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1HGU
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1hgu
HUMAN GROWTH HORMONE
Descriptor:HUMAN GROWTH HORMONE
Authors:Chantalat, L., Jones, N., Korber, F., Navaza, J., Pavlovsky, A.G.
Deposit date:1995-05-11
Release date:1995-12-07
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:THE CRYSTAL-STRUCTURE OF WILD-TYPE GROWTH-HORMONE AT 2.5 ANGSTROM RESOLUTION.
Protein Pept.Lett., 2, 1995
1HUW
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1huw
THE CRYSTAL STRUCTURE OF AFFINITY-MATURED HUMAN GROWTH HORMONE AT 2 ANGSTROMS RESOLUTION
Descriptor:HUMAN GROWTH HORMONE MUTANT WITH PHE 10 REPLACED BY ALA, MET 14 REPLACED BY TRP, HIS 18 REPLACED BY ASP, HIS 21 REPLACED BY ASN, LYS 41 REPLACED BY ILE, TYR 42 REPLACED BY HIS, LEU 45 REPLACED BY TRP, GLN 46 REPLACED BY TRP, PHE 54 REPLACED BY PRO, ARG 64 REPLACED BY LYS, ARG 167 REPLACED ASN, ASP 171 REPLACED BY SER, GLU 174 REPLACED BY SER, PHE 176 REPLACED BY TYR, ILE 179 REPLACED BY THR (F10A, M14W,H18D,H21N,K41I,Y42H,L45W,Q46W,F54P,R64K,R167N,D171S, E174S,F176Y,I179T)
Authors:Ultsch, M.H., Somers, W.S., Kossiakoff, A.A., De Vos, A.M.
Deposit date:1993-09-22
Release date:1994-01-31
Modification date:2009-11-03
Method:X-RAY DIFFRACTION (2 Å)
Cite:The crystal structure of affinity-matured human growth hormone at 2 A resolution.
J.Mol.Biol., 236, 1994
1RW5
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1rw5
SOLUTION STRUCTURE OF HUMAN PROLACTIN
Descriptor:prolactin
Authors:Teilum, K., Hoch, J., Martial, J.A., Kragelund, B.B.
Deposit date:2003-12-16
Release date:2005-02-22
Modification date:2009-02-24
Method:SOLUTION NMR
Cite:Solution structure of human prolactin
J.Mol.Biol., 351, 2005
1Z7C
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1z7c
CRYSTAL STRUCTURE OF HUMAN PLACENTAL LACTOGEN
Descriptor:Chorionic somatomammotropin hormone
Authors:Walsh, S.T.R., Kossiakoff, A.A.
Deposit date:2005-03-24
Release date:2006-03-07
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal Structure and Site 1 Binding Energetics of Human Placental Lactogen.
J.Mol.Biol., 358, 2006
2Q98
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2q98
X-RAY STRUCTURE OF A PROLACTIN ANTAGONIST
Descriptor:Prolactin
Authors:Broutin, I.J.L., Ducruix, A., Jomain, J.B., Goffin, V.
Deposit date:2007-06-12
Release date:2007-09-11
Modification date:2010-05-19
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural and thermodynamic bases for the design of pure prolactin receptor antagonists: X-ray structure of Del1-9-G129R-hPRL.
J.Biol.Chem., 282, 2007
1A22
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1a22
HUMAN GROWTH HORMONE BOUND TO SINGLE RECEPTOR
Descriptor:GROWTH HORMONE, GROWTH HORMONE RECEPTOR
Authors:De Vos, A.M., Ultsch, M.
Deposit date:1998-01-15
Release date:1998-04-29
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural and functional analysis of the 1:1 growth hormone:receptor complex reveals the molecular basis for receptor affinity.
J.Mol.Biol., 277, 1998
1AXI
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1axi
STRUCTURAL PLASTICITY AT THE HGH:HGHBP INTERFACE
Descriptor:GROWTH HORMONE, GROWTH HORMONE RECEPTOR
Authors:Atwell, S., Ultsch, M., De Vos, A.M., Wells, J.A.
Deposit date:1997-10-15
Release date:1998-01-28
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural plasticity in a remodeled protein-protein interface.
Science, 278, 1997
1BP3
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1bp3
THE XRAY STRUCTURE OF A GROWTH HORMONE-PROLACTIN RECEPTOR COMPLEX
Descriptor:PROTEIN (GROWTH HORMONE) MUTANT (G120R)
Authors:Somers, W., Ultsch, M., De Vos, A.M., Kossiakoff, A.A.
Deposit date:1998-08-12
Release date:1998-08-19
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:The X-ray structure of a growth hormone-prolactin receptor complex.
Nature, 372, 1994
1F6F
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1f6f
CRYSTAL STRUCTURE OF THE TERNARY COMPLEX BETWEEN OVINE PLACENTAL LACTOGEN AND THE EXTRACELLULAR DOMAIN OF THE RAT PROLACTIN RECEPTOR
Descriptor:PLACENTAL LACTOGEN/PROLACTIN RECEPTOR
Authors:Elkins, P.A., Christinger, H.W., Sandowski, Y., Sakal, E., Gertler, A., De Vos, A.M., Kossiakoff, A.A.
Deposit date:2000-06-21
Release date:2000-07-04
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Ternary complex between placental lactogen and the extracellular domain of the prolactin receptor.
Nat.Struct.Biol., 7, 2000
1HWG
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1hwg
1:2 COMPLEX OF HUMAN GROWTH HORMONE WITH ITS SOLUBLE BINDING PROTEIN
Descriptor:GROWTH HORMONE, GROWTH HORMONE BINDING PROTEIN
Authors:Sundstrom, S.M., Lundqvist, T.
Deposit date:1996-11-13
Release date:1997-11-19
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of an antagonist mutant of human growth hormone, G120R, in complex with its receptor at 2.9 A resolution.
J.Biol.Chem., 271, 1996
1HWH
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1hwh
1:1 COMPLEX OF HUMAN GROWTH HORMONE MUTANT G120R WITH ITS SOLUBLE BINDING PROTEIN
Descriptor:GROWTH HORMONE, GROWTH HORMONE BINDING PROTEIN
Authors:Sundstrom, S.M., Lundqvist, T.
Deposit date:1996-11-13
Release date:1997-11-19
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal structure of an antagonist mutant of human growth hormone, G120R, in complex with its receptor at 2.9 A resolution.
J.Biol.Chem., 271, 1996
1KF9
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1kf9
PHAGE DISPLAY DERIVED VARIANT OF HUMAN GROWTH HORMONE COMPLEXED WITH TWO COPIES OF THE EXTRACELLULAR DOMAIN OF ITS RECEPTOR
Descriptor:PHAGE DISPLAY DERIVED VARIANT HUMAN GROWTH HORMONE, EXTRACELLULAR DOMAIN HUMAN GROWTH HORMONE RECEPTOR (1-238)
Authors:Schiffer, C.A., Ultsch, M., Walsh, S., Somers, W., De Vos, A.M., Kossiakoff, A.A.
Deposit date:2001-11-19
Release date:2002-11-20
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure of a Phage Display Derived Variant of Human Growth Hormone Complexed to Two Copies of the Extracellular Domain of its Receptor: Evidence for Strong Structural Coupling between Receptor Binding Sites
J.Mol.Biol., 316, 2002
3D48
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3d48
CRYSTAL STRUCTURE OF A PROLACTIN RECEPTOR ANTAGONIST BOUND TO THE EXTRACELLULAR DOMAIN OF THE PROLACTIN RECEPTOR
Descriptor:Prolactin, Prolactin receptor
Authors:Svensson, L.A., Breinholt, J.
Deposit date:2008-05-14
Release date:2008-06-03
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of a prolactin receptor antagonist bound to the extracellular domain of the prolactin receptor
J.Biol.Chem., 283, 2008
3EW3
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3ew3
THE 1:2 COMPLEX BETWEEN A NTERMINAL ELONGATED PROLACTIN AND THE EXTRA CELLULAR DOMAIN OF THE RAT PROLACTIN RECEPTOR
Descriptor:Prolactin, Prolactin receptor
Authors:Broutin, I., Jomain, J.B., England, P., Goffin, V.
Deposit date:2008-10-14
Release date:2009-11-03
Modification date:2010-04-28
Method:X-RAY DIFFRACTION (3.8 Å)
Cite:Crystal structure of an affinity-matured prolactin complexed to its dimerized receptor reveals the topology of hormone binding site 2.
J.Biol.Chem., 285, 2010
3HHR
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3hhr
HUMAN GROWTH HORMONE AND EXTRACELLULAR DOMAIN OF ITS RECEPTOR: CRYSTAL STRUCTURE OF THE COMPLEX
Descriptor:HUMAN GROWTH HORMONE COMPLEXED WITH ITS RECEPTOR (EXTRACELLULAR DOMAIN)
Authors:De Vos, A.M., Ultsch, M., Kossiakoff, A.A.
Deposit date:1993-12-30
Release date:1994-04-30
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Human growth hormone and extracellular domain of its receptor: crystal structure of the complex.
Science, 255, 1992
3MZG
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3mzg
CRYSTAL STRUCTURE OF A HUMAN PROLACTIN RECEPTOR ANTAGONIST IN COMPLEX WITH THE EXTRACELLULAR DOMAIN OF THE HUMAN PROLACTIN RECEPTOR
Descriptor:Prolactin, Prolactin receptor
Authors:Kulkarni, M.V., Tettamanzi, M.C., Murphy, J.W., Keeler, C., Myszka, D.G., Chayen, N.E., Lolis, E.J., Hodsdon, M.E.
Deposit date:2010-05-12
Release date:2010-09-29
Modification date:2010-12-15
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Two Independent Histidines, One in Human Prolactin and One in Its Receptor, Are Critical for pH-dependent Receptor Recognition and Activation.
J.Biol.Chem., 285, 2010
3N06
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3n06
A MUTANT HUMAN PROLACTIN RECEPTOR ANTAGONIST H27A IN COMPLEX WITH THE EXTRACELLULAR DOMAIN OF THE HUMAN PROLACTIN RECEPTOR
Descriptor:Structural analysis of human Prolactin receptor antagonist in complex with the extracellular domain of the human prolactin receptor
Authors:Kulkarni, M.V., Tettamanzi, M.C., Murphy, J.W., Keeler, C., Myszka, D.G., Chayen, N.E., Lolis, E.J., Hodsdon, M.E.
Deposit date:2010-05-13
Release date:2010-09-29
Modification date:2010-12-15
Method:X-RAY DIFFRACTION (2 Å)
Cite:Two Independent Histidines, One in Human Prolactin and One in Its Receptor, Are Critical for pH-dependent Receptor Recognition and Activation.
J.Biol.Chem., 285, 2010
3N0P
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3n0p
A MUTANT HUMAN PROLACTIN RECEPTOR ANTAGONIST H30A IN COMPLEX WITH THE EXTRACELLULAR DOMAIN OF THE HUMAN PROLACTIN RECEPTOR
Descriptor:A mutant human Prolactin receptor antagonist H30A in complex with the extracellular domain of the human prolactin receptor
Authors:Kulkarni, M.V., Tettamanzi, M.C., Murphy, J.W., Keeler, C., Myszka, D.G., Chayen, N.E., Lolis, E.J., Hodsdon, M.E.
Deposit date:2010-05-14
Release date:2010-09-29
Modification date:2010-12-15
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Two Independent Histidines, One in Human Prolactin and One in Its Receptor, Are Critical for pH-dependent Receptor Recognition and Activation.
J.Biol.Chem., 285, 2010
3NCB
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3ncb
A MUTANT HUMAN PROLACTIN RECEPTOR ANTAGONIST H180A IN COMPLEX WITH THE EXTRACELLULAR DOMAIN OF THE HUMAN PROLACTIN RECEPTOR
Descriptor:A mutant human Prolactin receptor antagonist H27A in complex with the extracellular domain of the human prolactin receptor
Authors:Kulkarni, M.V., Tettamanzi, M.C., Murphy, J.W., Keeler, C., Myszka, D.G., Chayen, N.E., Lolis, E.J., Hodsdon, M.E.
Deposit date:2010-06-04
Release date:2010-09-29
Modification date:2010-12-15
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Two Independent Histidines, One in Human Prolactin and One in Its Receptor, Are Critical for pH-dependent Receptor Recognition and Activation.
J.Biol.Chem., 285, 2010
3NCC
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3ncc
A HUMAN PROLACTIN RECEPTOR ANTAGONIST IN COMPLEX WITH THE MUTANT EXTRACELLULAR DOMAIN H188A OF THE HUMAN PROLACTIN RECEPTOR
Descriptor:Prolactin, Prolactin receptor
Authors:Kulkarni, M.V., Tettamanzi, M.C., Murphy, J.W., Keeler, C., Myszka, D.G., Chayen, N.E., Lolis, E.J., Hodsdon, M.E.
Deposit date:2010-06-04
Release date:2010-09-29
Modification date:2010-12-15
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Two Independent Histidines, One in Human Prolactin and One in Its Receptor, Are Critical for pH-dependent Receptor Recognition and Activation.
J.Biol.Chem., 285, 2010
3NCE
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3nce
A MUTANT HUMAN PROLACTIN RECEPTOR ANTAGONIST H27A IN COMPLEX WITH THE MUTANT EXTRACELLULAR DOMAIN H188A OF THE HUMAN PROLACTIN RECEPTOR
Descriptor:A mutant human Prolactin receptor antagonist H27A in complex with the extracellular domain of the human prolactin receptor
Authors:Kulkarni, M.V., Tettamanzi, M.C., Murphy, J.W., Keeler, C., Myszka, D.G., Chayen, N.E., Lolis, E.J., Hodsdon, M.E.
Deposit date:2010-06-04
Release date:2010-09-29
Modification date:2010-12-15
Method:X-RAY DIFFRACTION (2 Å)
Cite:Two Independent Histidines, One in Human Prolactin and One in Its Receptor, Are Critical for pH-dependent Receptor Recognition and Activation.
J.Biol.Chem., 285, 2010
3NCF
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3ncf
A MUTANT HUMAN PROLACTIN RECEPTOR ANTAGONIST H30A IN COMPLEX WITH THE MUTANT EXTRACELLULAR DOMAIN H188A OF THE HUMAN PROLACTIN RECEPTOR
Descriptor:Prolactin, Prolactin receptor
Authors:Kulkarni, M.V., Tettamanzi, M.C., Murphy, J.W., Keeler, C., Myszka, D.G., Chayen, N.E., Lolis, E.J., Hodsdon, M.E.
Deposit date:2010-06-04
Release date:2010-09-29
Modification date:2010-12-15
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Two Independent Histidines, One in Human Prolactin and One in Its Receptor, Are Critical for pH-dependent Receptor Recognition and Activation.
J.Biol.Chem., 285, 2010
3NPZ
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3npz
PROLACTIN RECEPTOR (PRLR) COMPLEXED WITH THE NATURAL HORMONE (PRL)
Descriptor:Prolactin, Prlr protein
Authors:Van Agthoven, J., England, P., Goffin, V., Broutin, I.
Deposit date:2010-06-29
Release date:2010-10-06
Modification date:2011-03-30
Method:X-RAY DIFFRACTION (3.35 Å)
Cite:Structural characterization of the stem-stem dimerization interface between prolactin receptor chains complexed with the natural hormone.
J.Mol.Biol., 404, 2010
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