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7UTZ
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BU of 7utz by Molmil
Human thyrotropin analog TR1402 bound to human Thyrotropin receptor in complex with miniGs399 (composite structure)
Descriptor: (2S)-3-hydroxypropane-1,2-diyl dihexadecanoate, 2-acetamido-2-deoxy-beta-D-glucopyranose, Glycoprotein hormones alpha chain analog TR1402, ...
Authors:Faust, B, Cheng, Y, Manglik, A.
Deposit date:2022-04-28
Release date:2022-08-03
Last modified:2022-10-05
Method:ELECTRON MICROSCOPY (2.4 Å)
Cite:Autoantibody mimicry of hormone action at the thyrotropin receptor.
Nature, 609, 2022
4AY9
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BU of 4ay9 by Molmil
Structure of follicle-stimulating hormone in complex with the entire ectodomain of its receptor
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, FOLLICLE-STIMULATING HORMONE RECEPTOR, FOLLITROPIN SUBUNIT BETA, ...
Authors:Jiang, X, Liu, H, Chen, X, He, X.
Deposit date:2012-06-19
Release date:2012-08-08
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of Follicle-Stimulating Hormone in Complex with the Entire Ectodomain of its Receptor.
Proc.Natl.Acad.Sci.USA, 109, 2012
1HCN
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BU of 1hcn by Molmil
STRUCTURE OF HUMAN CHORIONIC GONADOTROPIN AT 2.6 ANGSTROMS RESOLUTION FROM MAD ANALYSIS OF THE SELENOMETHIONYL PROTEIN
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, HUMAN CHORIONIC GONADOTROPIN
Authors:Wu, H, Lustbader, J.W, Liu, Y, Canfield, R.E, Hendrickson, W.A.
Deposit date:1994-07-01
Release date:1994-09-30
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure of human chorionic gonadotropin at 2.6 A resolution from MAD analysis of the selenomethionyl protein.
Structure, 2, 1994
8I2G
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BU of 8i2g by Molmil
FSHR-Follicle stimulating hormone-compound 716340-Gs complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL, ...
Authors:Duan, J, Xu, P, Yang, J, Ji, Y, Zhang, H, Mao, C, Luan, X, Jiang, Y, Zhang, Y, Zhang, S, Xu, H.E.
Deposit date:2023-01-14
Release date:2023-03-29
Last modified:2023-04-05
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Mechanism of hormone and allosteric agonist mediated activation of follicle stimulating hormone receptor.
Nat Commun, 14, 2023
7T9I
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BU of 7t9i by Molmil
Native human TSH bound to human Thyrotropin receptor in complex with miniGs399 (composite structure)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glycoprotein hormones alpha chain, ...
Authors:Faust, B, Cheng, Y, Manglik, A.
Deposit date:2021-12-19
Release date:2022-08-03
Last modified:2022-10-05
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Autoantibody mimicry of hormone action at the thyrotropin receptor.
Nature, 609, 2022
4MQW
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BU of 4mqw by Molmil
Structure of follicle-stimulating hormone in complex with the entire ectodomain of its receptor (P31)
Descriptor: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, Follicle-stimulating hormone receptor, ...
Authors:Jiang, X, Liu, H, Chen, X, He, X.
Deposit date:2013-09-16
Release date:2014-04-09
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Evidence for Follicle-stimulating Hormone Receptor as a Functional Trimer.
J.Biol.Chem., 289, 2014
1XWD
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BU of 1xwd by Molmil
Crystal Structure of Human Follicle Stimulating Hormone Complexed with its Receptor
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Follicle stimulating hormone receptor, ...
Authors:Fan, Q.R, Hendrickson, W.A.
Deposit date:2004-10-30
Release date:2005-01-25
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.92 Å)
Cite:Structure of human follicle-stimulating hormone in complex with its receptor.
Nature, 433, 2005
7XW5
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BU of 7xw5 by Molmil
TSHR-thyroid stimulating hormone-Gs-ML109 complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL, Glycoprotein hormones alpha chain, ...
Authors:Duan, J, Xu, P, Luan, X, Ji, Y, Yuan, Q, He, X, Ye, J, Cheng, X, Jiang, H, Zhang, S, Jiang, Y, Xu, H.E.
Deposit date:2022-05-26
Release date:2022-08-24
Last modified:2022-10-05
Method:ELECTRON MICROSCOPY (2.96 Å)
Cite:Hormone- and antibody-mediated activation of the thyrotropin receptor.
Nature, 609, 2022
1HRP
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BU of 1hrp by Molmil
CRYSTAL STRUCTURE OF HUMAN CHORIONIC GONADOTROPIN
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, HUMAN CHORIONIC GONADOTROPIN
Authors:Lapthorn, A.J, Harris, D.C, Isaacs, N.W.
Deposit date:1994-08-15
Release date:1994-11-01
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal structure of human chorionic gonadotropin.
Nature, 369, 1994
1FL7
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BU of 1fl7 by Molmil
HUMAN FOLLICLE STIMULATING HORMONE
Descriptor: 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, FOLLICLE STIMULATING PROTEIN ALPHA CHAIN, ...
Authors:Fox, K.M, Dias, J.A, Van Roey, P.
Deposit date:2000-08-11
Release date:2001-03-14
Last modified:2021-11-03
Method:X-RAY DIFFRACTION (3 Å)
Cite:Three-dimensional structure of human follicle-stimulating hormone.
Mol.Endocrinol., 15, 2001
7FIH
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BU of 7fih by Molmil
luteinizing hormone/choriogonadotropin receptor(S277I)-chorionic gonadotropin-Gs-Org43553 complex
Descriptor: 5-azanyl-N-tert-butyl-2-methylsulfanyl-4-[3-(2-morpholin-4-ylethanoylamino)phenyl]thieno[2,3-d]pyrimidine-6-carboxamide, Choriogonadotropin subunit beta 3, Engineered Guanine nucleotide-binding protein G(s) subunit alpha, ...
Authors:Duan, J, Xu, P, Cheng, X, Mao, C, Croll, T, He, X, Shi, J, Luan, X, Yin, W, You, E, Liu, Q, Zhang, S, Jiang, H, Zhang, Y, Jiang, Y, Xu, H.E.
Deposit date:2021-07-31
Release date:2021-09-29
Last modified:2022-02-16
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Structures of full-length glycoprotein hormone receptor signalling complexes.
Nature, 598, 2021
1QFW
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BU of 1qfw by Molmil
TERNARY COMPLEX OF HUMAN CHORIONIC GONADOTROPIN WITH FV ANTI ALPHA SUBUNIT AND FV ANTI BETA SUBUNIT
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, ANTIBODY (ANTI ALPHA SUBUNIT) (HEAVY CHAIN), ANTIBODY (ANTI ALPHA SUBUNIT) (LIGHT CHAIN), ...
Authors:Tegoni, M, Spinelli, S, Cambillau, C.
Deposit date:1999-04-15
Release date:2000-04-26
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Crystal structure of a ternary complex between human chorionic gonadotropin (hCG) and two Fv fragments specific for the alpha and beta-subunits.
J.Mol.Biol., 289, 1999
7FIG
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BU of 7fig by Molmil
luteinizing hormone/choriogonadotropin receptor(S277I)-chorionic gonadotropin-Gs complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Camelid antibody VHH fragment Nb35, Choriogonadotropin subunit beta 3, ...
Authors:Duan, J, Xu, P, Cheng, X, Mao, C, Croll, T, He, X, Shi, J, Luan, X, Yin, W, You, E, Liu, Q, Zhang, S, Jiang, H, Zhang, Y, Jiang, Y, Xu, H.E.
Deposit date:2021-07-31
Release date:2021-09-29
Last modified:2022-02-16
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Structures of full-length glycoprotein hormone receptor signalling complexes.
Nature, 598, 2021
7FII
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BU of 7fii by Molmil
luteinizing hormone/choriogonadotropin receptor-chorionic gonadotropin-Gs complex
Descriptor: Choriogonadotropin subunit beta 3, Engineered Guanine nucleotide-binding protein G(s) subunit alpha, Glycoprotein hormones alpha chain, ...
Authors:Duan, J, Xu, P, Cheng, X, Mao, C, Croll, T, He, X, Shi, J, Luan, X, Yin, W, You, E, Liu, Q, Zhang, S, Jiang, H, Zhang, Y, Jiang, Y, Xu, H.E.
Deposit date:2021-07-31
Release date:2021-09-29
Last modified:2022-02-16
Method:ELECTRON MICROSCOPY (4.3 Å)
Cite:Structures of full-length glycoprotein hormone receptor signalling complexes.
Nature, 598, 2021
1DZ7
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BU of 1dz7 by Molmil
Solution structure of the a-subunit of human chorionic gonadotropin [modeled without carbohydrate residues]
Descriptor: CHORIONIC GONADOTROPIN
Authors:Erbel, P.J.A, Karimi-Nejad, Y, De Beer, T, Boelens, R, Kamerling, J.P, Vliegenthart, J.F.G.
Deposit date:2000-02-18
Release date:2000-02-29
Last modified:2019-10-09
Method:SOLUTION NMR
Cite:Solution structure of the alpha-subunit of human chorionic gonadotropin.
Eur.J.Biochem., 260, 1999
1E9J
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BU of 1e9j by Molmil
SOLUTION STRUCTURE OF THE A-SUBUNIT OF HUMAN CHORIONIC GONADOTROPIN [INCLUDING A SINGLE GLCNAC RESIDUE AT ASN52 AND ASN78]
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CHORIONIC GONADOTROPIN
Authors:Erbel, P.J.A, Karimi-Nejad, Y, van Kuik, J.A, Boelens, R, Kamerling, J.P, Vliegenthart, J.F.G.
Deposit date:2000-10-18
Release date:2002-07-25
Last modified:2020-07-29
Method:SOLUTION NMR
Cite:Effects of the N-linked glycans on the 3D structure of the free alpha-subunit of human chorionic gonadotropin.
Biochemistry, 39, 2000
1HD4
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BU of 1hd4 by Molmil
SOLUTION STRUCTURE OF THE A-SUBUNIT OF HUMAN CHORIONIC GONADOTROPIN [MODELED WITH DIANTENNARY GLYCAN AT ASN78]
Descriptor: CHORIONIC GONADOTROPIN, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
Authors:Erbel, P.J.A, Karimi-Nejad, Y, van Kuik, J.A, Boelens, R, Kamerling, J.P, Vliegenthart, J.F.G.
Deposit date:2000-11-07
Release date:2000-12-07
Last modified:2020-07-29
Method:SOLUTION NMR
Cite:Effects of the N-Linked Glycans on the 3D Structure of the Free A-Subunit of Human Chorionic Gonadotropin
Biochemistry, 39, 2000

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