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3TB8
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3tb8
CRYSTAL STRUCTURE OF FULL-LENGTH MYRISTOYLATED HIV-1 NEF
Descriptor:Protein Nef
Authors:Dennis, C.A., Harris, M., Jaeger, J.
Deposit date:2011-08-05
Release date:2012-10-03
Method:X-RAY DIFFRACTION (3.71 Å)
Cite:Crystal structure of full-length myristoylated HIV-1 Nef
To be Published
1AVV
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1avv
HIV-1 NEF PROTEIN, UNLIGANDED CORE DOMAIN
Descriptor:NEGATIVE FACTOR
Authors:Arold, S., Franken, P., Dumas, C.
Deposit date:1997-09-21
Release date:1998-03-25
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (3 Å)
Cite:The crystal structure of HIV-1 Nef protein bound to the Fyn kinase SH3 domain suggests a role for this complex in altered T cell receptor signaling.
Structure, 5, 1997
1QA4
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1qa4
HIV-1 NEF ANCHOR DOMAIN, NMR, 2 STRUCTURES
Descriptor:HIV-1 NEF ANCHOR DOMAIN (2-57)
Authors:Geyer, M., Kalbitzer, H.R.
Deposit date:1999-04-12
Release date:1999-05-26
Modification date:2009-02-24
Method:SOLUTION NMR
Cite:Structure of the anchor-domain of myristoylated and non-myristoylated HIV-1 Nef protein.
J.Mol.Biol., 289, 1999
1QA5
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1qa5
MYRISTOYLATED HIV-1 NEF ANCHOR DOMAIN, NMR, 2 STRUCTURES
Descriptor:MYRISTOYLATED HIV-1 NEF ANCHOR DOMAIN (MYRISTATE-GLY2 TO TRP57)
Authors:Geyer, M., Kalbitzer, H.R.
Deposit date:1999-04-12
Release date:1999-05-26
Modification date:2009-02-24
Method:SOLUTION NMR
Cite:Structure of the anchor-domain of myristoylated and non-myristoylated HIV-1 Nef protein.
J.Mol.Biol., 289, 1999
2NEF
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2nef
HIV-1 NEF (REGULATORY FACTOR), NMR, 40 STRUCTURES
Descriptor:NEGATIVE FACTOR (F-PROTEIN)
Authors:Grzesiek, S., Bax, A., Clore, G.M., Gronenborn, A.M., Hu, J.S., Kaufman, J., Palmer, I., Stahl, S.J., Tjandra, N., Wingfield, P.T.
Deposit date:1997-02-12
Release date:1997-07-07
Modification date:2011-07-13
Method:SOLUTION NMR
Cite:Refined solution structure and backbone dynamics of HIV-1 Nef.
Protein Sci., 6, 1997
3IK5
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3ik5
SIVMAC239 NEF IN COMPLEX WITH TCR ZETA ITAM 1 POLYPEPTIDE (A63-R80)
Descriptor:Protein Nef, T-cell surface glycoprotein CD3 zeta chain
Authors:Kim, W.M., Sigalov, A.B., Stern, L.J.
Deposit date:2009-08-05
Release date:2010-02-02
Modification date:2012-03-28
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Pseudo-merohedral twinning and noncrystallographic symmetry in orthorhombic crystals of SIVmac239 Nef core domain bound to different-length TCRzeta fragments.
Acta Crystallogr.,Sect.D, 66, 2010
2XI1
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2xi1
CRYSTAL STRUCTURE OF THE HIV-1 NEF SEQUENCED FROM A PATIENT'S SAMPLE
Descriptor:NEF
Authors:Yadav, G.P., Singh, P., Gupta, S., Tripathi, A.K., Tripathi, R.K., Ramachandran, R.
Deposit date:2010-06-25
Release date:2011-08-10
Modification date:2011-11-23
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:A Novel Dimer-Tetramer Transition Captured by the Crystal Structure of the HIV-1 Nef.
Plos One, 6, 2011
1AVZ
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1avz
V-1 NEF PROTEIN IN COMPLEX WITH WILD TYPE FYN SH3 DOMAIN
Descriptor:NEGATIVE FACTOR, FYN TYROSINE KINASE
Authors:Arold, S., Franken, P., Dumas, C.
Deposit date:1997-09-23
Release date:1998-03-25
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (3 Å)
Cite:The crystal structure of HIV-1 Nef protein bound to the Fyn kinase SH3 domain suggests a role for this complex in altered T cell receptor signaling.
Structure, 5, 1997
3IOZ
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3ioz
SIVMAC239 NEF IN COMPLEX WITH A TCR ZETA POLYPEPTIDE DP1 (L51-D93)
Descriptor:Protein Nef, T-cell surface glycoprotein CD3 zeta chain
Authors:Kim, W.M., Sigalov, A.B., Stern, L.J.
Deposit date:2009-08-15
Release date:2010-02-02
Modification date:2012-03-28
Method:X-RAY DIFFRACTION (3.699 Å)
Cite:Pseudo-merohedral twinning and noncrystallographic symmetry in orthorhombic crystals of SIVmac239 Nef core domain bound to different-length TCRzeta fragments.
Acta Crystallogr.,Sect.D, 66, 2010
3RBB
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3rbb
HIV-1 NEF PROTEIN IN COMPLEX WITH ENGINEERED HCK SH3 DOMAIN
Descriptor:Protein Nef, Tyrosine-protein kinase HCK (E.C.2.7.10.2)
Authors:Horenkamp, F.A., Schulte, A., Weyand, M., Geyer, M.
Deposit date:2011-03-29
Release date:2011-04-27
Modification date:2011-06-29
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Conformation of the Dileucine-Based Sorting Motif in HIV-1 Nef Revealed by Intermolecular Domain Assembly.
Traffic, 12, 2011
3REA
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3rea
HIV-1 NEF PROTEIN IN COMPLEX WITH ENGINEERED HCK-SH3 DOMAIN
Descriptor:Protein Nef, Tyrosine-protein kinase HCK (E.C.2.7.10.2)
Authors:Schulte, A., Blankenfeldt, W., Geyer, M.
Deposit date:2011-04-04
Release date:2011-06-01
Method:X-RAY DIFFRACTION (2 Å)
Cite:Molecular Design, Functional Characterization and Structural Basis of a Protein Inhibitor Against the HIV-1 Pathogenicity Factor Nef
PLOS ONE, 6, 2011
3REB
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3reb
HIV-1 NEF PROTEIN IN COMPLEX WITH ENGINEERED HCK-SH3 DOMAIN
Descriptor:Protein Nef, Tyrosine-protein kinase HCK (E.C.2.7.10.2)
Authors:Schulte, A., Blankenfeldt, W., Geyer, M.
Deposit date:2011-04-04
Release date:2011-06-01
Method:X-RAY DIFFRACTION (3.45 Å)
Cite:Molecular Design, Functional Characterization and Structural Basis of a Protein Inhibitor Against the HIV-1 Pathogenicity Factor Nef
PLOS ONE, 6, 2011
4EMZ
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4emz
HIV-1 NEF IN COMPLEX WITH MHC-I CYTOPLASMIC DOMAIN AND MU1 ADAPTIN SUBUNIT OF AP1 ADAPTOR (SECOND DOMAIN)
Descriptor:Protein Nef, MHC-I, AP-1 complex subunit mu-1
Authors:Jia, X., Xiong, Y.
Deposit date:2012-04-12
Release date:2012-06-20
Modification date:2012-07-25
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural basis of evasion of cellular adaptive immunity by HIV-1 Nef.
Nat.Struct.Mol.Biol., 19, 2012
1EFN
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1efn
HIV-1 NEF PROTEIN IN COMPLEX WITH R96I MUTANT FYN SH3 DOMAIN
Descriptor:FYN TYROSINE KINASE, HIV-1 NEF PROTEIN
Authors:Lee, C.-H., Kuriyan, J.
Deposit date:1996-06-29
Release date:1997-01-11
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of the conserved core of HIV-1 Nef complexed with a Src family SH3 domain.
Cell(Cambridge,Mass.), 85, 1996
4D8D
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4d8d
CRYSTAL STRUCTURE OF HIV-1 NEF FYN-SH3 R96W VARIANT
Descriptor:Tyrosine-protein kinase Fyn (E.C.2.7.10.2), Protein Nef
Authors:Arold, S.T., Hoh, F., Dumas, C.
Deposit date:2012-01-10
Release date:2013-01-16
Method:X-RAY DIFFRACTION (2.5201 Å)
Cite:SH3 domain specificity
To be Published
4EN2
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4en2
HIV-1 NEF IN COMPLEX WITH MHC-I CYTOPLASMIC DOMAIN AND MU1 ADAPTIN SUBUNIT OF AP1 ADAPTOR (SECOND DOMAIN)
Descriptor:AP-1 complex subunit mu-1, Protein Nef, MHC-I
Authors:Jia, X., Xiong, Y.
Deposit date:2012-04-12
Release date:2012-06-20
Modification date:2012-07-25
Method:X-RAY DIFFRACTION (2.58 Å)
Cite:Structural basis of evasion of cellular adaptive immunity by HIV-1 Nef.
Nat.Struct.Mol.Biol., 19, 2012
4NEE
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4nee
CRYSTAL STRUCTURE OF AP-2 ALPHA/SIMGA2 COMPLEX BOUND TO HIV-1 NEF
Descriptor:AP-2 complex subunit sigma, AP-2 complex subunit alpha-2, Protein Nef
Authors:Hurley, J.H., Bonifacino, J.S., Ren, X., Park, S.Y.
Deposit date:2013-10-29
Release date:2014-01-29
Modification date:2014-03-05
Method:X-RAY DIFFRACTION (2.8841 Å)
Cite:How HIV-1 Nef hijacks the AP-2 clathrin adaptor to downregulate CD4.
Elife, 3, 2014
4ORZ
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4orz
HIV-1 NEF PROTEIN IN COMPLEX WITH SINGLE DOMAIN ANTIBODY SDAB19 AND AN ENGINEERED HCK SH3 DOMAIN
Descriptor:Tyrosine-protein kinase HCK (E.C.2.7.10.2), Protein Nef (E.C.1 M:B_ARV2/SF2 ), single domain antibody sdAb19 derived from llama
Authors:Geyer, M., Lulf, S.
Deposit date:2014-02-12
Release date:2014-03-26
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis for the inhibition of HIV-1 Nef by a high-affinity binding single-domain antibody.
Retrovirology, 11, 2014
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