Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

8XP5
DownloadVisualize
BU of 8xp5 by Molmil
The Crystal Structure of p53/BCL-xL fusion complex from Biortus.
Descriptor: Bcl-2-like protein 1,Cellular tumor antigen p53, ZINC ION
Authors:Wang, F, Cheng, W, Yuan, Z, Lin, D, Bao, C.
Deposit date:2024-01-03
Release date:2024-03-06
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:The Crystal Structure of p53/BCL-xL fusion complex from Biortus.
To Be Published
8U27
DownloadVisualize
BU of 8u27 by Molmil
Bcl-2-xL complexed with compound 35
Descriptor: Apoptosis regulator Bcl-2, Bcl-2-like protein 1 chimera, propan-2-yl {4-[(5S)-1-(4-bromobenzoyl)-5-phenyl-4,5-dihydro-1H-pyrazol-3-yl]phenyl}carbamate
Authors:Rizo, J, Pan, Y.-Z.
Deposit date:2023-09-05
Release date:2023-09-13
Last modified:2023-11-08
Method:SOLUTION NMR
Cite:Structural insights for selective disruption of Beclin 1 binding to Bcl-2.
Commun Biol, 6, 2023
8SVY
DownloadVisualize
BU of 8svy by Molmil
MBP-Mcl1 in complex with ligand 10
Descriptor: (15P)-17-chloro-33-fluoro-12-[(2-methoxyethoxy)methyl]-5,14,22-trimethyl-28-oxa-9-thia-5,6,13,14,22-pentaazaheptacyclo[27.7.1.1~4,7~.0~11,15~.0~16,21~.0~20,24~.0~30,35~]octatriaconta-1(36),4(38),6,11(15),12,16,18,20,23,29(37),30,32,34-tridecaene-23-carboxylic acid, 1,2-ETHANEDIOL, GLYCEROL, ...
Authors:Miller, B.R, Shaffer, P.
Deposit date:2023-05-17
Release date:2023-08-09
Method:X-RAY DIFFRACTION (1.47 Å)
Cite:Macrocyclic Carbon-Linked Pyrazoles As Novel Inhibitors of MCL-1.
Acs Med.Chem.Lett., 14, 2023
8SVK
DownloadVisualize
BU of 8svk by Molmil
Crystal structure of Bax D71N core domain BH3-groove dimer
Descriptor: Apoptosis regulator BAX, DI(HYDROXYETHYL)ETHER, SULFATE ION, ...
Authors:Miller, M.S, Czabotar, P.E, Colman, P.M.
Deposit date:2023-05-16
Release date:2023-12-27
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Sequence differences between BAX and BAK core domains manifest as differences in their interactions with lipids.
Febs J., 2023
8SRY
DownloadVisualize
BU of 8sry by Molmil
Crystal structure of BAK-BAX heterodimer with C12E8
Descriptor: 2-(2-METHOXYETHOXY)ETHANOL, 3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL, 3,6,9,12,15-PENTAOXATRICOSAN-1-OL, ...
Authors:Brouwer, J.M, Czabotar, P.E, Colman, P.M, Miller, M.S.
Deposit date:2023-05-08
Release date:2023-12-27
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Sequence differences between BAX and BAK core domains manifest as differences in their interactions with lipids.
Febs J., 2023
8SRX
DownloadVisualize
BU of 8srx by Molmil
Crystal structure of BAK-BAX heterodimer with lysoPC
Descriptor: 1,2-ETHANEDIOL, Apoptosis regulator BAX, Bcl-2 homologous antagonist/killer, ...
Authors:Brouwer, J.M, Czabotar, P.E, Colman, P.M, Miller, M.S.
Deposit date:2023-05-07
Release date:2023-12-27
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:Sequence differences between BAX and BAK core domains manifest as differences in their interactions with lipids.
Febs J., 2023
8SPZ
DownloadVisualize
BU of 8spz by Molmil
Crystal structure of Bax core domain BH3-groove dimer - hexameric fraction with dioctanoyl phosphatidylserine
Descriptor: Apoptosis regulator BAX, SULFATE ION
Authors:Cowan, A.D, Colman, P.M, Czabotar, P.E, Miller, M.S.
Deposit date:2023-05-04
Release date:2023-12-27
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Sequence differences between BAX and BAK core domains manifest as differences in their interactions with lipids.
Febs J., 2023
8SPF
DownloadVisualize
BU of 8spf by Molmil
Crystal structure of Bax core domain BH3-groove dimer - hexameric fraction with 2-stearoyl lysoPC
Descriptor: 1,2-ETHANEDIOL, Apoptosis regulator BAX, DODECANE, ...
Authors:Cowan, A.D, Miller, M.S, Czabotar, P.E, Colman, P.M.
Deposit date:2023-05-03
Release date:2023-12-27
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Sequence differences between BAX and BAK core domains manifest as differences in their interactions with lipids.
Febs J., 2023
8SPE
DownloadVisualize
BU of 8spe by Molmil
Crystal structure of Bax core domain BH3-groove dimer - tetrameric fraction P31
Descriptor: 1,2-ETHANEDIOL, Apoptosis regulator BAX, DI(HYDROXYETHYL)ETHER, ...
Authors:Miller, M.S, Cowan, A.D, Colman, P.M, Czabotar, P.E.
Deposit date:2023-05-03
Release date:2023-12-27
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Sequence differences between BAX and BAK core domains manifest as differences in their interactions with lipids.
Febs J., 2023
8SM5
DownloadVisualize
BU of 8sm5 by Molmil
Crystal Structure of BHRF1 from Epstein Barr Virus in complex with BID BH3 peptide
Descriptor: Apoptosis regulator BHRF1, BID BH3
Authors:Wyatt, S, Sinha, S.
Deposit date:2023-04-25
Release date:2023-10-11
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.61002612 Å)
Cite:Epstein-Barr Virus Encoded BCL2, BHRF1, Downregulates Autophagy by Noncanonical Binding of BECN1.
Biochemistry, 62, 2023
8QSO
DownloadVisualize
BU of 8qso by Molmil
Crystal structure of human Mcl-1 in complex with compound 1
Descriptor: (13S,16R,19S)-16-benzyl-43-ethoxy-N-methyl-7,11,14,17-tetraoxo-13-phenyl-5-oxa-2,8,12,15,18-pentaaza-1(1,4),4(1,2)-dibenzena-9(1,4)-cyclohexanacycloicosaphane-19-carboxamide, Maltose/maltodextrin-binding periplasmic protein,Induced myeloid leukemia cell differentiation protein Mcl-1, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose
Authors:Hekking, K.F.W, Gremmen, S, Maroto, S, Keefe, A.D, Zhang, Y.
Deposit date:2023-10-10
Release date:2024-02-14
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.106 Å)
Cite:Development of Potent Mcl-1 Inhibitors: Structural Investigations on Macrocycles Originating from a DNA-Encoded Chemical Library Screen.
J.Med.Chem., 67, 2024
8IVB
DownloadVisualize
BU of 8ivb by Molmil
K113-Ubiquitinated BAK
Descriptor: Bcl-2 homologous antagonist/killer, Ubiquitin
Authors:Dong, X, Cheng, P, Hou, Y.Z, Chen, Y.K, Liu, Z.
Deposit date:2023-03-26
Release date:2024-01-31
Method:SOLUTION NMR
Cite:Parkin-mediated ubiquitination inhibits BAK apoptotic activity by blocking its canonical hydrophobic groove.
Commun Biol, 6, 2023
8IQM
DownloadVisualize
BU of 8iqm by Molmil
Structural basis of the specificity and interaction mechanism of Bmf binding to pro-survival proteins
Descriptor: Bcl2 modifying factor, Induced myeloid leukemia cell differentiation protein Mcl-1
Authors:Wang, H, Guo, M, Wei, H, Chen, Y.
Deposit date:2023-03-16
Release date:2023-08-23
Method:X-RAY DIFFRACTION (1.967 Å)
Cite:Structural basis of the specificity and interaction mechanism of Bmf binding to pro-survival Bcl-2 family proteins.
Comput Struct Biotechnol J, 21, 2023
8IQL
DownloadVisualize
BU of 8iql by Molmil
Structural basis of the specificity and interaction mechanism of Bmf binding to pro-survival proteins
Descriptor: Apoptosis regulator Bcl-2, Bcl-2-modifying factor
Authors:Wang, H, Guo, M, Wei, H, Chen, Y.
Deposit date:2023-03-16
Release date:2023-08-23
Method:X-RAY DIFFRACTION (2.9577 Å)
Cite:Structural basis of the specificity and interaction mechanism of Bmf binding to pro-survival Bcl-2 family proteins.
Comput Struct Biotechnol J, 21, 2023
8IQK
DownloadVisualize
BU of 8iqk by Molmil
Structural basis of the specificity and interaction mechanism of Bmf binding to pro-survival proteins
Descriptor: Bcl-2-like protein 1, Bcl-2-modifying factor
Authors:Wang, H, Guo, M, Wei, H, Chen, Y.
Deposit date:2023-03-16
Release date:2023-08-23
Method:X-RAY DIFFRACTION (2.879 Å)
Cite:Structural basis of the specificity and interaction mechanism of Bmf binding to pro-survival Bcl-2 family proteins.
Comput Struct Biotechnol J, 21, 2023
8IGC
DownloadVisualize
BU of 8igc by Molmil
Crystal structure of Bak bound to Bnip5 BH3
Descriptor: Bcl-2 homologous antagonist/killer, Protein BNIP5
Authors:Ku, B, Lim, D.
Deposit date:2023-02-20
Release date:2023-09-20
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.697 Å)
Cite:Crystal structure of Bak bound to the BH3 domain of Bnip5, a noncanonical BH3 domain-containing protein.
Proteins, 92, 2024
8HLN
DownloadVisualize
BU of 8hln by Molmil
Crystal structure of p53/BCL2 fusion complex(complex3)
Descriptor: Apoptosis regulator Bcl-2, Cellular tumor antigen p53, ZINC ION
Authors:Guo, M, Wei, H, Wang, H, Chen, Y.
Deposit date:2022-11-30
Release date:2023-07-26
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.354 Å)
Cite:Structures of p53/BCL-2 complex suggest a mechanism for p53 to antagonize BCL-2 activity.
Nat Commun, 14, 2023
8HLM
DownloadVisualize
BU of 8hlm by Molmil
Crystal structure of p53/BCL2 fusion complex (complex 2)
Descriptor: Apoptosis regulator Bcl-2, Cellular tumor antigen p53, ZINC ION
Authors:Guo, M, Wang, H, Wei, H, Chen, Y.
Deposit date:2022-11-30
Release date:2023-07-26
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.522 Å)
Cite:Structures of p53/BCL-2 complex suggest a mechanism for p53 to antagonize BCL-2 activity.
Nat Commun, 14, 2023
8HLL
DownloadVisualize
BU of 8hll by Molmil
Crystal structure of p53/BCL2 fusion complex (complex 1)
Descriptor: Apoptosis regulator Bcl-2, Cellular tumor antigen p53, ZINC ION
Authors:Wei, H, Guo, M, Wang, H, Chen, Y.
Deposit date:2022-11-30
Release date:2023-07-26
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.62 Å)
Cite:Structures of p53/BCL-2 complex suggest a mechanism for p53 to antagonize BCL-2 activity.
Nat Commun, 14, 2023
8H7B
DownloadVisualize
BU of 8h7b by Molmil
The crystal structure of human mcl1 kinase domain in complex with MCL1-M-EBA
Descriptor: 7-[3-(isoquinolin-7-yloxymethyl)-1,5-dimethyl-pyrazol-4-yl]-3-(3-naphthalen-1-yloxypropyl)-1H-indole-2-carboxylic acid, Induced myeloid leukemia cell differentiation protein Mcl-1
Authors:Zhu, C.J, Zhang, Z.M.
Deposit date:2022-10-19
Release date:2023-02-22
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.46408451 Å)
Cite:2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases.
J.Am.Chem.Soc., 2023
8GSV
DownloadVisualize
BU of 8gsv by Molmil
Crystal structure of human BAK in complex with the Pxt1 BH3 domain
Descriptor: Bcl-2 homologous antagonist/killer, Peroxisomal testis-specific protein 1
Authors:Lim, D, Ku, B.
Deposit date:2022-09-07
Release date:2023-05-10
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural basis for proapoptotic activation of Bak by the noncanonical BH3-only protein Pxt1.
Plos Biol., 21, 2023
8G3Y
DownloadVisualize
BU of 8g3y by Molmil
MBP-Mcl1 in complex with ligand 34
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ...
Authors:Miller, B.R, Shaffer, P.
Deposit date:2023-02-08
Release date:2023-05-17
Last modified:2023-05-24
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Discovery of an Oral, Beyond-Rule-of-Five Mcl-1 Protein-Protein Interaction Modulator with the Potential of Treating Hematological Malignancies.
J.Med.Chem., 66, 2023
8G3X
DownloadVisualize
BU of 8g3x by Molmil
MBP-Mcl1 in complex with ligand 32
Descriptor: 1,2-ETHANEDIOL, Maltodextrin-binding protein, Induced myeloid leukemia cell differentiation protein Mcl-1 chimera, ...
Authors:Miller, B.R, Shaffer, P.
Deposit date:2023-02-08
Release date:2023-05-17
Last modified:2023-05-24
Method:X-RAY DIFFRACTION (1.46 Å)
Cite:Discovery of an Oral, Beyond-Rule-of-Five Mcl-1 Protein-Protein Interaction Modulator with the Potential of Treating Hematological Malignancies.
J.Med.Chem., 66, 2023
8G3W
DownloadVisualize
BU of 8g3w by Molmil
MBP-Mcl1 in complex with ligand 28
Descriptor: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, Maltodextrin-binding protein, ...
Authors:Miller, B.R, Shaffer, P.
Deposit date:2023-02-08
Release date:2023-05-17
Last modified:2023-05-24
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Discovery of an Oral, Beyond-Rule-of-Five Mcl-1 Protein-Protein Interaction Modulator with the Potential of Treating Hematological Malignancies.
J.Med.Chem., 66, 2023
8G3U
DownloadVisualize
BU of 8g3u by Molmil
MBP-Mcl1 in complex with ligand 21
Descriptor: (1'S,3aS,5R,16R,17S,19Z,21R,21aR)-6'-chloro-20-fluoro-21-{[(5S,9aS)-hexahydropyrazino[2,1-c][1,4]oxazin-8(1H)-yl]methyl}-21-methoxy-16,17-dimethyl-2,3,3',3a,4',16,17,18,21,21a-decahydro-2'H,6H,8H-15lambda~6~-spiro[10,12-(ethanediylidene)-15lambda~6~-furo[3,2-i][1,4]oxazepino[3,4-f][1,2,7]thiadiazacyclohexadecine-7,1'-naphthalene]-13,15,15(4H,14H)-trione, 1,2-ETHANEDIOL, Maltodextrin-binding protein, ...
Authors:Miller, B.R, Shaffer, P.
Deposit date:2023-02-08
Release date:2023-05-17
Last modified:2023-05-24
Method:X-RAY DIFFRACTION (1.94 Å)
Cite:Discovery of an Oral, Beyond-Rule-of-Five Mcl-1 Protein-Protein Interaction Modulator with the Potential of Treating Hematological Malignancies.
J.Med.Chem., 66, 2023

217705

PDB entries from 2024-03-27

PDB statisticsPDBj update infoContact PDBjnumon