8X3H
 
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8FEI
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8D6U
 | | Rana catesbeiana saxiphilin:F-STX (soaked) | | Descriptor: | (2P)-4-({6-[({[(3aS,4R,7R,10aS)-2,6-diamino-10,10-dihydroxy-3a,4,9,10-tetrahydro-3H,8H-pyrrolo[1,2-c]purin-4-yl]methoxy}carbonyl)amino]hexyl}carbamoyl)-2-{[4aP,9(9a)P]-6-hydroxy-3-oxo-3H-xanthen-9-yl}benzoic acid, Saxiphilin | | Authors: | Chen, Z, Zakrzewska, S, Minor, D.L. | | Deposit date: | 2022-06-06 | | Release date: | 2022-11-02 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2.65 Å) | | Cite: | Definition of a saxitoxin (STX) binding code enables discovery and characterization of the anuran saxiphilin family.
Proc.Natl.Acad.Sci.USA, 119, 2022
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8D6T
 | | Rana catesbeiana saxiphilin mutant - Y558I:STX (co-crystal) | | Descriptor: | CACODYLATE ION, Saxiphilin, [(3aS,4R,10aS)-2,6-diamino-10,10-dihydroxy-3a,4,9,10-tetrahydro-3H,8H-pyrrolo[1,2-c]purin-4-yl]methyl carbamate | | Authors: | Chen, Z, Zakrzewska, S, Minor, D.L. | | Deposit date: | 2022-06-06 | | Release date: | 2022-11-02 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2.15 Å) | | Cite: | Definition of a saxitoxin (STX) binding code enables discovery and characterization of the anuran saxiphilin family.
Proc.Natl.Acad.Sci.USA, 119, 2022
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8D6S
 | | Rana catesbeiana saxiphilin mutant - Y558A:STX (co-crystal) | | Descriptor: | Saxiphilin, [(3aS,4R,10aS)-2,6-diamino-10,10-dihydroxy-3a,4,9,10-tetrahydro-3H,8H-pyrrolo[1,2-c]purin-4-yl]methyl carbamate | | Authors: | Chen, Z, Zakrzewska, S, Minor, D.L. | | Deposit date: | 2022-06-06 | | Release date: | 2022-11-02 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Definition of a saxitoxin (STX) binding code enables discovery and characterization of the anuran saxiphilin family.
Proc.Natl.Acad.Sci.USA, 119, 2022
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8D6Q
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8D6P
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8BRC
 | | Crystal structure of the adduct between human serum transferrin and cisplatin | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, AMMONIA, FE (III) ION, ... | | Authors: | Troisi, R, Galardo, F, Ferraro, G, Sica, F, Merlino, A. | | Deposit date: | 2022-11-22 | | Release date: | 2023-01-18 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (3.17 Å) | | Cite: | Cisplatin Binding to Human Serum Transferrin: A Crystallographic Study.
Inorg.Chem., 62, 2023
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7Q1L
 | | Glycosilated Human Serum Apo-tranferrin | | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, ... | | Authors: | Gavira, J.A, Moreno, A, Campos-Escamilla, C, Gonzalez-Ramirez, L.A, Siliqi, D. | | Deposit date: | 2021-10-20 | | Release date: | 2022-03-16 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | X-ray Characterization of Conformational Changes of Human Apo- and Holo-Transferrin.
Int J Mol Sci, 22, 2021
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7N88
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7JRD
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7FFU
 | | Osmium-bound human serum transferrin | | Descriptor: | FE (III) ION, MALONATE ION, OSMIUM ION, ... | | Authors: | Wang, M, Sun, H. | | Deposit date: | 2021-07-23 | | Release date: | 2022-06-22 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.601 Å) | | Cite: | Binding of ruthenium and osmium at non‐iron sites of transferrin accounts for their iron-independent cellular uptake.
J.Inorg.Biochem., 234, 2022
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7FFM
 | | Human serum transferrin with five osmium binding sites | | Descriptor: | MALONATE ION, NITRILOTRIACETIC ACID, OSMIUM ION, ... | | Authors: | Wang, M, Sun, H. | | Deposit date: | 2021-07-23 | | Release date: | 2022-06-22 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (3.06 Å) | | Cite: | Binding of ruthenium and osmium at non‐iron sites of transferrin accounts for their iron-independent cellular uptake.
J.Inorg.Biochem., 234, 2022
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7FDW
 | | Crystal structure of pepsin cleaved lactoferrin C-lobe at 2.28 A resolution | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CARBONATE ION, FE (III) ION, ... | | Authors: | Singh, P.K, Singh, J, Maurya, A, Sharma, P, Sharma, S, Singh, T.P. | | Deposit date: | 2021-07-18 | | Release date: | 2021-08-04 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.277 Å) | | Cite: | A Peptide Bond from the Inter-lobe Segment in the Bilobal Lactoferrin Acts as a Preferred Site for Cleavage for Serine Proteases to Generate the Perfect C-lobe: Structure of the Pepsin Hydrolyzed Lactoferrin C-lobe at 2.28 angstrom Resolution.
Protein J., 40, 2021
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7EVQ
 | | Crystal structure of C-terminal half of lactoferrin obtained by limited proteolysis using pepsin at 2.6 A resolution | | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, BICARBONATE ION, ... | | Authors: | Viswanathan, V, Singh, J, Sharma, P, Sharma, S, Singh, T.P. | | Deposit date: | 2021-05-21 | | Release date: | 2021-06-09 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Crystal structure of C-terminal half of lactoferrin obtained by limited proteolysis using pepsin at 2.6 A resolution
To Be Published
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7EV0
 | | Crystal structure of pepsin cleaved C-terminal half of lactoferrin at 2.7A resolution | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CARBONATE ION, ... | | Authors: | Singh, J, Ahmad, M.I, Maurya, A, Sharma, P, Sharma, S, Singh, T.P. | | Deposit date: | 2021-05-19 | | Release date: | 2021-06-02 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Crystal structure of pepsin cleaved C-terminal half of lactoferrin at 2.7A resolution
To Be Published
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7EQU
 | | Crystal structure of the C-lobe of lactoferrin produced by limited proteolysis using pepsin at 2.74A resolution | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, BICARBONATE ION, FE (III) ION, ... | | Authors: | Maurya, A, Singh, J, Sharma, A, Sharma, P, Sharma, S, Singh, T.P. | | Deposit date: | 2021-05-04 | | Release date: | 2021-05-19 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.743 Å) | | Cite: | Crystal structure of the C-lobe of lactoferrin produced by limited proteolysis using pepsin at 2.74A resolution
To Be Published
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7ENU
 | | Crystal structure of iron-saturated C-terminal half of lactoferrin produced proteolytically using pepsin at 2.32A resolution | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CARBONATE ION, FE (III) ION, ... | | Authors: | Singh, J, Maurya, A, Viswanathan, V, Singh, P.K, Sharma, P, Sharma, S, Singh, T.P. | | Deposit date: | 2021-04-19 | | Release date: | 2021-05-19 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.322 Å) | | Cite: | Crystal structure of iron-saturated C-terminal half of lactoferrin produced proteolytically using pepsin at 2.32A resolution
To Be Published
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6XR0
 | | Crystal Structure of Human Melanotransferrin in complex with SC57.32 Fab | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, BICARBONATE ION, ... | | Authors: | Hayashi, K, Longenecker, K.L, Vivona, S. | | Deposit date: | 2020-07-10 | | Release date: | 2021-01-20 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (3.064 Å) | | Cite: | Complex of human Melanotransferrin and SC57.32 Fab fragment reveals novel interdomain arrangement with ferric N-lobe and open C-lobe.
Sci Rep, 11, 2021
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6WB6
 | | 2.05 A resolution structure of transferrin 1 from Manduca sexta | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CARBONATE ION, FE (III) ION, ... | | Authors: | Lovell, S, Kashipathy, M.M, Battaile, K.P, Weber, J.J, Gorman, M.J. | | Deposit date: | 2020-03-26 | | Release date: | 2020-11-25 | | Last modified: | 2021-03-03 | | Method: | X-RAY DIFFRACTION (2.05 Å) | | Cite: | Structural insight into the novel iron-coordination and domain interactions of transferrin-1 from a model insect, Manduca sexta.
Protein Sci., 30, 2021
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6UJ6
 | | X-ray Crystal Structure of Chromium-transferrin with Synergistic Anion Malonate | | Descriptor: | BICARBONATE ION, CHROMIUM ION, GLYCEROL, ... | | Authors: | Petersen, C.M, Edwards, K.C, Gilbert, N.C, Vincent, J.B, Thompson, M.K. | | Deposit date: | 2019-10-02 | | Release date: | 2020-09-30 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (2.68 Å) | | Cite: | X-ray structure of chromium(III)-containing transferrin: First structure of a physiological Cr(III)-binding protein.
J.Inorg.Biochem., 210, 2020
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6SOZ
 | | Glycosylated Trypanosoma brucei transferrin receptor in complex with human transferrin | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ESAG6, ... | | Authors: | Trevor, C, Carrington, M, Higgins, M.K. | | Deposit date: | 2019-08-30 | | Release date: | 2019-11-06 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (3.42 Å) | | Cite: | Structure of the trypanosome transferrin receptor reveals mechanisms of ligand recognition and immune evasion.
Nat Microbiol, 4, 2019
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6SOY
 | | Trypanosoma brucei transferrin receptor in complex with human transferrin | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ESAG6, subunit of heterodimeric transferrin receptor, ... | | Authors: | Trevor, C, Carrington, M, Higgins, M.K. | | Deposit date: | 2019-08-30 | | Release date: | 2019-11-06 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (2.75 Å) | | Cite: | Structure of the trypanosome transferrin receptor reveals mechanisms of ligand recognition and immune evasion.
Nat Microbiol, 4, 2019
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6O0F
 | | Saxiphilin:STX complex, co-crystal | | Descriptor: | Saxiphilin, [(3aS,4R,10aS)-2,6-diamino-10,10-dihydroxy-3a,4,9,10-tetrahydro-3H,8H-pyrrolo[1,2-c]purin-4-yl]methyl carbamate | | Authors: | Yen, T.J, Lolicato, M, Minor, D.L. | | Deposit date: | 2019-02-16 | | Release date: | 2019-07-10 | | Last modified: | 2019-12-04 | | Method: | X-RAY DIFFRACTION (2.12 Å) | | Cite: | Structure of the saxiphilin:saxitoxin (STX) complex reveals a convergent molecular recognition strategy for paralytic toxins.
Sci Adv, 5, 2019
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6O0E
 | | Saxiphilin:STX complex, soaking | | Descriptor: | Saxiphilin, [(3aS,4R,10aS)-2,6-diamino-10,10-dihydroxy-3a,4,9,10-tetrahydro-3H,8H-pyrrolo[1,2-c]purin-4-yl]methyl carbamate | | Authors: | Yen, T.J, Lolicato, M, Minor, D.L. | | Deposit date: | 2019-02-16 | | Release date: | 2019-07-10 | | Last modified: | 2019-12-04 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Structure of the saxiphilin:saxitoxin (STX) complex reveals a convergent molecular recognition strategy for paralytic toxins.
Sci Adv, 5, 2019
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