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6E1Z
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BU of 6e1z by Molmil
Displacement of WDR5 from chromatin by a pharmacological WIN site inhibitor with picomolar affinity
Descriptor: 5-[(1H-imidazol-1-yl)methyl]furan-2-carboxylic acid, WD repeat-containing protein 5
Authors:Phan, J, Fesik, S.W.
Deposit date:2018-07-10
Release date:2019-03-13
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Displacement of WDR5 from Chromatin by a WIN Site Inhibitor with Picomolar Affinity.
Cell Rep, 26, 2019
1YFQ
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BU of 1yfq by Molmil
High resolution S. cerevisiae Bub3 mitotic checkpoint protein
Descriptor: ACETATE ION, CALCIUM ION, Cell cycle arrest protein BUB3
Authors:Wilson, D.K, Cerna, D, Chew, E.
Deposit date:2005-01-03
Release date:2005-01-11
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:The 1.1-a structure of the spindle checkpoint protein bub3p reveals functional regions.
J.Biol.Chem., 280, 2005
6QTS
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BU of 6qts by Molmil
Crystal structure of a mutant Arabidopsis WD40 domain in complex with a photoreceptor
Descriptor: E3 ubiquitin-protein ligase COP1, GLYCEROL, SULFATE ION, ...
Authors:Hothorn, M, Lau, K.
Deposit date:2019-02-25
Release date:2019-07-10
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.11 Å)
Cite:Plant photoreceptors and their signaling components compete for COP1 binding via VP peptide motifs.
Embo J., 38, 2019
6U6W
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BU of 6u6w by Molmil
Discovery and optimization of salicyclic acid-derived sulfonamide inhibitors of the WDR5:MYC protein-protein interaction
Descriptor: 5-bromo-N-(5-chloro-2-hydroxyphenyl)-2-methoxybenzene-1-sulfonamide, WD repeat-containing protein 5
Authors:Zhao, B, Wang, F.
Deposit date:2019-08-30
Release date:2019-12-04
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Discovery and Optimization of Salicylic Acid-Derived Sulfonamide Inhibitors of the WD Repeat-Containing Protein 5-MYC Protein-Protein Interaction.
J.Med.Chem., 62, 2019
6E1Y
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BU of 6e1y by Molmil
Discovery of Potent 2-Aryl-6,7-Dihydro-5HPyrrolo[ 1,2-a]imidazoles as WDR5 WIN-site Inhibitors Using Fragment-Based Methods and Structure-Based Design
Descriptor: N-[(1S)-1-(3-chlorophenyl)ethyl]-3-{[(4,5-dihydro-1H-imidazol-2-yl)amino]methyl}benzamide, WD repeat-containing protein 5
Authors:Phan, J, Fesik, S.W.
Deposit date:2018-07-10
Release date:2019-03-13
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.219 Å)
Cite:Displacement of WDR5 from Chromatin by a WIN Site Inhibitor with Picomolar Affinity.
Cell Rep, 26, 2019
8EWX
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BU of 8ewx by Molmil
N-terminal WD40 domain of beta'-COPI subunit with two chains in the asymmetric unit
Descriptor: Coatomer subunit beta'
Authors:Dey, D, Hasan, S.S.
Deposit date:2022-10-24
Release date:2023-08-30
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.24 Å)
Cite:Strategies for rapid production of crystallization quality coatomer WD40 domains.
Protein Expr.Purif., 212, 2023
7S16
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BU of 7s16 by Molmil
Crystal structure of alpha-COP-WD40 domain R57A mutant
Descriptor: Coatomer subunit alpha, SODIUM ION
Authors:Dey, D, Singh, S, Khan, S, Martin, M, Schnicker, N, Gakhar, L, Pierce, B, Hasan, S.S.
Deposit date:2021-09-01
Release date:2022-02-16
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.24 Å)
Cite:An extended motif in the SARS-CoV-2 spike modulates binding and release of host coatomer in retrograde trafficking
Commun Biol, 5, 2022
6UHZ
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BU of 6uhz by Molmil
WDR5 in complex with Myc site fragment inhibitor
Descriptor: 1-cyclohexyl-1H-benzotriazole-5-carboxylic acid, WDR5
Authors:Wang, F, Fesik, S.w.
Deposit date:2019-09-29
Release date:2020-04-15
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.258 Å)
Cite:Discovery of WD Repeat-Containing Protein 5 (WDR5)-MYC Inhibitors Using Fragment-Based Methods and Structure-Based Design.
J.Med.Chem., 63, 2020
6UHY
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BU of 6uhy by Molmil
WDR5 in complex with Myc site fragment inhibitor
Descriptor: 1-cyclohexyl-1H-benzimidazole-5-carboxylic acid, WDR5
Authors:Wang, F, Fesik, S.W.
Deposit date:2019-09-29
Release date:2020-04-15
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.26 Å)
Cite:Discovery of WD Repeat-Containing Protein 5 (WDR5)-MYC Inhibitors Using Fragment-Based Methods and Structure-Based Design.
J.Med.Chem., 63, 2020
7BED
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BU of 7bed by Molmil
X-ray structure of WDR5 bound to the WDR5 win motif peptide
Descriptor: SULFATE ION, WD repeat-containing protein 5
Authors:McVey, C.E, Kaye, K.M.
Deposit date:2020-12-23
Release date:2021-12-08
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.26 Å)
Cite:MLL1 is regulated by KSHV LANA and is important for virus latency.
Nucleic Acids Res., 49, 2021
6U8B
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BU of 6u8b by Molmil
Discovery and optimization of salicyclic acid-derived sulfonamide inhibitors of the WDR5:MYC protein-protein interaction
Descriptor: 3-{[(5-bromo-2-methoxyphenyl)sulfonyl]amino}-5-chloro-2-hydroxybenzoic acid, WD repeat-containing protein 5
Authors:Zhao, B, Wang, F.
Deposit date:2019-09-04
Release date:2019-12-04
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.261 Å)
Cite:Discovery and Optimization of Salicylic Acid-Derived Sulfonamide Inhibitors of the WD Repeat-Containing Protein 5-MYC Protein-Protein Interaction.
J.Med.Chem., 62, 2019
6QTO
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BU of 6qto by Molmil
Crystal structure of an Arabidopsis WD40 domain in complex with a transcription factor
Descriptor: E3 ubiquitin-protein ligase COP1, GLYCEROL, SULFATE ION, ...
Authors:Hothorn, M, Lau, K.
Deposit date:2019-02-25
Release date:2019-07-10
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.27 Å)
Cite:Plant photoreceptors and their signaling components compete for COP1 binding via VP peptide motifs.
Embo J., 38, 2019
5U69
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BU of 5u69 by Molmil
Polycomb protein EED in complex with inhibitor: (3R,4S)-1-[(2-methoxyphenyl)methyl]-N,N-dimethyl-4-(1-methylindol-3-yl)pyrrolidin-3-amine
Descriptor: (3R,4S)-1-[(2-methoxyphenyl)methyl]-N,N-dimethyl-4-(1-methylindol-3-yl)pyrrolidin-3-amine, Polycomb protein EED
Authors:Jakob, C.G, Zhu, H.
Deposit date:2016-12-07
Release date:2017-03-15
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.28 Å)
Cite:SAR of amino pyrrolidines as potent and novel protein-protein interaction inhibitors of the PRC2 complex through EED binding.
Bioorg. Med. Chem. Lett., 27, 2017
6QTQ
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BU of 6qtq by Molmil
Crystal structure of an Arabidopsis WD40 domain in complex with photoreceptor
Descriptor: E3 ubiquitin-protein ligase COP1, GLYCEROL, SULFATE ION, ...
Authors:Hothorn, M, Lau, K.
Deposit date:2019-02-25
Release date:2019-07-10
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Plant photoreceptors and their signaling components compete for COP1 binding via VP peptide motifs.
Embo J., 38, 2019
6QTU
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BU of 6qtu by Molmil
Crystal structure of Arabidopsis WD40 domain in complex with a BBX transcription factor
Descriptor: B-box zinc finger protein 24, E3 ubiquitin-protein ligase COP1, GLYCEROL, ...
Authors:Hothorn, M, Lau, K.
Deposit date:2019-02-25
Release date:2019-07-10
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Plant photoreceptors and their signaling components compete for COP1 binding via VP peptide motifs.
Embo J., 38, 2019
7MT1
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BU of 7mt1 by Molmil
Crystal structure of Human Platelet-activating factor acetylhydrolase IB subunit beta (PAFAH1B1)
Descriptor: GLYCEROL, Platelet-activating factor acetylhydrolase IB subunit beta, UNKNOWN ATOM OR ION
Authors:Hutchinson, A, Seitova, A, Dong, A, Loppnau, P, Edwards, A.M, Arrowsmith, C.H, Halabelian, L, Structural Genomics Consortium (SGC)
Deposit date:2021-05-12
Release date:2021-06-09
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Crystal structure of Human Platelet-activating factor acetylhydrolase IB subunit beta (PAFAH1B1)
To Be Published
4ERY
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BU of 4ery by Molmil
X-ray structure of WDR5-MLL3 Win motif peptide binary complex
Descriptor: Histone-lysine N-methyltransferase MLL3, WD repeat-containing protein 5
Authors:Dharmarajan, V, Lee, J.-H, Patel, A, Skalnik, D.G, Cosgrove, M.S.
Deposit date:2012-04-21
Release date:2012-05-16
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Structural basis for WDR5 interaction (Win) motif recognition in human SET1 family histone methyltransferases.
J.Biol.Chem., 287, 2012
8F0E
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BU of 8f0e by Molmil
N-terminal WD40 domain of beta'-COPI subunit with four chains in the asymmetric unit
Descriptor: Coatomer subunit beta'
Authors:Dey, D, Hasan, S.S.
Deposit date:2022-11-02
Release date:2023-08-30
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.31 Å)
Cite:Strategies for rapid production of crystallization quality coatomer WD40 domains.
Protein Expr.Purif., 212, 2023
6QTV
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BU of 6qtv by Molmil
Crystal structure of an Arabidopsis WD40 domain in complex with an atypical bHLH transcription factor
Descriptor: E3 ubiquitin-protein ligase COP1, GLYCEROL, MALONATE ION, ...
Authors:Hothorn, M, Lau, K.
Deposit date:2019-02-25
Release date:2019-07-10
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.31 Å)
Cite:Plant photoreceptors and their signaling components compete for COP1 binding via VP peptide motifs.
Embo J., 38, 2019
8G3E
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BU of 8g3e by Molmil
Crystal structure of human WDR5 in complex with (1M)-N-[(3,5-difluoro[1,1'-biphenyl]-4-yl)methyl]-6-methyl-4-oxo-1-(pyridin-3-yl)-1,4-dihydropyridazine-3-carboxamide (compound 2, WDR5-MYC inhibitor)
Descriptor: (1M)-N-[(3,5-difluoro[1,1'-biphenyl]-4-yl)methyl]-6-methyl-4-oxo-1-(pyridin-3-yl)-1,4-dihydropyridazine-3-carboxamide, WD repeat-containing protein 5
Authors:Zhao, M.
Deposit date:2023-02-07
Release date:2023-06-28
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.33 Å)
Cite:Discovery and Structure-Based Design of Inhibitors of the WD Repeat-Containing Protein 5 (WDR5)-MYC Interaction.
J.Med.Chem., 66, 2023
5U8F
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BU of 5u8f by Molmil
Polycomb protein EED in complex with inhibitor: (3R,4S)-1-[(1S)-7-fluoro-2,3-dihydro-1H-inden-1-yl]-N,N-dimethyl-4-(1-methyl-1H-indol-3-yl)pyrrolidin-3-amine
Descriptor: (3R,4S)-1-[(1S)-7-fluoro-2,3-dihydro-1H-inden-1-yl]-N,N-dimethyl-4-(1-methyl-1H-indol-3-yl)pyrrolidin-3-amine, Polycomb protein EED
Authors:Jakob, C.G, Zhu, H.
Deposit date:2016-12-14
Release date:2017-03-15
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.343 Å)
Cite:SAR of amino pyrrolidines as potent and novel protein-protein interaction inhibitors of the PRC2 complex through EED binding.
Bioorg. Med. Chem. Lett., 27, 2017
3ODT
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BU of 3odt by Molmil
Crystal structure of WD40 beta propeller domain of Doa1
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, Protein DOA1
Authors:Pashkova, N, Gakhar, L, Winistorfer, S.C, Yu, L, Ramaswamy, S, Piper, R.C.
Deposit date:2010-08-11
Release date:2010-12-01
Last modified:2019-12-25
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:WD40 Repeat Propellers Define a Ubiquitin-Binding Domain that Regulates Turnover of F Box Proteins.
Mol.Cell, 40, 2010
4GGC
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BU of 4ggc by Molmil
Structural Analysis of Human Cdc20 Supports Multi-site Degron Recognition by APC/C
Descriptor: (4R)-2-METHYLPENTANE-2,4-DIOL, Cell division cycle protein 20 homolog
Authors:Luo, X, Tian, W, Tomchick, D.R.
Deposit date:2012-08-06
Release date:2012-11-07
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Structural analysis of human Cdc20 supports multisite degron recognition by APC/C.
Proc.Natl.Acad.Sci.USA, 109, 2012
6QTR
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BU of 6qtr by Molmil
Crystal structure of a mutant Arabidopsis WD40 domain in complex with a transcription factor
Descriptor: E3 ubiquitin-protein ligase COP1, GLYCEROL, SULFATE ION, ...
Authors:Hothorn, M, Lau, K.
Deposit date:2019-02-25
Release date:2019-07-10
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.37 Å)
Cite:Plant photoreceptors and their signaling components compete for COP1 binding via VP peptide motifs.
Embo J., 38, 2019
3EMH
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BU of 3emh by Molmil
Structural basis of WDR5-MLL interaction
Descriptor: Mixed-lineage leukemia protein 1, SULFATE ION, WD repeat-containing protein 5
Authors:Song, J.J, Kingston, R.E.
Deposit date:2008-09-24
Release date:2008-10-07
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.37 Å)
Cite:WDR5 Interacts with Mixed Lineage Leukemia (MLL) Protein via the Histone H3-binding Pocket.
J.Biol.Chem., 283, 2008

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