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1FPP
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1fpp
PROTEIN FARNESYLTRANSFERASE COMPLEX WITH FARNESYL DIPHOSPHATE
Descriptor:PROTEIN FARNESYLTRANSFERASE, FARNESYL DIPHOSPHATE
Authors:Dunten, P., Kammlott, U., Crowther, R., Weber, D., Palermo, R., Birktoft, J.
Deposit date:1998-07-10
Release date:1999-06-08
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Protein farnesyltransferase: structure and implications for substrate binding.
Biochemistry, 37, 1998
1W6J
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1w6j
STRUCTURE OF HUMAN OSC IN COMPLEX WITH RO 48-8071
Descriptor:LANOSTEROL SYNTHASE (E.C.5.4.99.7)
Authors:Thoma, R., Schulz-Gasch, T., Arcy, B.D', Benz, J., Aebi, J., Dehmlow, H., Hennig, M., Ruf, A.
Deposit date:2004-08-18
Release date:2004-10-29
Modification date:2013-11-20
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Insight Into Steroid Scaffold Formation from the Structure of Human Oxidosqualene Cyclase
Nature, 432, 2004
1W6K
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1w6k
STRUCTURE OF HUMAN OSC IN COMPLEX WITH LANOSTEROL
Descriptor:LANOSTEROL SYNTHASE (E.C.5.4.99.7)
Authors:Thoma, R., Schulz-Gasch, T., D'Arcy, B., Benz, J., Aebi, J., Dehmlow, H., Hennig, M., Ruf, A.
Deposit date:2004-08-19
Release date:2004-10-29
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Insight Into Steroid Scaffold Formation from the Structure of Human Oxidosqualene Cyclase
Nature, 432, 2004
1D8D
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1d8d
CO-CRYSTAL STRUCTURE OF RAT PROTEIN FARNESYLTRANSFERASE COMPLEXED WITH A K-RAS4B PEPTIDE SUBSTRATE AND FPP ANALOG AT 2.0A RESOLUTION
Descriptor:farnesyltranserase (alpha subunit)/farnesyltranserase (beta subunit)/K-RAS4B PEPTIDE SUBSTRATE
Authors:Long, S.B., Casey, P.J., Beese, L.S.
Deposit date:1999-10-22
Release date:2000-02-09
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:The basis for K-Ras4B binding specificity to protein farnesyltransferase revealed by 2 A resolution ternary complex structures.
Structure Fold.Des., 8, 2000
1D8E
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1d8e
ZINC-DEPLETED FTASE COMPLEXED WITH K-RAS4B PEPTIDE SUBSTRATE AND FPP ANALOG.
Descriptor:FARNESYLTRANSFERASE (ALPHA SUBUNIT) (E.C.2.5.1.-)/ FARNESYLTRANSFERASE (BETA SUBUNIT) (E.C.2.5.1.-)/K-RAS4B PEPTIDE SUBSTRATE
Authors:Long, S.B., Casey, P.J., Beese, L.S.
Deposit date:1999-10-22
Release date:2000-03-20
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (3 Å)
Cite:The basis for K-Ras4B binding specificity to protein farnesyltransferase revealed by 2 A resolution ternary complex structures.
Structure Fold.Des., 8, 2000
1DCE
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1dce
CRYSTAL STRUCTURE OF RAB GERANYLGERANYLTRANSFERASE FROM RAT BRAIN
Descriptor:RAB GERANYLGERANYLTRANSFERASE (ALPHA AND BETA SUBUNIT)
Authors:Zhang, H., Seabra, M.C., Deisenhofer, H.
Deposit date:1999-11-04
Release date:2000-03-24
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of Rab geranylgeranyltransferase at 2.0 A resolution.
Structure Fold.Des., 8, 2000
1FT1
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1ft1
CRYSTAL STRUCTURE OF PROTEIN FARNESYLTRANSFERASE AT 2.25 ANGSTROMS RESOLUTION
Descriptor:PROTEIN FARNESYLTRANSFERASE
Authors:Beese, L.S., Park, H.-W.
Deposit date:1997-03-17
Release date:1998-03-18
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Crystal structure of protein farnesyltransferase at 2.25 angstrom resolution.
Science, 275, 1997
1FT2
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1ft2
CO-CRYSTAL STRUCTURE OF PROTEIN FARNESYLTRANSFERASE COMPLEXED WITH A FARNESYL DIPHOSPHATE SUBSTRATE
Descriptor:PROTEIN FARNESYLTRANSFERASE, FARNESYL DIPHOSPHATE
Authors:Beese, L.S., Casey, P.J., Long, S.B.
Deposit date:1998-06-02
Release date:1998-11-04
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Cocrystal structure of protein farnesyltransferase complexed with a farnesyl diphosphate substrate.
Biochemistry, 37, 1998
1GSZ
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1gsz
CRYSTAL STRUCTURE OF A SQUALENE CYCLASE IN COMPLEX WITH THE POTENTIAL ANTICHOLESTEREMIC DRUG RO48-8071
Descriptor:SQUALENE--HOPENE CYCLASE (E.C.5.4.99.17)
Authors:Lenhart, A., Weihofen, W.A., Pleschke, A.E.W., Schulz, G.E.
Deposit date:2002-01-09
Release date:2003-01-16
Modification date:2013-11-20
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal Structure of a Squalene Cyclase in Complex with the Potential Anticholesteremic Drug Ro48-8071
Chem.Biol., 9, 2002
1H35
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1h35
STRUCTURES OF HUMAN OXIDOSQUALENE CYCLASE INHIBITORS BOUND TO A HOMOLGOUS ENZYME
Descriptor:SQUALENE--HOPENE CYCLASE (E.C.5.4.99.17)
Authors:Lenhart, A., Reinert, D.J., Weihofen, W.A., Aebi, J.D., Dehmlow, H., Morand, O.H., Schulz, G.E.
Deposit date:2002-08-24
Release date:2003-08-21
Modification date:2013-11-20
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Binding Structures and Potencies of Oxidosqualene Cyclase Inhibitors with the Homologous Squalene-Hopene Cyclase
J.Med.Chem., 46, 2003
1H36
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1h36
STRUCTURES OF HUMAN OXIDOSQUALENE CYCLASE INHIBITORS BOUND TO A HOMOLGOUS ENZYME
Descriptor:SQUALENE--HOPENE CYCLASE (E.C.5.4.99.17)
Authors:Lenhart, A., Reinert, D.J., Weihofen, W.A., Aebi, J.D., Dehmlow, H., Morand, O.H., Schulz, G.E.
Deposit date:2002-08-24
Release date:2003-08-21
Modification date:2014-02-05
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Binding Structures and Potencies of Oxidosqualene Cyclase Inhibitors with the Homologous Squalene-Hopene Cyclase
J.Med.Chem., 46, 2003
1H37
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1h37
STRUCTURES OF HUMAN OXIDOSQUALENE CYCLASE INHIBITORS BOUND TO A HOMOLGOUS ENZYME
Descriptor:SQUALENE--HOPENE CYCLASE (E.C.5.4.99.17)
Authors:Lenhart, A., Reinert, D.J., Weihofen, W.A., Aebi, J.D., Dehmlow, H., Morand, O.H., Schulz, G.E.
Deposit date:2002-08-24
Release date:2003-08-21
Modification date:2013-11-20
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Binding Structures and Potencies of Oxidosqualene Cyclase Inhibitors with the Homologous Squalene-Hopene Cyclase
J.Med.Chem., 46, 2003
1H39
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1h39
STRUCTURES OF HUMAN OXIDOSQUALENE CYCLASE INHIBITORS BOUND TO A HOMOLGOUS ENZYME
Descriptor:SQUALENE--HOPENE CYCLASE (E.C.5.4.99.17)
Authors:Lenhart, A., Reinert, D.J., Weihofen, W.A., Aebi, J.D., Dehmlow, H., Morand, O.H., Schulz, G.E.
Deposit date:2002-08-24
Release date:2003-08-21
Modification date:2013-11-20
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Binding Structures and Potencies of Oxidosqualene Cyclase Inhibitors with the Homologous Squalene-Hopene Cyclase
J.Med.Chem., 46, 2003
1H3A
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1h3a
STRUCTURES OF HUMAN OXIDOSQUALENE CYCLASE INHIBITORS BOUND TO A HOMOLGOUS ENZYME
Descriptor:SQUALENE--HOPENE CYCLASE (E.C.5.4.99.17)
Authors:Lenhart, A., Reinert, D.J., Weihofen, W.A., Aebi, J.D., Dehmlow, H., Morand, O.H., Schulz, G.E.
Deposit date:2002-08-24
Release date:2003-08-21
Modification date:2013-11-20
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Binding Structures and Potencies of Oxidosqualene Cyclase Inhibitors with the Homologous Squalene-Hopene Cyclase
J.Med.Chem., 46, 2003
1H3B
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1h3b
SQUALENE-HOPENE CYCLASE
Descriptor:SQUALENE--HOPENE CYCLASE (E.C.5.4.99.17)
Authors:Lenhart, A., Reinert, D.J., Weihofen, W.A., Aebi, J.D., Dehmlow, H., Morand, O.H., Schulz, G.E.
Deposit date:2002-08-25
Release date:2003-08-21
Modification date:2013-11-20
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Binding Structures and Potencies of Oxidosqualene Cyclase Inhibitors with the Homologous Squalene-Hopene Cyclase
J.Med.Chem., 46, 2003
1H3C
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1h3c
STRUCTURES OF HUMAN OXIDOSQUALENE CYCLASE INHIBITORS BOUND TO A HOMOLGOUS ENZYME
Descriptor:SQUALENE--HOPENE CYCLASE (E.C.5.4.99.17)
Authors:Lenhart, A., Reinert, D.J., Weihofen, W.A., Aebi, J.D., Dehmlow, H., Morand, O.H., Schulz, G.E.
Deposit date:2002-08-25
Release date:2003-08-21
Modification date:2013-11-20
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Binding Structures and Potencies of Oxidosqualene Cyclase Inhibitors with the Homologous Squalene-Hopene Cyclase
J.Med.Chem., 46, 2003
1JCQ
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1jcq
CRYSTAL STRUCTURE OF HUMAN PROTEIN FARNESYLTRANSFERASE COMPLEXED WITH FARNESYL DIPHOSPHATE AND THE PEPTIDOMIMETIC INHIBITOR L-739,750
Descriptor:Protein Farnesyltransferase, alpha and beta subunits (E.C.2.5.1.-)
Authors:Long, S.B., Casey, P.J., Beese, L.S.
Deposit date:2001-06-11
Release date:2001-11-02
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The crystal structure of human protein farnesyltransferase reveals the basis for inhibition by CaaX tetrapeptides and their mimetics.
Proc.Natl.Acad.Sci.USA, 98, 2001
1JCR
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1jcr
CRYSTAL STRUCTURE OF RAT PROTEIN FARNESYLTRANSFERASE COMPLEXED WITH THE NON-SUBSTRATE TETRAPEPTIDE INHIBITOR CVFM AND FARNESYL DIPHOSPHATE SUBSTRATE
Descriptor:Protein Farnesyltransferase, alpha and beta subunits (E.C.2.5.1.-)
Authors:Long, S.B., Casey, P.J., Beese, L.S.
Deposit date:2001-06-11
Release date:2001-11-02
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:The crystal structure of human protein farnesyltransferase reveals the basis for inhibition by CaaX tetrapeptides and their mimetics.
Proc.Natl.Acad.Sci.USA, 98, 2001
1JCS
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1jcs
CRYSTAL STRUCTURE OF RAT PROTEIN FARNESYLTRANSFERASE COMPLEXED WITH THE PEPTIDE SUBSTRATE TKCVFM AND AN ANALOG OF FARNESYL DIPHOSPHATE
Descriptor:Protein Farnesyltransferase, alpha and beta subunits (E.C.2.5.1.-)
Authors:Long, S.B., Casey, P.J., Beese, L.S.
Deposit date:2001-06-11
Release date:2001-11-02
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The crystal structure of human protein farnesyltransferase reveals the basis for inhibition by CaaX tetrapeptides and their mimetics.
Proc.Natl.Acad.Sci.USA, 98, 2001
1KZO
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1kzo
PROTEIN FARNESYLTRANSFERASE COMPLEXED WITH FARNESYLATED K-RAS4B PEPTIDE PRODUCT AND FARNESYL DIPHOSPHATE SUBSTRATE BOUND SIMULTANEOUSLY
Descriptor:Protein Farnesyltransferase alpha subunit(E.C.2.5.1.21)/Protein Farnesyltransferase beta subunit(E.C.2.5.1.21)/Farnesylated K-Ras4B peptide product
Authors:Long, S.B., Casey, P.J., Beese, L.S.
Deposit date:2002-02-07
Release date:2002-10-16
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The Reaction Path of Protein Farnesyltransferase at Atomic Resolution
Nature, 419, 2002
1KZP
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1kzp
PROTEIN FARNESYLTRANSFERASE COMPLEXED WITH A FARNESYLATED K-RAS4B PEPTIDE PRODUCT
Descriptor:Protein Farnesyltransferase alpha subunit (E.C.2.5.1.21)/Protein Farnesyltransferase beta subunit (E.C.2.5.1.21)/Farnesylated K-Ras4B peptide product
Authors:Long, S.B., Casey, P.J., Beese, L.S.
Deposit date:2002-02-07
Release date:2002-10-16
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Reaction path of protein farnesyltransferase at atomic resolution
Nature, 419, 2002
1LD7
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1ld7
CO-CRYSTAL STRUCTURE OF HUMAN FARNESYLTRANSFERASE WITH FARNESYLDIPHOSPHATE AND INHIBITOR COMPOUND 66
Descriptor:protein farnesyltransferase alpha subunit (E.C.2.5.1.-)/protein farnesyltransferase beta subunit (E.C.2.5.1.-)
Authors:Taylor, J.S., Terry, K.L., Beese, L.S.
Deposit date:2002-04-08
Release date:2002-06-19
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:3-Aminopyrrolidinone farnesyltransferase inhibitors: design of macrocyclic compounds with improved pharmacokinetics and excellent cell potency.
J.Med.Chem., 45, 2002
1LD8
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1ld8
CO-CRYSTAL STRUCTURE OF HUMAN FARNESYLTRANSFERASE WITH FARNESYLDIPHOSPHATE AND INHIBITOR COMPOUND 49
Descriptor:protein farnesyltransferase alpha subunit (E.C.2.5.1.-), protein farnesyltransferase beta subunit (E.C.2.5.1.-)
Authors:Taylor, J.S., Terry, K.L., Beese, L.S.
Deposit date:2002-04-08
Release date:2002-06-19
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:3-Aminopyrrolidinone farnesyltransferase inhibitors: design of macrocyclic compounds with improved pharmacokinetics and excellent cell potency.
J.Med.Chem., 45, 2002
1LTX
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1ltx
STRUCTURE OF RAB ESCORT PROTEIN-1 IN COMPLEX WITH RAB GERANYLGERANYL TRANSFERASE AND ISOPRENOID
Descriptor:RAB GERANYLGERANYLTRANSFERASE ALPHA SUBUNIT(E.C.2.5.1._)/RAB GERANYLGERANYLTRANSFERASE BETA SUBUNIT(E.C.2.5.1._)/Rab Escort Protein 1
Authors:Pylypenko, O., Rak, A., Reents, R., Niculae, A., Thoma, N.H., Waldmann, H., Schlichting, I., Goody, R.S., Alexandrov, K.
Deposit date:2002-05-21
Release date:2003-05-21
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structure of Rab Escort Protein-1 in Complex with Rab Geranylgeranyltransferase
Mol.Cell, 11, 2003
1MZC
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1mzc
CO-CRYSTAL STRUCTURE OF HUMAN FARNESYLTRANSFERASE WITH FARNESYLDIPHOSPHATE AND INHIBITOR COMPOUND 33A
Descriptor:Protein Farnesyltransferase alpha Subunit (E.C.2.5.1.-)/Protein Farnesyltransferase beta Subunit (E.C.2.5.1.-)
Authors:deSolms, S.J., Ciccarone, T.M., MacTough, S.C., Shaw, A.W., Buser, C.A., Ellis-Hutchings, M., Fernandes, C., Hamilton, K.A., Huber, H.E., Kohl, N.E., Lobell, R.B., Robinson, R.G., Tsou, N.N., Walsh, E.S., Graham, S.L., Beese, L.S., Taylor, J.S.
Deposit date:2002-10-07
Release date:2003-07-08
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Dual Protein Farnesyltransferase-Geranylgeranyltransferase-I Inhibitors as Potential Cancer Chemotherapeutic Agents.
J.Med.Chem., 46, 2003
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104537
entries available on 2014-10-29
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