4ZIU
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CRYSTAL STRUCTURE OF NATIVE ALPHA-2-MACROGLOBULIN FROM ESCHERICHIA COLI SPANNING THE RESIDUES FROM DOMAIN MG7 TO THE C-TERMINUS.
Descriptor:alpha-2-Macroglobulin
Authors:Garcia-Ferrer, I., Arede, P., Gomez-Blanco, J., Luque, D., Duquerroy, S., Caston, J.R., Goulas, T., Gomis-Ruth, X.F.
Deposit date:2015-04-28
Release date:2015-06-10
Modification date:2015-07-15
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural and functional insights into Escherichia coli alpha 2-macroglobulin endopeptidase snap-trap inhibition.
Proc.Natl.Acad.Sci.USA, 112, 2015
3CU7
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HUMAN COMPLEMENT COMPONENT 5
Descriptor:Complement C5
Authors:Fredslund, F., Andersen, G.R.
Deposit date:2008-04-16
Release date:2008-06-10
Modification date:2013-11-06
Method:X-RAY DIFFRACTION (3.105 Å)
Cite:Structure of and influence of a tick complement inhibitor on human complement component 5
Nat.Immunol., 9, 2008
4U48
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CRYSTAL STRUCTURE OF SALMONELLA ALPHA-2-MACROGLOBULIN
Descriptor:alpha-2-macroglobulin
Authors:Wong, S.G., Dessen, A.
Deposit date:2014-07-23
Release date:2014-09-17
Modification date:2015-09-23
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Structure of a bacterial alpha 2-macroglobulin reveals mimicry of eukaryotic innate immunity.
Nat Commun, 5, 2014
4U4J
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CRYSTAL STRUCTURE OF SALMONELLA ALPHA-2-MACROGLOBULIN MUTANT Y1175G
Descriptor:alpha-2-macroglobulin
Authors:Wong, S.G., Dessen, A.
Deposit date:2014-07-23
Release date:2014-09-17
Modification date:2014-10-01
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structure of a bacterial alpha 2-macroglobulin reveals mimicry of eukaryotic innate immunity.
Nat Commun, 5, 2014
4U59
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CRYSTAL STRUCTURE OF SALMONELLA ALPHA-2-MACROGLOBULIN REACTED WITH METHYLAMINE
Descriptor:alpha-2-macroglobulin
Authors:Wong, S.G., Dessen, A.
Deposit date:2014-07-24
Release date:2014-09-17
Modification date:2014-10-01
Method:X-RAY DIFFRACTION (3.09 Å)
Cite:Structure of a bacterial alpha 2-macroglobulin reveals mimicry of eukaryotic innate immunity.
Nat Commun, 5, 2014
4ZIQ
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CRYSTAL STRUCTURE OF TRYPSIN ACTIVATED ALPHA-2-MACROGLOBULIN FROM ESCHERICHIA COLI.
Descriptor:alpha-2-Macroglobulin
Authors:Garcia-Ferrer, I., Arede, P., Gomez-Blanco, J., Luque, D., Duquerroy, S., Caston, J.R., Goulas, T., Gomis-Ruth, X.F.
Deposit date:2015-04-28
Release date:2015-06-10
Modification date:2015-07-15
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Structural and functional insights into Escherichia coli alpha 2-macroglobulin endopeptidase snap-trap inhibition.
Proc.Natl.Acad.Sci.USA, 112, 2015
5A42
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CRYO-EM SINGLE PARTICLE 3D RECONSTRUCTION OF THE NATIVE CONFORMATION OF E. COLI ALPHA-2-MACROGLOBULIN (ECAM)
Descriptor:UNCHARACTERIZED LIPOPROTEIN YFHM
Authors:Garcia-Ferrer, I., Arede, P., Gomez-Blanco, J., Luque, D., Duquerroy, S., Caston, J.R., Goulas, T., Gomis-Ruth, F.X.
Deposit date:2015-06-04
Release date:2015-07-29
Modification date:2015-08-19
Method:ELECTRON MICROSCOPY (16 Å)
Cite:Structural and Functional Insights Into Escherichia Coli Alpha2- Macroglobulin Endopeptidase Snap-Trap Inhibition.
Proc.Natl.Acad.Sci.USA, 112, 2015
2B39
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STRUCTURE OF MAMMALIAN C3 WITH AN INTACT THIOESTER AT 3A RESOLUTION
Descriptor:C3
Authors:Fredslund, F., Jenner, L., Husted, L.B., Nyborg, J., Andersen, G.R., Sottrup-Jensen, L.
Deposit date:2005-09-20
Release date:2006-06-13
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:The structure of bovine complement component 3 reveals the basis for thioester function.
J.Mol.Biol., 361, 2006
3KLS
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STRUCTURE OF COMPLEMENT C5 IN COMPLEX WITH SSL7
Descriptor:Complement C5, Exotoxin 1
Authors:Laursen, N.S., Gordon, N., Hermans, S., Lorenz, N., Jackson, N., Wines, B., Spillner, E., Christensen, J.B., Jensen, M., Fredslund, F., Bjerre, M., Sottrup-Jensen, L., Fraser, J.D., Andersen, G.R.
Deposit date:2009-11-09
Release date:2009-11-24
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:Structural basis for inhibition of complement C5 by the SSL7 protein from Staphylococcus aureus
Proc.Natl.Acad.Sci.USA, 107, 2010
3KM9
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STRUCTURE OF COMPLEMENT C5 IN COMPLEX WITH THE C-TERMINAL BETA-GRASP DOMAIN OF SSL7
Descriptor:Complement C5, Staphylococcal enterotoxin-like toxin
Authors:Laursen, N.S., Gordon, N., Hermans, S., Lorenz, N., Jackson, N., Wines, B., Spillner, E., Christensen, J.B., Jensen, M., Fredslund, F., Bjerre, M., Sottrup-Jensen, L., Fraser, J.D., Andersen, G.R.
Deposit date:2009-11-10
Release date:2009-12-01
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (4.2 Å)
Cite:Structural basis for inhibition of complement C5 by the SSL7 protein from Staphylococcus aureus
Proc.Natl.Acad.Sci.USA, 107, 2010
3PRX
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STRUCTURE OF COMPLEMENT C5 IN COMPLEX WITH CVF AND SSL7
Descriptor:Complement C5, Cobra venom factor, Superantigen-like protein 7
Authors:Laursen, N.S., Andersen, G.R., Sottrup-Jensen, L., Andersen, K.R., Spillner, E., Braren, I.
Deposit date:2010-11-30
Release date:2011-01-19
Modification date:2011-04-13
Method:X-RAY DIFFRACTION (4.3 Å)
Cite:Substrate recognition by complement convertases revealed in the C5-cobra venom factor complex.
Embo J., 30, 2011
3PVM
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STRUCTURE OF COMPLEMENT C5 IN COMPLEX WITH CVF
Descriptor:Complement C5, Cobra venom factor
Authors:Laursen, N.S., Andersen, K.R., Braren, I., Sottrup-Jensen, L., Spillner, E., Andersen, G.R.
Deposit date:2010-12-07
Release date:2011-01-19
Modification date:2014-01-22
Method:X-RAY DIFFRACTION (4.3 Å)
Cite:Substrate recognition by complement convertases revealed in the C5-cobra venom factor complex.
Embo J., 30, 2011
4A5W
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CRYSTAL STRUCTURE OF C5B6
Descriptor:COMPLEMENT C5, COMPLEMENT COMPONENT C6
Authors:Hadders, M.A., Bubeck, D., Forneris, F., Pangburn, M., Llorca, O., Lea, S.M., Gros, P.
Deposit date:2011-10-28
Release date:2012-03-14
Modification date:2012-10-31
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Assembly and Regulation of the Membrane Attack Complex Based on Structures of C5B6 and Sc5B9.
Cell Rep., 1, 2012
4ACQ
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ALPHA-2 MACROGLOBULIN
Descriptor:ALPHA-2-MACROGLOBULIN
Authors:Marrero, A., Duquerroy, S., Trapani, S., Goulas, T., Guevara, T., Andersen, G.R., Navaza, J., Sottrup-Jensen, L., Gomis-Ruth, F.X.
Deposit date:2011-12-17
Release date:2012-02-22
Modification date:2014-12-17
Method:X-RAY DIFFRACTION (4.3 Å)
Cite:The Crystal Structure of Human Alpha(2)-Macroglobulin Reveals a Unique Molecular Cage.
Angew.Chem.Int.Ed.Engl., 51, 2012
4E0S
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CRYSTAL STRUCTURE OF C5B-6
Descriptor:Complement C5, Complement component C6
Authors:Aleshin, A.E., Stec, B., DiScipio, R., Liddington, R.C.
Deposit date:2012-03-05
Release date:2012-04-18
Modification date:2012-06-20
Method:X-RAY DIFFRACTION (4.21 Å)
Cite:Crystal structure of c5b-6 suggests structural basis for priming assembly of the membrane attack complex.
J.Biol.Chem., 287, 2012
4RTD
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ESCHERICHIA COLI ALPHA-2-MACROGLOBULIN ACTIVATED BY PORCINE ELASTASE
Descriptor:lipoprotein YfhM
Authors:Fyfe, C.D., Grinter, R., Roszak, A.W., Josts, I., Cogdell, R.J., Walker, D.
Deposit date:2014-11-14
Release date:2015-07-15
Modification date:2015-07-29
Method:X-RAY DIFFRACTION (3.65 Å)
Cite:Structure of protease-cleaved Escherichia coli alpha-2-macroglobulin reveals a putative mechanism of conformational activation for protease entrapment.
Acta Crystallogr.,Sect.D, 71, 2015
5HCC
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TERNARY COMPLEX OF HUMAN COMPLEMENT C5 WITH ORNITHODOROS MOUBATA OMCI AND DERMACENTOR ANDERSONI RACI3.
Descriptor:Complement C5, Complement inhibitor, Dermacentor andersoni RaCI3
Authors:Jore, M.M., Johnson, S., Lea, S.M.
Deposit date:2016-01-04
Release date:2016-03-30
Modification date:2016-05-11
Method:X-RAY DIFFRACTION (2.59 Å)
Cite:Structural basis for therapeutic inhibition of complement C5.
Nat.Struct.Mol.Biol., 23, 2016
5HCD
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TERNARY COMPLEX OF HUMAN COMPLEMENT C5 WITH ORNITHODOROS MOUBATA OMCI AND RHIPICEPHALUS MICROPLUS RACI2
Descriptor:Complement C5, Complement inhibitor, Rhipicephalus microplus RaCI2
Authors:Jore, M.M., Johnson, S., Lea, S.M.
Deposit date:2016-01-04
Release date:2016-03-30
Modification date:2016-05-11
Method:X-RAY DIFFRACTION (2.98 Å)
Cite:Structural basis for therapeutic inhibition of complement C5.
Nat.Struct.Mol.Biol., 23, 2016
5HCE
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TERNARY COMPLEX OF HUMAN COMPLEMENT C5 WITH ORNITHODOROS MOUBATA OMCI AND RHIPICEPHALUS APPENDICULATUS RACI1
Descriptor:Complement C5, Complement inhibitor, Rhipicephalus appendiculatus RaCI1
Authors:Jore, M.M., Johnson, S., Lea, S.M.
Deposit date:2016-01-04
Release date:2016-03-30
Modification date:2016-05-18
Method:X-RAY DIFFRACTION (3.12 Å)
Cite:Structural basis for therapeutic inhibition of complement C5.
Nat.Struct.Mol.Biol., 23, 2016
5I5K
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STRUCTURE OF COMPLEMENT C5 IN COMPLEX WITH ECULIZUMAB
Descriptor:Complement C5, Eculizumab heavy chain (variable domain), Eculizumab light chain (variable domain)
Authors:Schatz-Jakobsen, J.A., Andersen, G.R.
Deposit date:2016-02-15
Release date:2016-03-16
Modification date:2016-06-29
Method:X-RAY DIFFRACTION (4.2 Å)
Cite:Structural Basis for Eculizumab-Mediated Inhibition of the Complement Terminal Pathway.
J Immunol., 197, 2016
2A73
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HUMAN COMPLEMENT COMPONENT C3
Descriptor:Complement Component C3
Authors:Janssen, B.J.C., Huizinga, E.G., Raaijmakers, H.C.A., Roos, A., Daha, M.R., Nilsson-Ekdahl, K., Nilsson, B., Gros, P.
Deposit date:2005-07-04
Release date:2005-09-27
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Structures of complement component C3 provide insights into the function and evolution of immunity.
Nature, 437, 2005
2A74
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HUMAN COMPLEMENT COMPONENT C3C
Descriptor:Human Complement Component C3c
Authors:Janssen, B.J.C., Huizinga, E.G., Raaijmakers, H.C.A., Roos, A., Daha, M.R., Nilsson-Ekdahl, K., Nilsson, B., Gros, P.
Deposit date:2005-07-04
Release date:2005-09-27
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structures of complement component C3 provide insights into the function and evolution of immunity.
Nature, 437, 2005
2I07
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HUMAN COMPLEMENT COMPONENT C3B
Descriptor:Complement C3
Authors:Janssen, B.J.C., Christodoulidou, A., McCarthy, A., Lambris, J.D., Gros, P.
Deposit date:2006-08-10
Release date:2006-10-24
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (4 Å)
Cite:Structure of C3b reveals conformational changes that underlie complement activity.
Nature, 444, 2006
2ICE
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CRIG BOUND TO C3C
Descriptor:Complement C3 beta chain, Complement C3 alpha chain, V-set and immunoglobulin domain-containing protein 4
Authors:Wiesmann, C.
Deposit date:2006-09-12
Release date:2006-11-07
Modification date:2012-09-05
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structure of C3b in complex with CRIg gives insights into regulation of complement activation.
Nature, 444, 2006
2ICF
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CRIG BOUND TO C3B
Descriptor:Complement C3 beta chain, Complement C3 alpha chain, V-set and immunoglobulin domain-containing protein 4
Authors:Wiesmann, C.
Deposit date:2006-09-12
Release date:2006-11-07
Modification date:2013-09-18
Method:X-RAY DIFFRACTION (4.1 Å)
Cite:Structure of C3b in complex with CRIg gives insights into regulation of complement activation.
Nature, 444, 2006
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