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8T2V
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BU of 8t2v by Molmil
Cryo-EM Structures of Full-length Integrin alphaIIbbeta3 in Native Lipids
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Adair, B, Xiong, J.P, Yeager, M, Arnaout, M.A.
Deposit date:2023-06-06
Release date:2023-07-26
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Cryo-EM structures of full-length integrin alpha IIb beta 3 in native lipids.
Nat Commun, 14, 2023
8T2U
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BU of 8t2u by Molmil
Cryo-EM Structures of Full-length Integrin alphaIIbbeta3 in Native Lipids complexed with Eptifibatide
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Adair, B, Xiong, J.P, Yeager, M, Arnaout, M.A.
Deposit date:2023-06-06
Release date:2023-07-26
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Cryo-EM structures of full-length integrin alpha IIb beta 3 in native lipids.
Nat Commun, 14, 2023
8GCE
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BU of 8gce by Molmil
The Extracellular Domain of Integrin AlphaIIbBeta3 in Intermediate State
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Huo, T, Wu, H, Wang, Z.
Deposit date:2023-03-01
Release date:2024-03-06
Last modified:2024-04-17
Method:ELECTRON MICROSCOPY (3.12 Å)
Cite:Full-length alpha IIb beta 3 cryo-EM structure reveals intact integrin initiate-activation intrinsic architecture.
Structure, 2024
8GCD
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BU of 8gcd by Molmil
Full length Integrin AlphaIIbBeta3 in inactive state
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Huo, T, Wu, H, Wang, Z.
Deposit date:2023-03-01
Release date:2024-03-06
Last modified:2024-04-17
Method:ELECTRON MICROSCOPY (2.97 Å)
Cite:Full-length alpha IIb beta 3 cryo-EM structure reveals intact integrin initiate-activation intrinsic architecture.
Structure, 2024
7SFT
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BU of 7sft by Molmil
Filamin complex-2
Descriptor: Filamin-A, Integrin alpha-IIb light chain, form 2
Authors:Liu, J, Qin, J.
Deposit date:2021-10-04
Release date:2023-04-12
Last modified:2023-10-25
Method:SOLUTION NMR
Cite:A mechanism of platelet integrin alpha IIb beta 3 outside-in signaling through a novel integrin alpha IIb subunit-filamin-actin linkage.
Blood, 141, 2023
7SC4
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BU of 7sc4 by Molmil
filamin complex-1
Descriptor: Filamin-A/Integrin alpha-IIb light chain, form 2 chimera, SULFATE ION
Authors:Liu, J, Qin, J.
Deposit date:2021-09-27
Release date:2023-04-12
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:A mechanism of platelet integrin alpha IIb beta 3 outside-in signaling through a novel integrin alpha IIb subunit-filamin-actin linkage.
Blood, 141, 2023
7LA4
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BU of 7la4 by Molmil
Integrin AlphaIIbBeta3-PT25-2 Complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Bush, M.W, Walz, T, Coller, B, Filizola, M, Spasic, A, Nesic, D, Li, J.
Deposit date:2021-01-05
Release date:2022-01-12
Last modified:2022-07-27
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Electron microscopy shows that binding of monoclonal antibody PT25-2 primes integrin alpha IIb beta 3 for ligand binding.
Blood Adv, 5, 2021
7KN0
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BU of 7kn0 by Molmil
Structure of the integrin aIIb(W968V)b3 transmembrane complex
Descriptor: Integrin alpha-IIb, Integrin beta-3
Authors:Situ, A.J, Kim, J, An, W, Kim, C, Ulmer, T.S.
Deposit date:2020-11-03
Release date:2021-09-15
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Insight Into Pathological Integrin alpha IIb beta 3 Activation From Safeguarding The Inactive State.
J.Mol.Biol., 433, 2021
6UJC
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BU of 6ujc by Molmil
Integrin alpha-v beta-8 in complex with the Fabs C6-RGD3 and 11D12v2
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, C6-RGD3 heavy chain Fab, ...
Authors:Campbell, M.G, Cormier, A, Cheng, Y, Nishimura, S.L.
Deposit date:2019-10-02
Release date:2020-02-05
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (3.56 Å)
Cite:Cryo-EM Reveals Integrin-Mediated TGF-beta Activation without Release from Latent TGF-beta.
Cell, 180, 2020
6UJB
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BU of 6ujb by Molmil
Integrin alpha-v beta-8 in complex with the Fabs C6D4 and 11D12v2
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, C6D4 heavy chain Fab, ...
Authors:Campbell, M.G, Cormier, A, Cheng, Y, Nishimura, S.L.
Deposit date:2019-10-02
Release date:2020-02-05
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (3.51 Å)
Cite:Cryo-EM Reveals Integrin-Mediated TGF-beta Activation without Release from Latent TGF-beta.
Cell, 180, 2020
6UJA
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BU of 6uja by Molmil
Integrin alpha-v beta-8 in complex with pro-TGF-beta1
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Campbell, M.G, Cormier, A, Cheng, Y, Nishimura, S.L.
Deposit date:2019-10-02
Release date:2020-02-05
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Cryo-EM Reveals Integrin-Mediated TGF-beta Activation without Release from Latent TGF-beta.
Cell, 180, 2020
2N9Y
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BU of 2n9y by Molmil
Structure of the Integrin alphaIIb-beta3(A711P) Transmembrane Complex
Descriptor: Integrin alpha-IIb, Integrin beta-3
Authors:Schmidt, T, Situ, A.J, Ulmer, T.S.
Deposit date:2015-12-14
Release date:2016-08-03
Method:SOLUTION NMR
Cite:Structural and thermodynamic basis of proline-induced transmembrane complex stabilization.
Sci Rep, 6, 2016
2MTP
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BU of 2mtp by Molmil
The structure of Filamin repeat 21 bound to integrin
Descriptor: Filamin-A, Integrin alpha-IIb, Integrin beta-3
Authors:Liu, J, Qin, J.
Deposit date:2014-08-28
Release date:2015-04-01
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Structural mechanism of integrin inactivation by filamin.
Nat.Struct.Mol.Biol., 22, 2015
2M3E
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BU of 2m3e by Molmil
The Integrin Alpha L Transmembrane Domain in Bicelles: Structure and Interaction with Integrin Beta 2
Descriptor: Integrin alpha-L
Authors:Surya, W, Li, Y, Millet, O, Diercks, T, Torres, J.
Deposit date:2013-01-17
Release date:2014-01-29
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:The Integrin Alpha L Transmembrane Domain in Bicelles: Structure and Interaction with Integrin Beta 2
To be Published
2LUV
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BU of 2luv by Molmil
Structure and Binding Interface of the Cytosolic Tails of aXb2 Integrin
Descriptor: Integrin alpha-X
Authors:Chua, G.L, Tang, X, Patra, T.A, Tan, S.M, Bhattacharjya, S.
Deposit date:2012-06-21
Release date:2012-07-04
Method:SOLUTION NMR
Cite:Structure and Binding Interface of the Cytosolic Tails of aXb2 Integrin
To be Published
2LKJ
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BU of 2lkj by Molmil
Structures and Interaction Analyses of the Integrin Alpha-M Beta-2 Cytoplasmic Tails
Descriptor: Integrin alpha-M
Authors:Chua, G.L, Tang, X.Y, Amalraj, M, Tan, S.M, Bhattacharjya, S.
Deposit date:2011-10-12
Release date:2011-11-02
Last modified:2011-11-16
Method:SOLUTION NMR
Cite:Structures and interaction analyses of the integrin alphaMbeta2 cytoplasmic tails
J.Biol.Chem., 2011
2LKE
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BU of 2lke by Molmil
Structures and Interaction Analyses of the Integrin Alpha-M Beta-2 Cytoplasmic Tails
Descriptor: Integrin alpha-M
Authors:Chua, G.L, Tang, X.Y, Amalraj, M, Bhattacharjya, S, Tan, S.M.
Deposit date:2011-10-11
Release date:2011-11-02
Last modified:2011-11-16
Method:SOLUTION NMR
Cite:Structures and interaction analyses of the integrin alphaMbeta2 cytoplasmic tails
J.Biol.Chem., 2011
2KNC
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BU of 2knc by Molmil
Platelet integrin ALFAIIB-BETA3 transmembrane-cytoplasmic heterocomplex
Descriptor: Integrin alpha-IIb, Integrin beta-3
Authors:Yang, J, Ma, Y, Page, R.C, Misra, S, Plow, E.F, Qin, J.
Deposit date:2009-08-20
Release date:2009-09-29
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Structure of an integrin alphaIIb beta3 transmembrane-cytoplasmic heterocomplex provides insight into integrin activation.
Proc.Natl.Acad.Sci.USA, 106, 2009
2K9J
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BU of 2k9j by Molmil
Integrin alphaIIb-beta3 transmembrane complex
Descriptor: Integrin alpha-IIb light chain, Integrin beta-3
Authors:Lau, T, Kim, C, Ginsberg, M.H, Ulmer, T.S.
Deposit date:2008-10-15
Release date:2009-03-24
Last modified:2021-10-20
Method:SOLUTION NMR
Cite:The structure of the integrin alphaIIbbeta3 transmembrane complex explains integrin transmembrane signalling
Embo J., 28, 2009
2K8O
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BU of 2k8o by Molmil
Solution structure of integrin Alpha L
Descriptor: Integrin alpha-L
Authors:Bhunia, A, Bhattacharjya, S, Tan, S.
Deposit date:2008-09-17
Release date:2008-12-09
Last modified:2021-11-10
Method:SOLUTION NMR
Cite:NMR Solution Conformations and Interactions of Integrin {alpha}L{beta}2 Cytoplasmic Tails
J.Biol.Chem., 284, 2009
2K1A
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BU of 2k1a by Molmil
Bicelle-embedded integrin alpha(IIB) transmembrane segment
Descriptor: Integrin alpha-IIb
Authors:Lau, T.-L, Dua, V, Ulmer, T.S.
Deposit date:2008-02-25
Release date:2008-04-15
Last modified:2022-03-16
Method:SOLUTION NMR
Cite:Structure of the Integrin {alpha}IIb Transmembrane Segment.
J.Biol.Chem., 283, 2008
1S4W
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BU of 1s4w by Molmil
NMR structure of the cytoplasmic domain of integrin AIIb in DPC micelles
Descriptor: Integrin alpha-IIb
Authors:Vinogradova, O, Vaynberg, J, Kong, X, Haas, T.A, Plow, E.F, Qin, J.
Deposit date:2004-01-19
Release date:2004-03-09
Last modified:2022-03-02
Method:SOLUTION NMR
Cite:Membrane-mediated structural transitions at the cytoplasmic face during integrin activation.
Proc.Natl.Acad.Sci.USA, 101, 2004
1M8O
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BU of 1m8o by Molmil
Platelet integrin alfaIIb-beta3 cytoplasmic domain
Descriptor: platelet integrin alfaIIb subunit: cytoplasmic domain, platelet integrin beta3 subunit: cytoplasmic domain
Authors:Vinogradova, O, Velyvis, A, Velyviene, A, Hu, B, Haas, T, Plow, E.F, Qin, J.
Deposit date:2002-07-25
Release date:2002-09-18
Last modified:2022-02-23
Method:SOLUTION NMR
Cite:A Structural mechanism of integrin alfaiib beta3 "Inside-out" Activation as regulated by its cytoplasmic face.
Cell(Cambridge,Mass.), 110, 2002
1KUZ
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BU of 1kuz by Molmil
Solution Structure of the Membrane Proximal Regions of alpha-IIb and beta-3 Integrins
Descriptor: integrin alpha-IIb, integrin beta-3
Authors:Weljie, A.M, Hwang, P.M, Vogel, H.J.
Deposit date:2002-01-22
Release date:2002-05-08
Last modified:2022-02-23
Method:SOLUTION NMR
Cite:Solution structures of the cytoplasmic tail complex from platelet integrin alpha IIb- and beta 3-subunits.
Proc.Natl.Acad.Sci.USA, 99, 2002
1KUP
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BU of 1kup by Molmil
Solution Structure of the Membrane Proximal Regions of alpha-IIb and beta-3 Integrins
Descriptor: integrin alpha-IIb, integrin beta-3
Authors:Weljie, A.M, Hwang, P.M, Vogel, H.J.
Deposit date:2002-01-22
Release date:2002-05-08
Last modified:2022-02-23
Method:SOLUTION NMR
Cite:Solution structures of the cytoplasmic tail complex from platelet integrin alpha IIb- and beta 3-subunits.
Proc.Natl.Acad.Sci.USA, 99, 2002

 

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