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8UQN
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BU of 8uqn by Molmil
PLCb3-Gaq complex on membranes
Descriptor: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3, CALCIUM ION, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Falzone, M.E, MacKinnon, R.
Deposit date:2023-10-24
Release date:2023-12-06
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:The mechanism of G alpha q regulation of PLC beta 3 -catalyzed PIP2 hydrolysis.
Proc.Natl.Acad.Sci.USA, 120, 2023
8UQO
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BU of 8uqo by Molmil
PLCb3-Gbg-Gaq complex on membranes
Descriptor: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3, CALCIUM ION, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Falzone, M.E, MacKinnon, R.
Deposit date:2023-10-24
Release date:2023-12-06
Method:ELECTRON MICROSCOPY (3.37 Å)
Cite:The mechanism of G alpha q regulation of PLC beta 3 -catalyzed PIP2 hydrolysis.
Proc.Natl.Acad.Sci.USA, 120, 2023
8C5H
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BU of 8c5h by Molmil
NbSyt1 anti-(rat Synaptotagmin-1) nanobody bound to target cytosolic domain of Synaptotagmin-1
Descriptor: CALCIUM ION, GLYCEROL, NbSyt1 nanobody, ...
Authors:Martinez-Carranza, M, Stenmark, P.
Deposit date:2023-01-09
Release date:2023-08-02
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.68 Å)
Cite:A Versatile Synaptotagmin-1 Nanobody Provides Perturbation-Free Live Synaptic Imaging And Low Linkage-Error in Super-Resolution Microscopy.
Small Methods, 7, 2023
8FAF
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BU of 8faf by Molmil
Unedited Octopus bimaculoides Synaptotagmin 1 C2A at room temperature
Descriptor: Synaptotagmin
Authors:McNeme, S, Dominguez, M.J, Birk, M.A, Rosenthal, J.C, Sutton, R.B.
Deposit date:2022-11-26
Release date:2023-07-19
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Temperature-dependent RNA editing in octopus extensively recodes the neural proteome.
Cell, 186, 2023
8FAM
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BU of 8fam by Molmil
Edited Octopus bimaculoides Synaptotagmin 1 C2A (I248V) at room temperature
Descriptor: Synaptotagmin
Authors:McNeme, S, Dominguez, M.J, Birk, M.A, Rosenthal, J.J, Sutton, R.B.
Deposit date:2022-11-28
Release date:2023-07-19
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Temperature-dependent RNA editing in octopus extensively recodes the neural proteome.
Cell, 186, 2023
8EMW
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BU of 8emw by Molmil
Phospholipase C beta 3 (PLCb3) in complex with Gbg on liposomes
Descriptor: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3, CALCIUM ION, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Falzone, M.E, MacKinnon, R.
Deposit date:2022-09-28
Release date:2023-05-24
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:G beta gamma activates PIP2 hydrolysis by recruiting and orienting PLC beta on the membrane surface.
Proc.Natl.Acad.Sci.USA, 120, 2023
8EMX
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BU of 8emx by Molmil
Phospholipase C beta 3 (PLCb3) in complex with Gbg on lipid nanodiscs
Descriptor: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3, CALCIUM ION, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Falzone, M.E, MacKinnon, R.
Deposit date:2022-09-28
Release date:2023-05-24
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:G beta gamma activates PIP2 hydrolysis by recruiting and orienting PLC beta on the membrane surface.
Proc.Natl.Acad.Sci.USA, 120, 2023
8EMV
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BU of 8emv by Molmil
Phospholipase C beta 3 (PLCb3) in solution
Descriptor: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3, CALCIUM ION
Authors:Falzone, M.E, MacKinnon, R.
Deposit date:2022-09-28
Release date:2023-05-24
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:G beta gamma activates PIP2 hydrolysis by recruiting and orienting PLC beta on the membrane surface.
Proc.Natl.Acad.Sci.USA, 120, 2023
7TX9
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BU of 7tx9 by Molmil
Human Synaptotagmin-1 C2B Y312F Ca2+ bound
Descriptor: 2-(2-{2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHANOL, CALCIUM ION, CHLORIDE ION, ...
Authors:Dominguez, M.J, Karmakar, S, Fuson, K.L, Sutton, R.B.
Deposit date:2022-02-08
Release date:2023-03-29
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.34 Å)
Cite:Human Synaptotagmin-1 C2B Y312F Ca2+ bound
To Be Published
7TUA
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BU of 7tua by Molmil
Human Synaptotagmin-1 C2B Y312F without Ca2+
Descriptor: SULFATE ION, Synaptotagmin
Authors:Dominguez, M.J, Karmakar, S, Fuson, K.L, Sutton, R.B.
Deposit date:2022-02-02
Release date:2023-03-22
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Human Synaptotagmin-1 C2B Y312F without Ca2+
To Be Published
7U4Q
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BU of 7u4q by Molmil
Human Synaptotagmin-1 C2A Y181F Ca2+ bound
Descriptor: CALCIUM ION, Synaptotagmin-1
Authors:Dominguez, M.J, Karmakar, S, Fuson, K.L, Sutton, R.B.
Deposit date:2022-02-28
Release date:2023-03-15
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.56 Å)
Cite:Human Synaptotagmin-1 C2A Y181F Ca2+ bound
To Be Published
7T8T
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BU of 7t8t by Molmil
CryoEM structure of PLCg1
Descriptor: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma, CALCIUM ION
Authors:Endo-Streeter, S, Sondek, J.
Deposit date:2021-12-17
Release date:2022-12-21
Method:ELECTRON MICROSCOPY (3.68 Å)
Cite:CryoEM structure of PLCg1
To Be Published
7Z3J
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BU of 7z3j by Molmil
Structure of crystallisable rat Phospholipase C gamma 1 in complex with inositol 1,4,5-trisphosphate
Descriptor: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1, CALCIUM ION, D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE, ...
Authors:Pinotsis, N, Bunney, T.D, Katan, M.
Deposit date:2022-03-02
Release date:2022-07-20
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2 Å)
Cite:Characterization of the membrane interactions of phospholipase C gamma reveals key features of the active enzyme.
Sci Adv, 8, 2022
7PAG
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BU of 7pag by Molmil
The pore conformation of lymphocyte perforin
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Perforin-1
Authors:Ivanova, M.E, Lukoyanova, N, Malhotra, S, Topf, M, Trapani, J.A, Voskoboinik, I, Saibil, H.R.
Deposit date:2021-07-29
Release date:2022-02-16
Last modified:2022-02-23
Method:ELECTRON MICROSCOPY (4 Å)
Cite:The pore conformation of lymphocyte perforin.
Sci Adv, 8, 2022
7T7X
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BU of 7t7x by Molmil
Munc13-1 C1-C2B-MUN-C2C Upright conformation spanning two lipid bilayers
Descriptor: Protein unc-13 homolog A
Authors:Grushin, K, Sindelar, C.V.
Deposit date:2021-12-15
Release date:2022-02-09
Last modified:2024-02-28
Method:ELECTRON MICROSCOPY (10 Å)
Cite:Munc13 structural transitions and oligomers that may choreograph successive stages in vesicle priming for neurotransmitter release.
Proc.Natl.Acad.Sci.USA, 119, 2022
7T7C
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BU of 7t7c by Molmil
The hexagonal organization of Munc13-1 C1-C2B-MUN-C2C domains between lipid bilayers
Descriptor: Protein unc-13 homolog A Chimera
Authors:Grushin, K, Sindelar, C.V.
Deposit date:2021-12-15
Release date:2022-02-09
Last modified:2024-02-28
Method:ELECTRON MICROSCOPY (10 Å)
Cite:Munc13 structural transitions and oligomers that may choreograph successive stages in vesicle priming for neurotransmitter release.
Proc.Natl.Acad.Sci.USA, 119, 2022
7T7V
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BU of 7t7v by Molmil
Munc13-1 C1-C2B-MUN-C2C Lateral conformation on lipid bilayer surface
Descriptor: Protein unc-13 homolog A
Authors:Grushin, K, Sindelar, C.V.
Deposit date:2021-12-15
Release date:2022-02-09
Last modified:2024-02-28
Method:ELECTRON MICROSCOPY (10 Å)
Cite:Munc13 structural transitions and oligomers that may choreograph successive stages in vesicle priming for neurotransmitter release.
Proc.Natl.Acad.Sci.USA, 119, 2022
7T81
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BU of 7t81 by Molmil
Model of Munc13-1 C1-C2B-MUN-C2C 2D crystal between lipid bilayers.
Descriptor: Protein unc-13 homolog A
Authors:Grushin, K, Sindelar, C.V.
Deposit date:2021-12-15
Release date:2022-02-09
Last modified:2024-02-28
Method:ELECTRON MICROSCOPY (10 Å)
Cite:Munc13 structural transitions and oligomers that may choreograph successive stages in vesicle priming for neurotransmitter release.
Proc.Natl.Acad.Sci.USA, 119, 2022
7T7R
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BU of 7t7r by Molmil
Structure of Munc13-1 C1-C2B-MUN-C2C trimer between lipid bilayers
Descriptor: Protein unc-13 homolog A
Authors:Grushin, K, Sindelar, C.V.
Deposit date:2021-12-15
Release date:2022-02-09
Last modified:2024-02-28
Method:ELECTRON MICROSCOPY (10 Å)
Cite:Munc13 structural transitions and oligomers that may choreograph successive stages in vesicle priming for neurotransmitter release.
Proc.Natl.Acad.Sci.USA, 119, 2022
7SQ2
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BU of 7sq2 by Molmil
Reprocessed and refined structure of Phospholipase C-beta and Gq signaling complex
Descriptor: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3, ACETATE ION, CALCIUM ION, ...
Authors:Endo-Streeter, S.T, Sondek, J, Harden, T.K.
Deposit date:2021-11-04
Release date:2021-11-17
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Kinetic Scaffolding Mediated by a Phospholipase C-{beta} and Gq Signaling Complex
Science, 330, 2010
7ATP
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BU of 7atp by Molmil
2.0 angstrom structure in complex with Ca of plant Extended Synaptotagmin 1, C2A domain
Descriptor: CALCIUM ION, CHLORIDE ION, Synaptotagmin-1, ...
Authors:Benavente, J.L, Albert, A.
Deposit date:2020-10-30
Release date:2021-08-18
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The structure and flexibility analysis of the Arabidopsis synaptotagmin 1 reveal the basis of its regulation at membrane contact sites.
Life Sci Alliance, 4, 2021
7AS6
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BU of 7as6 by Molmil
2.0 angstrom structure of plant Extended Synaptotagmin 1, C2A domain
Descriptor: 1,2-ETHANEDIOL, CADMIUM ION, CHLORIDE ION, ...
Authors:Benavente, J.L, Albert, A.
Deposit date:2020-10-27
Release date:2021-08-18
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2 Å)
Cite:The structure and flexibility analysis of the Arabidopsis synaptotagmin 1 reveal the basis of its regulation at membrane contact sites.
Life Sci Alliance, 4, 2021
7JOF
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BU of 7jof by Molmil
Calcium-bound C2A Domain from Human Dysferlin
Descriptor: CALCIUM ION, Isoform 6 of Dysferlin
Authors:Tadayon, R, Wang, Y, Santamaria, L, Mercier, P, Forristal, C, Shaw, G.S.
Deposit date:2020-08-06
Release date:2021-06-16
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2 Å)
Cite:Calcium binds and rigidifies the dysferlin C2A domain in a tightly coupled manner.
Biochem.J., 478, 2021
7A1R
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BU of 7a1r by Molmil
Crystal structure of the C2B domain of Trypanosoma brucei extended synaptotagmin (E-Syt)
Descriptor: ACETATE ION, CALCIUM ION, CHLORIDE ION, ...
Authors:Dong, G.
Deposit date:2020-08-13
Release date:2021-06-02
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural studies of the shortest extended synaptotagmin with only two C2 domains from Trypanosoma brucei .
Iscience, 24, 2021
6LCY
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BU of 6lcy by Molmil
Crystal structure of Synaptotagmin-7 C2B in complex with IP6
Descriptor: INOSITOL HEXAKISPHOSPHATE, Synaptotagmin-7
Authors:Zhang, Y, Zhang, X, Rao, F, Wang, C.
Deposit date:2019-11-20
Release date:2021-03-03
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.301 Å)
Cite:5-IP 7 is a GPCR messenger mediating neural control of synaptotagmin-dependent insulin exocytosis and glucose homeostasis.
Nat Metab, 3, 2021

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PDB entries from 2024-03-27

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