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1SMY
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BU of 1smy by Molmil
Structural basis for transcription regulation by alarmone ppGpp
Descriptor: DNA-directed RNA polymerase alpha chain, DNA-directed RNA polymerase beta chain, DNA-directed RNA polymerase beta' chain, ...
Authors:Artsimovitch, I, Patlan, V, Sekine, S, Vassylyeva, M.N, Hosaka, T, Ochi, K, Yokoyama, S, Vassylyev, D.G, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2004-03-10
Release date:2004-05-18
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural basis for transcription regulation by alarmone ppGpp
Cell(Cambridge,Mass.), 117, 2004
4Q4Z
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BU of 4q4z by Molmil
Thermus thermophilus RNA polymerase de novo transcription initiation complex
Descriptor: 5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]methyl}phosphoryl]cytidine, ADENOSINE-5'-TRIPHOSPHATE, DNA (25-MER), ...
Authors:Murakami, K.S.
Deposit date:2014-04-15
Release date:2014-07-30
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural basis of transcription initiation by bacterial RNA polymerase holoenzyme.
J.Biol.Chem., 289, 2014
8U3B
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BU of 8u3b by Molmil
Cryo-EM structure of E. coli NarL-transcription activation complex at 3.2A
Descriptor: DNA (69-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ...
Authors:Liu, B, Kompaniiets, D, Wang, D.
Deposit date:2023-09-07
Release date:2024-01-17
Last modified:2024-02-21
Method:ELECTRON MICROSCOPY (3.23 Å)
Cite:Structural basis for transcription activation by the nitrate-responsive regulator NarL.
Nucleic Acids Res., 52, 2024
6JNX
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BU of 6jnx by Molmil
Cryo-EM structure of a Q-engaged arrested complex
Descriptor: Antiterminator Q protein, DNA (63-MER), DNA-directed RNA polymerase subunit alpha, ...
Authors:Feng, Y, Shi, J.
Deposit date:2019-03-18
Release date:2019-06-12
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (4.08 Å)
Cite:Structural basis of Q-dependent transcription antitermination.
Nat Commun, 10, 2019
1SIG
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BU of 1sig by Molmil
CRYSTAL STRUCTURE OF A SIGMA70 SUBUNIT FRAGMENT FROM ESCHERICHIA COLI RNA POLYMERASE
Descriptor: RNA POLYMERASE PRIMARY SIGMA FACTOR
Authors:Malhotra, A, Severinova, E, Darst, S.A.
Deposit date:1997-02-18
Release date:1997-05-15
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structure of a sigma 70 subunit fragment from E. coli RNA polymerase.
Cell(Cambridge,Mass.), 87, 1996
7ZF2
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BU of 7zf2 by Molmil
Protomeric substructure from an octameric assembly of M. tuberculosis RNA polymerase in complex with sigma-b initiation factor
Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Trapani, S, Bron, P, Lai Kee Him, J, Brodolin, K, Morichaud, Z, Vishwakarma, R.
Deposit date:2022-03-31
Release date:2023-02-08
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (3.86 Å)
Cite:Structural basis of the mycobacterial stress-response RNA polymerase auto-inhibition via oligomerization.
Nat Commun, 14, 2023
8AD1
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BU of 8ad1 by Molmil
RNA polymerase at U-rich pause bound to RNA putL triple mutant - pause prone, closed clamp state
Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Dey, S, Weixlbaumer, A.
Deposit date:2022-07-07
Release date:2022-10-19
Last modified:2022-11-02
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Structural insights into RNA-mediated transcription regulation in bacteria.
Mol.Cell, 82, 2022
3DXJ
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BU of 3dxj by Molmil
Crystal structure of thermus thermophilus rna polymerase holoenzyme in complex with the antibiotic myxopyronin
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, BACTERIAL RNA POLYMERASE BETA SUBUNIT; CHAIN C, M, ...
Authors:Das, K, Arnold, E.
Deposit date:2008-07-24
Release date:2008-10-14
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (3 Å)
Cite:The RNA polymerase "switch region" is a target for inhibitors.
Cell(Cambridge,Mass.), 135, 2008
3EQL
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BU of 3eql by Molmil
Crystal structure of the T. Thermophilus RNA polymerase holoenzyme in complex with antibiotic myxopyronin
Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Vassylyev, D.G, Vassylyeva, M.N, Artsimovitch, I.
Deposit date:2008-09-30
Release date:2008-10-28
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Transcription inactivation through local refolding of the RNA polymerase structure.
Nature, 457, 2009
8DY7
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BU of 8dy7 by Molmil
Streptomyces venezuelae RNAP transcription open promoter complex with WhiA and WhiB transcription factors
Descriptor: DNA (71-MER), DNA (78-MER), DNA-directed RNA polymerase subunit alpha, ...
Authors:Lilic, M, Campbell, E.A.
Deposit date:2022-08-03
Release date:2023-03-01
Last modified:2023-03-22
Method:ELECTRON MICROSCOPY (3.18 Å)
Cite:Structural basis of dual activation of cell division by the actinobacterial transcription factors WhiA and WhiB.
Proc.Natl.Acad.Sci.USA, 120, 2023
8DY9
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BU of 8dy9 by Molmil
Streptomyces venezuelae RNAP unconstrained open promoter complex with WhiA and WhiB transcription factors
Descriptor: DNA (38-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ...
Authors:Lilic, M, Campbell, E.A.
Deposit date:2022-08-03
Release date:2023-03-01
Last modified:2023-03-22
Method:ELECTRON MICROSCOPY (3.12 Å)
Cite:Structural basis of dual activation of cell division by the actinobacterial transcription factors WhiA and WhiB.
Proc.Natl.Acad.Sci.USA, 120, 2023
7RDQ
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BU of 7rdq by Molmil
Cryo-EM structure of Thermus thermophilus reiterative transcription complex with 11nt oligo-G RNA
Descriptor: DNA (31-MER) nontemplate strand, DNA (31-MER) template strand, DNA-directed RNA polymerase subunit alpha, ...
Authors:Liu, Y, Ebright, R.H.
Deposit date:2021-07-10
Release date:2022-02-02
Last modified:2022-02-09
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structural and mechanistic basis of reiterative transcription initiation.
Proc.Natl.Acad.Sci.USA, 119, 2022
8FTD
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BU of 8ftd by Molmil
Structure of Escherichia coli CedA in complex with transcription initiation complex
Descriptor: CHAPSO, Cell division activator CedA, DNA-directed RNA polymerase subunit alpha, ...
Authors:Liu, M, Vassyliev, N, Nudler, E.
Deposit date:2023-01-11
Release date:2024-01-10
Last modified:2024-01-31
Method:ELECTRON MICROSCOPY (2.76 Å)
Cite:General transcription factor from Escherichia coli with a distinct mechanism of action.
Nat.Struct.Mol.Biol., 31, 2024
7SZK
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BU of 7szk by Molmil
Cryo-EM structure of 27a bound to E. coli RNAP and rrnBP1 promoter complex
Descriptor: (2S,7R,7aR,13aP,16Z,18E,20S,21S,22R,23R,24R,25S,26R,27S,28E)-5,21,23-trihydroxy-27-methoxy-2,4,16,20,22,24,26-heptamethyl-10-[4-(2-methylpropyl)piperazin-1-yl]-12-({4-[(morpholin-4-yl)methyl]phenyl}methoxy)-1,6,15-trioxo-1,2,7,7a-tetrahydro-6H-2,7-(epoxypentadeca[1,11,13]trienoimino)[1]benzofuro[4,5-a]phenoxazin-25-yl acetate, DNA (5'-D(P*CP*TP*CP*GP*TP*AP*GP*AP*GP*TP*CP*CP*GP*TP*GP*TP*CP*A)-3'), DNA-directed RNA polymerase subunit alpha, ...
Authors:Shin, Y, Murakami, K.S.
Deposit date:2021-11-28
Release date:2022-07-13
Last modified:2024-02-28
Method:ELECTRON MICROSCOPY (2.94 Å)
Cite:Optimization of Benzoxazinorifamycins to Improve Mycobacterium tuberculosis RNA Polymerase Inhibition and Treatment of Tuberculosis.
Acs Infect Dis., 8, 2022
7SZJ
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BU of 7szj by Molmil
Cryo-EM structure of Rifamycin bound to E. coli RNAP and rrnBP1 promoter complex
Descriptor: DNA (49-MER), DNA (57-MER), DNA-directed RNA polymerase subunit alpha, ...
Authors:Shin, Y, Murakami, K.S.
Deposit date:2021-11-28
Release date:2022-07-13
Last modified:2024-02-28
Method:ELECTRON MICROSCOPY (3.11 Å)
Cite:Optimization of Benzoxazinorifamycins to Improve Mycobacterium tuberculosis RNA Polymerase Inhibition and Treatment of Tuberculosis.
Acs Infect Dis., 8, 2022
3UGP
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BU of 3ugp by Molmil
Crystal structure of RNA-polymerase sigma subunit domain 2 complexed with -10 promoter element ssDNA oligo (TATAAT)
Descriptor: 5'-D(*TP*GP*TP*AP*TP*AP*AP*TP*GP*GP*G)-3', POTASSIUM ION, RNA polymerase sigma factor
Authors:Feklistov, A, Darst, S.A.
Deposit date:2011-11-02
Release date:2011-12-07
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.697 Å)
Cite:Structural basis for promoter-10 element recognition by the bacterial RNA polymerase sigma subunit.
Cell(Cambridge,Mass.), 147, 2011
3UGO
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BU of 3ugo by Molmil
Crystal structure of RNA-polymerase sigma subunit domain 2 complexed with -10 promoter element ssDNA oligo (TACAAT)
Descriptor: 5'-D(*TP*GP*TP*AP*CP*AP*AP*TP*GP*GP*G)-3', POTASSIUM ION, RNA polymerase sigma factor
Authors:Feklistov, A, Darst, S.A.
Deposit date:2011-11-02
Release date:2011-12-07
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.096 Å)
Cite:Structural basis for promoter-10 element recognition by the bacterial RNA polymerase sigma subunit.
Cell(Cambridge,Mass.), 147, 2011
3LEV
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BU of 3lev by Molmil
HIV-1 antibody 2F5 in complex with epitope scaffold ES2
Descriptor: 2F5 ANTIBODY HEAVY CHAIN, 2F5 ANTIBODY LIGHT CHAIN, ADENOSINE-5'-TRIPHOSPHATE, ...
Authors:Ofek, G, Guenaga, F.J, Schief, W.R, Skinner, J, Baker, D, Wyatt, R, Kwong, P.D.
Deposit date:2010-01-15
Release date:2010-09-29
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Elicitation of structure-specific antibodies by epitope scaffolds.
Proc.Natl.Acad.Sci.USA, 107, 2010
3LES
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BU of 3les by Molmil
2F5 Epitope scaffold ES2
Descriptor: RNA polymerase sigma factor, SULFATE ION
Authors:Ofek, G, Guenaga, F.J, Schief, W.R, Skinner, J, Wyatt, R, Baker, D, Kwong, P.D.
Deposit date:2010-01-15
Release date:2010-09-29
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.77 Å)
Cite:Elicitation of structure-specific antibodies by epitope scaffolds.
Proc.Natl.Acad.Sci.USA, 107, 2010
3WOD
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BU of 3wod by Molmil
RNA polymerase-gp39 complex
Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Tagami, S, Sekine, S, Minakhin, L, Esyunina, D, Akasaka, R, Shirouzu, M, Kulbachinskiy, A, Severinov, K, Yokoyama, S.
Deposit date:2013-12-26
Release date:2014-03-12
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:Structural basis for promoter specificity switching of RNA polymerase by a phage factor.
Genes Dev., 28, 2014
7P5X
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BU of 7p5x by Molmil
Mycobacterial RNAP with transcriptional activator PafBC
Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Mueller, A.U, Kummer, E, Schilling, C.M, Ban, N, Weber-Ban, E.
Deposit date:2021-07-15
Release date:2021-12-22
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Transcriptional control of mycobacterial DNA damage response by sigma adaptation.
Sci Adv, 7, 2021
1IW7
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BU of 1iw7 by Molmil
Crystal structure of the RNA polymerase holoenzyme from Thermus thermophilus at 2.6A resolution
Descriptor: LEAD (II) ION, MAGNESIUM ION, RNA polymerase alpha subunit, ...
Authors:RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2002-04-22
Release date:2002-06-26
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structure of a bacterial RNA polymerase holoenzyme at 2.6 A resolution
NATURE, 417, 2002
7PP4
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BU of 7pp4 by Molmil
Cryo-EM structure of Mycobacterium tuberculosis RNA polymerase holoenzyme comprising sigma factor SigB
Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Brodolin, K.
Deposit date:2021-09-13
Release date:2022-09-21
Method:ELECTRON MICROSCOPY (3.84 Å)
Cite:Structural basis of the mycobacterial stress-response RNA polymerase auto-inhibition via oligomerization
Biorxiv, 2022
7Q59
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BU of 7q59 by Molmil
Cryo-EM structure of Mycobacterium tuberculosis RNA polymerase holoenzyme dimer comprising sigma factor SigB
Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Brodolin, K.
Deposit date:2021-11-03
Release date:2022-11-16
Last modified:2023-02-08
Method:ELECTRON MICROSCOPY (4.36 Å)
Cite:Structural basis of the mycobacterial stress-response RNA polymerase auto-inhibition via oligomerization
Nat Commun, 14, 2023
7Q4U
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BU of 7q4u by Molmil
Cryo-EM structure of Mycobacterium tuberculosis RNA polymerase holoenzyme octamer comprising sigma factor SigB
Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Brodolin, K.
Deposit date:2021-11-02
Release date:2022-11-16
Last modified:2023-02-08
Method:ELECTRON MICROSCOPY (4.39 Å)
Cite:Structural basis of the mycobacterial stress-response RNA polymerase auto-inhibition via oligomerization
Nat Commun, 14, 2023

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