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7QI1
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BU of 7qi1 by Molmil
Crystal structure of human 14-3-3 protein beta in complex with CFTR peptide pS753pS768 and PPI stabilizer CY007424
Descriptor: 14-3-3 protein theta, ARGININE, Cystic fibrosis transmembrane conductance regulator, ...
Authors:Stevers, L.M, Ottmann, C.
Deposit date:2021-12-14
Release date:2022-05-25
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.76 Å)
Cite:Macrocycle-stabilization of its interaction with 14-3-3 increases plasma membrane localization and activity of CFTR.
Nat Commun, 13, 2022
4QLI
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BU of 4qli by Molmil
A novel phospho-switch in the linker region of the snail zinc finger protein which regulates 14-3-3 association, DNA binding and epithelial-mesenchymal differentiation
Descriptor: 14-3-3 protein sigma, GLYCEROL, MAGNESIUM ION, ...
Authors:Bier, D, Ottmann, C.
Deposit date:2014-06-12
Release date:2015-06-17
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:A novel phospho-switch in the linker region of the snail zinc finger protein which regulates 14-3-3 association, DNA binding and epithelial-mesenchymal differentiation
To be Published
5ULO
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BU of 5ulo by Molmil
Crystal Structure of 14-3-3 zeta in Complex with a Serine 124-phosphorylated TBC1D7 peptide
Descriptor: 1,2-ETHANEDIOL, 14-3-3 protein zeta/delta, L-PROLINAMIDE, ...
Authors:DONG, A, HU, J, MADIGAN, J, WALKER, J.R, Bountra, C, Arrowsmith, C.H, Edwards, A.M, TONG, Y, Structural Genomics Consortium (SGC)
Deposit date:2017-01-25
Release date:2018-01-31
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.14 Å)
Cite:Crystal Structure of 14-3-3 zeta in Complex with a Serine 124-phosphorylated TBC1D7 peptide
to be published
2V7D
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BU of 2v7d by Molmil
14-3-3 protein zeta in complex with Thr758 phosphorylated integrin beta2 peptide
Descriptor: 14-3-3 PROTEIN ZETA/DELTA, INTEGRIN BETA CHAIN, BETA 2 VARIANT
Authors:Takala, H, Ylanne, J.
Deposit date:2007-07-30
Release date:2008-06-24
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Beta2 Integrin Phosphorylation on Thr758 Acts as a Molecular Switch to Regulate 14-3-3 and Filamin Binding.
Blood, 112, 2008
7V9B
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BU of 7v9b by Molmil
Crystal Structure of 14-3-3 epsilon with FOXO3a peptide
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 2-[3,6-bis(dimethylamino)xanthen-9-yl]-5-methanoyl-benzoate, ARG-ARG-ARG-ALA-VAL-SEP-MET-ASP-ASN-SER-ASN, ...
Authors:Mathivanan, S, Kamariah, N.
Deposit date:2021-08-24
Release date:2022-08-31
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structure of a 14-3-3 epsilon :FOXO3a pS253 Phosphopeptide Complex Reveals 14-3-3 Isoform-Specific Binding of Forkhead Box Class O Transcription Factor (FOXO) Phosphoproteins.
Acs Omega, 7, 2022
2WH0
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BU of 2wh0 by Molmil
Recognition of an intrachain tandem 14-3-3 binding site within protein kinase C epsilon
Descriptor: 14-3-3 PROTEIN ZETA/DELTA, CALCIUM ION, PROTEIN KINASE C EPSILON TYPE, ...
Authors:Kostelecky, B, Saurin, A.T, Purkiss, A, Parker, P.J, McDonald, N.Q.
Deposit date:2009-04-28
Release date:2009-08-18
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Recognition of an Intra-Chain Tandem 14-3-3 Binding Site within Pkc Epsilon.
Embo Rep., 10, 2009
7XBQ
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BU of 7xbq by Molmil
Crystal structure of potato 14-3-3 protein St14f
Descriptor: Putative 14-3-3 protein
Authors:Harada, K, Kojima, C, Yamashita, E, Nakagawa, A.
Deposit date:2022-03-21
Release date:2022-07-20
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Crystal structure of potato 14-3-3 protein St14f revealed the importance of helix I in StFDL1 recognition.
Sci Rep, 12, 2022
1A37
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BU of 1a37 by Molmil
14-3-3 PROTEIN ZETA BOUND TO PS-RAF259 PEPTIDE
Descriptor: 14-3-3 PROTEIN ZETA, PS-RAF259 PEPTIDE LSQRQRST(SEP)TPNVHM
Authors:Petosa, C, Masters, S.C, Pohl, J, Wang, B, Fu, H, Liddington, R.C.
Deposit date:1998-01-28
Release date:1999-03-02
Last modified:2016-08-17
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:14-3-3zeta binds a phosphorylated Raf peptide and an unphosphorylated peptide via its conserved amphipathic groove.
J.Biol.Chem., 273, 1998
1A4O
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BU of 1a4o by Molmil
14-3-3 PROTEIN ZETA ISOFORM
Descriptor: 14-3-3 PROTEIN ZETA
Authors:Liu, D, Bienkowska, J, Petosa, C, Collier, R.J, Fu, H, Liddington, R.C.
Deposit date:1998-02-01
Release date:1999-03-02
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure of the zeta isoform of the 14-3-3 protein.
Nature, 376, 1995
1A38
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BU of 1a38 by Molmil
14-3-3 PROTEIN ZETA BOUND TO R18 PEPTIDE
Descriptor: 14-3-3 PROTEIN ZETA, R18 PEPTIDE (PHCVPRDLSWLDLEANMCLP)
Authors:Petosa, C, Masters, S.C, Pohl, J, Wang, B, Fu, H, Liddington, R.C.
Deposit date:1998-01-28
Release date:1999-03-02
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (3.35 Å)
Cite:14-3-3zeta binds a phosphorylated Raf peptide and an unphosphorylated peptide via its conserved amphipathic groove.
J.Biol.Chem., 273, 1998
3IQU
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BU of 3iqu by Molmil
Crystal Structure of human 14-3-3 sigma in Complex with Raf1 peptide (6mer)
Descriptor: 14-3-3 protein sigma, 6-mer from RAF proto-oncogene serine/threonine-protein kinase, CHLORIDE ION, ...
Authors:Ottmann, C, Weyand, M.
Deposit date:2009-08-21
Release date:2010-09-01
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.05 Å)
Cite:Impaired binding of 14-3-3 to C-RAF in Noonan syndrome suggests new approaches in diseases with increased Ras signaling.
Mol.Cell.Biol., 30, 2010
3IQJ
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BU of 3iqj by Molmil
Crystal Structure of human 14-3-3 sigma in Complex with Raf1 peptide (10mer)
Descriptor: 10-mer peptide from RAF proto-oncogene serine/threonine-protein kinase, 14-3-3 protein sigma, CHLORIDE ION, ...
Authors:Ottmann, C, Weyand, M.
Deposit date:2009-08-20
Release date:2010-09-01
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.15 Å)
Cite:Impaired binding of 14-3-3 to C-RAF in Noonan syndrome suggests new approaches in diseases with increased Ras signaling.
Mol.Cell.Biol., 30, 2010
3IQV
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BU of 3iqv by Molmil
Crystal Structure of human 14-3-3 sigma in Complex with Raf1 peptide (6mer) and stabilisator Fusicoccin
Descriptor: 14-3-3 protein sigma, 6-mer peptide from RAF proto-oncogene serine/threonine-protein kinase, CHLORIDE ION, ...
Authors:Ottmann, C, Weyand, M.
Deposit date:2009-08-21
Release date:2010-09-01
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Impaired binding of 14-3-3 to C-RAF in Noonan syndrome suggests new approaches in diseases with increased Ras signaling.
Mol.Cell.Biol., 30, 2010
5HF3
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BU of 5hf3 by Molmil
Crystal structure of C-terminal modified Tau peptide-hybrid 201D with 14-3-3sigma
Descriptor: 14-3-3 protein sigma, modified Tau peptide
Authors:Bartel, M, Milroy, L.G, Brunsveld, L, Ottmann, C.
Deposit date:2016-01-06
Release date:2016-01-27
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Stabilizer-Guided Inhibition of Protein-Protein Interactions.
Angew.Chem.Int.Ed.Engl., 54, 2015
6KZH
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BU of 6kzh by Molmil
14-3-3 protein in Complex with CIC S173 phosphorylated peptide
Descriptor: 14-3-3 protein theta, CIC pS173 peptide
Authors:Wen, Y, Shao, Y.
Deposit date:2019-09-24
Release date:2020-09-30
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.645 Å)
Cite:14-3-3 protein in Complex with CIC S173 phosphorylated peptide
To Be Published
6KZG
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BU of 6kzg by Molmil
14-3-3 protein in Complex with CIC S301 phosphorylated peptide
Descriptor: 14-3-3 protein theta, ARG-SER-MET-SER-GLU-THR-GLY-THR
Authors:Wen, Y, Shao, Y.
Deposit date:2019-09-24
Release date:2020-09-30
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2 Å)
Cite:14-3-3 protein in Complex with CIC S301 phosphorylated peptide
To Be Published
2NPM
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BU of 2npm by Molmil
crystal structure of Cryptosporidium parvum 14-3-3 protein in complex with peptide
Descriptor: 14-3-3 domain containing protein, CONSENSUS PEPTIDE FOR 14-3-3 PROTEINS
Authors:Dong, A, Lew, J, Wasney, G, Ren, H, Lin, L, Hassanali, A, Qiu, W, Zhao, Y, Doyle, D, Vedadi, M, Koeieradzki, I, Edwards, A.M, Arrowsmith, C.H, Weigelt, J, Sundstrom, M, Bochkarev, A, Hui, R, Brokx, S, Structural Genomics Consortium (SGC)
Deposit date:2006-10-27
Release date:2006-11-07
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.52 Å)
Cite:Characterization of 14-3-3 proteins from Cryptosporidium parvum.
Plos One, 6, 2011
5IQP
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BU of 5iqp by Molmil
14-3-3 PROTEIN TAU ISOFORM
Descriptor: 14-3-3 protein theta, SULFATE ION
Authors:Xiao, B, Smerdon, S.J, Gamblin, S.J.
Deposit date:2016-03-11
Release date:2016-03-23
Method:X-RAY DIFFRACTION (2.602 Å)
Cite:Structure of a 14-3-3 protein and implications for coordination of multiple signalling pathways
Nature, 376, 1995
2O98
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BU of 2o98 by Molmil
Structure of the 14-3-3 / H+-ATPase plant complex
Descriptor: 14-3-3-like protein C, FUSICOCCIN, Plasma membrane H+ ATPase, ...
Authors:Ottmann, C, Weyand, M, Wittinghofer, A, Oecking, C.
Deposit date:2006-12-13
Release date:2007-04-03
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structure of a 14-3-3 coordinated hexamer of the plant plasma membrane H+ -ATPase by combining X-ray crystallography and electron cryomicroscopy
Mol.Cell, 25, 2007
4N7G
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BU of 4n7g by Molmil
Crystal structure of 14-3-3zeta in complex with a peptide derived from ExoS
Descriptor: 14-3-3 protein zeta/delta, Exoenzyme S, HEXAETHYLENE GLYCOL
Authors:Bier, D, Glas, A, Hahne, G, Grossmann, T, Ottmann, C.
Deposit date:2013-10-15
Release date:2014-02-19
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Constrained peptides with target-adapted cross-links as inhibitors of a pathogenic protein-protein interaction.
Angew.Chem.Int.Ed.Engl., 53, 2014
4N84
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BU of 4n84 by Molmil
Crystal structure of 14-3-3zeta in complex with a 12-carbon-linker cyclic peptide derived from ExoS
Descriptor: 14-3-3 protein zeta/delta, Exoenzyme S
Authors:Bier, D, Glas, A, Hahne, G, Grossmann, T, Ottmann, C.
Deposit date:2013-10-17
Release date:2014-02-19
Last modified:2014-03-12
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Constrained peptides with target-adapted cross-links as inhibitors of a pathogenic protein-protein interaction.
Angew.Chem.Int.Ed.Engl., 53, 2014
2O02
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BU of 2o02 by Molmil
Phosphorylation independent interactions between 14-3-3 and Exoenzyme S: from structure to pathogenesis
Descriptor: 14-3-3 protein zeta/delta, BENZOIC ACID, ExoS (416-430) peptide
Authors:Ottmann, C, Yasmin, L, Weyand, M, Hauser, A.R, Wittinghofer, A, Hallberg, B.
Deposit date:2006-11-27
Release date:2007-11-27
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Phosphorylation-independent interaction between 14-3-3 and exoenzyme S: from structure to pathogenesis
Embo J., 26, 2007
2O8P
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BU of 2o8p by Molmil
Crystal structure of a putative 14-3-3 protein from Cryptosporidium parvum, cgd7_2470
Descriptor: 14-3-3 domain containing protein
Authors:Dong, A, Lew, J, Wasney, G, Lin, L, Hassanali, A, Zhao, Y, Vedadi, M, Kozieradzki, I, Edwards, A.M, Arrowsmith, C.H, Weigelt, J, Sundstrom, M, Walker, J.R, Bochkarev, A, Hui, R, Brokx, S.J, Structural Genomics Consortium (SGC)
Deposit date:2006-12-12
Release date:2007-01-09
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:Characterization of 14-3-3 proteins from Cryptosporidium parvum.
Plos One, 6, 2011
3CU8
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BU of 3cu8 by Molmil
Impaired binding of 14-3-3 to Raf1 is linked to Noonan and LEOPARD syndrome
Descriptor: 14-3-3 protein zeta/delta, MAGNESIUM ION, PROPANOIC ACID, ...
Authors:Schumacher, B, Weyand, M, Kuhlmann, J, Ottmann, C.
Deposit date:2008-04-16
Release date:2009-05-05
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Impaired binding of 14-3-3 to C-RAF in Noonan syndrome suggests new approaches in diseases with increased Ras signaling.
Mol. Cell. Biol., 30, 2010
4N7Y
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BU of 4n7y by Molmil
Crystal structure of 14-3-3zeta in complex with a 8-carbon-linker cyclic peptide derived from ExoS
Descriptor: 14-3-3 protein zeta/delta, Exoenzyme S
Authors:Bier, D, Glas, A, Hahne, G, Grossmann, T, Ottmann, C.
Deposit date:2013-10-16
Release date:2014-02-19
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.16 Å)
Cite:Constrained peptides with target-adapted cross-links as inhibitors of a pathogenic protein-protein interaction.
Angew.Chem.Int.Ed.Engl., 53, 2014

217705

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