Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

8OM6
DownloadVisualize
BU of 8om6 by Molmil
Crystal structure of FGF2-STAB, a stable variant of human fibroblast growth factor 2
Descriptor: Fibroblast growth factor 2
Authors:Marek, M, Chaloupkova, R, de La Bourdonnaye, G.
Deposit date:2023-03-31
Release date:2024-03-06
Method:X-RAY DIFFRACTION (1.31 Å)
Cite:Crystal structure of FGF2-STAB, a stable variant of human fibroblast growth factor 2
To Be Published
7YSW
DownloadVisualize
BU of 7ysw by Molmil
Cryo-EM Structure of FGF23-FGFR4-aKlotho-HS Quaternary Complex
Descriptor: 2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid, COPPER (II) ION, Fibroblast growth factor 23, ...
Authors:Mohammadi, M, Chen, L.
Deposit date:2022-08-13
Release date:2023-06-14
Last modified:2023-07-05
Method:ELECTRON MICROSCOPY (3.03 Å)
Cite:Structural basis for FGF hormone signalling.
Nature, 618, 2023
7YSU
DownloadVisualize
BU of 7ysu by Molmil
Cryo-EM Structure of FGF23-FGFR3c-aKlotho-HS Quaternary Complex
Descriptor: 2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid, COPPER (II) ION, Fibroblast growth factor 23, ...
Authors:Mohammadi, M, Chen, L.
Deposit date:2022-08-13
Release date:2023-04-19
Last modified:2023-07-05
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Structural basis for FGF hormone signalling.
Nature, 618, 2023
7YSH
DownloadVisualize
BU of 7ysh by Molmil
Cryo-EM Structure of FGF23-FGFR1c-aKlotho-HS Quaternary Complex
Descriptor: 2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose, COPPER (II) ION, Fibroblast growth factor 23, ...
Authors:Mohammadi, M, Chen, L.
Deposit date:2022-08-12
Release date:2023-04-19
Last modified:2023-07-05
Method:ELECTRON MICROSCOPY (2.74 Å)
Cite:Structural basis for FGF hormone signalling.
Nature, 618, 2023
6M6F
DownloadVisualize
BU of 6m6f by Molmil
Solution structure of disulfide bond mutaion of the core domain of Fibroblast growth factor 21 (FGF21)
Descriptor: Fibroblast growth factor 21
Authors:Zhu, L, Zhao, H, Wang, J.
Deposit date:2020-03-14
Release date:2021-01-20
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Dynamic folding modulation generates FGF21 variant against diabetes.
Embo Rep., 22, 2021
6M6E
DownloadVisualize
BU of 6m6e by Molmil
Solution structure of the core domain of Fibroblast growth factor 21 (FGF21)
Descriptor: Fibroblast growth factor 21
Authors:Zhu, L, Zhao, H, Wang, J.
Deposit date:2020-03-14
Release date:2021-01-20
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Dynamic folding modulation generates FGF21 variant against diabetes.
Embo Rep., 22, 2021
6KTR
DownloadVisualize
BU of 6ktr by Molmil
Crystal structure of fibroblast growth factor 19 in complex with Fab
Descriptor: Fibroblast growth factor 19, G1A8-Fab-HC, G1A8-Fab-LC, ...
Authors:Liu, H, Zheng, S, Hou, X, Liu, X, Lv, X, Li, Y, Li, W, Sui, J.
Deposit date:2019-08-28
Release date:2020-07-08
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.59775758 Å)
Cite:Novel Abs targeting the N-terminus of fibroblast growth factor 19 inhibit hepatocellular carcinoma growth without bile-acid-related side-effects.
Cancer Sci., 111, 2020
6L4O
DownloadVisualize
BU of 6l4o by Molmil
Crystal structure of API5-FGF2 complex
Descriptor: Apoptosis inhibitor 5, Fibroblast growth factor 2
Authors:Lee, B.I, Bong, S.M.
Deposit date:2019-10-18
Release date:2020-04-29
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Regulation of mRNA export through API5 and nuclear FGF2 interaction.
Nucleic Acids Res., 48, 2020
5X1O
DownloadVisualize
BU of 5x1o by Molmil
PI(4,5)P2 lipid binding induced a reorientation of FGF2 molecules near membrane surface to facilitate the unconventional oligomerization-dependent secretion process as revealed by a combined FTIR/NMR/X-ray study
Descriptor: D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE, Fibroblast growth factor 2
Authors:Tsao, Y.H.
Deposit date:2017-01-26
Release date:2018-03-07
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:PI(4,5)P2 lipid binding induced a reorientation of FGF2 molecules near membrane surface to facilitate the unconventional oligomerization-dependent secretion process as revealed by a combined FTIR/NMR/X-ray study
To Be Published
5W21
DownloadVisualize
BU of 5w21 by Molmil
Crystal Structure of a 1:1:1 FGF23-FGFR1c-aKlotho Ternary Complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Fibroblast growth factor 23, Fibroblast growth factor receptor 1, ...
Authors:Mohammadi, M.
Deposit date:2017-06-05
Release date:2018-01-24
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3 Å)
Cite:alpha-Klotho is a non-enzymatic molecular scaffold for FGF23 hormone signalling.
Nature, 553, 2018
5W59
DownloadVisualize
BU of 5w59 by Molmil
Crystal structure of a monomeric human FGF9 in complex with the ectodomain of human FGFR1c
Descriptor: Fibroblast growth factor 9, Fibroblast growth factor receptor 1, SULFATE ION
Authors:Mohammadi, M, Ma, J, Liu, Y.
Deposit date:2017-06-14
Release date:2017-08-16
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.498 Å)
Cite:Regulation of Receptor Binding Specificity of FGF9 by an Autoinhibitory Homodimerization.
Structure, 25, 2017
4YOL
DownloadVisualize
BU of 4yol by Molmil
Human fibroblast growth factor-1 C16S/A66C/C117A/P134A
Descriptor: CITRATE ANION, Fibroblast growth factor 1, IMIDAZOLE
Authors:Xia, X, Blaber, M.
Deposit date:2015-03-11
Release date:2016-03-16
Last modified:2019-02-13
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:Engineering a Cysteine-Free Form of Human Fibroblast Growth Factor-1 for "Second Generation" Therapeutic Application.
J.Pharm.Sci., 105, 2016
4XKI
DownloadVisualize
BU of 4xki by Molmil
Human Fibroblast Growth Factor - 1 (FGF-1) mutant S116R
Descriptor: Fibroblast growth factor 1, GLYCEROL, NONAETHYLENE GLYCOL, ...
Authors:Xia, X.
Deposit date:2015-01-12
Release date:2016-01-20
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2 Å)
Cite:Biophysical characterizations of Fibroblast Growth Factor - 1 mutant with increased heparin binding affinity
To Be Published
4QO3
DownloadVisualize
BU of 4qo3 by Molmil
Crystal structure of C16S/N18S/K12V/C117V/P134V mutant of human acidic fibroblast growth factor
Descriptor: CITRATE ANION, Fibroblast growth factor 1, IMIDAZOLE
Authors:Blaber, M, Xia, X.
Deposit date:2014-06-19
Release date:2015-05-06
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.047 Å)
Cite:Thermodynamics of Cysteine Substitution Suggest Unique Structural Role for Cysteine in Proteins
To be Published
4QBC
DownloadVisualize
BU of 4qbc by Molmil
Crystal structure of C117T mutant of human acidic fibroblast growth factor in sodium formate buffer
Descriptor: FORMIC ACID, Fibroblast growth factor 1, SULFATE ION
Authors:Blaber, M, Xia, X.
Deposit date:2014-05-07
Release date:2015-03-11
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.519 Å)
Cite:Mutation choice to eliminate buried free cysteines in protein therapeutics.
J.Pharm.Sci., 104, 2015
4QBV
DownloadVisualize
BU of 4qbv by Molmil
Crystal structure of C117T mutant of human acidic fibroblast growth factor in sodium citrate buffer
Descriptor: CITRATE ANION, Fibroblast growth factor 1
Authors:Blaber, M, Xia, X.
Deposit date:2014-05-08
Release date:2015-03-11
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.497 Å)
Cite:Mutation choice to eliminate buried free cysteines in protein therapeutics.
J.Pharm.Sci., 104, 2015
4QC4
DownloadVisualize
BU of 4qc4 by Molmil
Crystal structure of C117S mutant of human acidic fibroblast growth factor
Descriptor: CITRATE ANION, Fibroblast growth factor 1, IMIDAZOLE, ...
Authors:Blaber, M, Xia, X.
Deposit date:2014-05-09
Release date:2015-03-11
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.491 Å)
Cite:Mutation choice to eliminate buried free cysteines in protein therapeutics.
J.Pharm.Sci., 104, 2015
4Q9P
DownloadVisualize
BU of 4q9p by Molmil
Crystal structure of C16T/K12V/C117V/P134V mutant of human acidic fibroblast growth factor
Descriptor: Fibroblast growth factor 1
Authors:Blaber, M, Xia, X.
Deposit date:2014-05-01
Release date:2015-03-11
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Mutation choice to eliminate buried free cysteines in protein therapeutics.
J.Pharm.Sci., 104, 2015
4Q91
DownloadVisualize
BU of 4q91 by Molmil
Crystal structure of C16A/K12V/C117V/P134V mutant of human acidic fibroblast growth factor
Descriptor: FORMIC ACID, Fibroblast growth factor 1, PHOSPHATE ION
Authors:Xia, X, Blaber, M.
Deposit date:2014-04-28
Release date:2015-03-11
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.799 Å)
Cite:Mutation choice to eliminate buried free cysteines in protein therapeutics.
J.Pharm.Sci., 104, 2015
4QAL
DownloadVisualize
BU of 4qal by Molmil
Crystal structure of C117A mutant of human acidic fibroblast growth factor
Descriptor: CITRATE ANION, Fibroblast growth factor 1
Authors:Blaber, M, Xia, X.
Deposit date:2014-05-05
Release date:2015-03-11
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Mutation choice to eliminate buried free cysteines in protein therapeutics.
J.Pharm.Sci., 104, 2015
4Q9G
DownloadVisualize
BU of 4q9g by Molmil
Crystal structure of K12V/C16S/C117V/P134V mutant of human acidic fibroblast growth factor
Descriptor: FORMIC ACID, Fibroblast growth factor 1, PHOSPHATE ION
Authors:Blaber, M, Xia, X.
Deposit date:2014-05-01
Release date:2015-03-11
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.554 Å)
Cite:Mutation choice to eliminate buried free cysteines in protein therapeutics.
J.Pharm.Sci., 104, 2015
4OEG
DownloadVisualize
BU of 4oeg by Molmil
Crystal Structure Analysis of FGF2-Disaccharide (S9I2) complex
Descriptor: 2-deoxy-3,6-di-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-1-O-methyl-2-O-sulfo-alpha-L-idopyranuronic acid, Fibroblast growth factor 2
Authors:Li, Y.C, Hsiao, C.D.
Deposit date:2014-01-13
Release date:2014-07-09
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Interactions that influence the binding of synthetic heparan sulfate based disaccharides to fibroblast growth factor-2.
Acs Chem.Biol., 9, 2014
4OEF
DownloadVisualize
BU of 4oef by Molmil
Crystal Structure Analysis of FGF2-Disaccharide (S6I2) complex
Descriptor: 2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-1-O-methyl-2-O-sulfo-alpha-L-idopyranuronic acid, Fibroblast growth factor 2
Authors:Li, Y.C, Hsiao, C.D.
Deposit date:2014-01-13
Release date:2014-07-09
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Interactions that influence the binding of synthetic heparan sulfate based disaccharides to fibroblast growth factor-2.
Acs Chem.Biol., 9, 2014
4OEE
DownloadVisualize
BU of 4oee by Molmil
Crystal Structure Analysis of FGF2-Disaccharide (S3I2) complex
Descriptor: 2-deoxy-3-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-1-O-methyl-2-O-sulfo-alpha-L-idopyranuronic acid, Fibroblast growth factor 2
Authors:Li, Y.C, Hsiao, C.D.
Deposit date:2014-01-13
Release date:2014-07-09
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Interactions that influence the binding of synthetic heparan sulfate based disaccharides to fibroblast growth factor-2.
Acs Chem.Biol., 9, 2014
4JQ0
DownloadVisualize
BU of 4jq0 by Molmil
Voltage-gated sodium channel 1.5 C-terminal domain in complex with FGF12B and Ca2+/calmodulin
Descriptor: CALCIUM ION, Calmodulin, Fibroblast growth factor 12, ...
Authors:Wang, C, Chung, B.C, Yan, H, Wang, H.G, Lee, S.Y, Pitt, G.S.
Deposit date:2013-03-19
Release date:2014-05-21
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (3.84 Å)
Cite:Structural analyses of Ca(2+)/CaM interaction with NaV channel C-termini reveal mechanisms of calcium-dependent regulation.
Nat Commun, 5, 2014

217705

PDB entries from 2024-03-27

PDB statisticsPDBj update infoContact PDBjnumon