1Y6Z
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MIDDLE DOMAIN OF PLASMODIUM FALCIPARUM PUTATIVE HEAT SHOCK PROTEIN PF14_0417
Descriptor:heat shock protein, putative
Authors:Lunin, V.V., Botchkareva, E., Loppnau, P., Amani, M., Bray, J., Vedadi, M., Edwards, A., Arrowsmith, C., Sundstrom, M., Bochkarev, A., Hui, R., Plotnikova, O., Structural Genomics Consortium (SGC)
Deposit date:2004-12-07
Release date:2005-02-08
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:Genome-scale protein expression and structural biology of Plasmodium falciparum and related Apicomplexan organisms.
Mol.Biochem.Parasitol., 151, 2007
1OSF
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HUMAN HSP90 IN COMPLEX WITH 17-DESMETHOXY-17-N,N-DIMETHYLAMINOETHYLAMINO-GELDANAMYCIN
Descriptor:heat shock 90kDa protein 1, alpha; heat shock 90kD protein 1, alpha, 17-DESMETHOXY-17-N,N-DIMETHYLAMINOETHYLAMINO-GELDANAMYCIN
Authors:Jez, J.M., Chen, J.C.-H., Rastelli, G., Stroud, R.M., Santi, D.V.
Deposit date:2003-03-19
Release date:2003-05-27
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Crystal Structure and Molecular Modeling of 17-DMAG in Complex with Human Hsp90
Chem.Biol., 10, 2003
1U0Y
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N-DOMAIN OF GRP94, WITH THE CHARGED DOMAIN, IN COMPLEX WITH THE NOVEL LIGAND N-PROPYL CARBOXYAMIDO ADENOSINE
Descriptor:Endoplasmin
Authors:Gewirth, D.T., Immormino, R.M.
Deposit date:2004-07-14
Release date:2005-07-05
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:N-Domain Of Grp94, with the Charged Domain, In Complex With the Novel Ligand N-Propyl Carboxyamido Adenosine
TO BE PUBLISHED
1UY6
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HUMAN HSP90-ALPHA WITH 9-BUTYL-8-(3,4,5-TRIMETHOXY-BENZYL)-9H-PURIN-6-YLAMINE
Descriptor:HEAT SHOCK PROTEIN HSP 90-ALPHA
Authors:Wright, L., Barril, X., Dymock, B., Sheridan, L., Surgenor, A., Beswick, M., Drysdale, M., Collier, A., Massey, A., Davies, N., Fink, A., Fromont, C., Aherne, W., Boxall, K., Sharp, S., Workman, P., Hubbard, R.E.
Deposit date:2004-03-02
Release date:2004-07-01
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure-Activity Relationships in Purine-Based Inhibitor Binding to Hsp90 Isoforms
Chem.Biol., 11, 2004
1UY8
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HUMAN HSP90-ALPHA WITH 9-BUTYL-8-(3-TRIMETHOXY-BENZYL)-9H-PURIN-6YLAMINE
Descriptor:HEAT SHOCK PROTEIN HSP 90-ALPHA
Authors:Wright, L., Barril, X., Dymock, B., Sheridan, L., Surgenor, A., Beswick, M., Drysdale, M., Collier, A., Massey, A., Davies, N., Fink, A., Fromont, C., Aherne, W., Boxall, K., Sharp, S., Workman, P., Hubbard, R.E.
Deposit date:2004-03-02
Release date:2004-07-01
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Structure-Activity Relationships in Purine-Based Inhibitor Binding to Hsp90 Isoforms
Chem.Biol., 11, 2004
1UY9
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HUMAN HSP90-ALPHA WITH 8-BENZO[1,3]DIOXOL-,5-YLMETHYL-9-BUTYL-9H-PURIN-6-YLAMINE
Descriptor:HEAT SHOCK PROTEIN HSP 90-ALPHA
Authors:Wright, L., Barril, X., Dymock, B., Sheridan, L., Surgenor, A., Beswick, M., Drysdale, M., Collier, A., Massey, A., Davies, N., Fink, A., Fromont, C., Aherne, W., Boxall, K., Sharp, S., Workman, P., Hubbard, R.E.
Deposit date:2004-03-02
Release date:2004-07-01
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure-Activity Relationships in Purine-Based Inhibitor Binding to Hsp90 Isoforms
Chem.Biol., 11, 2004
1UYC
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HUMAN HSP90-ALPHA WITH 9-BUTYL-8-(2,5-DIMETHOXY-BENZYL)-9H-PURIN-6-YLAMINE
Descriptor:HEAT SHOCK PROTEIN HSP 90-ALPHA
Authors:Wright, L., Barril, X., Dymock, B., Sheridan, L., Surgenor, A., Beswick, M., Drysdale, M., Collier, A., Massey, A., Davies, N., Fink, A., Fromont, C., Aherne, W., Boxall, K., Sharp, S., Workman, P., Hubbard, R.E.
Deposit date:2004-03-02
Release date:2004-07-01
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure-Activity Relationships in Purine-Based Inhibitor Binding to Hsp90 Isoforms
Chem.Biol., 11, 2004
1UYD
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HUMAN HSP90-ALPHA WITH 9-BUTYL-8-(2-CHLORO-3,4,5-TRIMETHOXY-BENZYL)-9H-PURIN-6-YLAMINE
Descriptor:HEAT SHOCK PROTEIN HSP 90-ALPHA
Authors:Wright, L., Barril, X., Dymock, B., Sheridan, L., Surgenor, A., Beswick, M., Drysdale, M., Collier, A., Massey, A., Davies, N., Fink, A., Fromont, C., Aherne, W., Boxall, K., Sharp, S., Workman, P., Hubbard, R.E.
Deposit date:2004-03-02
Release date:2004-07-01
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure-Activity Relationships in Purine-Based Inhibitor Binding to Hsp90 Isoforms
Chem.Biol., 11, 2004
1UYE
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HUMAN HSP90-ALPHA WITH 8-(2-CHLORO-3,4,5-TRIMETHOXY-BENZYL) -9-PENT-4-YLNYL-9H-PURIN-6-YLAMINE
Descriptor:HEAT SHOCK PROTEIN HSP 90-ALPHA
Authors:Wright, L., Barril, X., Dymock, B., Sheridan, L., Surgenor, A., Beswick, M., Drysdale, M., Collier, A., Massey, A., Davies, N., Fink, A., Fromont, C., Aherne, W., Boxall, K., Sharp, S., Workman, P., Hubbard, R.E.
Deposit date:2004-03-02
Release date:2004-07-01
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure-Activity Relationships in Purine-Based Inhibitor Binding to Hsp90 Isoforms
Chem.Biol., 11, 2004
1UYF
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HUMAN HSP90-ALPHA WITH 8-(2-CHLORO-3,4,5-TRIMETHOXY-BENZYL) -2-FLUORO-9-PENT-4-YLNYL-9H-PURIN-6-YLAMINE
Descriptor:HEAT SHOCK PROTEIN HSP 90-ALPHA
Authors:Wright, L., Barril, X., Dymock, B., Sheridan, L., Surgenor, A., Beswick, M., Drysdale, M., Collier, A., Massey, A., Davies, N., Fink, A., Fromont, C., Aherne, W., Boxall, K., Sharp, S., Workman, P., Hubbard, R.E.
Deposit date:2004-03-02
Release date:2004-07-01
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure-Activity Relationships in Purine-Based Inhibitor Binding to Hsp90 Isoforms
Chem.Biol., 11, 2004
1UYG
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HUMAN HSP90-ALPHA WITH 8-(2,5-DIMETHOXY-BENZYL)-2-FLUORO-9H-PURIN-6-YLAMINE
Descriptor:HEAT SHOCK PROTEIN HSP 90-ALPHA
Authors:Wright, L., Barril, X., Dymock, B., Sheridan, L., Surgenor, A., Beswick, M., Drysdale, M., Collier, A., Massey, A., Davies, N., Fink, A., Fromont, C., Aherne, W., Boxall, K., Sharp, S., Workman, P., Hubbard, R.E.
Deposit date:2004-03-02
Release date:2004-07-01
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure-Activity Relationships in Purine-Based Inhibitor Binding to Hsp90 Isoforms
Chem.Biol., 11, 2004
1UYH
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HUMAN HSP90-ALPHA WITH 9-BUTYL-8-(2,5-DIMETHOXY-BENZYL)-2-FLUORO-9H-PURIN-6-YLAMINE
Descriptor:HEAT SHOCK PROTEIN HSP 90-ALPHA
Authors:Wright, L., Barril, X., Dymock, B., Sheridan, L., Surgenor, A., Beswick, M., Drysdale, M., Collier, A., Massey, A., Davies, N., Fink, A., Fromont, C., Aherne, W., Boxall, K., Sharp, S., Workman, P., Hubbard, R.E.
Deposit date:2004-03-02
Release date:2004-07-01
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure-Activity Relationships in Purine-Based Inhibitor Binding to Hsp90 Isoforms
Chem.Biol., 11, 2004
1UYI
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HUMAN HSP90-ALPHA WITH 8-(2,5-DIMETHOXY-BENZYL)-2-FLUORO-9-PENT-9H-PURIN-6-YLAMINE
Descriptor:HEAT SHOCK PROTEIN HSP 90-ALPHA
Authors:Wright, L., Barril, X., Dymock, B., Sheridan, L., Surgenor, A., Beswick, M., Drysdale, M., Collier, A., Massey, A., Davies, N., Fink, A., Fromont, C., Aherne, W., Boxall, K., Sharp, S., Workman, P., Hubbard, R.E.
Deposit date:2004-03-02
Release date:2004-07-01
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure-Activity Relationships in Purine-Based Inhibitor Binding to Hsp90 Isoforms
Chem.Biol., 11, 2004
1UYK
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HUMAN HSP90-ALPHA WITH 8-BENZO[1,3]DIOXOL-,5-YLMETHYL-9-BUT YL-2-FLUORO-9H-PURIN-6-YLAMINE
Descriptor:HEAT SHOCK PROTEIN HSP 90-ALPHA
Authors:Wright, L., Barril, X., Dymock, B., Sheridan, L., Surgenor, A., Beswick, M., Drysdale, M., Collier, A., Massey, A., Davies, N., Fink, A., Fromont, C., Aherne, W., Boxall, K., Sharp, S., Workman, P., Hubbard, R.E.
Deposit date:2004-03-02
Release date:2004-07-01
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure-Activity Relationships in Purine-Based Inhibitor Binding to Hsp90 Isoforms
Chem.Biol., 11, 2004
1UYL
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STRUCTURE-ACTIVITY RELATIONSHIPS IN PURINE-BASED INHIBITOR BINDING TO HSP90 ISOFORMS
Descriptor:HEAT SHOCK PROTEIN HSP 90-ALPHA
Authors:Wright, L., Barril, X., Dymock, B., Sheridan, L., Surgenor, A., Beswick, M., Drysdale, M., Collier, A., Massey, A., Davies, N., Fink, A., Fromont, C., Aherne, W., Boxall, K., Sharp, S., Workman, P., Hubbard, R.E.
Deposit date:2004-03-02
Release date:2004-07-01
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Structure-Activity Relationships in Purine-Based Inhibitor Binding to Hsp90 Isoforms
Chem.Biol., 11, 2004
1UYM
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HUMAN HSP90-BETA WITH PU3 (9-BUTYL-8(3,4,5-TRIMETHOXY-BENZYL)-9H-PURIN-6-YLAMINE)
Descriptor:HEAT SHOCK PROTEIN HSP 90-BETA
Authors:Wright, L., Barril, X., Dymock, B., Sheridan, L., Surgenor, A., Beswick, M., Drysdale, M., Collier, A., Massey, A., Davies, N., Fink, A., Fromont, C., Aherne, W., Boxall, K., Sharp, S., Workman, P., Hubbard, R.E.
Deposit date:2004-03-02
Release date:2004-08-17
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Structure-Activity Relationships in Purine-Based Inhibitor Binding to Hsp90 Isoforms
Chem.Biol., 11, 2004
1YSZ
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CRYSTAL STRUCTURE OF THE UNLIGANDED FORM OF GRP94, THE ER HSP90: BASIS FOR NUCLEOTIDE-INDUCED CONFORMATIONAL CHANGE, GRP94N(DELTA)41 APO CRYSTAL SOAKED WITH NECA
Descriptor:Endoplasmin
Authors:Dollins, D.E., Immormino, R.M., Gewirth, D.T.
Deposit date:2005-02-09
Release date:2005-06-14
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Structure of Unliganded GRP94, the Endoplasmic Reticulum Hsp90: BASIS FOR NUCLEOTIDE-INDUCED CONFORMATIONAL CHANGE
J.Biol.Chem., 280, 2005
1YT0
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CRYSTAL STRUCTURE OF THE UNLIGANDED FORM OF GRP94, THE ER HSP90: BASIS FOR NUCLEOTIDE-INDUCED CONFORMATIONAL CHANGE, GRP94N(DELTA)41 APO CRYSTAL SOAKED WITH ADP
Descriptor:Endoplasmin
Authors:Dollins, D.E., Immormino, R.M., Gewirth, D.T.
Deposit date:2005-02-09
Release date:2005-06-14
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure of Unliganded GRP94, the Endoplasmic Reticulum Hsp90: BASIS FOR NUCLEOTIDE-INDUCED CONFORMATIONAL CHANGE
J.Biol.Chem., 280, 2005
2BSM
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NOVEL, POTENT SMALL MOLECULE INHIBITORS OF THE MOLECULAR CHAPERONE HSP90 DISCOVERED THROUGH STRUCTURE-BASED DESIGN
Descriptor:HEAT SHOCK PROTEIN HSP90-ALPHA
Authors:Dymock, B.W., Barril, X., Brough, P.A., Cansfield, J.E., Massey, A., Mcdonald, E., Hubbard, R.E., Surgenor, A., Roughley, S.D., Webb, P., Workman, P., Wright, L., Drysdale, M.J.
Deposit date:2005-05-23
Release date:2005-06-02
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Novel, Potent Small-Molecule Inhibitors of the Molecular Chaperone Hsp90 Discovered Through Structure-Based Design.
J.Med.Chem., 48, 2005
2BYH
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3-(5-CHLORO-2,4-DIHYDROXYPHENYL)-PYRAZOLE-4-CARBOXAMIDES AS INHIBITORS OF THE HSP90 MOLECULAR CHAPERONE
Descriptor:HEAT SHOCK PROTEIN HSP90-ALPHA
Authors:Brough, P.A., Barril, X., Beswick, M., Dymock, B.W., Drysdale, M.J., Wright, L., Grant, K., Massey, A., Surgenor, A., Workman, P.
Deposit date:2005-08-02
Release date:2005-10-12
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:3-(5-Chloro-2,4-Dihydroxyphenyl)-Pyrazole-4-Carboxamides as Inhibitors of the Hsp90 Molecular Chaperone.
Bioorg.Med.Chem.Lett., 15, 2005
2BYI
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3-(5-CHLORO-2,4-DIHYDROXYPHENYL)-PYRAZOLE-4-CARBOXAMIDES AS INHIBITORS OF THE HSP90 MOLECULAR CHAPERONE
Descriptor:HEAT SHOCK PROTEIN HSP90-ALPHA
Authors:Brough, P.A., Barril, X., Beswick, M., Dymock, B.W., Drysdale, M.J., Wright, L., Grant, K., Massey, A., Surgenor, A., Workman, P.
Deposit date:2005-08-02
Release date:2005-10-12
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:3-(5-Chloro-2,4-Dihydroxyphenyl)-Pyrazole-4-Carboxamides as Inhibitors of the Hsp90 Molecular Chaperone.
Bioorg.Med.Chem.Lett., 15, 2005
2CCS
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HUMAN HSP90 WITH 4-CHLORO-6-(4-PIPERAZIN-1-YL-1H-PYRAZOL-3-YL)-BENZENE-1,2-DIOL
Descriptor:HEAT SHOCK PROTEIN HSP-90 ALPHA
Authors:Barril, X., Beswick, M.C., Collier, A., Drysdale, M.J., Dymock, B.W., Fink, A., Grant, K., Howes, R., Jordan, A.M., Massey, A., Surgenor, A., Wayne, J., Workman, P., Wright, L.
Deposit date:2006-01-18
Release date:2006-02-22
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:4-Amino Derivatives of the Hsp90 Inhibitor Cct018159.
Bioorg.Med.Chem.Lett., 16, 2006
2CCT
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HUMAN HSP90 WITH 5-(5-CHLORO-2,4-DIHYDROXY-PHENYL)-4-PIPERAZIN-1-YL-2H-PYRAZOLE-3-CARBOXYLIC ACID ETHYLAMIDE
Descriptor:HEAT SHOCK PROTEIN HSP-90 ALPHA
Authors:Barril, X., Beswick, M.C., Collier, A., Drysdale, M.J., Dymock, B.W., Fink, A., Grant, K., Howes, R., Jordan, A.M., Massey, A., Surgenor, A., Wayne, J., Workman, P., Wright, L.
Deposit date:2006-01-18
Release date:2006-02-22
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:4-Amino Derivatives of the Hsp90 Inhibitor Cct018159.
Bioorg.Med.Chem.Lett., 16, 2006
2CCU
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HUMAN HSP90 WITH 4-CHLORO-6-(4-(4-(4-METHANESULPHONYL-BENZYL)-PIERAZIN-1-YL)-1H-PYRAZOL-3-YL)-BENZENE-1,3-DIOL
Descriptor:HEAT SHOCK PROTEIN HSP-90 ALPHA
Authors:Barril, X., Beswick, M.C., Collier, A., Drysdale, M.J., Dymock, B.W., Fink, A., Grant, K., Howes, R., Jordan, A.M., Massey, A., Surgenor, A., Wayne, J., Workman, P., Wright, L.
Deposit date:2006-01-18
Release date:2006-02-22
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:4-Amino Derivatives of the Hsp90 Inhibitor Cct018159.
Bioorg.Med.Chem.Lett., 16, 2006
2FWY
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STRUCTURE OF HUMAN HSP90-ALPHA BOUND TO THE POTENT WATER SOLUBLE INHIBITOR PU-H64
Descriptor:Heat shock protein HSP 90-alpha
Authors:Immormino, R.M., Gewirth, D.T.
Deposit date:2006-02-03
Release date:2006-10-03
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural and quantum chemical studies of 8-aryl-sulfanyl adenine class Hsp90 inhibitors.
J.Med.Chem., 49, 2006
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