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7U8V
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hTRAP1 with inhibitors
Descriptor: (4-hydroxy-1,3-phenylene)bis[(2H-isoindol-2-yl)methanone], Heat shock protein 75 kDa, mitochondrial
Authors:Deng, J, Matts, R, Peng, S.
Deposit date:2022-03-09
Release date:2023-08-16
Method:X-RAY DIFFRACTION (1.448 Å)
Cite:Elucidation of novel TRAP1-Selective inhibitors that regulate mitochondrial processes.
Eur.J.Med.Chem., 258, 2023
7U8X
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hTRAP1 with inhibitors
Descriptor: Heat shock protein 75 kDa, mitochondrial, [5-(4-fluoro-2H-isoindole-2-carbonyl)-2-hydroxyphenyl](5-methoxy-2H-isoindol-2-yl)methanone
Authors:Deng, J, Matts, R, Peng, S.
Deposit date:2022-03-09
Release date:2023-08-16
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Elucidation of novel TRAP1-Selective inhibitors that regulate mitochondrial processes.
Eur.J.Med.Chem., 258, 2023
7U8W
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BU of 7u8w by Molmil
hTRAP1 with inhibitors
Descriptor: Heat shock protein 75 kDa, mitochondrial, [5-(4-fluoro-2H-isoindole-2-carbonyl)-2-hydroxyphenyl](5-fluoro-2H-isoindol-2-yl)methanone
Authors:Deng, J, Matts, R, Peng, S.
Deposit date:2022-03-09
Release date:2023-08-16
Method:X-RAY DIFFRACTION (1.706 Å)
Cite:Elucidation of novel TRAP1-Selective inhibitors that regulate mitochondrial processes.
Eur.J.Med.Chem., 258, 2023
4IVG
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BU of 4ivg by Molmil
Crystal structure of mitochondrial Hsp90 (TRAP1) NTD-Middle domain dimer with AMPPNP
Descriptor: MAGNESIUM ION, PHOSPHATE ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
Authors:Partridge, J.R, Lavery, L.A, Agard, D.A.
Deposit date:2013-01-22
Release date:2014-01-22
Last modified:2014-08-27
Method:X-RAY DIFFRACTION (1.749 Å)
Cite:Structural asymmetry in the closed state of mitochondrial Hsp90 (TRAP1) supports a two-step ATP hydrolysis mechanism.
Mol.Cell, 53, 2014
1Y6Z
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BU of 1y6z by Molmil
Middle domain of Plasmodium falciparum putative heat shock protein PF14_0417
Descriptor: heat shock protein, putative
Authors:Lunin, V.V, Botchkareva, E, Loppnau, P, Amani, M, Bray, J, Vedadi, M, Edwards, A, Arrowsmith, C, Sundstrom, M, Bochkarev, A, Hui, R, Plotnikova, O, Structural Genomics Consortium (SGC)
Deposit date:2004-12-07
Release date:2005-02-08
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:Genome-scale protein expression and structural biology of Plasmodium falciparum and related Apicomplexan organisms.
Mol.Biochem.Parasitol., 151, 2007
2GQ0
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Crystal Structure of the Middle Domain of HtpG, the E. coli Hsp90
Descriptor: Chaperone protein htpG
Authors:Harris, S.F, Shiau, A.K, Agard, D.A.
Deposit date:2006-04-19
Release date:2006-10-31
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural Analysis of E. coli hsp90 reveals dramatic nucleotide-dependent conformational rearrangements.
Cell(Cambridge,Mass.), 127, 2006
1USU
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The Structure of the complex between Aha1 and HSP90
Descriptor: AHA1, GLYCEROL, HEAT SHOCK PROTEIN HSP82
Authors:Meyer, P, Roe, S.M, Pearl, L.H.
Deposit date:2003-12-01
Release date:2004-01-29
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structural Basis for Recruitment of the ATPase Activator Aha1 to the Hsp90 Chaperone Machinery.
Embo J., 23, 2004
7RY0
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BU of 7ry0 by Molmil
human Hsp90_MC domain structure
Descriptor: DIMETHYL SULFOXIDE, GLYCEROL, Heat shock protein HSP 90-alpha
Authors:Peng, S, Deng, J, Matts, R.
Deposit date:2021-08-24
Release date:2022-12-28
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural basis of the key residue W320 responsible for Hsp90 conformational change.
J.Biomol.Struct.Dyn., 2022
5TVX
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Crystal structure of mitochondrial Hsp90 (TRAP1) with ATP in absence of Mg, fully hydrolyzed
Descriptor: ADENOSINE-5'-DIPHOSPHATE, TNF receptor-associated protein 1
Authors:Elnatan, D, Betegon, M, Agard, D.A.
Deposit date:2016-11-10
Release date:2017-10-25
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Symmetry broken and rebroken during the ATP hydrolysis cycle of the mitochondrial Hsp90 TRAP1.
Elife, 6, 2017
6KSQ
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BU of 6ksq by Molmil
Middle Domain of Human HSP90 Alpha
Descriptor: Heat shock protein HSP 90-alpha
Authors:Su, H.X, Zhou, C, Zhang, N.X, Xu, Y.C.
Deposit date:2019-08-25
Release date:2020-02-26
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.202 Å)
Cite:Allosteric Regulation of Hsp90 alpha's Activity by Small Molecules Targeting the Middle Domain of the Chaperone.
Iscience, 23, 2020
3PRY
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BU of 3pry by Molmil
Crystal structure of the middle domain of human HSP90-beta refined at 2.3 A resolution
Descriptor: 1,2-ETHANEDIOL, GLYCEROL, Heat shock protein HSP 90-beta, ...
Authors:Chaikuad, A, Pilka, E, Sharpe, T.D, Cooper, C.D.O, Phillips, C, Berridge, G, Ayinampudi, V, Fedorov, O, Keates, T, Thangaratnarajah, C, Zimmermann, T, Vollmar, M, Yue, W.W, Che, K.H, Krojer, T, Muniz, J.R.C, von Delft, F, Bountra, C, Arrowsmith, C.H, Weigelt, J, Edwards, A, Bullock, A, Structural Genomics Consortium (SGC)
Deposit date:2010-11-30
Release date:2010-12-15
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.28 Å)
Cite:Crystal structure of the middle domain of human HSP90-beta refined at 2.3 A resolution
To be Published
4IPE
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BU of 4ipe by Molmil
Crystal structure of mitochondrial Hsp90 (TRAP1) with AMPPNP
Descriptor: COBALT (II) ION, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
Authors:Partridge, J.R, Lavery, L.A, Agard, D.A.
Deposit date:2013-01-09
Release date:2014-01-22
Last modified:2014-08-27
Method:X-RAY DIFFRACTION (2.289 Å)
Cite:Structural asymmetry in the closed state of mitochondrial Hsp90 (TRAP1) supports a two-step ATP hydrolysis mechanism.
Mol.Cell, 53, 2014
7EXP
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BU of 7exp by Molmil
Crystal structure of zebrafish TRAP1 with AMPPNP and MitoQ
Descriptor: 2,3-dimethoxy-5-methyl-6-[10-(triphenyl-$l^{5}-phosphanyl)decyl]cyclohexa-2,5-diene-1,4-dione, COBALT (II) ION, MAGNESIUM ION, ...
Authors:Lee, H, Yoon, N.G, Kang, B.H, Lee, C.
Deposit date:2021-05-28
Release date:2022-01-05
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.297 Å)
Cite:Mitoquinone Inactivates Mitochondrial Chaperone TRAP1 by Blocking the Client Binding Site.
J.Am.Chem.Soc., 143, 2021
3K60
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BU of 3k60 by Molmil
Crystal structure of N-terminal domain of Plasmodium falciparum Hsp90 (PF07_0029) bound to ADP
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Heat shock protein 86, SULFATE ION
Authors:Corbett, K.D, Berger, J.M.
Deposit date:2009-10-08
Release date:2010-08-18
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure of the ATP-binding domain of Plasmodium falciparum Hsp90.
Proteins, 78, 2010
4IYN
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BU of 4iyn by Molmil
Structure of mitochondrial Hsp90 (TRAP1) with ADP-ALF4-
Descriptor: ADENOSINE-5'-DIPHOSPHATE, COBALT (II) ION, MAGNESIUM ION, ...
Authors:Partridge, J.R, Lavery, L.A, Agard, D.A.
Deposit date:2013-01-28
Release date:2014-01-22
Last modified:2014-08-27
Method:X-RAY DIFFRACTION (2.312 Å)
Cite:Structural asymmetry in the closed state of mitochondrial Hsp90 (TRAP1) supports a two-step ATP hydrolysis mechanism.
Mol.Cell, 53, 2014
7ULK
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BU of 7ulk by Molmil
Human TRAP1 NM in complex with 42C
Descriptor: CALCIUM ION, Heat shock protein 75 kDa, mitochondrial, ...
Authors:Stachowski, T.R, Nithianantham, S, Vanarotti, M, Fischer, M.
Deposit date:2022-04-05
Release date:2023-04-12
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.34 Å)
Cite:Pan-HSP90 ligand binding reveals isoform-specific differences in plasticity and water networks.
Protein Sci., 32, 2023
4J0B
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BU of 4j0b by Molmil
Structure of mitochondrial Hsp90 (TRAP1) with ADP-BeF3
Descriptor: ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, COBALT (II) ION, ...
Authors:Partridge, J.R, Lavery, L.A, Agard, D.A.
Deposit date:2013-01-30
Release date:2014-01-22
Last modified:2014-08-27
Method:X-RAY DIFFRACTION (2.352 Å)
Cite:Structural asymmetry in the closed state of mitochondrial Hsp90 (TRAP1) supports a two-step ATP hydrolysis mechanism.
Mol.Cell, 53, 2014
5Y3N
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BU of 5y3n by Molmil
Structure of TRAP1 complexed with DN401
Descriptor: 1-[(6-bromanyl-1,3-benzodioxol-5-yl)methyl]-4-chloranyl-pyrazolo[3,4-d]pyrimidin-6-amine, Heat shock protein 75 kDa, mitochondrial
Authors:Jeong, H, Park, H.K, Kang, S, Kang, B.H, Lee, C.
Deposit date:2017-07-29
Release date:2017-08-30
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Paralog Specificity Determines Subcellular Distribution, Action Mechanism, and Anticancer Activity of TRAP1 Inhibitors.
J. Med. Chem., 60, 2017
2O1U
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BU of 2o1u by Molmil
Structure of full length GRP94 with AMP-PNP bound
Descriptor: Endoplasmin, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
Authors:Dollins, D.E, Warren, J.J, Immormino, R.M, Gewirth, D.T.
Deposit date:2006-11-29
Release date:2007-10-23
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structures of GRP94-Nucleotide Complexes Reveal Mechanistic Differences between the hsp90 Chaperones.
Mol.Cell, 28, 2007
5HPH
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BU of 5hph by Molmil
Structure of TRAP1 fragment
Descriptor: GLYCEROL, Heat shock protein 75 kDa, mitochondrial, ...
Authors:Sung, N, Chang, C, Lee, S, Tsai, F.T.F.
Deposit date:2016-01-20
Release date:2016-08-10
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.429 Å)
Cite:2.4 angstrom resolution crystal structure of human TRAP1NM, the Hsp90 paralog in the mitochondrial matrix.
Acta Crystallogr D Struct Biol, 72, 2016
2O1V
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Structure of full length GRP94 with ADP bound
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Endoplasmin, MAGNESIUM ION
Authors:Dollins, D.E, Warren, J.J, Immormino, R.M, Gewirth, D.T.
Deposit date:2006-11-29
Release date:2007-10-23
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Structures of GRP94-Nucleotide Complexes Reveal Mechanistic Differences between the hsp90 Chaperones.
Mol.Cell, 28, 2007
1HK7
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BU of 1hk7 by Molmil
Middle Domain of HSP90
Descriptor: CADMIUM ION, HEAT SHOCK PROTEIN HSP82, MAGNESIUM ION
Authors:Meyer, P, Prodromou, C, Roe, S.M, Pearl, L.H.
Deposit date:2003-03-06
Release date:2004-01-29
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural and Functional Analysis of the Middle Segment of Hsp90. Implications for ATP Hydrolysis and Client Protein and Cochaperone Interactions
Mol.Cell, 11, 2003
6D14
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BU of 6d14 by Molmil
Zebrafish TRAP1 bound to AMPPNP and calcium in the asymmetric closed state
Descriptor: CALCIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, TNF receptor-associated protein 1
Authors:Elnatan, D, Agard, D.A.
Deposit date:2018-04-11
Release date:2018-04-25
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Calcium binding to a remote site can replace magnesium as cofactor for mitochondrial Hsp90 (TRAP1) ATPase activity.
J.Biol.Chem., 293, 2018
3HJC
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BU of 3hjc by Molmil
Crystal structure of the carboxy-terminal domain of HSP90 from Leishmania major, LmjF33.0312
Descriptor: Heat shock protein 83-1, SULFATE ION
Authors:Wernimont, A.K, Tempel, W, Walker, J, Lin, Y.H, Hutchinson, A, Mackenzie, F, Fairlamb, A, Kozieradzki, I, Cossar, D, Zhao, Y, Schapira, M, Bochkarev, A, Arrowsmith, C.H, Bountra, C, Weigelt, J, Edwards, A.M, Ferguson, M.A.J, Hui, R, Pizarro, J.C, Hills, T, Structural Genomics Consortium (SGC)
Deposit date:2009-05-21
Release date:2009-06-02
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal Structure of the middle and carboxy-terminal domain of HSP90 from Leishmania major, LMJF33.0312
To be Published
5TVW
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Crystal structure of mitochondrial Hsp90 (TRAP1) with ATP in absence of Mg, hemi-hydrolyzed
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, COBALT (II) ION, ...
Authors:Elnatan, D, Betegon, M, Agard, D.A, Northeast Structural Genomics Consortium (NESG)
Deposit date:2016-11-10
Release date:2018-03-14
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Symmetry broken and rebroken during the ATP hydrolysis cycle of the mitochondrial Hsp90 TRAP1.
Elife, 6, 2017

 

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