteins.
Biochemistry, 45, 2006
3UMS
DownloadVisualize
BU of 3ums by Molmil
Crystal structure of the G202A mutant of human G-alpha-i1
Descriptor: CHLORIDE ION, GUANOSINE-5'-DIPHOSPHATE, Guanine nucleotide-binding protein G(i) subunit alpha-1, ...
Authors:Lambert, N.A, Johnston, C.A, Cappell, S.D, Kuravi, S, Kimple, A.J, Willard, F.S, Siderovski, D.P.
Deposit date:2011-11-14
Release date:2012-02-08
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.343 Å)
Cite:Correction for Regulators of G-protein Signaling accelerate GPCR signaling kinetics and govern sensitivity solely by accelerating GTPase activity
Proc.Natl.Acad.Sci.USA, 2012
3UMR
DownloadVisualize
BU of 3umr by Molmil
Crystal structure of the G202D mutant of human G-alpha-i1
Descriptor: CHLORIDE ION, GLYCEROL, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Johnston, C.A, Afshar, K, Snyder, J.T, Tall, G.G, Gonczy, P, Siderovski, D.P, Willard, F.S.
Deposit date:2011-11-14
Release date:2012-10-24
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.04 Å)
Cite:Structural Determinants Underlying the Temperature-sensitive Nature of a G-alpha Mutant in Asymmetric Cell Division of Caenorhabditis elegans
To be Published
3V00
DownloadVisualize
BU of 3v00 by Molmil
Studies of a constitutively active G-alpha subunit provide insights into the mechanism of G protein activation.
Descriptor: GUANOSINE-5'-DIPHOSPHATE, Guanine nucleotide-binding protein G(t) subunit alpha-1/ Guanine nucleotide-binding protein G(i) subunit alpha-1 chimeric protein
Authors:Singh, G, Cerione, R.A.
Deposit date:2011-12-07
Release date:2012-04-18
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:A constitutively active G-alpha subunit provide insights into the mechanism of G protein activation
Biochemistry, 51, 2012
3QE0
DownloadVisualize
BU of 3qe0 by Molmil
A Galpha-i1 P-loop mutation prevents transition to the activated state
Descriptor: GUANOSINE-5'-DIPHOSPHATE, Guanine nucleotide-binding protein G(i) subunit alpha-1, KB752 peptide, ...
Authors:Bosch, D.E, Willard, F.S, Kimple, A.J, Miley, M.J, Siderovski, D.P.
Deposit date:2011-01-19
Release date:2012-01-25
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:A P-loop Mutation in Galpha Subunits Prevents Transition to the Active State: Implications for G-protein Signaling in Fungal Pathogenesis
Plos Pathog., 8, 2012
2XTZ
DownloadVisualize
BU of 2xtz by Molmil
Crystal structure of the G alpha protein AtGPA1 from Arabidopsis thaliana
Descriptor: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, CHLORIDE ION, GUANINE NUCLEOTIDE-BINDING PROTEIN ALPHA-1 SUBUNIT, ...
Authors:Jones, J.C, Duffy, J.W, Machius, M, Temple, B.R.S, Dohlman, H.G, Jones, A.M.
Deposit date:2010-10-13
Release date:2011-02-16
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.34 Å)
Cite:The Crystal Structure of a Self-Activating G Protein Alpha Subunit Reveals its Distinct Mechanism of Signal Initiation
Sci.Signal., 159, 2011
2ZJZ
DownloadVisualize
BU of 2zjz by Molmil
Structure of the K349P mutant of Gi alpha 1 subunit bound to GDP
Descriptor: GUANOSINE-5'-DIPHOSPHATE, Guanine nucleotide-binding protein G(i), alpha-1 subunit
Authors:Morikawa, T, Muroya, A, Sugio, S, Wakamatsu, K, Kohno, T.
Deposit date:2008-03-11
Release date:2009-03-24
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:How GPCRs activate G proteins: Structural changes from C-terminal tail to GDP binding pocket
To be Published
2ZJY
DownloadVisualize
BU of 2zjy by Molmil
Structure of the K349P mutant of Gi alpha 1 subunit bound to ALF4 and GDP
Descriptor: GUANOSINE-5'-DIPHOSPHATE, Guanine nucleotide-binding protein G(i), alpha-1 subunit, ...
Authors:Morikawa, T, Muroya, A, Sugio, S, Wakamatsu, K, Kohno, T.
Deposit date:2008-03-11
Release date:2009-03-24
Last modified:2021-11-10
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:How GPCRs activate G proteins: Structural changes form C-terminal tail to GDP binding pocket
To be Published
1BH2
DownloadVisualize
BU of 1bh2 by Molmil
A326S MUTANT OF AN INHIBITORY ALPHA SUBUNIT
Descriptor: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, GUANINE NUCLEOTIDE-BINDING PROTEIN, MAGNESIUM ION
Authors:Mixon, M.B, Posner, B.A, Wall, M.A, Gilman, A.G, Sprang, S.R.
Deposit date:1998-06-12
Release date:1998-11-04
Last modified:2023-08-02
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The A326S mutant of Gialpha1 as an approximation of the receptor-bound state.
J.Biol.Chem., 273, 1998
1AS2
DownloadVisualize
BU of 1as2 by Molmil
GDP+PI BOUND G42V GIA1
Descriptor: GIA1, GUANOSINE-5'-DIPHOSPHATE, PHOSPHATE ION
Authors:Raw, A.S, Coleman, D.E, Gilman, A.G, Sprang, S.R.
Deposit date:1997-08-11
Release date:1997-11-12
Last modified:2023-08-02
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural and biochemical characterization of the GTPgammaS-, GDP.Pi-, and GDP-bound forms of a GTPase-deficient Gly42 --> Val mutant of Gialpha1.
Biochemistry, 36, 1997
1AS0
DownloadVisualize
BU of 1as0 by Molmil
GTP-GAMMA-S BOUND G42V GIA1
Descriptor: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, GIA1, MAGNESIUM ION, ...
Authors:Raw, A.S, Coleman, D.E, Gilman, A.G, Sprang, S.R.
Deposit date:1997-08-11
Release date:1997-11-12
Last modified:2023-08-02
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural and biochemical characterization of the GTPgammaS-, GDP.Pi-, and GDP-bound forms of a GTPase-deficient Gly42 --> Val mutant of Gialpha1.
Biochemistry, 36, 1997
1AS3
DownloadVisualize
BU of 1as3 by Molmil
GDP BOUND G42V GIA1
Descriptor: GIA1, GUANOSINE-5'-DIPHOSPHATE, SULFATE ION
Authors:Raw, A.S, Coleman, D.E, Gilman, A.G, Sprang, S.R.
Deposit date:1997-08-11
Release date:1997-11-12
Last modified:2023-08-02
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural and biochemical characterization of the GTPgammaS-, GDP.Pi-, and GDP-bound forms of a GTPase-deficient Gly42 --> Val mutant of Gialpha1.
Biochemistry, 36, 1997
1BOF
DownloadVisualize
BU of 1bof by Molmil
GI-ALPHA-1 BOUND TO GDP AND MAGNESIUM
Descriptor: GI ALPHA 1, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Coleman, D.E, Sprang, S.R.
Deposit date:1998-08-04
Release date:1999-01-06
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structures of the G protein Gi alpha 1 complexed with GDP and Mg2+: a crystallographic titration experiment.
Biochemistry, 37, 1998
2G83
DownloadVisualize
BU of 2g83 by Molmil
Structure of activated G-alpha-i1 bound to a nucleotide-state-selective peptide: Minimal determinants for recognizing the active form of a G protein alpha subunit
Descriptor: GUANOSINE-5'-DIPHOSPHATE, Guanine nucleotide-binding protein G(i), alpha-1 subunit, ...
Authors:Johnston, C.A, Ramer, J.K, Blaesius, R, Kuhlman, B, Arshavsky, V.Y, Siderovski, D.P.
Deposit date:2006-03-01
Release date:2006-10-10
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Minimal Determinants for Binding Activated Galpha from the Structure of a Galpha(i1)-Peptide Dimer.
Biochemistry, 45, 2006
4FID
DownloadVisualize
BU of 4fid by Molmil
Crystal structure of a heterotrimeric G-Protein subunit from entamoeba histolytica, EHG-ALPHA-1
Descriptor: G protein alpha subunit, GUANOSINE-5'-DIPHOSPHATE
Authors:Bosch, D.E, Kimple, A.J, Muller, R.E, Gigure, P.M, Willard, F.S, Machius, M, Temple, B.R, Siderovski, D.P.
Deposit date:2012-06-08
Release date:2012-11-28
Last modified:2013-06-26
Method:X-RAY DIFFRACTION (2.62 Å)
Cite:Heterotrimeric G-protein Signaling Is Critical to Pathogenic Processes in Entamoeba histolytica.
Plos Pathog., 8, 2012
4N0E
DownloadVisualize
BU of 4n0e by Molmil
Crystal structure of the K345L variant of the Gi alpha1 subunit bound to GDP
Descriptor: GUANOSINE-5'-DIPHOSPHATE, Guanine nucleotide-binding protein G(i) subunit alpha-1, SULFATE ION
Authors:Thaker, T.M, Preininger, A.M, Sarwar, M, Hamm, H.E, Iverson, T.M.
Deposit date:2013-10-01
Release date:2014-03-12
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:A Transient Interaction between the Phosphate Binding Loop and Switch I Contributes to the Allosteric Network between Receptor and Nucleotide in G alpha i1.
J.Biol.Chem., 289, 2014
4N0D
DownloadVisualize
BU of 4n0d by Molmil
Crystal structure of the K345L variant of the Gi alpha1 subunit bound to GTPgammaS
Descriptor: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, Guanine nucleotide-binding protein G(i) subunit alpha-1, MAGNESIUM ION, ...
Authors:Thaker, T.M, Preininger, A.M, Sarwar, M, Hamm, H.E, Iverson, T.M.
Deposit date:2013-10-01
Release date:2014-03-12
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:A Transient Interaction between the Phosphate Binding Loop and Switch I Contributes to the Allosteric Network between Receptor and Nucleotide in G alpha i1.
J.Biol.Chem., 289, 2014
4PAN
DownloadVisualize
BU of 4pan by Molmil
A conserved phenylalanine as relay between the 5 helix and the GDP binding region of heterotrimeric G protein
Descriptor: CHLORIDE ION, GUANOSINE-5'-DIPHOSPHATE, Guanine nucleotide-binding protein G(i) subunit alpha-1, ...
Authors:Kaya, A.I, Lokits, A.D, Gilbert, J, Iverson, T.M, Meiler, J, Hamm, H.E.
Deposit date:2014-04-09
Release date:2014-07-30
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:A Conserved Phenylalanine as a Relay between the alpha 5 Helix and the GDP Binding Region of Heterotrimeric Gi Protein alpha Subunit.
J.Biol.Chem., 289, 2014
4PAQ
DownloadVisualize
BU of 4paq by Molmil
A conserved phenylalanine as relay between the 5 helix and the GDP binding region of heterotrimeric G protein
Descriptor: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, Guanine nucleotide-binding protein G(i) subunit alpha-1, MAGNESIUM ION
Authors:Kaya, A.I, Lokits, A.D, Gilbert, J, Iverson, T.M, Meiler, J, Hamm, H.E.
Deposit date:2014-04-09
Release date:2014-07-30
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2 Å)
Cite:A Conserved Phenylalanine as a Relay between the alpha 5 Helix and the GDP Binding Region of Heterotrimeric Gi Protein alpha Subunit.
J.Biol.Chem., 289, 2014

217705

PDB entries from 2024-03-27

PDB statisticsPDBj update infoContact PDBjnumon