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1A5Y
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1a5y
PROTEIN TYROSINE PHOSPHATASE 1B CYSTEINYL-PHOSPHATE INTERMEDIATE
Descriptor:PROTEIN TYROSINE PHOSPHATASE 1B
Authors:Pannifer, A.D.P., Flint, A.J., Tonks, N.K., Barford, D.
Deposit date:1998-02-19
Release date:1998-06-17
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Visualization of the cysteinyl-phosphate intermediate of a protein-tyrosine phosphatase by x-ray crystallography.
J.Biol.Chem., 273, 1998
1AAX
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1aax
CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH TWO BIS(PARA-PHOSPHOPHENYL)METHANE (BPPM) MOLECULES
Descriptor:PROTEIN TYROSINE PHOSPHATASE 1B, 4-PHOSPHONOOXY-PHENYL-METHYL-[4-PHOSPHONOOXY]BENZEN
Authors:Puius, Y.A., Zhao, Y., Sullivan, M., Lawrence, D., Almo, S.C., Zhang, Z.-Y.
Deposit date:1997-01-16
Release date:1998-03-04
Modification date:2012-07-18
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Identification of a second aryl phosphate-binding site in protein-tyrosine phosphatase 1B: a paradigm for inhibitor design.
Proc.Natl.Acad.Sci.USA, 94, 1997
1BZC
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1bzc
HUMAN PTP1B CATALYTIC DOMAIN COMPLEXED WITH TPI
Descriptor:PROTEIN (PROTEIN-TYROSINE-PHOSPHATASE) (3.1.3.48)
Authors:Groves, M.R., Yao, Z.J., Jr Burke, T.R., Barford, D.
Deposit date:1998-10-27
Release date:1999-02-16
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Structural basis for inhibition of the protein tyrosine phosphatase 1B by phosphotyrosine peptide mimetics.
Biochemistry, 37, 1998
1BZH
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1bzh
CYCLIC PEPTIDE INHIBITOR OF HUMAN PTP1B
Descriptor:PROTEIN (PROTEIN-TYROSINE-PHOSPHATASE) (3.1.3.48)
Authors:Groves, M.R., Yao, Z.J., Burke Jr., T.R., Barford, D.
Deposit date:1998-10-28
Release date:1999-02-16
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural basis for inhibition of the protein tyrosine phosphatase 1B by phosphotyrosine peptide mimetics.
Biochemistry, 37, 1998
1BZJ
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1bzj
HUMAN PTP1B COMPLEXED WITH TPICOOH
Descriptor:PROTEIN (PROTEIN-TYROSINE-PHOSPHATASE) (3.1.3.48)
Authors:Groves, M.R., Yao, Z.-J., Barford Jr., D.T.B.
Deposit date:1998-10-29
Release date:1999-02-16
Modification date:2010-03-02
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structural basis for inhibition of the protein tyrosine phosphatase 1B by phosphotyrosine peptide mimetics.
Biochemistry, 37, 1998
1C83
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1c83
CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH 6-(OXALYL-AMINO)-1H-INDOLE-5-CARBOXYLIC ACID
Descriptor:PROTEIN-TYROSINE PHOSPHATASE 1B (E.C.3.1.3.48)
Authors:Andersen, H.S., Iversen, L.F., Branner, S., Rasmussen, H.B., Moller, N.P.
Deposit date:2000-04-14
Release date:2000-05-03
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:2-(oxalylamino)-benzoic acid is a general, competitive inhibitor of protein-tyrosine phosphatases.
J.Biol.Chem., 275, 2000
1C84
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1c84
CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH 3-(OXALYL-AMINO)-NAPHTHALENE-2-CARBOXLIC ACID
Descriptor:PROTEIN-TYROSINE PHOSPHATASE 1B (E.C.3.1.3.48)
Authors:Andersen, H.S., Iversen, L.F., Branner, S., Rasmussen, H.B., Moller, N.P.
Deposit date:2000-04-14
Release date:2000-05-03
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:2-(oxalylamino)-benzoic acid is a general, competitive inhibitor of protein-tyrosine phosphatases.
J.Biol.Chem., 275, 2000
1C85
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1c85
CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH 2-(OXALYL-AMINO)-BENZOIC ACID
Descriptor:PROTEIN-TYROSINE PHOSPHATASE 1B (E.C.3.1.3.48)
Authors:Andersen, H.S., Iversen, L.F., Branner, S., Rasmussen, H.B., Moller, N.P.
Deposit date:2000-04-16
Release date:2000-05-03
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.72 Å)
Cite:2-(oxalylamino)-benzoic acid is a general, competitive inhibitor of protein-tyrosine phosphatases.
J.Biol.Chem., 275, 2000
1C86
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1c86
CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B (R47V,D48N) COMPLEXED WITH 2-(OXALYL-AMINO-4,7-DIHYDRO-5H-THIENO[2,3-C]PYRAN-3-CARBOXYLIC ACID
Descriptor:PROTEIN-TYROSINE PHOSPHATASE 1B (E.C.3.1.3.48)
Authors:Iversen, L.F., Andersen, H.S., Mortensen, S.B., Moller, N.P.
Deposit date:2000-04-16
Release date:2000-05-03
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure-based design of a low molecular weight, nonphosphorus, nonpeptide, and highly selective inhibitor of protein-tyrosine phosphatase 1B.
J.Biol.Chem., 275, 2000
1C87
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1c87
CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH 2-(OXALYL-AMINO-4,7-DIHYDRO-5H-THIENO[2,3-C]PYRAN-3-CARBOXYLIC ACID
Descriptor:PROTEIN-TYROSINE PHOSPHATASE 1B (E.C.3.1.3.48)
Authors:Iversen, L.F., Andersen, H.S., Mortensen, S.B., Moller, N.P.
Deposit date:2000-04-16
Release date:2000-05-03
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure-based design of a low molecular weight, nonphosphorus, nonpeptide, and highly selective inhibitor of protein-tyrosine phosphatase 1B.
J.Biol.Chem., 275, 2000
1C88
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1c88
CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH 2-(OXALYL-AMINO)-4,5,6,7-TETRAHYDRO-THIENO[2,3-C]PYRIDINE-3-CARBOXYLIC ACID
Descriptor:PROTEIN-TYROSINE PHOSPHATASE 1B (E.C.3.1.3.48)
Authors:Iversen, L.F., Andersen, H.S., Mortensen, S.B., Moller, N.P.
Deposit date:2000-04-16
Release date:2000-05-03
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure-based design of a low molecular weight, nonphosphorus, nonpeptide, and highly selective inhibitor of protein-tyrosine phosphatase 1B.
J.Biol.Chem., 275, 2000
1ECV
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1ecv
CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH 5-IODO-2-(OXALYL-AMINO)-BENZOIC ACID
Descriptor:PROTEIN-TYROSINE PHOSPHATASE 1B (E.C.3.1.3.48)
Authors:Andersen, H.S., Iversen, L.F., Branner, S., Rasmussen, H.B., Moller, N.P.H.
Deposit date:2000-01-26
Release date:2000-03-15
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:2-(oxalylamino)-benzoic acid is a general, competitive inhibitor of protein-tyrosine phosphatases.
J.Biol.Chem., 275, 2000
1EEN
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1een
CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH ACETYL-D-A-D-BPA-PTYR-L-I-P-Q-Q-G
Descriptor:PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH ACETYL-D-A- D-BPA-PTYR-L-I-P-Q-Q-G
Authors:Puius, Y.A., Zhao, Y., Almo, S.C., Zhang, Z.Y.
Deposit date:2000-02-01
Release date:2001-02-01
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural basis of plasticity in protein tyrosine phosphatase 1B substrate recognition.
Biochemistry, 39, 2000
1EEO
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1eeo
CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH ACETYL-E-L-E-F-PTYR-M-D-Y-E-NH2
Descriptor:PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH ACETYL-E-L- E-F-PTYR-M-D-Y-E-NH2
Authors:Sarmiento, M., Puius, Y.A., Vetter, S.W., Lawrence, D.S., Almo, S.C., Zhang, Z.Y.
Deposit date:2000-02-01
Release date:2001-02-01
Modification date:2012-07-18
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural basis of plasticity in protein tyrosine phosphatase 1B substrate recognition.
Biochemistry, 39, 2000
1FPR
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1fpr
CRYSTAL STRUCTURE OF THE COMPLEX FORMED BETWEEN THE CATALYTIC DOMAIN OF SHP-1 AND AN IN VITRO PEPTIDE SUBSTRATE PY469 DERIVED FROM SHPS-1.
Descriptor:PROTEIN-TYROSINE PHOSPHATASE 1C (E.C.3.1.3.48)
Authors:Yang, J., Cheng, Z., Niu, Z., Zhao, Z.J., Zhou, G.W.
Deposit date:2000-08-31
Release date:2001-03-07
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural basis for substrate specificity of protein-tyrosine phosphatase SHP-1.
J.Biol.Chem., 275, 2000
1G1F
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1g1f
CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH A TRI-PHOSPHORYLATED PEPTIDE (RDI(PTR)ETD(PTR)(PTR)RK) FROM THE INSULIN RECEPTOR KINASE
Descriptor:PROTEIN TYROSINE PHOSPHATASE 1B (E.C.3.1.3.48), INSULIN RECEPTOR KINASE FRAGMENT
Authors:Salmeen, A., Andersen, J.N., Myers, M.P., Tonks, N.K., Barford, D.
Deposit date:2000-10-11
Release date:2001-01-17
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Molecular basis for the dephosphorylation of the activation segment of the insulin receptor by protein tyrosine phosphatase 1B.
Mol.Cell, 6, 2000
1G1G
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1g1g
CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH A MONO-PHOSPHORYLATED PEPTIDE (ETDY(PTR)RKGGKGLL) FROM THE INSULIN RECEPTOR KINASE
Descriptor:PROTEIN TYROSINE PHOSPHATASE 1B (E.C.3.1.3.48), INSULIN RECEPTOR KINASE FRAGMENT
Authors:Salmeen, A., Andersen, J.N., Myers, M.P., Tonks, N.K., Barford, D.
Deposit date:2000-10-11
Release date:2001-01-17
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Molecular basis for the dephosphorylation of the activation segment of the insulin receptor by protein tyrosine phosphatase 1B.
Mol.Cell, 6, 2000
1G1H
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1g1h
CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH A BIS-PHOSPHORYLATED PEPTIDE (ETD(PTR)(PTR)RKGGKGLL) FROM THE INSULIN RECEPTOR KINASE
Descriptor:PROTEIN TYROSINE PHOSPHATASE 1B (E.C.3.1.3.48), INSULIN RECEPTOR KINASE FRAGMENT
Authors:Salmeen, A., Andersen, J.N., Myers, M.P., Tonks, N.K., Barford, D.
Deposit date:2000-10-11
Release date:2001-01-17
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Molecular basis for the dephosphorylation of the activation segment of the insulin receptor by protein tyrosine phosphatase 1B.
Mol.Cell, 6, 2000
1G7F
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1g7f
HUMAN PTP1B CATALYTIC DOMAIN COMPLEXED WITH PNU177496
Descriptor:PROTEIN-TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 1 (E.C.3.1.3.48)
Authors:Bleasdale, J.E., Ogg, D., Larsen, S.D.
Deposit date:2000-11-10
Release date:2001-06-06
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Small molecule peptidomimetics containing a novel phosphotyrosine bioisostere inhibit protein tyrosine phosphatase 1B and augment insulin action.
Biochemistry, 40, 2001
1G7G
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1g7g
HUMAN PTP1B CATALYTIC DOMAIN COMPLEXES WITH PNU179326
Descriptor:PROTEIN-TYROSINE PHOSPHOTASE, NON RECEPTOR TYPE 1 (E.C.3.1.3.48)
Authors:Bleasdale, J.E., Ogg, D., Larsen, S.D.
Deposit date:2000-11-10
Release date:2001-06-06
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Small molecule peptidomimetics containing a novel phosphotyrosine bioisostere inhibit protein tyrosine phosphatase 1B and augment insulin action.
Biochemistry, 40, 2001
1GFY
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1gfy
RESIDUE 259 IS A KEY DETERMINANT OF SUBSTRATE SPECIFICITY OF PROTEIN-TYROSINE PHOSPHATASE 1B AND ALPHA
Descriptor:PROTEIN-TYROSINE PHOSPHATASE 1B (E.C.3.1.3.48)
Authors:Iversen, L.F.
Deposit date:2000-06-26
Release date:2000-07-04
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.13 Å)
Cite:Residue 259 is a key determinant of substrate specificity of protein-tyrosine phosphatases 1B and alpha.
J.Biol.Chem., 275, 2000
1GWZ
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1gwz
CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF THE PROTEIN TYROSINE PHOSPHATASE SHP-1
Descriptor:SHP-1
Authors:Yang, J., Liang, X., Niu, T., Meng, W., Zhao, Z., Zhou, G.W.
Deposit date:1998-08-22
Release date:1999-08-22
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of the catalytic domain of protein-tyrosine phosphatase SHP-1.
J.Biol.Chem., 273, 1998
1I57
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1i57
CRYSTAL STRUCTURE OF APO HUMAN PTP1B (C215S) MUTANT
Descriptor:PHOSPHO-TYROSINE PHOSPHATASE 1B (E.C.3.1.3.48)
Authors:Scapin, G., Patel, S., Patel, V., Kennedy, B., Asante-Appiah, E.
Deposit date:2001-02-26
Release date:2001-08-08
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The structure of apo protein-tyrosine phosphatase 1B C215S mutant: more than just an S --> O change.
Protein Sci., 10, 2001
1JF7
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1jf7
HUMAN PTP1B CATALYTIC DOMAIN COMPLEXED WITH PNU177836
Descriptor:PROTEIN-TYROSINE PHOSPHATASE 1B (E.C.3.1.3.48)
Authors:Larsen, S.D., Barf, T., Liljebris, C., May, P.D., Ogg, D., O'Sullivan, T.J., Palazuk, B.J., Schostarez, H.J., Stevens, F.C., Bleasdale, J.E.
Deposit date:2001-06-20
Release date:2002-02-13
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Synthesis and biological activity of a novel class of small molecular weight peptidomimetic competitive inhibitors of protein tyrosine phosphatase 1B.
J.Med.Chem., 45, 2002
1JLN
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1jln
CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF PROTEIN TYROSINE PHOSPHATASE PTP-SL/BR7
Descriptor:Protein Tyrosine Phosphatase (E.C.3.1.3.48)
Authors:Szedlacsek, S.E., Aricescu, A.R., Fulga, T.A., Renault, L., Scheidig, A.J.
Deposit date:2001-07-16
Release date:2001-08-17
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (1.81 Å)
Cite:Crystal structure of PTP-SL/PTPBR7 catalytic domain: implications for MAP kinase regulation.
J.Mol.Biol., 311, 2001
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