PDB: 603 resultsInfo pagesStatus searchChemie searchBIRD

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8QTT	Crystal structure of a C-terminally truncated version of Arabidopsis thaliana 14-3-3 omega in complex with a phosphopeptide from the inhibitor protein BKI1. Descriptor: 1,2-ETHANEDIOL, 14-3-3-like protein GF14 omega, BRI1 kinase inhibitor 1, ... Authors: Hothorn, M, Obergfell, E. Deposit date: 2023-10-13 Release date: 2023-11-15 Method: X-RAY DIFFRACTION (2.35 Å) Cite: Mechanistic insights into the function of 14-3-3 proteins as negative regulators of brassinosteroid signaling. To Be Published
8QT5	Crystal structure of Arabidopsis thaliana 14-3-3 isoform lambda in complex with a phosphopeptide from the transcription factor BZR1. Descriptor: 14-3-3-like protein G-BOX factor 14 lambda,Protein BRASSINAZOLE-RESISTANT 1, ACETATE ION Authors: Hothorn, M, Obergfell, E. Deposit date: 2023-10-12 Release date: 2023-10-25 Method: X-RAY DIFFRACTION (2.69 Å) Cite: Mechanistic insights into the function of 14-3-3 proteins as negative regulators of brassinosteroid signaling. To Be Published
8QTC	Crystal structure of Arabidopsis thaliana 14-3-3 omega in complex with a phosphopeptide from the transcription factor BZR1. Descriptor: 14-3-3-like protein GF14 omega, COBALT (II) ION, Protein BRASSINAZOLE-RESISTANT 1, ... Authors: Hothorn, M, Obergfell, E. Deposit date: 2023-10-12 Release date: 2023-11-15 Method: X-RAY DIFFRACTION (3.5 Å) Cite: Mechanistic insights into the function of 14-3-3 proteins as negative regulators of brassinosteroid signaling. To Be Published
8QTF	Crystal structure of a C-terminally truncated version of Arabidopsis thaliana 14-3-3 omega in complex with a phosphopeptide from the transcription factor BZR1. Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 1,2-ETHANEDIOL, 14-3-3-like protein GF14 omega, ... Authors: Hothorn, M, Obergfell, E. Deposit date: 2023-10-12 Release date: 2023-11-22 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Mechanistic insights into the function of 14-3-3 proteins as negative regulators of brassinosteroid signaling. To Be Published
8Q4L	GBP1 bound by 14-3-3sigma Descriptor: 14-3-3 protein sigma, Guanylate-binding protein 1 Authors: Pfleiderer, M.M, Liu, X, Fisch, D, Anastasakou, E, Frickel, E.M, Galej, W.P. Deposit date: 2023-08-07 Release date: 2023-10-11 Last modified: 2023-10-18 Method: ELECTRON MICROSCOPY (5.12 Å) Cite: PIM1 controls GBP1 activity to limit self-damage and to guard against pathogen infection. Science, 382, 2023
8Q1S	Pathogenic mutations of human phosphorylation sites affect protein-protein interactions Descriptor: 1,2-ETHANEDIOL, 14-3-3 protein epsilon, BROMIDE ION, ... Authors: Roske, Y, Daumke, O, Rrustemi, T, Selbach, M. Deposit date: 2023-08-01 Release date: 2024-02-21 Last modified: 2024-04-24 Method: X-RAY DIFFRACTION (3.23 Å) Cite: Pathogenic mutations of human phosphorylation sites affect protein-protein interactions. Nat Commun, 15, 2024
8P1H	Crystal structure of the chimera of human 14-3-3 zeta and phosphorylated cytoplasmic loop fragment of the alpha7 acetylcholine receptor Descriptor: 1,2-ETHANEDIOL, AZIDE ION, BENZOIC ACID, ... Authors: Boyko, K.M, Kapitonova, A.A, Tugaeva, K.V, Varfolomeeva, L.A, Lyukmanova, E.N, Sluchanko, N.N. Deposit date: 2023-05-12 Release date: 2023-10-18 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Crystal structure reveals canonical recognition of the phosphorylated cytoplasmic loop of human alpha7 nicotinic acetylcholine receptor by 14-3-3 protein. Biochem.Biophys.Res.Commun., 682, 2023
8P0D	Human 14-3-3 sigma in complex with human MDM2 peptide Descriptor: 14-3-3 protein sigma, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... Authors: Roversi, P, Ward, J, Doveston, R, Kwon, H, Romartinez Alonso, B. Deposit date: 2023-05-10 Release date: 2024-02-21 Method: X-RAY DIFFRACTION (1.31 Å) Cite: Characterizing the protein-protein interaction between MDM2 and 14-3-3 sigma ; proof of concept for small molecule stabilization. J.Biol.Chem., 300, 2024
8BYO	fragment-linked stabilizer for ERa - 14-3-3 interaction (1074361) Descriptor: 14-3-3 protein sigma, ERalpha peptide, MAGNESIUM ION, ... Authors: Visser, E.J, Vandenboorn, E.M.F, Ottmann, C. Deposit date: 2023-01-18 Release date: 2023-08-02 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.2 Å) Cite: From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
8C4F	Small molecule amidine soak in 14-3-3/ERa (AZ037) Descriptor: 14-3-3 protein sigma, 5-(cyclohexylamino)-4-phenyl-thiophene-2-carboximidamide, ERalpha peptide, ... Authors: Visser, E.J, Sijbesma, E, Ottmann, C. Deposit date: 2023-01-03 Release date: 2023-08-02 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.4 Å) Cite: From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
8C4G	Small molecule amidine soak in 14-3-3/ERa (AZ132) Descriptor: 14-3-3 protein sigma, ERalpha peptide, MAGNESIUM ION, ... Authors: Visser, E.J, Sijbesma, E, Ottmann, C. Deposit date: 2023-01-03 Release date: 2023-08-02 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.46 Å) Cite: From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
8C40	14-3-3sigma bound to PKA-responsive ERa phosphopeptide Descriptor: 14-3-3 protein sigma, Estrogen Receptor alpha phosphopeptide, MAGNESIUM ION Authors: Somsen, B.A, Ottmann, C. Deposit date: 2022-12-30 Release date: 2023-12-27 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Molecular basis and dual ligand regulation of tetrameric estrogen receptor alpha /14-3-3 zeta protein complex. J.Biol.Chem., 299, 2023
8C3Z	14-3-3sigma bound to strep-tagged PKA-responsive ERa phosphopeptide Descriptor: 14-3-3 protein sigma, Estrogen receptor, MAGNESIUM ION Authors: Somsen, B.A, Ottmann, C. Deposit date: 2022-12-30 Release date: 2023-12-27 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Molecular basis and dual ligand regulation of tetrameric estrogen receptor alpha /14-3-3 zeta protein complex. J.Biol.Chem., 299, 2023
8C42	Ternary structure of 14-3-3sigma, PKA-responsive ERa phosphopeptide and Fusicoccin-A Descriptor: 14-3-3 protein sigma, De-acetylated Fusicoccin, Estrogen receptor, ... Authors: Somsen, B.A, Ottmann, C. Deposit date: 2022-12-30 Release date: 2023-12-27 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Molecular basis and dual ligand regulation of tetrameric estrogen receptor alpha /14-3-3 zeta protein complex. J.Biol.Chem., 299, 2023
8C43	Ternary structure of 14-3-3sigma, strep-tagged PKA-responsive ERa phosphopeptide, and Fusicoccin-A. Descriptor: 14-3-3 protein sigma, De-acetylated Fusicoccin, Estrogen Receptor alpha phosphopeptide, ... Authors: Somsen, B.A, Ottmann, C. Deposit date: 2022-12-30 Release date: 2023-12-27 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Molecular basis and dual ligand regulation of tetrameric estrogen receptor alpha /14-3-3 zeta protein complex. J.Biol.Chem., 299, 2023
8C3C	14-3-3 sigma with Pin1 binding site pS72 and bound Fusicoccin A Descriptor: 14-3-3 protein sigma, FUSICOCCIN, MAGNESIUM ION, ... Authors: Verhoef, C.J, Cossar, P. Deposit date: 2022-12-23 Release date: 2023-06-14 Last modified: 2023-07-05 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Tracking the mechanism of covalent molecular glue stabilization using native mass spectrometry. Chem Sci, 14, 2023
8C30	Crystal structure of 14-3-3 in complex with PyrinpS242 and a protein/peptide interface fragment Descriptor: 14-3-3 protein sigma, 3,6,9,12,15,18,21,24-OCTAOXAHEXACOSAN-1-OL, CALCIUM ION, ... Authors: Lau, R, Ottmann, C. Deposit date: 2022-12-23 Release date: 2024-01-10 Method: X-RAY DIFFRACTION (1.4 Å) Cite: 14-3-3/Pyrin complex To Be Published
8C2Y	14-3-3 in complex with Pyrinp pS242 Descriptor: 14-3-3 protein sigma, Pyrin pS242 peptide Authors: Lau, R, Ottmann, C, Hann, M. Deposit date: 2022-12-23 Release date: 2024-01-10 Method: X-RAY DIFFRACTION (1.46 Å) Cite: 14-3-3/Pyrin complex To Be Published
8C2G	14-3-3 sigma with Pin1 binding site pS72 and covalently bound CV1040 Descriptor: 14-3-3 protein sigma, 2-iodanyl-4-(2-phenylimidazol-1-yl)benzaldehyde, MAGNESIUM ION, ... Authors: Verhoef, C.J, Cossar, P. Deposit date: 2022-12-22 Release date: 2023-06-14 Last modified: 2023-07-05 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Tracking the mechanism of covalent molecular glue stabilization using native mass spectrometry. Chem Sci, 14, 2023
8C2D	14-3-3 in complex with Pyrin pS208 Descriptor: 14-3-3 protein sigma, MAGNESIUM ION, Pyrin pS208 peptide Authors: Lau, R, Ottmann, C, Hann, M. Deposit date: 2022-12-22 Release date: 2023-07-26 Method: X-RAY DIFFRACTION (2.15 Å) Cite: Crystal structure and ligandability of the 14-3-3/pyrin interface. Biochem.Biophys.Res.Commun., 651, 2023
8C2E	Structure of 14-3-3 sigma delta C with electrophilic peptide 4IEA-5 Descriptor: 14-3-3 protein sigma, ARG-SER-ALA-SEP-CYS-PRO-SER-LEU, CHLORIDE ION, ... Authors: van den Oetelaar, M.C.M, Ottmann, C. Deposit date: 2022-12-22 Release date: 2023-11-01 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.2 Å) Cite: A simple method for developing lysine targeted covalent protein reagents. Nat Commun, 14, 2023
8C2F	Structure of 14-3-3 sigma delta C with electrophilic peptide 3MHR-5 Descriptor: 14-3-3 protein sigma, ARG-ALA-HIS-SEP-CYS-PRO-ALA-SER-LEU-GLN, CHLORIDE ION, ... Authors: van den Oetelaar, M.C.M, Ottmann, C. Deposit date: 2022-12-22 Release date: 2023-11-01 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.3 Å) Cite: A simple method for developing lysine targeted covalent protein reagents. Nat Commun, 14, 2023
8C28	14-3-3 in complex with PyrinpS208pS242 Descriptor: 14-3-3 protein sigma, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Pyrin Authors: Lau, R, Ottmann, C, Hann, M. Deposit date: 2022-12-21 Release date: 2024-01-10 Method: X-RAY DIFFRACTION (1.6 Å) Cite: 14-3-3/Pyrin complex To Be Published
8C0K	fragment-linked stabilizer for ERa - 14-3-3 interaction (1075302) Descriptor: 14-3-3 protein sigma, ERalpha peptide, MAGNESIUM ION, ... Authors: Visser, E.J, Vandenboorn, E.M.F, Ottmann, C. Deposit date: 2022-12-17 Release date: 2023-08-02 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.4 Å) Cite: From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
8C04	Co-soaked stabilizers for ERa - 14-3-3 interaction (884_AZ354) Descriptor: 14-3-3 protein sigma, 2-(4-chloranylphenoxy)-2-methyl-~{N}-(2-sulfanylethyl)propanamide, 4-chloranyl-7-propan-2-yloxy-1-benzothiophene-2-carboximidamide, ... Authors: Visser, E.J, Sijbesma, E, Ottmann, C. Deposit date: 2022-12-15 Release date: 2023-08-02 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.1 Å) Cite: From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023

 

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