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3TB8
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3tb8
CRYSTAL STRUCTURE OF FULL-LENGTH MYRISTOYLATED HIV-1 NEF
Descriptor:Protein Nef
Authors:Dennis, C.A., Harris, M., Jaeger, J.
Deposit date:2011-08-05
Release date:2012-10-03
Method:X-RAY DIFFRACTION (3.71 Å)
Cite:Crystal structure of full-length myristoylated HIV-1 Nef
To be Published
1AVV
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1avv
HIV-1 NEF PROTEIN, UNLIGANDED CORE DOMAIN
Descriptor:NEGATIVE FACTOR
Authors:Arold, S., Franken, P., Dumas, C.
Deposit date:1997-09-21
Release date:1998-03-25
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (3 Å)
Cite:The crystal structure of HIV-1 Nef protein bound to the Fyn kinase SH3 domain suggests a role for this complex in altered T cell receptor signaling.
Structure, 5, 1997
1QA4
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1qa4
HIV-1 NEF ANCHOR DOMAIN, NMR, 2 STRUCTURES
Descriptor:HIV-1 NEF ANCHOR DOMAIN (2-57)
Authors:Geyer, M., Kalbitzer, H.R.
Deposit date:1999-04-12
Release date:1999-05-26
Modification date:2009-02-24
Method:SOLUTION NMR
Cite:Structure of the anchor-domain of myristoylated and non-myristoylated HIV-1 Nef protein.
J.Mol.Biol., 289, 1999
1QA5
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1qa5
MYRISTOYLATED HIV-1 NEF ANCHOR DOMAIN, NMR, 2 STRUCTURES
Descriptor:MYRISTOYLATED HIV-1 NEF ANCHOR DOMAIN (MYRISTATE-GLY2 TO TRP57)
Authors:Geyer, M., Kalbitzer, H.R.
Deposit date:1999-04-12
Release date:1999-05-26
Modification date:2009-02-24
Method:SOLUTION NMR
Cite:Structure of the anchor-domain of myristoylated and non-myristoylated HIV-1 Nef protein.
J.Mol.Biol., 289, 1999
1ZEC
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1zec
NMR SOLUTION STRUCTURE OF NEF1-25, 20 STRUCTURES
Descriptor:NEF1-25
Authors:Barnham, K.J., Monks, S.A., Hinds, M.G., Azad, A.A., Norton, R.S.
Deposit date:1996-12-18
Release date:1998-01-07
Modification date:2011-06-15
Method:SOLUTION NMR
Cite:Solution structure of a polypeptide from the N terminus of the HIV protein Nef.
Biochemistry, 36, 1997
2NEF
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2nef
HIV-1 NEF (REGULATORY FACTOR), NMR, 40 STRUCTURES
Descriptor:NEGATIVE FACTOR (F-PROTEIN)
Authors:Grzesiek, S., Bax, A., Clore, G.M., Gronenborn, A.M., Hu, J.S., Kaufman, J., Palmer, I., Stahl, S.J., Tjandra, N., Wingfield, P.T.
Deposit date:1997-02-12
Release date:1997-07-07
Modification date:2011-07-13
Method:SOLUTION NMR
Cite:Refined solution structure and backbone dynamics of HIV-1 Nef.
Protein Sci., 6, 1997
2XI1
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2xi1
CRYSTAL STRUCTURE OF THE HIV-1 NEF SEQUENCED FROM A PATIENT'S SAMPLE
Descriptor:NEF
Authors:Yadav, G.P., Singh, P., Gupta, S., Tripathi, A.K., Tripathi, R.K., Ramachandran, R.
Deposit date:2010-06-25
Release date:2011-08-10
Modification date:2011-11-23
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:A Novel Dimer-Tetramer Transition Captured by the Crystal Structure of the HIV-1 Nef.
Plos One, 6, 2011
1AVZ
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1avz
V-1 NEF PROTEIN IN COMPLEX WITH WILD TYPE FYN SH3 DOMAIN
Descriptor:NEGATIVE FACTOR, FYN TYROSINE KINASE
Authors:Arold, S., Franken, P., Dumas, C.
Deposit date:1997-09-23
Release date:1998-03-25
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (3 Å)
Cite:The crystal structure of HIV-1 Nef protein bound to the Fyn kinase SH3 domain suggests a role for this complex in altered T cell receptor signaling.
Structure, 5, 1997
3IK5
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3ik5
SIVMAC239 NEF IN COMPLEX WITH TCR ZETA ITAM 1 POLYPEPTIDE (A63-R80)
Descriptor:Protein Nef, T-cell surface glycoprotein CD3 zeta chain
Authors:Kim, W.M., Sigalov, A.B., Stern, L.J.
Deposit date:2009-08-05
Release date:2010-02-02
Modification date:2012-03-28
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Pseudo-merohedral twinning and noncrystallographic symmetry in orthorhombic crystals of SIVmac239 Nef core domain bound to different-length TCRzeta fragments.
Acta Crystallogr.,Sect.D, 66, 2010
3RBB
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3rbb
HIV-1 NEF PROTEIN IN COMPLEX WITH ENGINEERED HCK SH3 DOMAIN
Descriptor:Protein Nef, Tyrosine-protein kinase HCK (E.C.2.7.10.2)
Authors:Horenkamp, F.A., Schulte, A., Weyand, M., Geyer, M.
Deposit date:2011-03-29
Release date:2011-04-27
Modification date:2011-06-29
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Conformation of the Dileucine-Based Sorting Motif in HIV-1 Nef Revealed by Intermolecular Domain Assembly.
Traffic, 12, 2011
3REA
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3rea
HIV-1 NEF PROTEIN IN COMPLEX WITH ENGINEERED HCK-SH3 DOMAIN
Descriptor:Protein Nef, Tyrosine-protein kinase HCK (E.C.2.7.10.2)
Authors:Schulte, A., Blankenfeldt, W., Geyer, M.
Deposit date:2011-04-04
Release date:2011-06-01
Method:X-RAY DIFFRACTION (2 Å)
Cite:Molecular Design, Functional Characterization and Structural Basis of a Protein Inhibitor Against the HIV-1 Pathogenicity Factor Nef
PLOS ONE, 6, 2011
3REB
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3reb
HIV-1 NEF PROTEIN IN COMPLEX WITH ENGINEERED HCK-SH3 DOMAIN
Descriptor:Protein Nef, Tyrosine-protein kinase HCK (E.C.2.7.10.2)
Authors:Schulte, A., Blankenfeldt, W., Geyer, M.
Deposit date:2011-04-04
Release date:2011-06-01
Method:X-RAY DIFFRACTION (3.45 Å)
Cite:Molecular Design, Functional Characterization and Structural Basis of a Protein Inhibitor Against the HIV-1 Pathogenicity Factor Nef
PLOS ONE, 6, 2011
4U5W
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4u5w
CRYSTAL STRUCTURE OF HIV-1 NEF-SF2 CORE DOMAIN IN COMPLEX WITH THE SRC FAMILY KINASE HCK SH3-SH2 TANDEM REGULATORY DOMAINS
Descriptor:HIV-1 Nef Core domain 62-209, Hck Tyrosine Kinase SH3-SH2 regulatory domains 72-242 (E.C.2.7.10.2)
Authors:Alvarado, J.J., Yeh, J.I., Smithgall, T.E.
Deposit date:2014-07-25
Release date:2014-08-20
Modification date:2014-10-22
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Interaction with the Src Homology (SH3-SH2) Region of the Src-family Kinase Hck Structures the HIV-1 Nef Dimer for Kinase Activation and Effector Recruitment.
J.Biol.Chem., 289, 2014
1EFN
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1efn
HIV-1 NEF PROTEIN IN COMPLEX WITH R96I MUTANT FYN SH3 DOMAIN
Descriptor:FYN TYROSINE KINASE, HIV-1 NEF PROTEIN
Authors:Lee, C.-H., Kuriyan, J.
Deposit date:1996-06-29
Release date:1997-01-11
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of the conserved core of HIV-1 Nef complexed with a Src family SH3 domain.
Cell(Cambridge,Mass.), 85, 1996
1QVO
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1qvo
STRUCTURES OF HLA-A*1101 IN COMPLEX WITH IMMUNODOMINANT NONAMER AND DECAMER HIV-1 EPITOPES CLEARLY REVEAL THE PRESENCE OF A MIDDLE ANCHOR RESIDUE
Descriptor:HLA class I histocompatibility antigen, A-11 alpha chain, Beta-2-microglobulin, Negative factor
Authors:Li, L., McNicholl, J.M., Bouvier, M.
Deposit date:2003-08-28
Release date:2004-06-01
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.22 Å)
Cite:Structures of HLA-A*1101 complexed with immunodominant nonamer and decamer HIV-1 epitopes clearly reveal the presence of a middle, secondary anchor residue.
J.Immunol., 172, 2004
3JTT
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3jtt
CYSTAL STRUCTURE OF RHESUS MACAQUE MHC CLASS I:MAMU-A*02
Descriptor:MHC class I Mamu-A*02, Beta-2-microglobulin, peptide of Protein Nef
Authors:Dai, L., Feng, Y., Qi, J., Gao, G.F.
Deposit date:2009-09-14
Release date:2010-09-15
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure of Rhesus macaque MHC class I:Mamu-A*02
To be Published
3NFN
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3nfn
RECOGNITION OF PEPTIDE-MHC BY A V-DELTA/V-BETA TCR
Descriptor:HLA class I histocompatibility antigen, A-24 alpha chain, Beta-2-microglobulin, 10-mer peptide from Protein Nef
Authors:Shi, Y., Qi, J., Gao, F., Gao, G.F.
Deposit date:2010-06-10
Release date:2011-07-13
Modification date:2013-09-11
Method:X-RAY DIFFRACTION (2.392 Å)
Cite:Plasticity of human CD8 alpha alpha binding to peptide-HLA-A*2402
Mol.Immunol., 48, 2011
3QZW
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3qzw
PLASTICITY OF HUMAN CD8 BINDING TO PEPTIDE-HLA-A*2402
Descriptor:HLA class I histocompatibility antigen, A-24 alpha chain, Beta-2-microglobulin, 10-mer peptide from Protein Nef, T-cell surface glycoprotein CD8 alpha chain
Authors:Shi, Y., Qi, J., Gao, G.F.
Deposit date:2011-03-07
Release date:2011-06-29
Modification date:2013-07-03
Method:X-RAY DIFFRACTION (2.798 Å)
Cite:Plasticity of human CD8alpha alpha binding to peptide-HLA-A*2402
Mol.Immunol., 48, 2011
3RL2
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3rl2
HIV NEF DERIVED PEPTIDE NEF73 COMPLEXED TO HLA-A*0301
Descriptor:HLA class I histocompatibility antigen, A-3 alpha chain, Beta-2-microglobulin, Nef73 peptide from Protein Nef
Authors:Zhang, S., Liu, J., Cheng, H., Tan, S., Qi, J., Yan, J., Gao, G.F.
Deposit date:2011-04-19
Release date:2012-02-29
Method:X-RAY DIFFRACTION (2.386 Å)
Cite:Structural basis of cross-allele presentation by HLA-A*0301 and HLA-A*1101 revealed by two HIV-derived peptide complexes
Mol.Immunol., 49, 2011
3RWC
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3rwc
CRYSTAL STRUCTURE OF RHESUS MACAQUE MHC CLASS I MOLECULE MAMU-B*17-IW9
Descriptor:Major histocompatibility complex class I, Beta-2-microglobulin, Nef IW9 peptide from Protein Nef
Authors:Wu, Y., Gao, F., Liu, J., Qi, J.X., Price, D.A., Gao, G.F.
Deposit date:2011-05-09
Release date:2012-03-21
Method:X-RAY DIFFRACTION (2.502 Å)
Cite:Structural basis of diverse peptide accommodation by the rhesus macaque MHC class I molecule Mamu-B*17: insights into immune protection from simian immunodeficiency virus
J.Immunol., 187, 2011
3RWD
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3rwd
RHESUS MACAQUE MHC CLASS I MOLECULE MAMU-B*17-IW11
Descriptor:Major histocompatibility complex class I, Beta-2-microglobulin, Nef IW11 peptide from Protein Nef
Authors:Wu, Y., Gao, F., Liu, J., Qi, J.X., Price, D.A., Gao, G.F.
Deposit date:2011-05-09
Release date:2012-03-21
Method:X-RAY DIFFRACTION (2.602 Å)
Cite:Structural basis of diverse peptide accommodation by the rhesus macaque MHC class I molecule Mamu-B*17: insights into immune protection from simian immunodeficiency virus
J.Immunol., 187, 2011
3RWF
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3rwf
RHESUS MACAQUE MHC CLASS I MOLECULE MAMU-B*17-QW9
Descriptor:Major histocompatibility complex class I, Beta-2-microglobulin, Nef QW9 peptide from Protein Nef
Authors:Wu, Y., Gao, F., Liu, J., Qi, J.X., Price, D.A., Gao, G.F.
Deposit date:2011-05-09
Release date:2012-03-21
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural basis of diverse peptide accommodation by the rhesus macaque MHC class I molecule Mamu-B*17: insights into immune protection from simian immunodeficiency virus
J.Immunol., 187, 2011
3RWG
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3rwg
RHESUS MACAQUE MHC CLASS I MOLECULE MAMU-B*17-MW9
Descriptor:Major histocompatibility complex class I, Beta-2-microglobulin, Nef MW9 peptide from Protein Nef
Authors:Wu, Y., Gao, F., Liu, J., Qi, J.X., Price, D.A., Gao, G.F.
Deposit date:2011-05-09
Release date:2012-03-21
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural basis of diverse peptide accommodation by the rhesus macaque MHC class I molecule Mamu-B*17: insights into immune protection from simian immunodeficiency virus
J.Immunol., 187, 2011
3VXM
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3vxm
THE COMPLEX BETWEEN C1-28 TCR AND HLA-A24 BOUND TO HIV-1 NEF134-10(2F) PEPTIDE
Descriptor:HLA class I histocompatibility antigen, A-24 alpha chain, Beta-2-microglobulin, 10-mer peptide from Protein Nef, C1-28 TCR alpha chain, C1-28 TCR beta chain
Authors:Shimizu, A., Fukai, S., Yamagata, A., Iwamoto, A.
Deposit date:2012-09-20
Release date:2013-10-23
Modification date:2013-11-20
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of TCR and antigen complexes at an immunodominant CTL epitope in HIV-1 infection
SCI REP, 3, 2013
3VXN
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3vxn
HLA-A24 IN COMPLEX WITH HIV-1 NEF134-10(WT)
Descriptor:HLA class I histocompatibility antigen, A-24 alpha chain, Beta-2-microglobulin, 10-mer peptide from Protein Nef
Authors:Shimizu, A., Fukai, S., Yamagata, A., Iwamoto, A.
Deposit date:2012-09-20
Release date:2013-10-23
Modification date:2013-11-20
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structure of TCR and antigen complexes at an immunodominant CTL epitope in HIV-1 infection
SCI REP, 3, 2013
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