2A65
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CRYSTAL STRUCTURE OF LEUTAA, A BACTERIAL HOMOLOG OF NA+/CL--DEPENDENT NEUROTRANSMITTER TRANSPORTERS
Descriptor:Na(+):neurotransmitter symporter (Snf family)
Authors:Yamashita, A., Singh, S.K., Kawate, T., Jin, Y., Gouaux, E.
Deposit date:2005-07-01
Release date:2005-08-02
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Crystal structure of a bacterial homologue of Na(+)/Cl(-)-dependent neurotransmitter transporters.
Nature, 437, 2005
2Q6H
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CRYSTAL STRUCTURE ANALYSIS OF LEUT COMPLEXED WITH L-LEUCINE, SODIUM, AND CLOMIPRAMINE
Descriptor:Transporter
Authors:Singh, S.K., Yamashita, A., Gouaux, E.
Deposit date:2007-06-05
Release date:2007-08-21
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Antidepressant binding site in a bacterial homologue of neurotransmitter transporters.
Nature, 448, 2007
2Q72
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CRYSTAL STRUCTURE ANALYSIS OF LEUT COMPLEXED WITH L-LEUCINE, SODIUM, AND IMIPRAMINE
Descriptor:Transporter
Authors:Singh, S.K., Yamashita, A., Gouaux, E.
Deposit date:2007-06-05
Release date:2007-08-21
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Antidepressant binding site in a bacterial homologue of neurotransmitter transporters.
Nature, 448, 2007
2QB4
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CRYSTAL STRUCTURE ANALYSIS OF LEUT COMPLEXED WITH L-LEUCINE, SODIUM AND DESIPRAMINE
Descriptor:Transporter
Authors:Singh, S.K., Yamashita, A., Gouaux, E.
Deposit date:2007-06-15
Release date:2007-08-21
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Antidepressant binding site in a bacterial homologue of neurotransmitter transporters.
Nature, 448, 2007
2QEI
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CRYSTAL STRUCTURE ANALYSIS OF LEUT COMPLEXED WITH L-ALANINE, SODIUM, AND CLOMIPRAMINE
Descriptor:Transporter
Authors:Singh, S.K., Yamashita, A., Gouaux, E.
Deposit date:2007-06-25
Release date:2007-08-21
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Antidepressant binding site in a bacterial homologue of neurotransmitter transporters.
Nature, 448, 2007
2QJU
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CRYSTAL STRUCTURE OF AN NSS HOMOLOG WITH BOUND ANTIDEPRESSANT
Descriptor:Transporter
Authors:Zhou, Z., Karpowich, N.K., Wang, D.N., New York Consortium on Membrane Protein Structure (NYCOMPS)
Deposit date:2007-07-09
Release date:2007-08-21
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:LeuT-desipramine structure reveals how antidepressants block neurotransmitter reuptake.
Science, 317, 2007
3F3A
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CRYSTAL STRUCTURE OF LEUT BOUND TO L-TRYPTOPHAN AND SODIUM
Descriptor:Transporter
Authors:Singh, S.K., Piscitelli, C.L., Yamashita, A., Gouaux, E.
Deposit date:2008-10-30
Release date:2008-12-23
Modification date:2009-03-10
Method:X-RAY DIFFRACTION (2 Å)
Cite:A competitive inhibitor traps LeuT in an open-to-out conformation.
Science, 322, 2008
3F3C
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CRYSTAL STRUCTURE OF LEUT BOUND TO 4-FLUORO-L-PHENYLALANINE AND SODIUM
Descriptor:Transporter
Authors:Singh, S.K., Piscitelli, C.L., Yamashita, A., Gouaux, E.
Deposit date:2008-10-30
Release date:2008-12-23
Modification date:2009-03-10
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:A competitive inhibitor traps LeuT in an open-to-out conformation.
Science, 322, 2008
3F3D
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CRYSTAL STRUCTURE OF LEUT BOUND TO L-METHIONINE AND SODIUM
Descriptor:Transporter
Authors:Singh, S.K., Piscitelli, C.L., Yamashita, A., Gouaux, E.
Deposit date:2008-10-30
Release date:2008-12-23
Modification date:2009-03-10
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:A competitive inhibitor traps LeuT in an open-to-out conformation.
Science, 322, 2008
3F3E
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CRYSTAL STRUCTURE OF LEUT BOUND TO L-LEUCINE (30 MM) AND SODIUM
Descriptor:Transporter
Authors:Singh, S.K., Piscitelli, C.L., Yamashita, A., Gouaux, E.
Deposit date:2008-10-30
Release date:2008-12-23
Modification date:2009-03-10
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:A competitive inhibitor traps LeuT in an open-to-out conformation.
Science, 322, 2008
3F48
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CRYSTAL STRUCTURE OF LEUT BOUND TO L-ALANINE AND SODIUM
Descriptor:Transporter
Authors:Singh, S.K., Piscitelli, C.L., Yamashita, A., Gouaux, E.
Deposit date:2008-10-31
Release date:2008-12-23
Modification date:2009-03-10
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:A competitive inhibitor traps LeuT in an open-to-out conformation.
Science, 322, 2008
3F4I
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CRYSTAL STRUCTURE OF LEUT BOUND TO L-SELENOMETHIONINE AND SODIUM
Descriptor:Transporter
Authors:Singh, S.K., Piscitelli, C.L., Yamashita, A., Gouaux, E.
Deposit date:2008-10-31
Release date:2008-12-23
Modification date:2009-03-10
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:A competitive inhibitor traps LeuT in an open-to-out conformation.
Science, 322, 2008
3F4J
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CRYSTAL STRUCTURE OF LEUT BOUND TO GLYCINE AND SODIUM
Descriptor:Transporter
Authors:Singh, S.K., Piscitelli, C.L., Yamashita, A., Gouaux, E.
Deposit date:2008-10-31
Release date:2008-12-23
Modification date:2009-03-10
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:A competitive inhibitor traps LeuT in an open-to-out conformation.
Science, 322, 2008
3GJC
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CRYSTAL STRUCTURE OF THE E290S MUTANT OF LEUT WITH BOUND OG
Descriptor:Transporter
Authors:Winther, A.M.L., Quick, M., Javitch, J.A., Nissen, P.
Deposit date:2009-03-08
Release date:2009-04-28
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Binding of an octylglucoside detergent molecule in the second substrate (S2) site of LeuT establishes an inhibitor-bound conformation
Proc.Natl.Acad.Sci.USA, 106, 2009
3GJD
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CRYSTAL STRUCTURE OF LEUT WITH BOUND OG
Descriptor:Transporter
Authors:Winther, A.M.L., Quick, M., Javitch, J.A., Nissen, P.
Deposit date:2009-03-08
Release date:2009-04-28
Modification date:2010-01-19
Method:X-RAY DIFFRACTION (2 Å)
Cite:Binding of an octylglucoside detergent molecule in the second substrate (S2) site of LeuT establishes an inhibitor-bound conformation
Proc.Natl.Acad.Sci.USA, 106, 2009
3GWU
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LEUCINE TRANSPORTER LEUT IN COMPLEX WITH SERTRALINE
Descriptor:Transporter
Authors:Zhou, Z., Zhen, J., Karpowich, N.K., Law, C.J., Reith, M.E.A., Wang, D.N.
Deposit date:2009-04-01
Release date:2009-05-12
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.14 Å)
Cite:Antidepressant specificity of serotonin transporter suggested by three LeuT-SSRI structures.
Nat.Struct.Mol.Biol., 16, 2009
3GWV
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LEUCINE TRANSPORTER LEUT IN COMPLEX WITH R-FLUOXETINE
Descriptor:Crystal structure of transporter LeuT in complex with sertraline
Authors:Zhou, Z., Zhen, J., Karpowich, N.K., Law, C.J., Reith, M.E.A., Wang, D.N.
Deposit date:2009-04-01
Release date:2009-05-12
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Antidepressant specificity of serotonin transporter suggested by three LeuT-SSRI structures.
Nat.Struct.Mol.Biol., 16, 2009
3GWW
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LEUCINE TRANSPORTER LEUT IN COMPLEX WITH S-FLUOXETINE
Descriptor:Crystal structure of transporter LeuT in complex with sertraline
Authors:Zhou, Z., Zhen, J., Karpowich, N.K., Law, C.J., Reith, M.E.A., Wang, D.N.
Deposit date:2009-04-01
Release date:2009-05-12
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.46 Å)
Cite:Antidepressant specificity of serotonin transporter suggested by three LeuT-SSRI structures.
Nat.Struct.Mol.Biol., 16, 2009
3MPN
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F177R1 MUTANT OF LEUT
Descriptor:Transporter
Authors:Kroncke, B.M.
Deposit date:2010-04-27
Release date:2010-12-01
Modification date:2013-06-19
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structural origins of nitroxide side chain dynamics on membrane protein alpha-helical sites.
Biochemistry, 49, 2010
3MPQ
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I204R1 MUTANT OF LEUT
Descriptor:Transporter
Authors:Kroncke, B.M.
Deposit date:2010-04-27
Release date:2010-12-01
Modification date:2013-06-19
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structural origins of nitroxide side chain dynamics on membrane protein alpha-helical sites.
Biochemistry, 49, 2010
3QS4
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CRYSTAL STRUCTURE OF LEUT MUTANT F259V BOUND TO SODIUM AND L-TRYPTOPHAN
Descriptor:Na(+):neurotransmitter symporter (Snf family)
Authors:Piscitelli, C.L., Gouaux, E.
Deposit date:2011-02-19
Release date:2011-10-12
Modification date:2012-02-29
Method:X-RAY DIFFRACTION (2.631 Å)
Cite:Insights into transport mechanism from LeuT engineered to transport tryptophan.
Embo J., 31, 2012
3QS5
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CRYSTAL STRUCTURE OF LEUT MUTANT I359Q BOUND TO SODIUM AND L-TRYPTOPHAN
Descriptor:Na(+):neurotransmitter symporter (Snf family)
Authors:Piscitelli, C.L., Gouaux, E.
Deposit date:2011-02-19
Release date:2011-10-12
Modification date:2012-02-29
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Insights into transport mechanism from LeuT engineered to transport tryptophan.
Embo J., 31, 2012
3QS6
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CRYSTAL STRUCTURE OF LEUT MUTANT F259V,I359Q BOUND TO SODIUM AND L-TRYPTOPHAN
Descriptor:Na(+):neurotransmitter symporter (Snf family)
Authors:Piscitelli, C.L., Gouaux, E.
Deposit date:2011-02-19
Release date:2011-10-12
Modification date:2012-02-29
Method:X-RAY DIFFRACTION (2.801 Å)
Cite:Insights into transport mechanism from LeuT engineered to transport tryptophan.
Embo J., 31, 2012
3TT1
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CRYSTAL STRUCTURE OF LEUT IN THE OUTWARD-OPEN CONFORMATION IN COMPLEX WITH FAB
Descriptor:Leucine transporter LeuT, mouse monoclonal 1gG2a Fab fragment, heavy chain, mouse monoclonal 1gG2a Fab fragment, kappa light chain
Authors:Krishnamurthy, H., Gouaux, E.
Deposit date:2011-09-13
Release date:2012-01-04
Modification date:2012-02-01
Method:X-RAY DIFFRACTION (3.099 Å)
Cite:X-ray structures of LeuT in substrate-free outward-open and apo inward-open states.
Nature, 481, 2012
3TT3
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CRYSTAL STRUCTURE OF LEUT IN THE INWARD-OPEN CONFORMATION IN COMPLEX WITH FAB
Descriptor:Leucine transporter LeuT, mouse monoclonal 1gG1 Fab fragment, heavy chain, mouse monoclonal 1gG1 Fab fragment, kappa light chain
Authors:Krishnamurthy, H., Gouaux, E.
Deposit date:2011-09-13
Release date:2012-01-04
Modification date:2012-02-01
Method:X-RAY DIFFRACTION (3.22 Å)
Cite:X-ray structures of LeuT in substrate-free outward-open and apo inward-open states.
Nature, 481, 2012
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