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1A5Y
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1a5y
PROTEIN TYROSINE PHOSPHATASE 1B CYSTEINYL-PHOSPHATE INTERMEDIATE
Descriptor:PROTEIN TYROSINE PHOSPHATASE 1B
Authors:Pannifer, A.D.P., Flint, A.J., Tonks, N.K., Barford, D.
Deposit date:1998-02-19
Release date:1998-06-17
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Visualization of the cysteinyl-phosphate intermediate of a protein-tyrosine phosphatase by x-ray crystallography.
J.Biol.Chem., 273, 1998
1AAX
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1aax
CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH TWO BIS(PARA-PHOSPHOPHENYL)METHANE (BPPM) MOLECULES
Descriptor:PROTEIN TYROSINE PHOSPHATASE 1B, 4-PHOSPHONOOXY-PHENYL-METHYL-[4-PHOSPHONOOXY]BENZEN
Authors:Puius, Y.A., Zhao, Y., Sullivan, M., Lawrence, D., Almo, S.C., Zhang, Z.-Y.
Deposit date:1997-01-16
Release date:1998-03-04
Modification date:2012-07-18
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Identification of a second aryl phosphate-binding site in protein-tyrosine phosphatase 1B: a paradigm for inhibitor design.
Proc.Natl.Acad.Sci.USA, 94, 1997
1BZC
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1bzc
HUMAN PTP1B CATALYTIC DOMAIN COMPLEXED WITH TPI
Descriptor:PROTEIN (PROTEIN-TYROSINE-PHOSPHATASE) (3.1.3.48)
Authors:Groves, M.R., Yao, Z.J., Jr Burke, T.R., Barford, D.
Deposit date:1998-10-27
Release date:1999-02-16
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Structural basis for inhibition of the protein tyrosine phosphatase 1B by phosphotyrosine peptide mimetics.
Biochemistry, 37, 1998
1EEN
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1een
CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH ACETYL-D-A-D-BPA-PTYR-L-I-P-Q-Q-G
Descriptor:PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH ACETYL-D-A- D-BPA-PTYR-L-I-P-Q-Q-G
Authors:Puius, Y.A., Zhao, Y., Almo, S.C., Zhang, Z.Y.
Deposit date:2000-02-01
Release date:2001-02-01
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural basis of plasticity in protein tyrosine phosphatase 1B substrate recognition.
Biochemistry, 39, 2000
1EEO
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1eeo
CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH ACETYL-E-L-E-F-PTYR-M-D-Y-E-NH2
Descriptor:PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH ACETYL-E-L- E-F-PTYR-M-D-Y-E-NH2
Authors:Sarmiento, M., Puius, Y.A., Vetter, S.W., Lawrence, D.S., Almo, S.C., Zhang, Z.Y.
Deposit date:2000-02-01
Release date:2001-02-01
Modification date:2012-07-18
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural basis of plasticity in protein tyrosine phosphatase 1B substrate recognition.
Biochemistry, 39, 2000
1FPR
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1fpr
CRYSTAL STRUCTURE OF THE COMPLEX FORMED BETWEEN THE CATALYTIC DOMAIN OF SHP-1 AND AN IN VITRO PEPTIDE SUBSTRATE PY469 DERIVED FROM SHPS-1.
Descriptor:PROTEIN-TYROSINE PHOSPHATASE 1C (E.C.3.1.3.48)
Authors:Yang, J., Cheng, Z., Niu, Z., Zhao, Z.J., Zhou, G.W.
Deposit date:2000-08-31
Release date:2001-03-07
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural basis for substrate specificity of protein-tyrosine phosphatase SHP-1.
J.Biol.Chem., 275, 2000
1G1F
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1g1f
CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH A TRI-PHOSPHORYLATED PEPTIDE (RDI(PTR)ETD(PTR)(PTR)RK) FROM THE INSULIN RECEPTOR KINASE
Descriptor:PROTEIN TYROSINE PHOSPHATASE 1B (E.C.3.1.3.48), INSULIN RECEPTOR KINASE FRAGMENT
Authors:Salmeen, A., Andersen, J.N., Myers, M.P., Tonks, N.K., Barford, D.
Deposit date:2000-10-11
Release date:2001-01-17
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Molecular basis for the dephosphorylation of the activation segment of the insulin receptor by protein tyrosine phosphatase 1B.
Mol.Cell, 6, 2000
1G1G
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1g1g
CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH A MONO-PHOSPHORYLATED PEPTIDE (ETDY(PTR)RKGGKGLL) FROM THE INSULIN RECEPTOR KINASE
Descriptor:PROTEIN TYROSINE PHOSPHATASE 1B (E.C.3.1.3.48), INSULIN RECEPTOR KINASE FRAGMENT
Authors:Salmeen, A., Andersen, J.N., Myers, M.P., Tonks, N.K., Barford, D.
Deposit date:2000-10-11
Release date:2001-01-17
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Molecular basis for the dephosphorylation of the activation segment of the insulin receptor by protein tyrosine phosphatase 1B.
Mol.Cell, 6, 2000
1G1H
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1g1h
CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH A BIS-PHOSPHORYLATED PEPTIDE (ETD(PTR)(PTR)RKGGKGLL) FROM THE INSULIN RECEPTOR KINASE
Descriptor:PROTEIN TYROSINE PHOSPHATASE 1B (E.C.3.1.3.48), INSULIN RECEPTOR KINASE FRAGMENT
Authors:Salmeen, A., Andersen, J.N., Myers, M.P., Tonks, N.K., Barford, D.
Deposit date:2000-10-11
Release date:2001-01-17
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Molecular basis for the dephosphorylation of the activation segment of the insulin receptor by protein tyrosine phosphatase 1B.
Mol.Cell, 6, 2000
1I57
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1i57
CRYSTAL STRUCTURE OF APO HUMAN PTP1B (C215S) MUTANT
Descriptor:PHOSPHO-TYROSINE PHOSPHATASE 1B (E.C.3.1.3.48)
Authors:Scapin, G., Patel, S., Patel, V., Kennedy, B., Asante-Appiah, E.
Deposit date:2001-02-26
Release date:2001-08-08
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The structure of apo protein-tyrosine phosphatase 1B C215S mutant: more than just an S --> O change.
Protein Sci., 10, 2001
1JLN
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1jln
CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF PROTEIN TYROSINE PHOSPHATASE PTP-SL/BR7
Descriptor:Protein Tyrosine Phosphatase (E.C.3.1.3.48)
Authors:Szedlacsek, S.E., Aricescu, A.R., Fulga, T.A., Renault, L., Scheidig, A.J.
Deposit date:2001-07-16
Release date:2001-08-17
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (1.81 Å)
Cite:Crystal structure of PTP-SL/PTPBR7 catalytic domain: implications for MAP kinase regulation.
J.Mol.Biol., 311, 2001
1L8G
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1l8g
CRYSTAL STRUCTURE OF PTP1B COMPLEXED WITH 7-(1,1-DIOXO-1H-BENZO[D]ISOTHIAZOL-3-YLOXYMETHYL)-2-(OXALYL-AMINO)-4,7-DIHYDRO-5H-THIENO[2,3-C]PYRAN-3-CARBOXYLIC ACID
Descriptor:PROTEIN-TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 1 (E.C.3.1.3.48)
Authors:Iversen, L.F., Andersen, H.S., Moller, K.B., Olsen, O.H., Peters, G.H., Branner, S., Mortensen, S.B., Hansen, T.K., Lau, J., Ge, Y., Holsworth, D.D., Newman, M.J., Moller, N.P.H.
Deposit date:2002-03-20
Release date:2002-05-08
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Steric hindrance as a basis for structure-based design of selective inhibitors of protein-tyrosine phosphatases.
Biochemistry, 40, 2001
1L8K
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1l8k
T CELL PROTEIN-TYROSINE PHOSPHATASE STRUCTURE
Descriptor:T-cell protein-tyrosine phosphatase (E.C.3.1.3.48)
Authors:Iversen, L.F.
Deposit date:2002-03-21
Release date:2002-05-08
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.56 Å)
Cite:Structure determination of T cell protein-tyrosine phosphatase.
J.Biol.Chem., 277, 2002
1LAR
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1lar
CRYSTAL STRUCTURE OF THE TANDEM PHOSPHATASE DOMAINS OF RPTP LAR
Descriptor:LAR
Authors:Nam, H.-J., Poy, F., Krueger, N., Saito, H., Frederick, C.A.
Deposit date:1999-04-20
Release date:2000-04-25
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of the tandem phosphatase domains of RPTP LAR.
Cell(Cambridge,Mass.), 97, 1999
1LYV
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1lyv
HIGH-RESOLUTION STRUCTURE OF THE CATALYTICALLY INACTIVE YERSINIA TYROSINE PHOSPHATASE C403A MUTANT IN COMPLEX WITH PHOSPHATE.
Descriptor:PROTEIN-TYROSINE PHOSPHATASE YOPH (E.C.3.1.3.48)
Authors:Evdokimov, A.G., Waugh, D.S., Routzahn, K., Tropea, J., Cherry, S.
Deposit date:2002-06-08
Release date:2002-07-03
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (1.363 Å)
Cite:High-resolution structure of the catalytically inactive yersinia tyrosine phosphatase C403A mutant in complex with phosphate.
To be Published
1NL9
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1nl9
POTENT, SELECTIVE PROTEIN TYROSINE PHOSPHATASE 1B INHIBITOR COMPOUND 12 USING A LINKED-FRAGMENT STRATEGY
Descriptor:Protein-tyrosine phosphatase, non-receptor type 1 (E.C.3.1.3.48)
Authors:Szczepankiewicz, B.G., Liu, G., Hajduk, P.J., Abad-Zapatero, C., Pei, Z., Xin, Z., Lubben, T., Trevillyan, J.M., Stashko, M.A., Ballaron, S.J., Liang, H., Huang, F., Hutchins, C.W., Fesik, S.W., Jirousek, M.R.
Deposit date:2003-01-06
Release date:2003-04-08
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Discovery of a Potent, Selective Protein Tyrosine Phosphatase 1B Inhibitor Using a Linked-Fragment Strategy
J.Am.Chem.Soc., 125, 2003
1NNY
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1nny
POTENT, SELECTIVE PROTEIN TYROSINE PHOSPHATASE 1B INHIBITOR COMPOUND 23 USING A LINKED-FRAGMENT STRATEGY
Descriptor:Protein-tyrosine phosphatase, non-receptor type 1 (E.C.3.1.3.48)
Authors:Szczepankiewicz, B.G., Liu, G., Hajduk, P.J., Abad-Zapatero, C., Pei, Z., Xin, Z., Lubben, T., Trevillyan, J.M., Stashko, M.A., Ballaron, S.J., Liang, H., Huang, F., Hutchins, C.W., Fesik, S.W., Jirousek, M.R.
Deposit date:2003-01-14
Release date:2003-04-08
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Discovery of a Potent, Selective Protein Tyrosine Phosphatase 1B Inhibitor Using a Linked-Fragment Strategy
J.Am.Chem.Soc., 125, 2003
1NO6
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1no6
POTENT, SELECTIVE PROTEIN TYROSINE PHOSPHATASE 1B INHIBITOR COMPOUND 5 USING A LINKED-FRAGMENT STRATEGY
Descriptor:Protein-tyrosine phosphatase, non-receptor type 1 (E.C.3.1.3.48)
Authors:Szczepankiewicz, B.G., Liu, G., Hajduk, P.J., Abad-Zapatero, C., Pei, Z., Xin, Z., Lubben, T., Trevillyan, J.M., Stashko, M.A., Ballaron, S.J., Liang, H., Huang, F., Hutchins, C.W., Fesik, S.W., Jirousek, M.R.
Deposit date:2003-01-15
Release date:2003-04-08
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Discovery of a Potent, Selective Protein Tyrosine Phosphatase 1B Inhibitor Using a Linked-Fragment Strategy
J.Am.Chem.Soc., 125, 2003
1NZ7
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1nz7
POTENT, SELECTIVE INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE 1B USING A SECOND PHOSPHOTYROSINE BINDING SITE, COMPLEXED WITH COMPOUND 19.
Descriptor:Protein-tyrosine phosphatase, non-receptor type 1 (E.C.3.1.3.48)
Authors:Xin, Z., Oost, T.K., Abad-Zapatero, C., Hajduk, P.J., Pei, Z., Szczepankiewicz, B.G., Hutchins, C.W., Ballaron, S.J., Stashko, M.A., Lubben, T., Trevillyan, J.M., Jirousek, M.R., Liu, G.
Deposit date:2003-02-16
Release date:2003-05-20
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Potent, Selective Inhibitors of Protein Tyrosine Phosphatase 1B
BIOORG.MED.CHEM.LETT., 13, 2003
1OEM
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1oem
PTP1B WITH THE CATALYTIC CYSTEINE OXIDIZED TO A SULFENYL-AMIDE BOND
Descriptor:PROTEIN-TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 1 (E.C.3.1.3.48)
Authors:Salmeen, A., Andersen, J.N., Myers, M.P., Meng, T.C., Hinks, J.A., Tonks, N.K., Barford, D.
Deposit date:2003-03-28
Release date:2003-06-12
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Redox Regulation of Protein Tyrosine Phosphatase Involves a Sulfenyl-Amide Intermediate
Nature, 423, 2003
1OEO
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1oeo
PTP1B WITH THE CATALYTIC CYSTEINE OXIDIZED TO SULFONIC ACID
Descriptor:PROTEIN-TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 1 (E.C.3.1.3.48)
Authors:Salmeen, A., Andersen, J.N., Myers, M.P., Meng, T.C., Hinks, J.A., Tonks, N.K., Barford, D.
Deposit date:2003-03-28
Release date:2003-06-12
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Redox Regulation of Protein Tyrosine Phosphatase Involves a Sulfenyl-Amide Intermediate
Nature, 423, 2003
1OES
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1oes
OXIDATION STATE OF PROTEIN TYROSINE PHOSPHATASE 1B
Descriptor:PROTEIN-TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 1 (E.C.3.1.3.48)
Authors:Van Montfort, R.L.M., Congreve, M., Tisi, D., Carr, R., Jhoti, H.
Deposit date:2003-03-31
Release date:2003-06-12
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Oxidation State of the Active-Site Cysteine in Protein Tyrosine Phosphatase 1B
Nature, 423, 2003
1OET
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1oet
OXIDATION STATE OF PROTEIN TYROSINE PHOSPHATASE 1B
Descriptor:-TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 1 (E.C.3.1.3.48)
Authors:Van Montfort, R.L.M., Congreve, M., Tisi, D., Carr, R., Jhoti, H.
Deposit date:2003-03-31
Release date:2003-06-12
Modification date:2010-02-02
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Oxidation State of the Active-Site Cysteine in Protein Tyrosine Phosphatase 1B
Nature, 423, 2003
1OEU
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1oeu
OXIDATION STATE OF PROTEIN TYROSINE PHOSPHATASE 1B
Descriptor:PROTEIN-TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 1 (E.C.3.1.3.48)
Authors:Van Montfort, R.L.M., Congreve, M., Tisi, D., Carr, R., Jhoti, H.
Deposit date:2003-03-31
Release date:2003-06-12
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Oxidation State of the Active-Site Cysteine in Protein Tyrosine Phosphatase 1B
Nature, 423, 2003
1OEV
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1oev
OXIDATION STATE OF PROTEIN TYROSINE PHOSPHATASE 1B
Descriptor:PROTEIN-TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 1 (E.C.3.1.3.48)
Authors:Van Montfort, R.L.M., Congreve, M., Tisi, D., Carr, R., Jhoti, H.
Deposit date:2003-03-31
Release date:2003-06-12
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Oxidation State of the Active-Site Cysteine in Protein Tyrosine Phosphatase 1B
Nature, 423, 2003
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