1C3B
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AMPC BETA-LACTAMASE FROM E. COLI COMPLEXED WITH INHIBITOR, BENZO(B)THIOPHENE-2-BORONIC ACID (BZB)
Descriptor:CEPHALOSPORINASE
Authors:Powers, R.A., Blazquez, J., Weston, G.S., Morosini, M.I., Baquero, F., Shoichet, B.K.
Deposit date:1999-07-27
Release date:1999-11-24
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:The complexed structure and antimicrobial activity of a non-beta-lactam inhibitor of AmpC beta-lactamase.
Protein Sci., 8, 1999
1FCM
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CRYSTAL STRUCTURE OF THE E.COLI AMPC BETA-LACTAMASE MUTANT Q120L/Y150E COVALENTLY ACYLATED WITH THE INHIBITORY BETA-LACTAM, CLOXACILLIN
Descriptor:BETA-LACTAMASE (E.C.3.5.2.6)/INHIBITOR COMPLEX
Authors:Patera, A., Blaszczak, L.C., Shoichet, B.K.
Deposit date:2000-07-18
Release date:2000-12-04
Modification date:2011-08-24
Method:X-RAY DIFFRACTION (2.46 Å)
Cite:Crystal Structures of Substrate and Inhibitor Complexes with AmpC -Lactamase: Possible Implications for Substrate-Assisted Catalysis
J.Am.Chem.Soc., 122, 2000
1FCN
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CRYSTAL STRUCTURE OF THE E. COLI AMPC BETA-LACTAMASE MUTANT Q120L/Y150E COVALENTLY ACYLATED WITH THE SUBSTRATE BETA-LACTAM LORACARBEF
Descriptor:BETA-LACTAMASE (E.C.3.5.2.6)/INHIBITOR COMPLEX
Authors:Patera, A., Blaszczak, L.C., Shoichet, B.K.
Deposit date:2000-07-18
Release date:2000-12-04
Modification date:2011-08-24
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Crystal Structures of Substrate and Inhibitor Complexes with AmpC -Lactamase: Possible Implications for Substrate-Assisted Catalysis
J.Am.Chem.Soc., 122, 2000
1FCO
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CRYSTAL STRUCTURE OF THE E. COLI AMPC BETA-LACTAMASE COVALENTLY ACYLATED WITH THE INHIBITORY BETA-LACTAM, MOXALACTAM
Descriptor:BETA-LACTAMASE (E.C.3.5.2.6)/INHIBITOR COMPLEX
Authors:Patera, A., Blaszczak, L.C., Shoichet, B.K.
Deposit date:2000-07-19
Release date:2000-12-04
Modification date:2011-08-24
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal Structures of Substrate and Inhibitor Complexes with AmpC -Lactamase: Possible Implications for Substrate-Assisted Catalysis
J.Am.Chem.Soc., 122, 2000
1FSW
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AMPC BETA-LACTAMASE FROM E. COLI COMPLEXED WITH INHIBITOR CEPHALOTHINBORONIC ACID
Descriptor:CEPHALOSPORINASE (E.C.3.5.2.6)
Authors:Caselli, E., Powers, R.A., Blaszczak, L.C., Wu, C.Y., Prati, F., Shoichet, B.K.
Deposit date:2000-09-11
Release date:2001-03-14
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Energetic, structural, and antimicrobial analyses of beta-lactam side chain recognition by beta-lactamases.
Chem.Biol., 8, 2001
1FSY
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AMPC BETA-LACTAMASE FROM E. COLI COMPLEXED WITH INHIBITOR CLOXACILLINBORONIC ACID
Descriptor:CEPHALOSPORINASE (E.C.3.5.2.6)
Authors:Caselli, E., Powers, R.A., Blasczcak, L.C., Wu, C.Y., Prati, F., Shoichet, B.K.
Deposit date:2000-09-11
Release date:2001-03-14
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Energetic, structural, and antimicrobial analyses of beta-lactam side chain recognition by beta-lactamases.
Chem.Biol., 8, 2001
1GA9
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CRYSTAL STRUCTURE OF AMPC BETA-LACTAMASE FROM E. COLI COMPLEXED WITH NON-BETA-LACTAMASE INHIBITOR (2, 3-(4-BENZENESULFONYL-THIOPHENE-2-SULFONYLAMINO)-PHENYLBORONIC ACID)
Descriptor:BETA-LACTAMASE (E.C.3.5.2.6)
Authors:Tondi, D., Powers, R.A., Caselli, E., Negri, M.C., Blazquez, J., Costi, M.P., Shoichet, B.K.
Deposit date:2000-11-29
Release date:2001-07-25
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure-based design and in-parallel synthesis of inhibitors of AmpC beta-lactamase.
Chem.Biol., 8, 2001
1I5Q
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CRYSTAL STRUCTURE OF THE E. COLI AMPC BETA-LACTAMASE MUTANT N152A COVALENTLY ACYLATED WITH THE INHIBITORY BETA-LACTAM, MOXALACTAM
Descriptor:BETA-LACTAMASE (E.C.3.5.2.6)
Authors:Trehan, I., Beadle, B.M., Shoichet, B.K.
Deposit date:2001-02-28
Release date:2001-06-20
Modification date:2011-08-24
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:Inhibition of AmpC beta-lactamase through a destabilizing interaction in the active site.
Biochemistry, 40, 2001
1IEL
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CRYSTAL STRUCTURE OF AMPC BETA-LACTAMASE FROM E. COLI IN COMPLEX WITH CEFTAZIDIME
Descriptor:beta-lactamase (E.C.3.5.2.6)
Authors:Powers, R.A., Caselli, E., Focia, P.J., Prati, F., Shoichet, B.K.
Deposit date:2001-04-10
Release date:2001-08-15
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structures of ceftazidime and its transition-state analogue in complex with AmpC beta-lactamase: implications for resistance mutations and inhibitor design.
Biochemistry, 40, 2001
1IEM
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CRYSTAL STRUCTURE OF AMPC BETA-LACTAMASE FROM E. COLI IN COMPLEX WITH A BORONIC ACID INHIBITOR (1, CEFB4)
Descriptor:beta-lactamase (E.C.3.5.2.6)
Authors:Powers, R.A., Caselli, E., Focia, P.J., Prati, F., Shoichet, B.K.
Deposit date:2001-04-10
Release date:2001-08-15
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structures of ceftazidime and its transition-state analogue in complex with AmpC beta-lactamase: implications for resistance mutations and inhibitor design.
Biochemistry, 40, 2001
1KDS
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X-RAY CRYSTAL STRUCTURE OF AMPC BETA-LACTAMASE FROM E. COLI IN COMPLEX WITH THE INHIBITOR 3-NITROPHENYLBORONIC ACID
Descriptor:BETA-LACTAMASE (E.C.3.5.2.6)
Authors:Powers, R.A., Shoichet, B.K.
Deposit date:2001-11-13
Release date:2002-07-17
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structure-based approach for binding site identification on AmpC beta-lactamase.
J.Med.Chem., 45, 2002
1KDW
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X-RAY CRYSTAL STRUCTURE OF AMPC BETA-LACTAMASE FROM E. COLI IN COMPLEX WITH THE INHIBITOR 4-CARBOXYPHENYLBORONIC ACID
Descriptor:beta-lactamase (E.C.3.5.2.6)
Authors:Powers, R.A., Shoichet, B.K.
Deposit date:2001-11-13
Release date:2002-07-17
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.28 Å)
Cite:Structure-based approach for binding site identification on AmpC beta-lactamase.
J.Med.Chem., 45, 2002
1KE0
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X-RAY CRYSTAL STRUCTURE OF AMPC BETA-LACTAMASE FROM E. COLI IN COMPLEX WITH THE INHIBITOR 4-(CARBOXYVIN-2-YL)PHENYLBORONIC ACID
Descriptor:beta-lactamase (E.C.3.5.2.6)
Authors:Powers, R.A., Shoichet, B.K.
Deposit date:2001-11-13
Release date:2002-07-17
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure-based approach for binding site identification on AmpC beta-lactamase.
J.Med.Chem., 45, 2002
1KE3
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X-RAY CRYSTAL STRUCTURE OF AMPC BETA-LACTAMASE FROM E. COLI IN COMPLEX WITH THE INHIBITOR 4,4'-BIPHENYLDIBORONIC ACID
Descriptor:beta-lactamase (E.C.3.5.2.6)
Authors:Powers, R.A., Shoichet, B.K.
Deposit date:2001-11-14
Release date:2002-07-17
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structure-based approach for binding site identification on AmpC beta-lactamase.
J.Med.Chem., 45, 2002
1KE4
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X-RAY CRYSTAL STRUCTURE OF AMPC BETA-LACTAMASE FROM E. COLI
Descriptor:beta-lactamase (E.C.3.5.2.6)
Authors:Powers, R.A., Shoichet, B.K.
Deposit date:2001-11-14
Release date:2002-07-17
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (1.72 Å)
Cite:Structure-based approach for binding site identification on AmpC beta-lactamase.
J.Med.Chem., 45, 2002
1KVL
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X-RAY CRYSTAL STRUCTURE OF AMPC S64G MUTANT BETA-LACTAMASE IN COMPLEX WITH SUBSTRATE AND PRODUCT FORMS OF CEPHALOTHIN
Descriptor:beta-lactamase (E.C.3.5.2.6)
Authors:Beadle, B.M., Trehan, I., Focia, P.J., Shoichet, B.K.
Deposit date:2002-01-27
Release date:2002-03-13
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (1.53 Å)
Cite:Structural milestones in the reaction pathway of an amide hydrolase: substrate, acyl, and product complexes of cephalothin with AmpC beta-lactamase.
Structure, 10, 2002
1KVM
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X-RAY CRYSTAL STRUCTURE OF AMPC WT BETA-LACTAMASE IN COMPLEX WITH COVALENTLY BOUND CEPHALOTHIN
Descriptor:beta-lactamase (E.C.3.5.2.6)
Authors:Beadle, B.M., Trehan, I., Focia, P.J., Shoichet, B.K.
Deposit date:2002-01-27
Release date:2002-03-13
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.06 Å)
Cite:Structural milestones in the reaction pathway of an amide hydrolase: substrate, acyl, and product complexes of cephalothin with AmpC beta-lactamase.
Structure, 10, 2002
1L0D
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X-RAY CRYSTAL STRUCTURE OF AMPC S64D MUTANT BETA-LACTAMASE
Descriptor:beta-lactamase (E.C.3.5.2.6)
Authors:Beadle, B.M., Shoichet, B.K.
Deposit date:2002-02-09
Release date:2002-08-14
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (1.53 Å)
Cite:Structural bases of stability-function tradeoffs in enzymes.
J.Mol.Biol., 321, 2002
1L0E
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X-RAY CRYSTAL STRUCTURE OF AMPC K67Q MUTANT BETA-LACTAMASE
Descriptor:beta-lactamase (E.C.3.5.2.6)
Authors:Beadle, B.M., Shoichet, B.K.
Deposit date:2002-02-09
Release date:2002-08-14
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural bases of stability-function tradeoffs in enzymes.
J.Mol.Biol., 321, 2002
1L0F
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X-RAY CRYSTAL STRUCTURE OF AMPC N152H MUTANT BETA-LACTAMASE
Descriptor:beta-lactamase (E.C.3.5.2.6)
Authors:Beadle, B.M., Shoichet, B.K.
Deposit date:2002-02-09
Release date:2002-08-14
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (1.66 Å)
Cite:Structural bases of stability-function tradeoffs in enzymes.
J.Mol.Biol., 321, 2002
1L0G
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X-RAY CRYSTAL STRUCTURE OF AMPC S64G MUTANT BETA-LACTAMASE
Descriptor:beta-lactamase (E.C.3.5.2.6)
Authors:Beadle, B.M., Shoichet, B.K.
Deposit date:2002-02-09
Release date:2002-08-14
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural bases of stability-function tradeoffs in enzymes.
J.Mol.Biol., 321, 2002
1L2S
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X-RAY CRYSTAL STRUCTURE OF AMPC BETA-LACTAMASE FROM E. COLI IN COMPLEX WITH A DOCK-PREDICTED NON-COVALENT INHIBITOR
Descriptor:beta-lactamase (E.C.3.5.2.6)
Authors:Powers, R.A., Morandi, F., Shoichet, B.K.
Deposit date:2002-02-24
Release date:2002-07-17
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (1.94 Å)
Cite:Structure-based discovery of a novel, noncovalent inhibitor of AmpC beta-lactamase.
Structure, 10, 2002
1LL5
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X-RAY CRYSTAL STRUCTURE OF AMPC WT BETA-LACTAMASE IN COMPLEX WITH COVALENTLY BOUND IMIPENEM
Descriptor:beta-lactamase (E.C.3.5.2.6)
Authors:Beadle, B.M., Shoichet, B.K.
Deposit date:2002-04-26
Release date:2002-11-27
Modification date:2011-08-31
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural Basis for Imipenem Inhibition of Class C beta-lactamases
ANTIMICROB.AGENTS CHEMOTHER., 46, 2002
1LL9
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CRYSTAL STRUCTURE OF AMPC BETA-LACTAMASE FROM E. COLI IN COMPLEX WITH AMOXICILLIN
Descriptor:beta-lactamase (E.C.3.5.2.6)
Authors:Trehan, I., Morandi, F., Blaszczak, L.C., Shoichet, B.K.
Deposit date:2002-04-26
Release date:2002-10-02
Modification date:2012-03-28
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:Using steric hindrance to design new inhibitors of class C beta-lactamases.
Chem.Biol., 9, 2002
1LLB
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CRYSTAL STRUCTURE OF AMPC BETA-LACTAMASE FROM E. COLI IN COMPLEX WITH ATMO-PENICILLIN
Descriptor:beta-lactamase (E.C.3.5.2.6)
Authors:Trehan, I., Morandi, F., Blaszczak, L.C., Shoichet, B.K.
Deposit date:2002-04-26
Release date:2002-10-02
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (1.72 Å)
Cite:Using steric hindrance to design new inhibitors of class C beta-lactamases.
Chem.Biol., 9, 2002
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