1NJW
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GUANINE-THYMINE MISMATCH AT THE POLYMERASE ACTIVE SITE
Descriptor:DNA POLYMERASE I (E.C.2.7.7.7)/DNA Complex
Authors:Johnson, S.J., Beese, L.S.
Deposit date:2003-01-02
Release date:2004-03-30
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structures of mismatch replication errors observed in a DNA polymerase.
Cell(Cambridge,Mass.), 116, 2004
1UA0
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AMINOFLUORENE DNA ADDUCT AT THE PRE-INSERTION SITE OF A DNA POLYMERASE
Descriptor:DNA polymerase I (E.C.2.7.7.7)/DNA Complex
Authors:Hsu, G.W., Kiefer, J.R., Becherel, O.J., Fuchs, R.P.P., Beese, L.S.
Deposit date:2004-08-11
Release date:2004-09-28
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Observing translesion synthesis of an aromatic amine DNA adduct by a high-fidelity DNA polymerase
J.Biol.Chem., 279, 2004
2HHU
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C:O6-METHYL-GUANINE IN THE POLYMERASE POSTINSERTION SITE (-1 BASEPAIR POSITION)
Descriptor:DNA Polymerase I (E.C.2.7.7.7)/DNA Complex
Authors:Warren, J.J., Forsberg, L.J., Beese, L.S.
Deposit date:2006-06-28
Release date:2006-12-12
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The structural basis for the mutagenicity of O6-methyl-guanine lesions.
Proc.Natl.Acad.Sci.Usa, 103, 2006
2HHV
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T:O6-METHYL-GUANINE IN THE POLYMERASE-2 BASEPAIR POSITION
Descriptor:DNA Polymerase I (E.C.2.7.7.7)/DNA Complex
Authors:Warren, J.J., Forsberg, L.J., Beese, L.S.
Deposit date:2006-06-28
Release date:2006-12-12
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:The structural basis for the mutagenicity of O6-methyl-guanine lesions.
Proc.Natl.Acad.Sci.Usa, 103, 2006
2HHW
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DDTTP:O6-METHYL-GUANINE PAIR IN THE POLYMERASE ACTIVE SITE, IN THE CLOSED CONFORMATION
Descriptor:DNA Polymerase I (E.C.2.7.7.7)/DNA Complex
Authors:Warren, J.J., Forsberg, L.J., Beese, L.S.
Deposit date:2006-06-28
Release date:2006-12-12
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:The structural basis for the mutagenicity of O6-methyl-guanine lesions.
Proc.Natl.Acad.Sci.Usa, 103, 2006
2HHX
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O6-METHYL-GUANINE IN THE POLYMERASE TEMPLATE PREINSERTION SITE
Descriptor:DNA polymerase I(E.C.2.7.7.7)/DNA Complex
Authors:Warren, J.J., Forsberg, L.J., Beese, L.S.
Deposit date:2006-06-28
Release date:2006-12-12
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.26 Å)
Cite:The structural basis for the mutagenicity of O6-methyl-guanine lesions.
Proc.Natl.Acad.Sci.Usa, 103, 2006
2HVI
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DDCTP:G PAIR IN THE POLYMERASE ACTIVE SITE (0 POSITION)
Descriptor:DNA polymerase I(E.C.2.7.7.7)/DNA Complex
Authors:Warren, J.J., Forsberg, L.J., Beese, L.S.
Deposit date:2006-07-28
Release date:2006-12-12
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:The structural basis for the mutagenicity of O6-methyl-guanine lesions.
Proc.Natl.Acad.Sci.Usa, 103, 2006
3HP6
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CRYSTAL STRUCTURE OF FRAGMENT DNA POLYMERASE I FROM BACILLUS STEAROTHERMOPHILUS F710Y MUTANT BOUND TO G:T MISMATCH
Descriptor:DNA polymerase I, large fragment (E.C.2.7.7.7)
Authors:Wu, E.Y., Beese, L.S.
Deposit date:2009-06-03
Release date:2010-06-23
Modification date:2011-06-29
Method:X-RAY DIFFRACTION (1.81 Å)
Cite:The structure of a high fidelity DNA polymerase bound to a mismatched nucleotide reveals an "ajar" intermediate conformation in the nucleotide selection mechanism.
J.Biol.Chem., 286, 2011
3HPO
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CRYSTAL STRUCTURE OF FRAGMENT DNA POLYMERASE I FROM BACILLUS STEAROTHERMOPHILUS Y714S MUTANT BOUND TO G:T MISMATCH
Descriptor:DNA polymerase I, large fragment (E.C.2.7.7.7)
Authors:Wu, E.Y., Beese, L.S.
Deposit date:2009-06-04
Release date:2010-06-23
Modification date:2011-06-29
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:The structure of a high fidelity DNA polymerase bound to a mismatched nucleotide reveals an "ajar" intermediate conformation in the nucleotide selection mechanism.
J.Biol.Chem., 286, 2011
3PV8
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CRYSTAL STRUCTURE OF BACILLUS DNA POLYMERASE I LARGE FRAGMENT BOUND TO DNA AND DDTTP-DA IN CLOSED CONFORMATION
Descriptor:DNA polymerase I (E.C.2.7.7.7)
Authors:Wang, W., Beese, L.S.
Deposit date:2010-12-06
Release date:2011-10-19
Modification date:2011-11-09
Method:X-RAY DIFFRACTION (1.52 Å)
Cite:Structural evidence for the rare tautomer hypothesis of spontaneous mutagenesis.
Proc.Natl.Acad.Sci.USA, 108, 2011
3PX0
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CRYSTAL STRUCTURE OF BACILLUS DNA POLYMERASE I LARGE FRAGMENT BOUND TO DNA AND DCTP-DA MISMATCH (TAUTOMER) IN CLOSED CONFORMATION
Descriptor:DNA polymerase I (E.C.2.7.7.7)
Authors:Wang, W., Beese, L.S.
Deposit date:2010-12-09
Release date:2011-10-19
Modification date:2011-11-09
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:Structural evidence for the rare tautomer hypothesis of spontaneous mutagenesis.
Proc.Natl.Acad.Sci.USA, 108, 2011
3PX4
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CRYSTAL STRUCTURE OF BACILLUS DNA POLYMERASE I LARGE FRAGMENT BOUND TO DNA AND DDCTP-DA MISMATCH (WOBBLE) IN AJAR CONFORMATION
Descriptor:DNA polymerase I (E.C.2.7.7.7)
Authors:Wang, W., Beese, L.S.
Deposit date:2010-12-09
Release date:2011-10-19
Modification date:2011-11-09
Method:X-RAY DIFFRACTION (1.582 Å)
Cite:Structural evidence for the rare tautomer hypothesis of spontaneous mutagenesis.
Proc.Natl.Acad.Sci.USA, 108, 2011
3PX6
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CRYSTAL STRUCTURE OF BACILLUS DNA POLYMERASE I LARGE FRAGMENT BOUND TO DNA AND DDCTP-DA MISMATCH (TAUTOMER) IN CLOSED CONFORMATION
Descriptor:DNA polymerase I (E.C.2.7.7.7)
Authors:Wang, W., Beese, L.S.
Deposit date:2010-12-09
Release date:2011-10-19
Modification date:2011-11-09
Method:X-RAY DIFFRACTION (1.59 Å)
Cite:Structural evidence for the rare tautomer hypothesis of spontaneous mutagenesis.
Proc.Natl.Acad.Sci.USA, 108, 2011
4DQI
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TERNARY COMPLEX OF BACILLUS DNA POLYMERASE I LARGE FRAGMENT, DNA DUPLEX, AND DCTP (PAIRED WITH DG OF TEMPLATE)
Descriptor:DNA polymerase I (E.C.2.7.7.7)/DNA complex
Authors:Wang, W., Beese, L.S.
Deposit date:2012-02-15
Release date:2012-06-06
Modification date:2012-09-05
Method:X-RAY DIFFRACTION (1.69 Å)
Cite:Structural factors that determine selectivity of a high fidelity DNA polymerase for deoxy-, dideoxy-, and ribonucleotides.
J.Biol.Chem., 287, 2012
4DQP
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TERNARY COMPLEX OF BACILLUS DNA POLYMERASE I LARGE FRAGMENT, DNA DUPLEX, AND DDCTP (PAIRED WITH DG OF TEMPLATE)
Descriptor:DNA polymerase (E.C.2.7.7.7)/DNA
Authors:Wang, W., Beese, L.S.
Deposit date:2012-02-16
Release date:2012-06-06
Modification date:2012-11-21
Method:X-RAY DIFFRACTION (1.74 Å)
Cite:Structural factors that determine selectivity of a high fidelity DNA polymerase for deoxy-, dideoxy-, and ribonucleotides.
J.Biol.Chem., 287, 2012
4DQQ
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TERNARY COMPLEX OF BACILLUS DNA POLYMERASE I LARGE FRAGMENT E658A, DNA DUPLEX, AND RCTP (PAIRED WITH DG OF TEMPLATE) IN PRESENCE OF MG2+
Descriptor:DNA polymerase (E.C.2.7.7.7)/DNA
Authors:Wang, W., Beese, L.S.
Deposit date:2012-02-16
Release date:2012-06-06
Modification date:2012-11-21
Method:X-RAY DIFFRACTION (1.595 Å)
Cite:Structural factors that determine selectivity of a high fidelity DNA polymerase for deoxy-, dideoxy-, and ribonucleotides.
J.Biol.Chem., 287, 2012
4DQR
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TERNARY COMPLEX OF BACILLUS DNA POLYMERASE I LARGE FRAGMENT E658A, DNA DUPLEX, AND RCTP (PAIRED WITH DG OF TEMPLATE) IN PRESENCE OF MN2+
Descriptor:DNA polymerase (E.C.2.7.7.7)/DNA
Authors:Wang, W., Beese, L.S.
Deposit date:2012-02-16
Release date:2012-06-06
Modification date:2012-11-21
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structural factors that determine selectivity of a high fidelity DNA polymerase for deoxy-, dideoxy-, and ribonucleotides.
J.Biol.Chem., 287, 2012
4DQS
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BINARY COMPLEX OF BACILLUS DNA POLYMERASE I LARGE FRAGMENT AND DUPLEX DNA WITH RC IN PRIMER TERMINUS PAIRED WITH DG OF TEMPLATE
Descriptor:DNA polymerase (E.C.2.7.7.7)/DNA
Authors:Wang, W., Beese, L.S.
Deposit date:2012-02-16
Release date:2012-06-06
Modification date:2012-11-21
Method:X-RAY DIFFRACTION (1.66 Å)
Cite:Structural factors that determine selectivity of a high fidelity DNA polymerase for deoxy-, dideoxy-, and ribonucleotides.
J.Biol.Chem., 287, 2012
4DS4
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TERNARY COMPLEX OF BACILLUS DNA POLYMERASE I LARGE FRAGMENT, DNA DUPLEX, AND RCTP IN PRESENCE OF MN2+
Descriptor:DNA polymerase (E.C.2.7.7.7)/DNA
Authors:Wang, W., Beese, L.S.
Deposit date:2012-02-17
Release date:2012-06-06
Modification date:2012-11-21
Method:X-RAY DIFFRACTION (1.681 Å)
Cite:Structural factors that determine selectivity of a high fidelity DNA polymerase for deoxy-, dideoxy-, and ribonucleotides.
J.Biol.Chem., 287, 2012
4DS5
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TERNARY COMPLEX OF BACILLUS DNA POLYMERASE I LARGE FRAGMENT, DNA DUPLEX, AND RCTP IN PRESENCE OF MG2+
Descriptor:DNA polymerase (E.C.2.7.7.7)/DNA
Authors:Wang, W., Beese, L.S.
Deposit date:2012-02-17
Release date:2012-06-06
Modification date:2012-11-21
Method:X-RAY DIFFRACTION (1.68 Å)
Cite:Structural factors that determine selectivity of a high fidelity DNA polymerase for deoxy-, dideoxy-, and ribonucleotides.
J.Biol.Chem., 287, 2012
4DSE
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TERNARY COMPLEX OF BACILLUS DNA POLYMERASE I LARGE FRAGMENT F710Y, DNA DUPLEX, AND RCTP (PAIRED WITH DG OF TEMPLATE) IN PRESENCE OF MG2+
Descriptor:DNA polymerase (E.C.2.7.7.7)/DNA
Authors:Wang, W., Beese, L.S.
Deposit date:2012-02-18
Release date:2012-06-06
Modification date:2012-11-21
Method:X-RAY DIFFRACTION (1.67 Å)
Cite:Structural factors that determine selectivity of a high fidelity DNA polymerase for deoxy-, dideoxy-, and ribonucleotides.
J.Biol.Chem., 287, 2012
4DSF
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TERNARY COMPLEX OF BACILLUS DNA POLYMERASE I LARGE FRAGMENT F710Y, DNA DUPLEX, AND RCTP (PAIRED WITH DG OF TEMPLATE) IN PRESENCE OF MN2+
Descriptor:DNA polymerase (E.C.2.7.7.7)/DNA
Authors:Wang, W., Beese, L.S.
Deposit date:2012-02-18
Release date:2012-06-06
Modification date:2012-11-21
Method:X-RAY DIFFRACTION (1.661 Å)
Cite:Structural factors that determine selectivity of a high fidelity DNA polymerase for deoxy-, dideoxy-, and ribonucleotides.
J.Biol.Chem., 287, 2012
4E0D
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BINARY COMPLEX OF BACILLUS DNA POLYMERASE I LARGE FRAGMENT E658A AND DUPLEX DNA
Descriptor:DNA polymerase (E.C.2.7.7.7)/DNA complex
Authors:Wang, W., Beese, L.S.
Deposit date:2012-03-02
Release date:2012-06-06
Modification date:2012-09-05
Method:X-RAY DIFFRACTION (1.58 Å)
Cite:Structural factors that determine selectivity of a high fidelity DNA polymerase for deoxy-, dideoxy-, and ribonucleotides.
J.Biol.Chem., 287, 2012
4EZ6
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BACILLUS DNA POLYMERASE I LARGE FRAGMENT COMPLEX 1
Descriptor:DNA polymerase (E.C.2.7.7.7)/dna
Authors:Wang, W., Beese, L.S.
Deposit date:2012-05-02
Release date:2013-07-24
Method:X-RAY DIFFRACTION (1.64 Å)
Cite:Structures of a High-fidelity DNA Polymerase
to be published
4EZ9
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BACILLUS DNA POLYMERASE I LARGE FRAGMENT COMPLEX 2
Descriptor:DNA polymerase (E.C.2.7.7.7)/dna
Authors:Wang, W., Beese, L.S.
Deposit date:2012-05-02
Release date:2013-07-24
Modification date:2015-02-04
Method:X-RAY DIFFRACTION (1.64 Å)
Cite:Structures of a High-fidelity DNA Polymerase
to be published
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