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1ALU
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1alu
HUMAN INTERLEUKIN-6
Descriptor:INTERLEUKIN-6, TARTARIC ACID
Authors:Somers, W.S., Stahl, M., Seehra, J.S.
Deposit date:1997-06-03
Release date:1998-06-03
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:1.9 A crystal structure of interleukin 6: implications for a novel mode of receptor dimerization and signaling.
EMBO J., 16, 1997
1BGC
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1bgc
CRYSTAL STRUCTURE OF CANINE AND BOVINE GRANULOCYTE-COLONY STIMULATING FACTOR (G-CSF)
Descriptor:GRANULOCYTE COLONY-STIMULATING FACTOR (RBG-CSF)
Authors:Lovejoy, B., Cascio, D., Eisenberg, D.
Deposit date:1993-04-27
Release date:1993-10-31
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal structure of canine and bovine granulocyte-colony stimulating factor (G-CSF).
J.Mol.Biol., 234, 1993
1BGD
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1bgd
CRYSTAL STRUCTURE OF CANINE AND BOVINE GRANULOCYTE-COLONY STIMULATING FACTOR (G-CSF)
Descriptor:GRANULOCYTE COLONY-STIMULATING FACTOR (FORM I, RCG-CSFI)
Authors:Lovejoy, B., Cascio, D., Eisenberg, D.
Deposit date:1993-04-27
Release date:1993-10-31
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of canine and bovine granulocyte-colony stimulating factor (G-CSF).
J.Mol.Biol., 234, 1993
1BGE
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1bge
CRYSTAL STRUCTURE OF CANINE AND BOVINE GRANULOCYTE-COLONY STIMULATING FACTOR (G-CSF)
Descriptor:GRANULOCYTE COLONY-STIMULATING FACTOR (FORM II RCG-CSFII)
Authors:Lovejoy, B., Cascio, D., Eisenberg, D.
Deposit date:1993-04-27
Release date:1993-10-31
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of canine and bovine granulocyte-colony stimulating factor (G-CSF).
J.Mol.Biol., 234, 1993
1CD9
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1cd9
2:2 COMPLEX OF G-CSF WITH ITS RECEPTOR
Descriptor:GRANULOCYTE COLONY-STIMULATING FACTOR/G-CSF RECEPTOR COMPLEX
Authors:Aritomi, M., Kunishima, N., Okamoto, T., Kuroki, R., Ota, Y., Morikawa, K.
Deposit date:1999-03-08
Release date:2000-03-08
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Atomic structure of the GCSF-receptor complex showing a new cytokine-receptor recognition scheme.
Nature, 401, 1999
1GNC
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1gnc
STRUCTURE AND DYNAMICS OF THE HUMAN GRANULOCYTE COLONY-STIMULATING FACTOR DETERMINED BY NMR SPECTROSCOPY. LOOP MOBILITY IN A FOUR-HELIX-BUNDLE PROTEIN
Descriptor:GRANULOCYTE COLONY STIMULATING FACTOR (RH-G-CSF) (NMR, 10 STRUCTURES)
Authors:Zink, T.W., Ross, A., Rudolph, R., Holak, T.A.
Deposit date:1994-03-08
Release date:1994-07-31
Modification date:2009-02-24
Method:SOLUTION NMR
Cite:Structure and dynamics of the human granulocyte colony-stimulating factor determined by NMR spectroscopy. Loop mobility in a four-helix-bundle protein.
Biochemistry, 33, 1994
1IL6
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1il6
HUMAN INTERLEUKIN-6, NMR, MINIMIZED AVERAGE STRUCTURE
Descriptor:INTERLEUKIN-6
Authors:Xu, G.Y., Yu, H.A., Hong, J., Stahl, M., Mcdonagh, T., Kay, L.E., Cumming, D.A.
Deposit date:1997-01-31
Release date:1998-02-04
Modification date:2009-02-24
Method:SOLUTION NMR
Cite:Solution structure of recombinant human interleukin-6.
J.Mol.Biol., 268, 1997
1PGR
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1pgr
2:2 COMPLEX OF G-CSF WITH ITS RECEPTOR
Descriptor:GRANULOCYTE COLONY-STIMULATING FACTOR/G-CSF RECEPTOR COMPLEX
Authors:Aritomi, M., Kunishima, N., Okamoto, T., Kuroki, R., Ota, Y., Morikawa, K.
Deposit date:1999-03-08
Release date:2000-03-08
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Atomic structure of the GCSF-receptor complex showing a new cytokine-receptor recognition scheme.
Nature, 401, 1999
1RHG
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1rhg
THE STRUCTURE OF GRANULOCYTE-COLONY-STIMULATING FACTOR AND ITS RELATIONSHIP TO THOSE OF OTHER GROWTH FACTORS
Descriptor:GRANULOCYTE-COLONY STIMULATING FACTOR (R-HU-GCSF)
Authors:Hill, C.P., Osslund, T.D., Eisenberg, D.
Deposit date:1993-01-29
Release date:1994-01-31
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The structure of granulocyte-colony-stimulating factor and its relationship to other growth factors.
Proc.Natl.Acad.Sci.USA, 90, 1993
2IL6
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2il6
HUMAN INTERLEUKIN-6, NMR, 32 STRUCTURES
Descriptor:INTERLEUKIN-6
Authors:Xu, G.Y., Yu, H.A., Hong, J., Stahl, M., Mcdonagh, T., Kay, L.E., Cumming, D.A.
Deposit date:1997-01-31
Release date:1998-02-04
Modification date:2009-02-24
Method:SOLUTION NMR
Cite:Solution structure of recombinant human interleukin-6.
J.Mol.Biol., 268, 1997
2L3Y
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2l3y
SOLUTION STRUCTURE OF MOUSE IL-6
Descriptor:Interleukin-6
Authors:Veverka, V., Redpath, N.T., Carrington, B., Muskett, F.W., Taylor, R.J., Henry, A.J., Carr, M.D.
Deposit date:2010-09-25
Release date:2011-09-28
Modification date:2013-01-02
Method:SOLUTION NMR
Cite:Conservation of functional sites on interleukin-6 and implications for evolution of signaling complex assembly and therapeutic intervention.
J.Biol.Chem., 287, 2012
4NI7
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4ni7
CRYSTAL STRUCTURE OF HUMAN INTERLEUKIN 6 IN COMPLEX WITH A MODIFIED NUCLEOTIDE APTAMER (SOMAMER SL1025)
Descriptor:Interleukin-6
Authors:Davies, D., Edwards, T., Gelinas, A., Jarvis, T., Clifton, M.
Deposit date:2013-11-05
Release date:2014-01-22
Modification date:2014-04-09
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of interleukin-6 in complex with a modified nucleic Acid ligand.
J.Biol.Chem., 289, 2014
4NI9
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4ni9
CRYSTAL STRUCTURE OF HUMAN INTERLEUKIN 6 IN COMPLEX WITH A MODIFIED NUCLEOTIDE APTAMER (SOMAMER SL1025), FORM 2
Descriptor:PROTEIN/DNA Complex
Authors:Davies, D., Edwards, T., Gelinas, A., Jarvis, T., Clifton, M.
Deposit date:2013-11-05
Release date:2014-01-22
Modification date:2014-04-09
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Crystal structure of interleukin-6 in complex with a modified nucleic Acid ligand.
J.Biol.Chem., 289, 2014
2D9Q
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2d9q
CRYSTAL STRUCTURE OF THE HUMAN GCSF-RECEPTOR SIGNALING COMPLEX
Descriptor:CSF3, Granulocyte colony-stimulating factor receptor
Authors:Tamada, T., Kuroki, R.
Deposit date:2005-12-12
Release date:2006-02-07
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Homodimeric cross-over structure of the human granulocyte colony-stimulating factor (GCSF) receptor signaling complex
Proc.Natl.Acad.Sci.Usa, 103, 2006
3D87
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3d87
CRYSTAL STRUCTURE OF INTERLEUKIN-23
Descriptor:Interleukin-23 subunit p19/Interleukin-12 subunit p40
Authors:Beyer, B.M., Ingram, R., Ramanathan, L., Reichert, P., Le, H., Madison, V.
Deposit date:2008-05-22
Release date:2008-09-02
Modification date:2008-12-23
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal structures of the pro-inflammatory cytokine interleukin-23 and its complex with a high-affinity neutralizing antibody
J.Mol.Biol., 382, 2008
4GRW
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4grw
STRUCTURE OF A COMPLEX OF HUMAN IL-23 WITH 3 NANOBODIES (LLAMA VHHS)
Descriptor:Interleukin-23 subunit alpha, Interleukin-12 subunit beta, Nanobody 124C4, Nanobody 37D5, Nanobody 22E11
Authors:Desmyter, A., Spinelli, S., Button, C., Saunders, M., de Haard, H., Rommelaere, H., Union, A., Cambillau, C.
Deposit date:2012-08-27
Release date:2014-02-19
Modification date:2014-04-16
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Potent Multitopic Nanobody Inhibitors of the Chronic Inflammation Promoting Cytokine hIL23.
To be Published
1I1R
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1i1r
CRYSTAL STRUCTURE OF A CYTOKINE/RECEPTOR COMPLEX
Descriptor:Interleukin-6 receptor beta chain/viral IL-6 complex
Authors:Chow, D., He, X., Snow, A.L., Rose-John, S., Garcia, K.C.
Deposit date:2001-02-02
Release date:2001-03-28
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure of an extracellular gp130 cytokine receptor signaling complex.
Science, 291, 2001
1P9M
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1p9m
CRYSTAL STRUCTURE OF THE HEXAMERIC HUMAN IL-6/IL-6 ALPHA RECEPTOR/GP130 COMPLEX
Descriptor:Interleukin-6 receptor beta chain, Interleukin-6, Interleukin-6 receptor alpha chain
Authors:Boulanger, M.J., Chow, D.C., Brevnova, E.E., Garcia, K.C.
Deposit date:2003-05-12
Release date:2003-07-01
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (3.65 Å)
Cite:Hexameric Structure and Assembly of the Interleukin-6/IL-6 alpha-Receptor/gp130 Complex
Science, 300, 2003
3D85
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3d85
CRYSTAL STRUCTURE OF IL-23 IN COMPLEX WITH NEUTRALIZING FAB
Descriptor:FAB of antibody 7G10 light and heavy chains/Interleukin-23 subunit p19/Interleukin-12 subunit p40
Authors:Beyer, B.M., Ingram, R., Ramanathan, L., Reichert, P., Le, H., Madison, V.
Deposit date:2008-05-22
Release date:2008-09-02
Modification date:2008-12-23
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structures of the pro-inflammatory cytokine interleukin-23 and its complex with a high-affinity neutralizing antibody
J.Mol.Biol., 382, 2008
3DUH
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3duh
STRUCTURE OF INTERLEUKIN-23
Descriptor:Interleukin-12 subunit beta precursor, Interleukin-23 subunit alpha precursor
Authors:Lupardus, P.J., Garcia, K.C.
Deposit date:2008-07-17
Release date:2008-08-19
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The structure of interleukin-23 reveals the molecular basis of p40 subunit sharing with interleukin-12.
J.Mol.Biol., 382, 2008
3QWR
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3qwr
CRYSTAL STRUCTURE OF IL-23 IN COMPLEX WITH AN ADNECTIN
Descriptor:Interleukin-12 subunit beta, Interleukin-23 subunit alpha, ADNECTIN
Authors:Wei, A., Sheriff, S.
Deposit date:2011-02-28
Release date:2012-02-01
Modification date:2012-02-29
Method:X-RAY DIFFRACTION (3.25 Å)
Cite:Structures of adnectin/protein complexes reveal an expanded binding footprint.
Structure, 20, 2012
4J4L
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4j4l
MODULAR EVOLUTION AND DESIGN OF THE PROTEIN BINDING INTERFACE
Descriptor:Internalin B, Variable lymphocyte receptor B, Interleukin-6
Authors:Cheong, H.K., Kim, H.J.
Deposit date:2013-02-07
Release date:2014-02-12
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Modular evolution and design of the protein binding interface
To be Published
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entries available on 2014-10-01
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