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8QO9
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BU of 8qo9 by Molmil
Cryo-EM structure of a human spliceosomal B complex protomer
Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, MINX pre-mRNA, Microfibrillar-associated protein 1, ...
Authors:Zhang, Z, Kumar, V, Dybkov, O, Will, C.L, Urlaub, H, Stark, H, Luehrmann, R.
Deposit date:2023-09-28
Release date:2024-01-24
Method:ELECTRON MICROSCOPY (5.29 Å)
Cite:New insights into the functions of B complex proteins revealed by cryo-EM of dimerized spliceosomes
To Be Published
8Q7N
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BU of 8q7n by Molmil
cryo-EM structure of the human spliceosomal B complex protomer (tri-snRNP core region)
Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, MINX pre-mRNA, Microfibrillar-associated protein 1, ...
Authors:Zhang, Z, Kumar, V, Dybkov, O, Will, C.L, Urlaub, H, Stark, H, Luehrmann, R.
Deposit date:2023-08-16
Release date:2024-01-24
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:New insights into the functions of B complex proteins revealed by cryo-EM of dimerized spliceosomes
To Be Published
7SUQ
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BU of 7suq by Molmil
Two-state solution NMR structure of Pin1 bound to peptide FFpSPR
Descriptor: Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1
Authors:Born, A, Vogeli, B.
Deposit date:2021-11-17
Release date:2022-08-17
Method:SOLUTION NMR
Cite:Ligand-specific conformational change drives interdomain allostery in Pin1.
Nat Commun, 13, 2022
7SUR
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BU of 7sur by Molmil
Two-state solution NMR structure of Pin1 bound to peptide pCDC25c
Descriptor: Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1
Authors:Born, A, Vogeli, B.
Deposit date:2021-11-17
Release date:2022-08-17
Method:SOLUTION NMR
Cite:Ligand-specific conformational change drives interdomain allostery in Pin1.
Nat Commun, 13, 2022
7EKV
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BU of 7ekv by Molmil
Crystal Structure of human Pin1 complexed with a covalent inhibitor
Descriptor: 3,6,9,12,15,18,21-HEPTAOXATRICOSANE-1,23-DIOL, 8-(2-chloroacetyl)-4-((5-phenylfuran-2-yl)methyl)-1-thia-4,8-diazaspiro[4.5]decan-3-one, Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1
Authors:Liu, L, Li, J.
Deposit date:2021-04-06
Release date:2022-02-16
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Computational and Structure-Based Development of High Potent Cell-Active Covalent Inhibitor Targeting the Peptidyl-Prolyl Isomerase NIMA-Interacting-1 (Pin1).
J.Med.Chem., 65, 2022
7EFJ
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BU of 7efj by Molmil
Crystal Structure Analysis of human PIN1
Descriptor: 3,6,9,12,15,18,21-HEPTAOXATRICOSANE-1,23-DIOL, 8-(2-chloroacetyl)-4-(furan-2-ylmethyl)-1-thia-4,8-diazaspiro[4.5]decan-3-one, Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1
Authors:Liu, L, Li, J.
Deposit date:2021-03-21
Release date:2022-02-16
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.992 Å)
Cite:Computational and Structure-Based Development of High Potent Cell-Active Covalent Inhibitor Targeting the Peptidyl-Prolyl Isomerase NIMA-Interacting-1 (Pin1).
J.Med.Chem., 65, 2022
7EFX
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BU of 7efx by Molmil
Crystal Structure of human PIN1 complexed with covalent inhibitor
Descriptor: 4-((5-bromofuran-2-yl)methyl)-8-(2-chloroacetyl)-1-thia-4,8-diazaspiro[4.5]decan-3-one, Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1
Authors:Liu, L, Li, J, Zhu, R, Pei, Y.
Deposit date:2021-03-23
Release date:2022-02-16
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.41 Å)
Cite:Computational and Structure-Based Development of High Potent Cell-Active Covalent Inhibitor Targeting the Peptidyl-Prolyl Isomerase NIMA-Interacting-1 (Pin1).
J.Med.Chem., 65, 2022
7F0M
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BU of 7f0m by Molmil
Crystal Structure of human Pin1 complexed with a potent covalent inhibitor
Descriptor: 3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL, 8-(2-chloranylethanoyl)-4-[(5-naphthalen-1-ylfuran-2-yl)methyl]-1-thia-4,8-diazaspiro[4.5]decan-3-one, Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1
Authors:Liu, L, Li, J.
Deposit date:2021-06-05
Release date:2022-02-16
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Computational and Structure-Based Development of High Potent Cell-Active Covalent Inhibitor Targeting the Peptidyl-Prolyl Isomerase NIMA-Interacting-1 (Pin1).
J.Med.Chem., 65, 2022
7SA5
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BU of 7sa5 by Molmil
Two-state solution NMR structure of Apo Pin1
Descriptor: Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1
Authors:Born, A, Vogeli, B.
Deposit date:2021-09-22
Release date:2021-10-20
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Reconstruction of Coupled Intra- and Interdomain Protein Motion from Nuclear and Electron Magnetic Resonance.
J.Am.Chem.Soc., 143, 2021
7OQE
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BU of 7oqe by Molmil
Saccharomyces cerevisiae spliceosomal pre-A complex (delta BS-A ACT1)
Descriptor: 56 kDa U1 small nuclear ribonucleoprotein component, ACT1 pre-mRNA (delta BS-A), Cold sensitive U2 snRNA suppressor 1, ...
Authors:Zhang, Z, Rigo, N, Dybkov, O, Fourmann, J, Will, C.L, Kumar, V, Urlaub, H, Stark, H, Luehrmann, R.
Deposit date:2021-06-03
Release date:2021-08-11
Last modified:2021-09-29
Method:ELECTRON MICROSCOPY (5.9 Å)
Cite:Structural insights into how Prp5 proofreads the pre-mRNA branch site.
Nature, 596, 2021
7LP1
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BU of 7lp1 by Molmil
Structure of Nedd4L WW3 domain
Descriptor: E3 ubiquitin-protein ligase NEDD4-like, GLYCEROL, NITRATE ION
Authors:Alian, A, Alam, S.L, Thompson, T, Rheinemann, L, Sundquist, W.I.
Deposit date:2021-02-11
Release date:2021-07-28
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Interactions between AMOT PPxY motifs and NEDD4L WW domains function in HIV-1 release.
J.Biol.Chem., 297, 2021
7LP3
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BU of 7lp3 by Molmil
Structure of Nedd4L WW3 domain
Descriptor: Angiomotin, E3 ubiquitin-protein ligase NEDD4-like, SULFATE ION
Authors:Alian, A, Alam, S.L, Thompson, T, Rheinemann, L, Sundquist, W.I.
Deposit date:2021-02-11
Release date:2021-07-28
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.61 Å)
Cite:Interactions between AMOT PPxY motifs and NEDD4L WW domains function in HIV-1 release.
J.Biol.Chem., 297, 2021
7LP2
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BU of 7lp2 by Molmil
Structure of Nedd4L WW3 domain
Descriptor: Angiomotin, E3 ubiquitin-protein ligase, GLYCEROL, ...
Authors:Alian, A, Alam, S.L, Thompson, T, Rheinemann, L, Sundquist, W.I.
Deposit date:2021-02-11
Release date:2021-07-28
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:Interactions between AMOT PPxY motifs and NEDD4L WW domains function in HIV-1 release.
J.Biol.Chem., 297, 2021
7LP5
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BU of 7lp5 by Molmil
Structure of Nedd4L WW3 domain
Descriptor: Angiomotin,E3 ubiquitin-protein ligase NEDD4-like
Authors:Alam, S.L, Alian, A, Thompson, T, Rheinemann, L, Volkman, B.F, Peterson, F.C, Sundquist, W.I.
Deposit date:2021-02-11
Release date:2021-07-28
Last modified:2021-08-25
Method:SOLUTION NMR
Cite:Interactions between AMOT PPxY motifs and NEDD4L WW domains function in HIV-1 release.
J.Biol.Chem., 297, 2021
7LP4
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BU of 7lp4 by Molmil
Structure of Nedd4L WW3 domain
Descriptor: E3 ubiquitin-protein ligase NEDD4-like
Authors:Alam, S.L, Alian, A, Thompson, T, Rheinemann, L, Volkman, B.F, Peterson, F.C, Sundquist, W.I.
Deposit date:2021-02-11
Release date:2021-07-28
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Interactions between AMOT PPxY motifs and NEDD4L WW domains function in HIV-1 release.
J.Biol.Chem., 297, 2021
7NMZ
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BU of 7nmz by Molmil
Structure of 14-3-3 eta in complex with Nedd4-2(335-455) containing two 14-3-3 binding motifs Ser342 and Ser448
Descriptor: 14-3-3 protein eta, E3 ubiquitin-protein ligase NEDD4-like
Authors:Pohl, P, Obsil, T, Obsilova, V.
Deposit date:2021-02-23
Release date:2021-07-21
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.303 Å)
Cite:14-3-3-protein regulates Nedd4-2 by modulating interactions between HECT and WW domains.
Commun Biol, 4, 2021
7KKF
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BU of 7kkf by Molmil
Crystal Structure of S. cerevisiae Ess1
Descriptor: Peptidyl-prolyl cis-trans isomerase ESS1
Authors:Namitz, K.E.W, Alicea-Velazquez, N.L, Cosgrove, M.S, Hanes, S.D.
Deposit date:2020-10-27
Release date:2021-03-31
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure analysis suggests Ess1 isomerizes the carboxy-terminal domain of RNA polymerase II via a bivalent anchoring mechanism.
Commun Biol, 4, 2021
6VAJ
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BU of 6vaj by Molmil
Crystal Structure Analysis of human PIN1
Descriptor: 2-chloro-N-(2,2-dimethylpropyl)-N-[(3R)-1,1-dioxo-1lambda~6~-thiolan-3-yl]acetamide, Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, SULFATE ION, ...
Authors:Seo, H.-S, Dhe-Paganon, S.
Deposit date:2019-12-17
Release date:2020-12-30
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.42 Å)
Cite:Sulfopin is a covalent inhibitor of Pin1 that blocks Myc-driven tumors in vivo.
Nat.Chem.Biol., 17, 2021
7ABG
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BU of 7abg by Molmil
Human pre-Bact-1 spliceosome
Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE-5'-GUANOSINE, Cell division cycle 5-like protein, ...
Authors:Townsend, C, Kastner, B, Leelaram, M.N, Bertram, K, Stark, H, Luehrmann, R.
Deposit date:2020-09-07
Release date:2020-12-23
Last modified:2020-12-30
Method:ELECTRON MICROSCOPY (7.8 Å)
Cite:Mechanism of protein-guided folding of the active site U2/U6 RNA during spliceosome activation.
Science, 370, 2020
7ABF
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BU of 7abf by Molmil
Human pre-Bact-1 spliceosome core structure
Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, ...
Authors:Townsend, C, Kastner, B, Leelaram, M.N, Bertram, K, Stark, H, Luehrmann, R.
Deposit date:2020-09-07
Release date:2020-12-09
Last modified:2020-12-30
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Mechanism of protein-guided folding of the active site U2/U6 RNA during spliceosome activation.
Science, 370, 2020
6SVE
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BU of 6sve by Molmil
Protein allostery of the WW domain at atomic resolution: pCdc25C bound structure
Descriptor: Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1
Authors:Strotz, D, Orts, J, Friedmann, M, Guntert, P, Vogeli, B, Riek, R.
Deposit date:2019-09-18
Release date:2020-10-07
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Protein Allostery at Atomic Resolution.
Angew.Chem.Int.Ed.Engl., 59, 2020
6SVC
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BU of 6svc by Molmil
Protein allostery of the WW domain at atomic resolution: apo structure
Descriptor: Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1
Authors:Strotz, D, Orts, J, Friedmann, M, Guntert, P, Vogeli, B, Riek, R.
Deposit date:2019-09-18
Release date:2020-09-30
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Protein Allostery at Atomic Resolution.
Angew.Chem.Int.Ed.Engl., 59, 2020
6SVH
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BU of 6svh by Molmil
Protein allostery of the WW domain at atomic resolution: FFpSPR bound structure
Descriptor: Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1
Authors:Strotz, D, Orts, J, Friedmann, M, Guntert, P, Vogeli, B, Riek, R.
Deposit date:2019-09-18
Release date:2020-09-30
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Protein Allostery at Atomic Resolution.
Angew.Chem.Int.Ed.Engl., 59, 2020
7BQF
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BU of 7bqf by Molmil
Dimerization of SAV1 WW tandem
Descriptor: 1,4-DIETHYLENE DIOXIDE, Protein salvador homolog 1
Authors:Lin, Z, Zhang, M.
Deposit date:2020-03-24
Release date:2020-09-23
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.70037615 Å)
Cite:A WW Tandem-Mediated Dimerization Mode of SAV1 Essential for Hippo Signaling.
Cell Rep, 32, 2020
7BQG
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BU of 7bqg by Molmil
Complex structure of SAV1 and Dendrin
Descriptor: POTASSIUM ION, Protein salvador homolog 1,Dendrin
Authors:Lin, Z, Zhang, M.
Deposit date:2020-03-24
Release date:2020-09-23
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.55010867 Å)
Cite:A WW Tandem-Mediated Dimerization Mode of SAV1 Essential for Hippo Signaling.
Cell Rep, 32, 2020

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PDB entries from 2024-03-27

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